Abstract:
:We describe two cases of chemical necrotizing fasciitis in the upper extremities, anterior chest wall and epigastric region of the abdominal wall caused by household insecticide injection. We suggest that surgical debridement can be successfully performed in the subacute period under close observation in hemodynamically stable patients.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Terzi C,Bacakoğlu A,Unek T,Ozkan MHdoi
10.1191/0960327102ht308crsubject
Has Abstractpub_date
2002-12-01 00:00:00pages
687-90issue
12eissn
0960-3271issn
1477-0903journal_volume
21pub_type
杂志文章abstract::A sound understanding of the mechanisms determining percutaneous absorption is necessary for toxicological risk assessment of chemicals contacting the skin. As part of a programme investigating these mechanisms we have developed a physiologically based mathematical model. The structure of the model parallels the multi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719401300108
更新日期:1994-01-01 00:00:00
abstract::Enterococcus faecalis is a facultative anaerobic gram-positive commensal bacterium common in the gastrointestinal tract of animals and humans. This study aimed to investigate the protective effects of heat-killed E. faecalis EF-2001 (EF-2001) on acute gastric ulcer using a murine model of ethanol (EtOH)-induced acute ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119899987
更新日期:2020-05-01 00:00:00
abstract::1-Bromopropane (1-BP) is an increasingly used chemical solvent for cleaning metals and gradually replacing spraying adhesives. Workers exposed to 1-BP (WBP) showed nervous system dysfunction and other symptoms. This study focused on the proteomic change between healthy individuals (HIs), WBP and poisoned patients with...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117689911
更新日期:2018-01-01 00:00:00
abstract::The objective of this study is to analyze exposures concerning analgesics that were reported to Dokuz Eylul University Drug and Poison Information Center (DPIC) and admitted to the Department of Emergency Medicine in Dokuz Eylul University Hospital (EMDEU) between 1993 and 2004. Demographics of the patients, character...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107076836
更新日期:2007-08-01 00:00:00
abstract::Comparisons on a linear and the Rozman logarithmic scale for dosage versus carcinogenicity in rodents are presented for methyl eugenol (ME), nitrosodiethylamine (NDEA), ethyl carbamate (EC) and 2-acetylaminofluorene (AAF). Each of these chemicals has been shown to be carcinogenic in experimental animals and, in additi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327105ht525oa
更新日期:2005-06-01 00:00:00
abstract::The effects of the environmental toxicant, triethyltin, on Ca2+ mobilization in Madin-Darby canine kidney (MDCK) cells have been examined. Triethyltin induced an increase in cytosolic free Ca2+ levels ([Ca2+]i) at concentrations larger than 2 microM in a concentration-dependent manner. Within 5 min, the [Ca2+]i signal...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327102ht276oa
更新日期:2002-08-01 00:00:00
abstract::Tissue-dependent oestrogenic and anti-oestrogenic activity of polycyclic aromatic hydrocarbons (PAHs) has been suggested. In this study, the effect of two PAH mixtures, M1 composed of all 16 priority pollutants and M2 composed of five (noted in the highest levels) compounds, on follicle-stimulating hormone receptor (F...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327119886027
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abstract::beta-glucuronidase is considered a sensitive biomarker for acute organophosphorus poisoning. In this well-documented study, multiple plasma samples over time were collected. A decrease in plasma concentration of beta-glucuronidase was surprisingly observed, even within normal range. These findings do not support the h...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108094614
更新日期:2008-05-01 00:00:00
abstract::The principal impediment to gene therapy is the development of efficient, nontoxic gene carriers that can handle and deliver foreign genetic materials into various cell types, including healthy and cancerous cells. Poly-l-lysine (PLL) polymers are one of the most favorable gene carriers among nonviral vectors, and PLL...
journal_title:Human & experimental toxicology
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abstract::This study was designed to evaluate the maternal toxicity and teratogenicity of fenproporex, one of the most widely-used anorectic drugs in many countries, including Brazil. Three periods of exposure were evaluated: (a) 30 days before mating; (b) from gestational day (GD) 0 to 14; and (c) 30 days before mating and dur...
