Is one-time carbon monoxide intoxication harmless? Evaluation by argyrophilic nucleolar-organizing regions staining method.

abstract：:The mechanism of doxorubicin (DOX)-induced cardiotoxicity remains controversial. Wistar rats (n = 66) received DOX injections intraperitoneally and were randomly assigned to 2 experimental protocols: (1) rats were killed before (-24 h, n = 8) and 24 h after (+24 h, n = 8) a single dose of DOX (4 mg/kg body weight) to ...

journal_title：Human & experimental toxicology

authors： Segredo MP,Salvadori DM,Rocha NS,Moretto FC,Correa CR,Camargo EA,de Almeida DC,Reis RA,Freire CM,Braz MG,Tang G,Matsubara LS,Matsubara BB,Yeum KJ,Ferreira AL

更新日期：2014-07-01 00:00:00

abstract：:There is compelling evidence in support of positive associations between zinc (Zn) deficiency and high accumulation of cadmium (Cd) in biological samples of different cancerous patients. The incidence of mouth cancer has been increased among people who possess habit of drinking alcohol, tobacco smoking and chewing wit...

journal_title：Human & experimental toxicology

authors： Kazi TG,Wadhwa SK,Afridi HI,Kazi N,Kandhro GA,Baig JA,Shah AQ,Kolachi NF,Khan S

更新日期：2010-03-01 00:00:00

abstract：:1. Polyvinyl chloride (PVC) cot mattress covers from SIDS cases were investigated as potential sources of soluble (potentially ingestable) antimony in the cot environment. 2. Body fluids (urine, saliva) and proprietary domestic detergents/sterilizing fluids markedly enhanced leaching of antimony from PVC. Release of a...

journal_title：Human & experimental toxicology

authors： Jenkins RO,Craig PJ,Goessler W,Irgolic KJ

更新日期：1998-03-01 00:00:00

abstract：:1. This work examines the influence of age on some nephrotoxic signs of gentamicin in normal and diabetic rats (aged 1 and 24 months). 2. Gentamicin (80 mg-1 kg-1 day for 6 days, intramuscularly) produced the typical pattern of nephrotoxicity; significantly increasing the plasma concentrations of creatinine and urea, ...

journal_title：Human & experimental toxicology

authors： Ali BH,Bashir AK,Mugamer IT,Tanira MO

更新日期：1996-01-01 00:00:00

abstract：:D-Glucaro(1,4)lactone, a potent beta-glucuronidase inhibitor was attached via the carboxylic acid moiety to polyvinylbenzyl chloride (PVBC) using a bimolecular nucleophilic displacement reaction. First, the caesium salt of D-glucaro(1,4)lactone was prepared by titrating the carboxylic acid to neutrality with aqueous c...

journal_title：Human & experimental toxicology

authors： Sacco C,McEwen WE,Calabrese EJ

更新日期：1993-03-01 00:00:00

abstract：:Manganese (Mn) is an essential nutrient required for proper growth and maintenance of numerous biological systems. At high levels it is known to be neurotoxic. While focused research concerning the transport of Mn across the blood-brain barrier (BBB) is on-going, the exact identity of the transporter(s) responsible is...

journal_title：Human & experimental toxicology

authors： Fitsanakis VA,Piccola G,Marreilha dos Santos AP,Aschner JL,Aschner M

更新日期：2007-04-01 00:00:00

abstract：:The renin-angiotensin system (RAS) subserves vital physiological functions and also implicated in certain pathological states. Modulation of this system has been proposed in recent studies to be a promising strategy in treating liver fibrosis. We investigated the effect of the pharmacologic inhibition of RAS with angi...

journal_title：Human & experimental toxicology

authors： Ekor M,Odewabi AO,Kale OE,Oritogun KS,Adesanoye OA,Bamidele TO

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:The mortality rate associated with human glufosinate poisoning is high. We evaluated the usefulness of serum ammonia and sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation II (APACHE II) scores for early prediction of in-hospital mortality in glufosinate ammonium po...

journal_title：Human & experimental toxicology

authors： Lee J,Lee Y,Kim YS,Choi JG,Go TH,Kim H,Cha YS

更新日期：2019-09-01 00:00:00

abstract：:1. In humans CaNa2EDTA increases urinary excretion of lead as well as that of essential metals such as zinc, ferrum and manganese but not that of copper. 2. We studied the effect of CaNa2EDTA injection on serum dopamine-beta-hydroxylase, a copper-dependent enzyme, in three male lead welders hospitalized for suspected ...

journal_title：Human & experimental toxicology

authors： De Paris P,Caroldi S

更新日期：1994-04-01 00:00:00

abstract：:Diabetes mellitus promoted an overproduction of free radicals and an increased incidence of both diabetic nephropathy and liver disease. In this report, we evaluated the effects of Chinese and Brazilian propolis on streptozotocin-induced hepatorenal injury in rats. The results demonstrated that Chinese propolis-treate...

