Liver slice culture for assessing hepatotoxicity of freshwater cyanobacteria.

abstract：:Deregulated cancer cell metabolism plays an important role in cancer progression. Cancer cell metabolism has been in the centre of attention in therapeutical cancer cell targeting. Repurposed chemical agents, such as metformin and aspirin, have been studied extensively as preventive and therapeutic agents. Metformin i...

journal_title：Human & experimental toxicology

authors： Albayrak G,Konac E,Dikmen AU,Bilen CY

更新日期：2018-09-01 00:00:00

abstract：:The principal impediment to gene therapy is the development of efficient, nontoxic gene carriers that can handle and deliver foreign genetic materials into various cell types, including healthy and cancerous cells. Poly-l-lysine (PLL) polymers are one of the most favorable gene carriers among nonviral vectors, and PLL...

journal_title：Human & experimental toxicology

authors： Alinejad-Mofrad E,Malaekeh-Nikouei B,Gholami L,Mousavi SH,Sadeghnia HR,Mohajeri M,Darroudi M,Oskuee RK

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is the main clinical concern resulted from ischemia-reperfusion injury (IRI). Ample clinical data indicates that AKI is associated with distant organ dysfunctions and poor patients' outcomes. Oxidative stress and inflammation have a critical role in the pathogenesis of organ injurie...

journal_title：Human & experimental toxicology

authors： Bagheri Y,Aghajani S,Hosseinzadeh M,Hoshmandan F,Abdollahpour A,Vahed SZ

更新日期：2020-12-16 00:00:00

abstract：:Predictive toxicology plays a critical role in reducing the failure rate of new drugs in pharmaceutical research and development. Despite recent gains in our understanding of drug-induced toxicity, however, it is urgent that the utility and limitations of our current predictive tools be determined in order to identify...

journal_title：Human & experimental toxicology

authors： Naven RT,Louise-May S

更新日期：2015-12-01 00:00:00

abstract：:Stem cell transplantation has indicated great promise for cell therapy in a wide range of diseases, but poor and insufficient viability of cells within damaged tissues has limited its potential therapeutic effects. 17 β-Estradiol (E2) is a steroid hormone that plays an important role in expression of many genes and re...

journal_title：Human & experimental toxicology

authors： Mirzamohammadi S,Mehrabani M,Tekiyehmaroof N,Sharifi AM

更新日期：2016-03-01 00:00:00

abstract：:Mercury, a heavy metal, is widespread and persistent in the environment and has been elucidated as a possible risk factor in cardiovascular diseases. Mercury has been reported to selectively impair the nitric oxide (NO) pathway in the vascular endothelium as a consequence of oxidative stress. Conversely, mercury per s...

journal_title：Human & experimental toxicology

authors： Omanwar S,Saidullah B,Ravi K,Fahim M

更新日期：2014-09-01 00:00:00

abstract：:Enterococcus faecalis is a facultative anaerobic gram-positive commensal bacterium common in the gastrointestinal tract of animals and humans. This study aimed to investigate the protective effects of heat-killed E. faecalis EF-2001 (EF-2001) on acute gastric ulcer using a murine model of ethanol (EtOH)-induced acute ...

journal_title：Human & experimental toxicology

authors： Jeon DB,Shin HG,Lee BW,Jeong SH,Kim JH,Ha JH,Park JY,Kwon HJ,Kim WJ,Ryu YB,Lee IC

更新日期：2020-05-01 00:00:00

abstract：:The identification of biomarkers for toxicity prediction is crucial for drug development and safety evaluation. The selective and specific biomarkers for antihistamines-induced cardiotoxicity is not well identified yet. In order to evaluate the mechanism of the life-threatening effects caused by antihistamines, we use...

journal_title：Human & experimental toxicology

authors： Yun JS,Kim SY

更新日期：2015-08-01 00:00:00

abstract：:1. This study examines the effect of treating rats with gentamicin (80 mg kg-1 day-1 intramuscularly (i.m.), for 6 days) alone or with either L-thyroxine or the anti-thyroid drug carbimazole. 2. Gentamicin produced significant increases in serum creatinine and urea concentrations, and significantly reduced the activit...

journal_title：Human & experimental toxicology

authors： Ali BH,Bashir AA,Tanira MO

更新日期：1995-01-01 00:00:00

abstract：:The aim of the present investigation was to check the fluctuation in essential elements, such as Na, K, Mg, Mn, Cu, Zn, Cr and Ni in the brain, spinal cord, liver and kidney of mice during methylmercury chloride (MMC) toxication and therapy with monothiols (N-acetyl-DL-homocysteine thiolactone and glutathione) and vit...

