Acute initial haemodynamic changes in a rat isoprenaline model of cardiotoxicity.

abstract：:This study was designed to evaluate the hepato and neuroprotective activity of Daflon and low-dose γ radiation on thioacetamide (TAA)-induced liver damage and hepatic encephalopathy (HE) in rats. Effect of daily Daflon treatment (100 mg/kg body weight, Per OS (p.o.) for consecutive 3 days) and/or fractionated low-dose...

journal_title：Human & experimental toxicology

authors： Abdel-Rafei M,Amin MM,Hasan HF

更新日期：2017-01-01 00:00:00

abstract：:The aim of the present study was to investigate whether cognitive behavioral impairment, induced by nicotine in offspring rats, was associated with the alteration of hippocampal short-term potentiation (STP) and long-term potentiation (LTP) and to discuss the potential underlying mechanism. Young adult offspring rats ...

journal_title：Human & experimental toxicology

authors： Han G,An L,Yang B,Si L,Zhang T

更新日期：2014-02-01 00:00:00

abstract：:A sound understanding of the mechanisms determining percutaneous absorption is necessary for toxicological risk assessment of chemicals contacting the skin. As part of a programme investigating these mechanisms we have developed a physiologically based mathematical model. The structure of the model parallels the multi...

journal_title：Human & experimental toxicology

authors： Auton TR,Westhead DR,Woollen BH,Scott RC,Wilks MF

更新日期：1994-01-01 00:00:00

abstract：:Gamma-hydroxybutyrate (GHB) is a compound used in the treatment of alcohol withdrawal, narcolepsy, and for induction of anaesthesia. It is also contained in many products illegally marketed as "dietary supplements" and is increasingly being recognised as a potential drug of abuse. We report the case of a 44-year-old m...

journal_title：Human & experimental toxicology

authors： Dupont P,Thornton J

更新日期：2001-01-01 00:00:00

abstract：:The present study was undertaken to investigate the effects of maternal lead (Pb) exposure on the expression of interleukin (IL) 1β, IL 6, and glial fibrillary acidic protein (GFAP) in hippocampus of mice offspring. Pb exposure initiated from the beginning of gestation to weaning. Lead acetate (PbAc) administered in d...

journal_title：Human & experimental toxicology

authors： Li N,Liu X,Zhang P,Qiao M,Li H,Li X,Zhang H,Yu Z

更新日期：2015-04-01 00:00:00

abstract：:1. A modified mouse liver slice culture technique was established and the viability of the system was assessed on the basis of leakage of cytosolic enzymes viz. lactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartic aminotransferase (AST) and slice histology. 2. This system w...

journal_title：Human & experimental toxicology

authors： Bhattacharya R,Rao PV,Bhaskar AS,Pant SC,Dube SN

更新日期：1996-02-01 00:00:00

abstract：:The serial cognitive assessment of ten individuals made between 8 and 26 months after the water at Camelford in Cornwall was accidentally contaminated with aluminium sulphate, showed consistent evidence of impairment of information processing and memory. There was no obvious relationship between these impairments and ...

journal_title：Human & experimental toxicology

authors： McMillan TM,Freemont AJ,Herxheimer A,Denton J,Taylor AP,Pazianas M,Cummin AR,Eastwood JB

更新日期：1993-01-01 00:00:00

abstract：:The aim of this study was to determine the safety of azelaic acid (AA) and its derivatives in nanovesicles for pharmaceutical and cosmetic uses. The hydrophilic property of AA was modified by complexing AA with hydroxypropyl-beta-cyclodextrin (AACD). The lipophilic property of AA was improved to diethyl azelate (DA) b...

journal_title：Human & experimental toxicology

authors： Panyosak A,Manosroi J,Rojanasakul Y,Manosroi A

更新日期：2009-06-01 00:00:00

abstract：:Alcohol levels were measured in 15 cerebrospinal fluid (CSF) samples and 14 blood samples from grade III and IV male alcoholic patients with signs of nervous system involvement, and compared with levels detected in 11 CSF samples and 11 blood samples from abstemious patients or patients with grade I or II alcoholism w...

journal_title：Human & experimental toxicology

authors： Agapejev S,Vassilieff I,Curi PR

更新日期：1992-05-01 00:00:00

abstract：:Experimental studies have shown that prenatal exposure to lead (Pb) produces morphological changes related to extracellular matrix remodelling. To analyse whether the matrix metalloproteinases (MMPs), particularly MMP-2, MMP-9, and the tissue inhibitor of metalloproteinases-2 (TIMP-2), are associated with morphologica...

journal_title：Human & experimental toxicology

authors： González-Puebla E,González-Horta C,Infante-Ramírez R,Sanin LH,Levario-Carrillo M,Sánchez-Ramírez B

