Abstract:
:Diabetes mellitus promoted an overproduction of free radicals and an increased incidence of both diabetic nephropathy and liver disease. In this report, we evaluated the effects of Chinese and Brazilian propolis on streptozotocin-induced hepatorenal injury in rats. The results demonstrated that Chinese propolis-treated rats had a 7.4% reduction in the glycated hemoglobin (HbAlc) level compared with untreated diabetic rats. Additionally, Chinese propolis induced an increase in the serum superoxide dismutase (SOD) level significantly while Brazilian propolis raised serum SOD and reduced level of malonaldehyde (MDA) and nitric synthetase (NOS). Of the measurable decrease in serum alanine transaminase (ALT), aspartate transaminase (AST) and microalbuminuria demonstrated the propolis-mediated improvement of hepatorenal function, which was further confirmed by histological examination. We also observed that Chinese and Brazilian propolis increased hepatorenal glutathione peroxidase (GSH-px) level and inhibited MDA production significantly. These results suggested that propolis may prevent hepatorenal injury by inhibiting lipid peroxidation and enhancing the activities of antioxidant enzymes.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Zhu W,Li YH,Chen ML,Hu FLdoi
10.1177/0960327110387456subject
Has Abstractpub_date
2011-09-01 00:00:00pages
1246-55issue
9eissn
0960-3271issn
1477-0903pii
0960327110387456journal_volume
30pub_type
杂志文章abstract::beta-glucuronidase is considered a sensitive biomarker for acute organophosphorus poisoning. In this well-documented study, multiple plasma samples over time were collected. A decrease in plasma concentration of beta-glucuronidase was surprisingly observed, even within normal range. These findings do not support the h...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108094614
更新日期:2008-05-01 00:00:00
abstract::Pharmacological potential of curcumin was assessed in PC12 cells against hydrogen peroxide (H(2) O(2)) exposure. In MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and lactate dehydrogenase (LDH) assays, 24-hour exposure of H(2)O(2) (0.5 mM and above) was found to be cytotoxic. A significant (p < 0...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110371696
更新日期:2011-03-01 00:00:00
abstract::In Southern Africa, the medicinal plant Warburgia salutaris is commonly used for the treatment of inflammatory and other diseases. The methanol extracts of W. salutaris were investigated with regard to a) production of proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma; b) a...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108099536
更新日期:2008-11-01 00:00:00
abstract::The modulating effect of peroxisome proliferator-activated receptor α ligand on haemodynamic effects of phenylepherine (PE), angiotensin II (AII), endothelin 1 (ET1), acetylcholine (Ach), sodium nitroprusside (SNP) and isoproterenol (ISO) were evaluated in glycerol-induced acute kidney injury in rats. The effect of PE...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112454891
更新日期:2013-03-01 00:00:00
abstract::The aim of this study was to compare the number of inactivated-influenza vaccine-related spontaneous abortion and stillbirth (SB) reports in the Vaccine Adverse Event Reporting System (VAERS) database during three consecutive flu seasons beginning 2008/2009 and assess the relative fetal death reports associated with t...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112455067
更新日期:2013-05-01 00:00:00
abstract::The National Toxicology Program (NTP) Technical Reports online database was reviewed to find chemicals that were reported to show clear evidence of carcinogenicity in the NTP rodent studies and for which data on human exposure could be found. Six representative compounds were selected. Three volatile compounds: ethyl ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327103ht374oa
更新日期:2003-09-01 00:00:00
abstract:INTRODUCTION:Automatic dishwashing rinse aids are drying aids which contain non-ionic surfactants, usually ethoxylated alcohols, typically at concentrations of ≤30%. OBJECTIVE:To assess the reported toxicity of rinse aids. METHODS:Telephone enquiries to the UK National Poisons Information Service were analysed from J...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120901580
更新日期:2020-06-01 00:00:00
abstract::Pentavalent antimonial (Sb5+) drugs such as meglumine antimoniate (MA) are the mainstay treatment of leishmaniases in developing countries. The effects of these compounds on drug-metabolizing enzymes have not been characterized and their potential pharmacokinetic interactions with other drugs are therefore unknown. Th...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116637110