journal_title：Human & experimental toxicology

authors： Bapu C,Purohit RC,Sood PP

更新日期：1994-12-01 00:00:00

abstract：:Tripartite motif-containing protein 24 (TRIM24) has currently emerged as a crucial cancer-related gene present in a wide range of human cancer types. However, the involvement of TRIM24 in acute myeloid leukemia (AML) has not been well investigated. The present study aims to investigate the significance, cellular funct...

journal_title：Human & experimental toxicology

authors： Li C,Xin H,Shi Y,Mu J

更新日期：2020-12-01 00:00:00

abstract：:Dimerized translationally controlled tumor protein (dTCTP) plays a role in allergic diseases. A 7-mer peptide, dimerized translationally binding protein 2 (dTBP2), binds to dTCTP and inhibits dTCTP, suggesting that the 7-mer peptide may have therapeutic potential. We assessed the safety of dTBP2 by examining its cytot...

journal_title：Human & experimental toxicology

authors： Kim M,Jin YB,Lee K,Lee YS

更新日期：2013-11-01 00:00:00

abstract：:Celecoxib has been shown to have antitumor effect in previous studies but the mechanisms are unclear. The effect of celecoxib on cytosolic Ca(2+) concentrations ([Ca(2+)]i) and viability in HA59T human hepatoma cells was explored. The Ca(2+)-sensitive fluorescent dye fura-2 was applied to measure [Ca(2+)]i. Celecoxib ...

journal_title：Human & experimental toxicology

authors： Cheng HH,Chou CT,Lu YC,Lu T,Chi CC,Tseng LL,Liu SI,Cheng JS,Kuo CC,Liang WZ,Jan CR

更新日期：2014-11-01 00:00:00

abstract：:Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenicity of many xenobiotics. In the present study, we investigated the possible induction of lipid peroxidation by aluminium in human foreskin fibroblast cultures by assayin...

journal_title：Human & experimental toxicology

authors： Anane R,Creppy EE

更新日期：2001-09-01 00:00:00

abstract：:In vivo antidotal efficacy of new bis- quaternary 2-(hydroxyimino)- N-(pyridin-3yl) acetamide derivatives (HNK series), to counter multiples of lethal doses of nerve agent sarin (GB) and reactivation of acetylcholinesterase (AChE), was evaluated in Swiss albino mice. [Protection index PI; median lethal dose (LD50) of ...

journal_title：Human & experimental toxicology

authors： Swami D,Karade HN,Acharya J,Kumar P

更新日期：2017-01-01 00:00:00

abstract：:Members of the transforming growth factor (TGF) family have emerged as critical contributors to the choreography of cellular and tissue interactions underlying morphogenesis of the orofacial region. The TGFs beta, and their downstream effector molecules, the Smads, play a pivotal role in normal as well as abnormal dev...

journal_title：Human & experimental toxicology

authors： Greene RM,Pisano MM

更新日期：2005-01-01 00:00:00

abstract：:Pyrazinamide (PYZ)-an essential component of primary drug regimen used for the treatment and management of multidrug resistant or latent tuberculosis-is well known for its hepatoxicity. However, the mechanism of PYZ-induced hepatotoxicity is still unknown to researchers. Studies have shown that the drug is metabolized...

journal_title：Human & experimental toxicology

authors： Rawat A,Chaturvedi S,Singh AK,Guleria A,Dubey D,Keshari AK,Raj V,Rai A,Prakash A,Kumar U,Kumar D,Saha S

更新日期：2018-04-01 00:00:00

abstract：:The current study was undertaken to evaluate the effect of combined therapy of gabapentin and pantoprazole against forestomach and pylorus ligation-induced gastric esophageal reflux disease (GERD) in albino Wistar rats. Rats were randomly divided into five groups, each group consisting of six rats, fasted for 24 h, un...

journal_title：Human & experimental toxicology

authors： Arya P,Kaithwas G

更新日期：2020-04-01 00:00:00

abstract：:A liquid alcoholic extract of Papaver somniferum named Elixir Paregorico is extensively used for diarrheal diseases in Brazil. Its increased popularity has brought concerns and fears over the safety of this herbal product. Given the lack of investigative clinical studies, in this regard, this study investigated whethe...

journal_title：Human & experimental toxicology

authors： de Moraes M,Bezerra M,Bezerra F,de Moraes R,Cavalcanti P,Uchoa C,Lima F,Odorico de Moraes M

更新日期：2008-10-01 00:00:00

abstract：:The renin-angiotensin system (RAS) subserves vital physiological functions and also implicated in certain pathological states. Modulation of this system has been proposed in recent studies to be a promising strategy in treating liver fibrosis. We investigated the effect of the pharmacologic inhibition of RAS with angi...

