Abstract:
:1. 26Al and 67Ga were given as citrates to a healthy male volunteer by intravenous injection. The retention of both tracers was studied by body radioactivity measurement. Levels in blood and excreta were determined by gamma-ray spectrometry and/or accelerator mass spectrometry. 2. More than half of the 26Al had left the blood after 15 min and the decline continued, leaving < 1% in blood after 2 d; the losses occurred both to renal excretion and through uptake by other compartments. Estimated excretion up to 13 d was 83% (urine) and 1.8% (faeces). Whole-body retention of 15% at 13 d declined to approximately 4% at 1178 d, when the daily reduction corresponded to a biological half-life of 7 y, suggesting that sustained intake of dietary aluminium may lead to a progressively increasing internal deposit. 3. The metabolism of 67Ga differed markedly from that of 26Al in all aspects studied.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Priest ND,Newton D,Day JP,Talbot RJ,Warner AJdoi
10.1177/096032719501400309subject
Has Abstractpub_date
1995-03-01 00:00:00pages
287-93issue
3eissn
0960-3271issn
1477-0903journal_volume
14pub_type
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