journal_title：Human & experimental toxicology

authors： Zhu W,Li YH,Chen ML,Hu FL

更新日期：2011-09-01 00:00:00

abstract：:Clinical and experimental studies have shown the adverse effects of excess glucocorticoid on testicular testosterone production. The NADPH co-enzyme has been recognized as an important factor that regulates several steps in steroidogenesis, while glucose oxidation acts as a limiting factor on testicular testosterone p...

journal_title：Human & experimental toxicology

authors： Kavitha TS,Parthasarathy C,Sivakumar R,Badrinarayanan R,Balasubramanian K

更新日期：2006-03-01 00:00:00

abstract：:1. 26Al and 67Ga were given as citrates to a healthy male volunteer by intravenous injection. The retention of both tracers was studied by body radioactivity measurement. Levels in blood and excreta were determined by gamma-ray spectrometry and/or accelerator mass spectrometry. 2. More than half of the 26Al had left t...

journal_title：Human & experimental toxicology

authors： Priest ND,Newton D,Day JP,Talbot RJ,Warner AJ

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:Oxidative stress is one of the major mechanisms of cyclophosphamide (CPX)-induced toxicities. However, it is unknown how CPX induces oxidative stress. Based on the available information, we speculated that CPX could increase iron content in the tissues and then induce oxidative stress. METHOD:We tested this ...

journal_title：Human & experimental toxicology

authors： Sheng Y,Chen YJ,Qian ZM,Zheng J,Liu Y

更新日期：2020-07-01 00:00:00

abstract：:Nickel nanoparticles (Ni-NPs) have been widely used in various industries related to electronics, ceramics, textiles, and nanomedicine. Ambient and occupational exposure to Ni-NPs may bring about potential detrimental effects on animals and humans. Thus, there is a growing effort to identify compounds that can amelior...

journal_title：Human & experimental toxicology

authors： Iqbal S,Jabeen F,Peng C,Ijaz MU,Chaudhry AS

更新日期：2020-11-01 00:00:00

abstract：:The modulating effect of peroxisome proliferator-activated receptor α ligand on haemodynamic effects of phenylepherine (PE), angiotensin II (AII), endothelin 1 (ET1), acetylcholine (Ach), sodium nitroprusside (SNP) and isoproterenol (ISO) were evaluated in glycerol-induced acute kidney injury in rats. The effect of PE...

journal_title：Human & experimental toxicology

authors： Adedapo AA,Oyekan AO

更新日期：2013-03-01 00:00:00

abstract：:Cyfluthrin is a pyrethroid insecticide and common household pesticide. The effect of cyfluthrin on Ca2+-related physiology in human osteosarcoma is unclear. This study investigated the effect of cyfluthrin on cytosolic-free Ca2+ concentrations ([Ca2+]i) and viability in MG63 human osteosarcoma cells. Cyfluthrin concen...

journal_title：Human & experimental toxicology

authors： Lu YC,Liang WZ,Kuo CC,Hao LJ,Chou CT,Jan CR

更新日期：2020-09-01 00:00:00

abstract：:The effect of Glycyrrhiza glabra extract (GgE) as a natural antioxidant and melatonin (MEL) on ochratoxin A (OTA)-induced histopathological damages on the testes and oxidative stress was evaluated in male rats. The animals were assigned into four groups (n = 8) including control and test groups. The rats in control gr...

journal_title：Human & experimental toxicology

authors： Malekinejad H,Mirzakhani N,Razi M,Cheraghi H,Alizadeh A,Dardmeh F

更新日期：2011-02-01 00:00:00

abstract：:This study was focused on investigating the anticancer potential of indole-3-carbinol (I3C) against lung cancer H1299 cells via an increase in ROS levels. To investigate the induction of growth arrest and/or cell death in H1299 cells, a cell cycle arrest assay, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP...

journal_title：Human & experimental toxicology

authors： Lim HM,Park SH,Nam MJ

更新日期：2020-10-29 00:00:00

abstract：:From 1988 to 1991, 732 patients (91.1% Chinese) were admitted to four general medical wards at the Prince of Wales Hospital in Hong Kong with acute poisoning. The patients were predominantly female (68.9%) and relatively young (86.3% below the age of 40). Further analysis of 655 patients indicates that the vast majori...

journal_title：Human & experimental toxicology

authors： Chan TY,Critchley JA,Chan MT,Yu CM

更新日期：1994-07-01 00:00:00

abstract：:The effects of moderate lead exposure on testicular endocrine function were evaluated in a group of 90 males who were occupationally exposed to inorganic lead. Lead concentrations in blood and bone were measured as indices of short-term and long-term, cumulative exposure, respectively. The results of this study show t...