更新日期：2012-07-01 00:00:00

abstract：:Clobenpropit, an H( 3) receptor antagonist, has been reported to modulate both the release of neurotransmitters and also the activity of histidine decarboxylase (HDC). Therefore, a decarboxylase-positive modulator, namely pyridoxine, was taken for interaction studies with clobenpropit in the electroshock (ES) model of...

journal_title：Human & experimental toxicology

authors： Uma Devi P,Manocha A,Khanam R,Vohora D

更新日期：2011-01-01 00:00:00

abstract：:Coronary heart disease and in particular its most serious form - acute myocardial infarction (AMI) - represents the most common cause of mortality in developed countries. Better prognosis may be achieved by understanding the etiopathogenetic mechanisms of AMI. Therefore, a catecholamine model of myocardial injury, whi...

journal_title：Human & experimental toxicology

authors： Mladenka P,Hrdina R,Bobrovová Z,Semecky V,Vávrová J,Holecková M,Palicka V,Mazurová Y,Nachtigal P

更新日期：2009-10-01 00:00:00

abstract：:1 The urinary recovery of metabolites of aspirin (ASA) was studied in 45 volunteers who took a therapeutic dose (600 mg) of ASA by mouth and in 37 patients who took ASA in overdose. 2 The main metabolite recovered from the volunteers was the glycine conjugate, salicyluric acid (SUA), which accounted for 75.01 +/- 1.19...

journal_title：Human & experimental toxicology

authors： Patel DK,Hesse A,Ogunbona A,Notarianni LJ,Bennett PN

更新日期：1990-05-01 00:00:00

abstract：:Omeprazole is one of the most used acid-suppressing medications. This fact emphasizes the questions concerning the safety of this compound. Healthy volunteers (n=33) were included in this prospective study. All study subjects were analysed for their CYP2C19 genotype. Of the 33 individuals, 24 were homozygous for the w...

journal_title：Human & experimental toxicology

authors： Sinués B,Fanlo A,Bernal ML,Val M,Mayayo E

更新日期：2004-03-01 00:00:00

abstract：:Silver nanoparticles are used in many commercial products in daily life. Exposure to nanosilver has hepatotoxic effects in animals. This study investigated the cytotoxicity associated with polyvinylpyrrolidone-coated nanosilver (23.44 ± 4.92 nm in diameter) exposure in the human hepatoma cell line (HepG2) and normal h...

journal_title：Human & experimental toxicology

authors： Xue Y,Wang J,Huang Y,Gao X,Kong L,Zhang T,Tang M

更新日期：2018-12-01 00:00:00

abstract：:Kampo (Japanese traditional herbal) medicines have been produced by combining multiple crude drugs, almost all of plant origin but with some of animal or mineral origin, and contain a great many substances. Their effect is a combination of the various interactions of the constituent substances, whether they are enhanc...

journal_title：Human & experimental toxicology

authors： Ikegami F,Sumino M,Fujii Y,Akiba T,Satoh T

更新日期：2006-08-01 00:00:00

abstract：:We describe two cases of chemical necrotizing fasciitis in the upper extremities, anterior chest wall and epigastric region of the abdominal wall caused by household insecticide injection. We suggest that surgical debridement can be successfully performed in the subacute period under close observation in hemodynamical...

journal_title：Human & experimental toxicology

authors： Terzi C,Bacakoğlu A,Unek T,Ozkan MH

更新日期：2002-12-01 00:00:00

abstract：:Accidental ingestion of electrical batteries occurs commonly in children. This rarely is associated with severe morbidity and mortality. Significant symptoms can arise due to leakage of alkali or heavy metals from the battery after degradation in the gastrointestinal tract. The main heavy metal of concern in electrica...

journal_title：Human & experimental toxicology

authors： Mallon PT,White JS,Thompson RL

更新日期：2004-04-01 00:00:00

abstract：:A xenobiotic, well tolerated by the majority of treated patients, can cause serious complications in patients with individual susceptibility. Based on the hypothesis that such a phenomenon may occur in rare cases of rhabdomyolysis attributed to fenoverine (DCI), we designed a protocol to look for a genetic predisposit...

journal_title：Human & experimental toxicology

authors： Jouglard J,Kozak-Ribbens G,de Haro L,Cozzone PJ

更新日期：1996-10-01 00:00:00

abstract：INTRODUCTION:Poisoning from organophosphates and carbamates is a significant cause of morbidity and mortality worldwide. Concerns have been expressed over the safety and efficacy of the use of oximes such as pralidoxime (2-PAM) in patients with carbamate poisoning in general, and more so with carbaryl poisoning specifi...

