Abstract:
:beta-glucuronidase is considered a sensitive biomarker for acute organophosphorus poisoning. In this well-documented study, multiple plasma samples over time were collected. A decrease in plasma concentration of beta-glucuronidase was surprisingly observed, even within normal range. These findings do not support the hypothesis that beta-glucuronidase is a useful biomarker for acute organophosphorus poisoning in humans.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Sabbe MB,Desruelles D,Lissens Wdoi
10.1177/0960327108094614subject
Has Abstractpub_date
2008-05-01 00:00:00pages
431-3issue
5eissn
0960-3271issn
1477-0903pii
27/5/431journal_volume
27pub_type
杂志文章abstract::1. In humans CaNa2EDTA increases urinary excretion of lead as well as that of essential metals such as zinc, ferrum and manganese but not that of copper. 2. We studied the effect of CaNa2EDTA injection on serum dopamine-beta-hydroxylase, a copper-dependent enzyme, in three male lead welders hospitalized for suspected ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719401300405
更新日期:1994-04-01 00:00:00
abstract::The number of definite and probable human chemical carcinogens identified by IARC approaches between 1987 and June 2004 is reported to be 50 agents. However, overall, given the rapid expansion in the number of chemicals in use, the throughput of the current approach to identifying potential environmental carcinogens i...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327105ht559oa
更新日期:2005-11-01 00:00:00
abstract::The aim of the study was to evaluate the effect of bisphenol A (BPA) on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression by neutrophils with regard to sex and nuclear factor-κB (NF-κB) pathway participation in this process. This study demonstrated that BPA intensifies the production o...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327118793188
更新日期:2019-02-01 00:00:00
abstract::There is compelling evidence in support of positive associations between zinc (Zn) deficiency and high accumulation of cadmium (Cd) in biological samples of different cancerous patients. The incidence of mouth cancer has been increased among people who possess habit of drinking alcohol, tobacco smoking and chewing wit...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109360045
更新日期:2010-03-01 00:00:00
abstract::The phenomenon of subtoxic stimulation of organism response is not uncommon in aquatic toxicology experiments. We describe the presence of hormesis in both growth and reproduction experiments in aquatic toxicology where these responses are observed in both animals and plants and at different trophic levels of an ecosy...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1177/096032719801700505
更新日期:1998-05-01 00:00:00
abstract::Vulpinic acid, a lichen compound, has been shown to have many beneficial effects and its medicinal value increases day by day. As in atherosclerosis, endothelial damage is the basis of many diseases. The aim of this study is to investigate the effects of vulpinic acid against oxidative stress damage induced by hydroge...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119833745
更新日期:2019-06-01 00:00:00
abstract::Chronic mercury exposure impairs vascular function, leading to the depression of endothelium-dependent vasodilatation. Loss of the nitric oxide (NO) pathway has been implicated, but little is known about effects on other endothelial mediators. This study investigated the mechanisms of endothelial dysfunction in rats s...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110391389
更新日期:2011-11-01 00:00:00
abstract::Hormesis can be considered as a parameter which has a non-monotonic relationship with some endpoint. Since caloric intake is such a parameter, and the impact of this parameter on risk assessment has been fairly well characterized, it can provide clues as to how to integrate the information from a hormetic parameter in...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719801700810
更新日期:1998-08-01 00:00:00
abstract::Coronary heart disease and in particular its most serious form - acute myocardial infarction (AMI) - represents the most common cause of mortality in developed countries. Better prognosis may be achieved by understanding the etiopathogenetic mechanisms of AMI. Therefore, a catecholamine model of myocardial injury, whi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109350665
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Diphenhydramine (DPHM) overdose is a frequent cause of acute poisoning. Although its clinical features are well known, information about the dose-dependent toxicity of DPHM is still scarce. The objective of this study was to investigate the dose-dependent toxicity of DPHM in patients with acute DPHM poisonin...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032700671040438
更新日期:2000-09-01 00:00:00
abstract::In acute respiratory distress syndrome (ARDS), there is extensive overproduction of free radicals to the extent that endogenous anti-oxidants are overwhelmed, permitting oxidative cell damage. The present study examined the benefit of the anti-oxidant compound N-acetylcysteine (NAC) in the management of ARDS by measur...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,随机对照试验
doi:10.1177/0960327107083452
更新日期:2007-09-01 00:00:00
abstract::Dermal exposure is an important factor in risk characterization. In occupational settings it becomes relatively more important because of the continuous reduction in inhalation exposure. In the public health arena, dermal exposure may also form a significant contribution to the total exposure. Dermal exposure, however...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107085830
更新日期:2008-04-01 00:00:00
