Abstract:
:1. This study examines the effect of treating rats with gentamicin (80 mg kg-1 day-1 intramuscularly (i.m.), for 6 days) alone or with either L-thyroxine or the anti-thyroid drug carbimazole. 2. Gentamicin produced significant increases in serum creatinine and urea concentrations, and significantly reduced the activity of Na+,K+ATPase in renal cortex. The concentration of serum triiodothyronine (T3) was unaffected by graded doses (20, 40 and 80 mg kg-1) of the antibiotic. Histopathologically, gentamicin produced necrosis of proximal tubules in the renal cortical tissues of treated rats. 3. Treatment of rats with either L-thyroxine or carbimazole alone did not significantly affect any of the biochemical variables investigated. Carbimazole alone produced only mild tubular necrosis. 4. Treatment of rats with either L-thyroxine (100 micrograms kg-1 day-1, subcutaneously) for 10 days, and gentamicin (80 mg kg-1, i.m. daily during the last 6 days of treatment significantly reduced the gentamicin-induced increases in serum creatinine and urea concentrations, and increased the activity of cortical N+,K+ATPase to control levels. Histopathologically, the severity of gentamicin-induced tubular necrosis was reduced by L-thyroxine treatment. 5. Carbimazole (12 mg ml-1 in drinking water for 21 days) and gentamicin (80 mg kg-1 i.m.) daily during the last 6 days of treatment, stimulated the increase in serum urea concentration produced by gentamicin, but did not significantly affect the gentamicin-induced changes in serum creatinine or cortical N+,K+ATPase.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Ali BH,Bashir AA,Tanira MOdoi
10.1177/096032719501400103subject
Has Abstractpub_date
1995-01-01 00:00:00pages
13-7issue
1eissn
0960-3271issn
1477-0903journal_volume
14pub_type
杂志文章abstract::The effect of sympathomimetic intervention with dopamine or dobutamine on the myocardial uptake of d-propoxyphene was investigated experimentally in rats. The d-propoxyphene (19 mg kg-1 h-1) was continuously infused, intravenously, over 45 min. After 20 min of infusion the rats were given either dopamine (12.5 microgr...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719101000203
更新日期:1991-03-01 00:00:00
abstract::Mercury, a heavy metal, is widespread and persistent in the environment and has been elucidated as a possible risk factor in cardiovascular diseases. Mercury has been reported to selectively impair the nitric oxide (NO) pathway in the vascular endothelium as a consequence of oxidative stress. Conversely, mercury per s...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113512341
更新日期:2014-09-01 00:00:00
abstract::Chronic mercury exposure impairs vascular function, leading to the depression of endothelium-dependent vasodilatation. Loss of the nitric oxide (NO) pathway has been implicated, but little is known about effects on other endothelial mediators. This study investigated the mechanisms of endothelial dysfunction in rats s...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110391389
更新日期:2011-11-01 00:00:00
abstract::Paraquat (PQ) is a highly toxic herbicide that is used in most of the countries without restriction. The cytotoxic effect of PQ is mediated by radicals, which are the products of PQ reduction in cells. The anti-oxidative action of captopril, an angiotensin-converting enzyme inhibitor, appears to be through its ability...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107084533
更新日期:2007-10-01 00:00:00
abstract::Pharmacological potential of curcumin was assessed in PC12 cells against hydrogen peroxide (H(2) O(2)) exposure. In MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and lactate dehydrogenase (LDH) assays, 24-hour exposure of H(2)O(2) (0.5 mM and above) was found to be cytotoxic. A significant (p < 0...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110371696
更新日期:2011-03-01 00:00:00
abstract::Silver nanoparticles are used in many commercial products in daily life. Exposure to nanosilver has hepatotoxic effects in animals. This study investigated the cytotoxicity associated with polyvinylpyrrolidone-coated nanosilver (23.44 ± 4.92 nm in diameter) exposure in the human hepatoma cell line (HepG2) and normal h...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327118769718
更新日期:2018-12-01 00:00:00
abstract::Naringenin is a naturally occurring flavanones and has been found to exhibit free radical scavenging, enzyme inhibition, antioxidants, anti-inflammatory, and anticancer activities. Present study was designed to evaluate the protective role of naringenin against benzo[a]pyrene (B[a]P)-induced oxidative stress and pulmo...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116650009