journal_title：Human & experimental toxicology

authors： Ekor M,Odewabi AO,Kale OE,Oritogun KS,Adesanoye OA,Bamidele TO

更新日期：2011-11-01 00:00:00

abstract：:This article explores the implications of hormesis on toxic tort litigation, in particular litigation regarding claims for medical monitoring or subclinical harm. In considering medical monitoring issues, courts have described medical monitoring both as a remedy and as an independent claim. If medical monitoring is up...

journal_title：Human & experimental toxicology

authors： Juni RL

更新日期：2008-02-01 00:00:00

abstract：:1. This study investigated whether the reactive organohalogen gases perfluoroisobutene (PFIB) and phosgene, which cause death by overwhelming pulmonary oedema, affect the surfactant system or type II pneumocytes of rat lung. 2. The progression and type of pulmonary injury in Porton Wistar-derived rats was monitored ov...

journal_title：Human & experimental toxicology

authors： Jugg B,Jenner J,Rice P

更新日期：1999-11-01 00:00:00

abstract：:The fixed-dose procedure (FDP) was introduced as OECD Test Guideline 420 in 1992, as an alternative to the conventional median lethal dose (LD50) test for the assessment of acute oral toxicity (OECD Test Guideline 401). The FDP uses fewer animals and causes less suffering than the conventional test, while providing in...

journal_title：Human & experimental toxicology

authors： Stalla N,Whitehead A,Ridgway P

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due ...

journal_title：Human & experimental toxicology

authors： Attaran D,Lari SM,Khajehdaluee M,Ayatollahi H,Towhidi M,Asnaashari A,Marallu HG,Mazloomi M,Mood MB

更新日期：2009-12-01 00:00:00

abstract：:Osteosarcoma is characterized by high malignancy and high metastasis rate, resulting in high mortality and disability. MiR-663a has been reported in a variety of tumors to promote tumorigenesis. However, miR-663a has not been reported in the pathogenesis of osteosarcoma. Bioinformatics analysis and experiments includi...

journal_title：Human & experimental toxicology

authors： Zhao S,Xiong W,Xu K

更新日期：2020-12-01 00:00:00

abstract：:Lead exposure was assessed in a random cohort of 70 male papier mâché workers and compared with 35 age and sex matched controls. Blood-lead levels in workers were significantly higher than in controls (Mean 68.07 +/- 44.64 ug/dl vs 25.52 +/- 16.56 ug/dl respectively; P < 0.001). Urinary lead was also higher in workers...

journal_title：Human & experimental toxicology

authors： Wahid A,Koul PA,Shah SU,Khan AR,Bhat MS,Malik MA

更新日期：1997-05-01 00:00:00

abstract：:A retrospective review of medical records was carried out to determine the pattern of drug and chemical poisoning cases admitted to a teaching hospital in Malaysia. Medical records of patients admitted during the period January 1987 to December 1995 were reviewed. They accounted for 0.2% of total admissions during the...

journal_title：Human & experimental toxicology

authors： Ab Rahman AF

更新日期：2002-07-01 00:00:00

abstract：:The aim of this study was to investigate the possible protective role of caffeic acid phenethyl ester on testicular toxicity of methotrexate in rats. Nineteen male rats were divided into three groups as follows: group I, control; group II, methotrexate-treated; group III, methotrexate + caffeic acid phenethyl ester-tr...

journal_title：Human & experimental toxicology

authors： Armagan A,Uzar E,Uz E,Yilmaz HR,Kutluhan S,Koyuncuoglu HR,Soyupek S,Cam H,Serel TA

更新日期：2008-07-01 00:00:00

abstract：CONTEXT:Cardiac dysfunction is one of the most serious consequences of scorpion envenomation. The best tool to evaluate cardiac function is echocardiography, but it is not available at all emergency departments. Many studies aimed to describe biological predictive factors of cardiac dysfunction in scorpion envenomation...

journal_title：Human & experimental toxicology

authors： Chakroun-Walha O,Karray R,Jerbi M,Ben Rebeh A,Jammeli C,Bahloul M,Ammar R,Chabchoub I,Bouaziz M,Nasri A,Rekik N

更新日期：2018-06-01 00:00:00

abstract：AIM:To assess the systemic inflammatory response (SIR) and the multi-organ damage after large-volume liver radiofrequency ablation (RFA) with or without concurrent Pringle maneuver. METHODS:Wistar rats were subjected to 30% liver RFA (group RFA), liver RFA under 30-min Pringle maneuver (group RFA + P), Pringle only (g...

journal_title：Human & experimental toxicology

authors： Ypsilantis P,Lambropoulou M,Anagnostopoulos C,Tsigalou C,Vasiliadis C,Kortsaris A,Papadopoulos N,Simopoulos C

更新日期：2011-11-01 00:00:00