更新日期:2017-01-01 00:00:00
abstract::We describe two cases of chemical necrotizing fasciitis in the upper extremities, anterior chest wall and epigastric region of the abdominal wall caused by household insecticide injection. We suggest that surgical debridement can be successfully performed in the subacute period under close observation in hemodynamical...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327102ht308cr
更新日期:2002-12-01 00:00:00
abstract::The present study was designed to evaluate the cardioprotective potential of lycopene (LCP) against isoproterenol (ISP)-induced myocardial infarction (MI), by assessing hemodynamic, biochemical and histopathological parameters. Wistar male albino rats were orally administered with LCP (0.5, 1.0 and 1.5 mg/kg) or with ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112454890
更新日期:2013-05-01 00:00:00
abstract::To evaluate in vitro inhibitory effects of four types of histamine H2-receptor antagonist (H2-receptor antagonists), famotidine, roxatidine, cimetidine and ranitidine, on platelet function, we examined aggregating potency and P-selectin levels with agonist-induced aggregation. Ranitidine and cimetidine inhibited, in c...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032799678847069
更新日期:1999-08-01 00:00:00
abstract::Diallyl sulfide, a sulfur-containing volatile compound present in garlic (Allium sativum), exerts anticarcinogenic activity in various rodent tumor models. In the present study, apoptosis-inhibiting effects of diallyl sulfide against a carcinogenic polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108088978
更新日期:2008-01-01 00:00:00
abstract::Accumulating evidence has shown that ethanol-induced iron overload plays a crucial role in the development and progression of alcoholic liver disease. We designed the present study to investigate the potential protective effect of quercetin, a naturally occurring iron-chelating antioxidant on alcoholic iron overload a...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113499168
更新日期:2014-05-01 00:00:00
abstract::The mechanism of doxorubicin (DOX)-induced cardiotoxicity remains controversial. Wistar rats (n = 66) received DOX injections intraperitoneally and were randomly assigned to 2 experimental protocols: (1) rats were killed before (-24 h, n = 8) and 24 h after (+24 h, n = 8) a single dose of DOX (4 mg/kg body weight) to ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113512342
更新日期:2014-07-01 00:00:00
abstract::Pyrazinamide (PYZ)-an essential component of primary drug regimen used for the treatment and management of multidrug resistant or latent tuberculosis-is well known for its hepatoxicity. However, the mechanism of PYZ-induced hepatotoxicity is still unknown to researchers. Studies have shown that the drug is metabolized...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117705426
更新日期:2018-04-01 00:00:00
abstract::The objective of this study was to evaluate data retrospectively on accidental ingestion of ethylene glycol (EG), based on calls to the Czech Toxicological Information Centre and from toxicological laboratories, in the years 2000-2004. All patients who ingested a known amount of EG and/or subjects with measured serum ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107073831
更新日期:2007-01-01 00:00:00
abstract::Indomethacin, a non-steroidal anti-inflammatory drug is known to increase the efficacy and toxicity of methotrexate, the widely used anti-cancer drug in man. The mechanism for this interaction has not been clearly established. However, since these drugs bind with albumin, a possible displacement of methotrexate by ind...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719201100411
更新日期:1992-07-01 00:00:00
abstract::Public health issues have been raised regarding fructose toxicity and its serious metabolic disorders. Deleterious effects of high fructose intake on insulin sensitivity, body weight, lipid homeostasis have been identified. The new millennium has witnessed the emergence of a modern epidemic, the metabolic syndrome (MS...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120969960
更新日期:2020-10-29 00:00:00
abstract::1 The urinary recovery of metabolites of aspirin (ASA) was studied in 45 volunteers who took a therapeutic dose (600 mg) of ASA by mouth and in 37 patients who took ASA in overdose. 2 The main metabolite recovered from the volunteers was the glycine conjugate, salicyluric acid (SUA), which accounted for 75.01 +/- 1.19...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719000900302