journal_title:Human & experimental toxicology
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doi:10.1191/0960327105ht545oa
更新日期:2005-08-01 00:00:00
abstract::The renin-angiotensin system (RAS) subserves vital physiological functions and also implicated in certain pathological states. Modulation of this system has been proposed in recent studies to be a promising strategy in treating liver fibrosis. We investigated the effect of the pharmacologic inhibition of RAS with angi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111401051
更新日期:2011-11-01 00:00:00
abstract::The regulation of osteoblast proliferation is a key factor in maintaining bone mass. The enhancement of this process can be achieved by stimulating the proliferation of these cells. Mechanical stimulation is one of the important enhancing factors, but the exact cellular mechanisms of mechanical stimulation, i.e., mech...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327103ht362oa
更新日期:2003-05-01 00:00:00
abstract:INTRODUCTION:Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondial...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327116661020
更新日期:2017-07-01 00:00:00
abstract:INTRODUCTION:Accidental toxicity by organophosphate (OP) agents may occur among farmers during spraying season due to improper use and handling. Plasma cholinesterase (ChE) activity measurement is recommended to monitor the extent of exposure to the OP agent. The aim of the current study was to measure plasma ChE activ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115584990
更新日期:2016-03-01 00:00:00
abstract::The objective of this study was to evaluate data retrospectively on accidental ingestion of ethylene glycol (EG), based on calls to the Czech Toxicological Information Centre and from toxicological laboratories, in the years 2000-2004. All patients who ingested a known amount of EG and/or subjects with measured serum ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107073831
更新日期:2007-01-01 00:00:00
abstract::This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111426584
更新日期:2013-06-01 00:00:00
abstract::Teucrium polium L. (Lamiaceae) is a commonly used medicinal plant in folk medicine. Among several uses, T. polium is used to treat male fertility problems. This research was conducted to study the effect of T. polium on spermatogenesis, testosterone level, androgen receptor expression, and fertility in male rats. Admi...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327116688069
更新日期:2017-12-01 00:00:00
abstract::Sibutramine mesylate is a new anti-obesity drug. It is a crystalline salt of sibutramine developed to improve the solubility of sibutramine hydrochloride. Methanesulfonic acid was used as a salt-forming acid instead of hydrochloric acid, resulting in a greatly improved solubility of 1000 mg/mL in water. Sibutramine me...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327105ht510oa
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due ...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327109354311
更新日期:2009-12-01 00:00:00
abstract::Occupational chronic solvent encephalopathy (CSE) is associated with a number of neurobehavioural disorders including defects of visual perception. The purpose of this study was to characterize colour vision defects in CSE patients. Colour vision was tested in bright illumination with the Farnsworth-Munsell 100-hue te...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327107076820
更新日期:2007-04-01 00:00:00
abstract::The antidiabetic agent metformin was shown to further possess chemopreventive and chemotherapeutic effects against cancer. Despite the advances, the underlying molecular mechanisms involved in decreasing tumor formation are still unclear. The understanding of the participation of oxidative stress in the action mechani...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327117737145
更新日期:2018-09-01 00:00:00
abstract::Inhalation of zinc fumes may lead to the acute respiratory distress syndrome. The mechanisms of pulmonary zinc toxicity are not yet understood. Therefore we investigated zinc-dependent depression of protein and RNA synthesis in rat and human lung cell lines. 1. After exposure to 120 or 150 micromol/l zinc, RNA synthes...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719801701203
更新日期:1998-12-01 00:00:00
abstract::In this study, genotoxic activities of four halogenated anesthetics (halothane, isoflurane, sevoflurane and desflurane) were investigated in human peripheral blood lymphocytes (PBLs) and sperm cells in vitro by alkaline comet assay. For this purpose, sperm or lymphocyte suspension was exposed to different concentratio...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112446818
更新日期:2012-12-01 00:00:00
abstract::Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Attenuation of fibrogenic process can significantly lower the mortality rate. However, pharmaceutical intervention at fibrogenesis stage remains a major task in medicine. So there is a need for a natural compound to treat hepatic fibrosis. This ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116638727
更新日期:2017-02-01 00:00:00
abstract::Serrapeptase (SP) and nattokinase (NK) are proteolytic enzymes belonging to serine proteases. In this study, we hypothesized that SP and NK could modulate certain factors that are associated with Alzheimer's disease (AD) pathophysiology in the experimental model. Oral administration of aluminium chloride (AlCl3) in a ...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327112467040
更新日期:2013-07-01 00:00:00
abstract::The identification of biomarkers for toxicity prediction is crucial for drug development and safety evaluation. The selective and specific biomarkers for antihistamines-induced cardiotoxicity is not well identified yet. In order to evaluate the mechanism of the life-threatening effects caused by antihistamines, we use...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327114559988
更新日期:2015-08-01 00:00:00
abstract::The effect of sympathomimetic intervention with dopamine or dobutamine on the myocardial uptake of d-propoxyphene was investigated experimentally in rats. The d-propoxyphene (19 mg kg-1 h-1) was continuously infused, intravenously, over 45 min. After 20 min of infusion the rats were given either dopamine (12.5 microgr...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719101000203
更新日期:1991-03-01 00:00:00
abstract::The conventional method for the assessment of acute inhalation toxicity (OECD Test Guideline 403, 1981) uses death of animals as an endpoint to identify the median lethal concentration (LC50). A new OECD Testing Guideline called the Fixed Concentration Procedure (FCP) is being prepared to provide an alternative to Tes...
journal_title:Human & experimental toxicology
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更新日期:2003-11-01 00:00:00
abstract::A few landmarks in the development of dose response in toxicology are presented, with an explanation of why dose should only be considered on a logarithmic scale. Examples are shown, illustrating that the current practice of labeling dose-response curves for carcinogenesis as supralinear, linear or sublinear, is meani...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1191/0960327106ht633oa
更新日期:2006-07-01 00:00:00
abstract::1 The concentrations of a range of organochlorine pesticide residues have been determined in 168 samples of human milk collected between January 1997 and May 1998 in the UK. 2 Of the 18 residues sought, only p,p'-DTT, p,p'-DDE, dieldrin, HCB, beta-HCH and gamma-HCH were detected. 3 The continuing trend of a reduction ...
journal_title:Human & experimental toxicology
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更新日期:1999-10-01 00:00:00