journal_title：Human & experimental toxicology

authors： McGregor AJ,Mason HJ

更新日期：1990-11-01 00:00:00

abstract：:1. A chronic alcoholic with severe metabolic acidosis presents a difficult diagnostic problem. The most common cause is alcoholic ketoacidosis, a syndrome with a typical history but often misleading laboratory findings. This paper will focus on this important and probably underdiagnosed syndrome. 2. The disorder occur...

journal_title：Human & experimental toxicology

authors： Höjer J

更新日期：1996-06-01 00:00:00

abstract：:The aim of this study was to evaluate the scores of the Acute Physiology and Chronic Health Evaluation (APACHE) II and a modified APACHE II system (MAS), without parameters of biochemical tests; and to find prognostic value of individual elements of the APACHE II and MAS in predicting outcomes in organophosphate (OP) ...

journal_title：Human & experimental toxicology

authors： Eizadi-Mood N,Saghaei M,Jabalameli M

更新日期：2007-07-01 00:00:00

abstract：:The regulation of osteoblast proliferation is a key factor in maintaining bone mass. The enhancement of this process can be achieved by stimulating the proliferation of these cells. Mechanical stimulation is one of the important enhancing factors, but the exact cellular mechanisms of mechanical stimulation, i.e., mech...

journal_title：Human & experimental toxicology

authors： Rosenberg N

更新日期：2003-05-01 00:00:00

abstract：:Accumulating evidence has shown that ethanol-induced iron overload plays a crucial role in the development and progression of alcoholic liver disease. We designed the present study to investigate the potential protective effect of quercetin, a naturally occurring iron-chelating antioxidant on alcoholic iron overload a...

journal_title：Human & experimental toxicology

authors： Li Y,Deng Y,Tang Y,Yu H,Gao C,Liu L,Liu L,Yao P

更新日期：2014-05-01 00:00:00

abstract：:Alcohol levels were measured in 15 cerebrospinal fluid (CSF) samples and 14 blood samples from grade III and IV male alcoholic patients with signs of nervous system involvement, and compared with levels detected in 11 CSF samples and 11 blood samples from abstemious patients or patients with grade I or II alcoholism w...

journal_title：Human & experimental toxicology

authors： Agapejev S,Vassilieff I,Curi PR

更新日期：1992-05-01 00:00:00

abstract：:1. The methods used to evaluate the toxicological effects of PCBs in animals have been reviewed. 2. The data show that Toxic Equivalency Factors (TEFs) could be developed to assess the potential toxicity of PCB mixtures for certain specific target organ effects (such as the liver and immune system) but would be inappr...

journal_title：Human & experimental toxicology

authors： Battershill JM

更新日期：1994-09-01 00:00:00

abstract：:The effect of fendiline on cytosolic free Ca(2+) concentrations ([Ca(2+)](i)) and proliferation has not been explored in human oral cancer cells. This study examined whether fendiline altered Ca(2+) levels and caused cell death in OC2 human oral cancer cells. [Ca(2+)](i) and cell viability were measured using the fluo...

journal_title：Human & experimental toxicology

authors： Huang C,Huang C,Cheng J,Liu S,Chen I,Tsai J,Chou C,Tseng P,Jan C

更新日期：2009-01-01 00:00:00

abstract：:Brain tumors are often incurable despite current aggressive treatment modalities. Regional intracerebral administration of labeled monoclonal antibodies (Mabs) can maximize the radioisotope and Mab concentration to tumor sites while reducing systemic toxicity. h-R3 is a humanized antiepidermal growth factor receptor M...

journal_title：Human & experimental toxicology

authors： Gonzalez B,Casaco A,Alvarez P,Leon M,Arteaga M,Leon A,Santana E,Bada A,Figueredo R,Hernández R,Iznaga-Escobar N,González F,Perez R

更新日期：2000-12-01 00:00:00

abstract：:Three patients admitted to the Accident and Emergency Unit of Lagos University Teaching Hospital (LUTH) after eating a cassava based meal 'Gari' died shortly after admission. The patients vomited and complained of abdominal pain immediately after the meal. They were unconscious with renal failure and died of cardiopul...

journal_title：Human & experimental toxicology

authors： Akintonwa A,Tunwashe OL

更新日期：1992-01-01 00:00:00

abstract：:The US Environmental Protection Agency (EPA) recently issued a Staff Paper that articulates current risk assessment practices. In section 4.1.3, EPA states, "... effects that appear to be adaptive, non-adverse, or beneficial may not be mentioned." This statement may be perceived as precluding risk assessments based on...

journal_title：Human & experimental toxicology

authors： Mundt KA

更新日期：2006-01-01 00:00:00