更新日期:1990-05-01 00:00:00
abstract::Exposure to quartz induces pulmonary inflammation and development of fibrosis. In order to study the fibrosing process, we investigated morphology, function and phenotype of alveolar (AMs) and interstitial (IMs) macrophages at an early stage of fibrosis in rats. Rats were exposed by intratracheal instillations of 10 m...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032700678816124
更新日期:2000-07-01 00:00:00
abstract::The manufacture of fibreglass reinforced plastic products may give rise to substantial peak exposures to styrene. Such exposure patterns need further consideration in terms of styrene neurotoxicity. The aim of this study was to evaluate the neurotoxic effects of short-term peak exposures in volunteers, at levels respe...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327103ht384oa
更新日期:2003-08-01 00:00:00
abstract::Coronary heart disease and in particular its most serious form - acute myocardial infarction (AMI) - represents the most common cause of mortality in developed countries. Better prognosis may be achieved by understanding the etiopathogenetic mechanisms of AMI. Therefore, a catecholamine model of myocardial injury, whi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109350665
更新日期:2009-10-01 00:00:00
abstract:CONTEXT:Cardiac dysfunction is one of the most serious consequences of scorpion envenomation. The best tool to evaluate cardiac function is echocardiography, but it is not available at all emergency departments. Many studies aimed to describe biological predictive factors of cardiac dysfunction in scorpion envenomation...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117722822
更新日期:2018-06-01 00:00:00
abstract::The effect of Glycyrrhiza glabra extract (GgE) as a natural antioxidant and melatonin (MEL) on ochratoxin A (OTA)-induced histopathological damages on the testes and oxidative stress was evaluated in male rats. The animals were assigned into four groups (n = 8) including control and test groups. The rats in control gr...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110368416
更新日期:2011-02-01 00:00:00
abstract::In this study, genotoxic activities of four halogenated anesthetics (halothane, isoflurane, sevoflurane and desflurane) were investigated in human peripheral blood lymphocytes (PBLs) and sperm cells in vitro by alkaline comet assay. For this purpose, sperm or lymphocyte suspension was exposed to different concentratio...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112446818
更新日期:2012-12-01 00:00:00
abstract::Hypofibrinogenemia is an important clinical consequence following envenomation by Lachesis muta muta, usually attenuated or prevented by administration of antivenom. The venom of L. m. muta contains both a metalloproteinase fibrinogenase and a serine protease thrombin-like enzyme, and exposure of fibrinogen to iron (F...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116661401
更新日期:2017-07-01 00:00:00
abstract::The aim of the present study was to investigate whether cognitive behavioral impairment, induced by nicotine in offspring rats, was associated with the alteration of hippocampal short-term potentiation (STP) and long-term potentiation (LTP) and to discuss the potential underlying mechanism. Young adult offspring rats ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113494902
更新日期:2014-02-01 00:00:00
abstract::1. Osmolal and anion gaps are helpful in the diagnosis and evaluation of intoxications with methanol and ethylene glycol. Reported reference values for osmolal gap and anion gap are -1 (+/- 6) mosm kg-1 H2O and 16 (+/- 2) mmol l-1, respectively. However, we have repeatedly found unexplained increased gaps in patients ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719401300212
更新日期:1994-02-01 00:00:00
abstract::Potassium bromate (KBrO3) is a potent nephrotoxic agent. In this paper, we report the chemopreventive effect of Nigella sativa (black cumin) on KBrO3-mediated renal oxidative stress, toxicity and tumor promotion response in rats. KBrO3 (125 mg/kg body weight, intraperitoneally) enhances lipid peroxidation, gamma-gluta...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327103ht349oa
更新日期:2003-04-01 00:00:00
abstract::The aim of this study was to investigate the possible protective role of caffeic acid phenethyl ester on testicular toxicity of methotrexate in rats. Nineteen male rats were divided into three groups as follows: group I, control; group II, methotrexate-treated; group III, methotrexate + caffeic acid phenethyl ester-tr...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108092293
更新日期:2008-07-01 00:00:00