journal_title：Human & experimental toxicology

authors： Mercurio-Zappala M,Hack JB,Salvador A,Hoffman RS

更新日期：2007-02-01 00:00:00

abstract：:Nickel nanoparticles (Ni-NPs) have been widely used in various industries related to electronics, ceramics, textiles, and nanomedicine. Ambient and occupational exposure to Ni-NPs may bring about potential detrimental effects on animals and humans. Thus, there is a growing effort to identify compounds that can amelior...

journal_title：Human & experimental toxicology

authors： Iqbal S,Jabeen F,Peng C,Ijaz MU,Chaudhry AS

更新日期：2020-11-01 00:00:00

abstract：:Dermal exposure is an important factor in risk characterization. In occupational settings it becomes relatively more important because of the continuous reduction in inhalation exposure. In the public health arena, dermal exposure may also form a significant contribution to the total exposure. Dermal exposure, however...

journal_title：Human & experimental toxicology

authors： Boogaard PJ

更新日期：2008-04-01 00:00:00

abstract：AIM:To assess the systemic inflammatory response (SIR) and the multi-organ damage after large-volume liver radiofrequency ablation (RFA) with or without concurrent Pringle maneuver. METHODS:Wistar rats were subjected to 30% liver RFA (group RFA), liver RFA under 30-min Pringle maneuver (group RFA + P), Pringle only (g...

journal_title：Human & experimental toxicology

authors： Ypsilantis P,Lambropoulou M,Anagnostopoulos C,Tsigalou C,Vasiliadis C,Kortsaris A,Papadopoulos N,Simopoulos C

更新日期：2011-11-01 00:00:00

abstract：:Pesticides are used in agriculture to protect crops from insects-pests. Most of the field workers of North Indian population are exposed to commonly used insecticides. In the present study, pesticides induced oxidative stress as well as alterations in the level of acetylcholinesterase (AChE) in a total of 70 male heal...

journal_title：Human & experimental toxicology

authors： Sharma RK,Upadhyay G,Siddiqi NJ,Sharma B

更新日期：2013-11-01 00:00:00

abstract：:1. Methylxanthines, ACTH and stress are well known to produce testicular pathology (e.g. seminiferous tubule atrophy). Methylxanthines, ACTH and stress alter hormone secretion, particularly from the pituitary-adrenocortical system. Consequently, it has recently been suggested that there may be a causal relationship be...

journal_title：Human & experimental toxicology

authors： Harvey PW,Er J,Fernandes C,Rush KC,Major IR,Cockburn A

更新日期：1992-11-01 00:00:00

abstract：:1. The methods used to evaluate the toxicological effects of PCBs in animals have been reviewed. 2. The data show that Toxic Equivalency Factors (TEFs) could be developed to assess the potential toxicity of PCB mixtures for certain specific target organ effects (such as the liver and immune system) but would be inappr...

journal_title：Human & experimental toxicology

authors： Battershill JM

更新日期：1994-09-01 00:00:00

abstract：:Puerarin, a potent free radicals scavenger, has been demonstrated to have protective efficacy in oxidative damage induced by nephrotoxins. In the present study, the attenuating effect of puerarin (PU) on lead (Pb)-induced apoptosis and oxidative stress was investigated in cultured primary rat proximal tubular (rPT) ce...

journal_title：Human & experimental toxicology

authors： Liu G,Li Z,Wang J,Wang H,Wang Z,Wang L

更新日期：2014-10-01 00:00:00

abstract：:A liquid alcoholic extract of Papaver somniferum named Elixir Paregorico is extensively used for diarrheal diseases in Brazil. Its increased popularity has brought concerns and fears over the safety of this herbal product. Given the lack of investigative clinical studies, in this regard, this study investigated whethe...

journal_title：Human & experimental toxicology

authors： de Moraes M,Bezerra M,Bezerra F,de Moraes R,Cavalcanti P,Uchoa C,Lima F,Odorico de Moraes M

更新日期：2008-10-01 00:00:00

abstract：:This study was designed to investigate the effect of agmatine sulfate (AG, CAS2482-00-0) in nicotine (NIC)-induced vascular endothelial dysfunction (VED) in rabbits. NIC was administered to produce VED in rabbits with or without AG for 6 weeks. Serum lipid profile, serum thiobarbituric acid reactive substances, reduce...

journal_title：Human & experimental toxicology

authors： Nader MA,Gamiel NM,El-Kashef H,Zaghloul MS

更新日期：2016-05-01 00:00:00

abstract：:Boophone disticha (B. disticha) has been used systemically in traditional medical practice in Zimbabwe and neighbouring countries for the management of various central nervous system conditions including hysteria. Abuse of the plant by teenagers in Zimbabwe for its claimed hallucinogenic effects has also been reported...

journal_title：Human & experimental toxicology

authors： Gadaga LL,Tagwireyi D,Dzangare J,Nhachi CF

更新日期：2011-08-01 00:00:00