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Oxidative stress is one of the major mechanisms of cyclophosphamide (CPX)-induced toxicities. However, it is unknown how CPX induces oxidative stress. Based on the available information, we speculated that CPX could increase iron content in the tissues and then induce oxidative stress. METHOD:We tested this ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120909880
更新日期:2020-07-01 00:00:00
abstract::Methyl salicylate (oil of wintergreen) is widely available in many over-the-counter liniments, ointments, lotions or medicated oils for the relief of musculoskeletal aches and pains. Ingestion of methyl salicylate poses the threat of severe, rapid-onset salicylate poisoning because of its liquid, concentrated form and...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1177/096032719601500905
更新日期:1996-09-01 00:00:00
abstract::Until quite recently, pentabromodiphenyl ether (PentaBDE) was most commonly used as a flame retardant. Due to the considerably long atmospheric half-life of PentaBDE and its contribution to environmental pollution, it is categorized as a persistent organic pollutant (POP). As the data on the toxicity of PentaBDE is ra...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110371261
更新日期:2011-05-01 00:00:00
abstract::Drugs containing 5-acetylsalicylic acid (5-ASA) have been commonly used for inflammatory bowel diseases for more than half a century, but no case about overdose of suppository form of mesalazine which was taken both orally and rectally has been reported in the related literature up to now. In the present case, a 20-ye...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110379249
更新日期:2011-07-01 00:00:00
abstract::Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenicity of many xenobiotics. In the present study, we investigated the possible induction of lipid peroxidation by aluminium in human foreskin fibroblast cultures by assayin...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032701682693053
更新日期:2001-09-01 00:00:00
abstract::Progressive renal dysfunction in 5/6 nephrectomized (NX) rats can be physiologically divided into three stages, coinciding with morphological stages, after definition of physiological parameters for identification of stage. Now, for the establishment of a toxicity screening approach using 5/6 NX rats, our concept, "Di...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032701666840048
更新日期:2001-02-01 00:00:00
abstract::4-hydroxynonenal (4-HNE) and 6-hydroxydopamine (6-OHDA)-mediated damage in dopaminergic neurons is well documented. Protective potential of steroidal hormone (17β-estradiol) has also been suggested. However, therapeutic potential of such promising hormone is hampered due to complex brain anatomy and physiology. Thus, ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110382130
更新日期:2011-08-01 00:00:00
abstract::1. With DTPA as a comparison, the siderophore analogue 3,4,3-LIHOPO has been examined for its ability to remove 228Th nitrate from the rat after subcutaneous (sc) and intramuscular (im) injection to simulate wound contamination. The commencement of treatment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719501400202
更新日期:1995-02-01 00:00:00
abstract::Okadaic acid (OA) is the main toxin produced by dinoflagellates, which can accumulate in the hepatopancreas of mussels and cause diarrhoetic shellfish poisoning in consumers. This toxin is also a tumour promoter and a specific potent inhibitor of protein phosphatases 1 and 2A. The results in this study show for the fi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719601500307
更新日期:1996-03-01 00:00:00
abstract::1. Dettol liquid (chloroxylenol 4.8%, pine oil, isopropyl alcohol), a household disinfectant, has a corrosive action on the gastrointestinal mucosa when swallowed. The incidence of upper gastrointestinal haemorrhage and gastroscopic findings following Dettol poisoning was studied in 89 patients. 2. Five patients (5.6%...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719501400104
更新日期:1995-01-01 00:00:00
abstract::Arsenic trioxide (As2O3) is utilized for treating patients suffering from hematological malignancies particularly acute promyelocytic leukemia. Unfortunately, the extensive application of this chemotherapeutic agent has been limited due to its adverse effects such as cardiotoxicity. Ellagic acid, as a phenolic compoun...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117701986
更新日期:2018-04-01 00:00:00
abstract::Stem cell transplantation has indicated great promise for cell therapy in a wide range of diseases, but poor and insufficient viability of cells within damaged tissues has limited its potential therapeutic effects. 17 β-Estradiol (E2) is a steroid hormone that plays an important role in expression of many genes and re...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115586208
更新日期:2016-03-01 00:00:00
abstract::1. 26Al and 67Ga were given as citrates to a healthy male volunteer by intravenous injection. The retention of both tracers was studied by body radioactivity measurement. Levels in blood and excreta were determined by gamma-ray spectrometry and/or accelerator mass spectrometry. 2. More than half of the 26Al had left t...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719501400309
更新日期:1995-03-01 00:00:00
abstract::In this study, genotoxic activities of four halogenated anesthetics (halothane, isoflurane, sevoflurane and desflurane) were investigated in human peripheral blood lymphocytes (PBLs) and sperm cells in vitro by alkaline comet assay. For this purpose, sperm or lymphocyte suspension was exposed to different concentratio...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327112446818
更新日期:2012-12-01 00:00:00
abstract::In carbon monoxide (CO) poisoning, CO affects the oxygen-carrying capacity of the hemoglobin molecule. Nucleolar-organizing regions (NORs) are genetic loci on chromosomes that are composed of ribosomal DNA and proteins. NORs can be stained with silver. A total of 18 rats were exposed to CO in three different concentra...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327114531994
更新日期:2015-01-01 00:00:00
abstract::Safrole, a component of piper betle inflorescence, is a documented rodent hepatocarcinogen and inhibits bactericidal activity and the release of superoxide anion (O(2-)) by polymorphonuclear leukocytes (PMNs). In the present study, we investigated the effects of safrole on immune responses, including natural killer (N...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111421944
更新日期:2012-09-01 00:00:00
abstract::Information on the acute effects associated with the handling of 1,4-dioxane is sparse. Our aim was to evaluate the acute effects of 1,4-dioxane vapours. In a screening study, six healthy volunteers rated symptoms on a visual analogue scale (VAS), while exposed to stepwise increasing levels of 1,4-dioxane, from 1 to 2...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327106073805
更新日期:2006-12-01 00:00:00
abstract::A retrospective review of medical records was carried out to determine the pattern of drug and chemical poisoning cases admitted to a teaching hospital in Malaysia. Medical records of patients admitted during the period January 1987 to December 1995 were reviewed. They accounted for 0.2% of total admissions during the...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327102ht260oa
更新日期:2002-07-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) and dioxins are potentially toxic compounds which occur widely in the environment. Their effects on the growth and development of infants at the levels currently found in highly industrialised western countries is not well known. This Dutch multicenter study, combining animal and human...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,多中心研究
doi:10.1177/096032719401301213
更新日期:1994-12-01 00:00:00
abstract:INTRODUCTION:Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondial...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327116661020
更新日期:2017-07-01 00:00:00
abstract::1. Three indexes for evaluating the severity of paraquat poisoning based on plasma-paraquat concentration are presently in use; the curves of Proudfood et al. and Scherrmann et al. and the SIPP. Their effectiveness in determining the prognosis of patients with paraquat poisoning was evaluated. 2. To determine which in...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719101000104
更新日期:1991-01-01 00:00:00
abstract::Sterigmatocystin (Stg), a major secondary metabolite of Aspergillus versicolor and A. nidulans, is the precursor of aflatoxin B1. In this study, male albino rats were treated with Stg-contaminated diet for 30 days, resulting in reduced levels of glutathione, ascorbic acid, and alpha-tocopherol. The activity of catalas...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032701682692955
更新日期:2001-08-01 00:00:00
abstract::The Na+-taurocholate cotransporting polypeptide (NTCP) acts as the major hepatic basolateral uptake system, and plays a key role in balancing bile flow. The anti-tuberculosis drugs rifampin (RFP) can affect bile flow causing liver injury, while tanshinone IIA (TAN IIA) has the effect of protecting liver. This study ai...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120979030
更新日期:2020-12-14 00:00:00