abstract::Benzydamine is a nonsteroidal anti-inflammatory drug, currently available as mouthwash, aerosol, dermal cream, vaginal douche preparation, pills and otic drops. Up to now no cases of poisoning due to this drug have been reported. A 6-year-old girl with an accidental poisoning with benzydamine is described. The episode...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032799678840264
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:The present work aimed to investigate the relationship between occupational exposure to airborne molds, serum aflatoxin B1 (AFB1), and liver enzymes of workers handling wheat flour. METHODS:The study included 90 bakers, 100 flour milling workers, and 100 controls with no exposure to flour dust. Workplace asp...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115573596
更新日期:2016-01-01 00:00:00
abstract::3,4-Methylenedioxymethamphetamine (MDMA) is a powerfully addictive psychostimulant with pronounced effects on the central nervous system, but the precise mechanism of MDMA-induced toxicity remains unclear, specifically on the retina. This study was performed to investigate the effects of MDMA treatment on the retina a...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120930253
更新日期:2020-11-01 00:00:00
abstract::N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (PK1) is a novel polymeric anticancer agent containing doxorubicin (approximately 8 wt%) bound to the polymer backbone via a Gly-Phe-Leu-Gly peptidyl linker. The approximate LD50 of PK1 in MF1 mice after a single i.v. injection was 63 mg/kg (doxorubicin-eq...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719801700204
更新日期:1998-02-01 00:00:00
abstract::This study was designed to determine the levels of prolactin, leptin, osteopontin, and follistatin in workers chronically and subacutely exposed to lead compounds. The examined population consisted of three groups. The first group was composed of 56 male workers who were chronically exposed to lead for 13.38 ± 10.38 y...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116658106
更新日期:2017-06-01 00:00:00
abstract::Pharmaceutical research and new drug development rely extensively on animal research. The development of novel agents for intrathecal administration requires preclinical studies of toxic effects in an animal model. We have developed a nonrodent animal model for this purpose. Our sheep model: 1 Is an animal whose neura...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719901800204
更新日期:1999-02-01 00:00:00
abstract::D-Glucaro(1,4)lactone, a potent beta-glucuronidase inhibitor was attached via the carboxylic acid moiety to polyvinylbenzyl chloride (PVBC) using a bimolecular nucleophilic displacement reaction. First, the caesium salt of D-glucaro(1,4)lactone was prepared by titrating the carboxylic acid to neutrality with aqueous c...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719301200216
更新日期:1993-03-01 00:00:00
abstract::Phagocytes remove and store mercury (Hg) that enters the body. Macrophages and granulocytes respond in opposite ways to Hg: macrophages loose cell viability, and neutrophils become protected from apoptosis. We have investigated the cytology of early intake of Hg by macrophages and neutrophils after a short period (2-4...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327104ht472oa
更新日期:2004-08-01 00:00:00
abstract::This study deals with pesticide exposure profile in some European countries with a specific focus on ethylenebisdithiocarbamates (EBDC). In all, 55 Bulgarian greenhouse workers, 51 Finnish potato farmers, 48 Italian vineyard workers, 42 Dutch floriculture farmers, and 52 Bulgarian zineb producers entered the study. Ea...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,多中心研究
doi:10.1177/0960327108100003
更新日期:2008-09-01 00:00:00
abstract::The Na+-taurocholate cotransporting polypeptide (NTCP) acts as the major hepatic basolateral uptake system, and plays a key role in balancing bile flow. The anti-tuberculosis drugs rifampin (RFP) can affect bile flow causing liver injury, while tanshinone IIA (TAN IIA) has the effect of protecting liver. This study ai...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120979030
更新日期:2020-12-14 00:00:00
abstract::The aim of this study was focused on investigating the possible protective effect of erdosteine against gamma radiation-induced renal lesions in male albino rats. Twenty-eight albino rats were divided into four equal groups as follows: control group, irradiated group (animals subjected to whole-body gamma irradiation ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115574919
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Calcium channel blockers (CCBs) were the most common agents associated with a significant morbidity and mortality rate. The main objective of this study was to examine the publication pattern related to CCBs poisoning at the global level using bibliometric analysis of articles published in SciVerse Scopus onlin...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115571768
更新日期:2015-11-01 00:00:00
abstract::The US Environmental Protection Agency (EPA) recently issued a Staff Paper that articulates current risk assessment practices. In section 4.1.3, EPA states, "... effects that appear to be adaptive, non-adverse, or beneficial may not be mentioned." This statement may be perceived as precluding risk assessments based on...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327106ht580oa
更新日期:2006-01-01 00:00:00
abstract::This descriptive and retrospective study was conducted at the poisoning ward of Imam teaching hospital, Sari, Iran, with the aim of evaluating the pattern of poisoning. Hence, the medical profiles of 2057 patients, who were admitted, were carefully reviewed during the period from April 2006 to March 2008 for 2 years. ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110361501
更新日期:2010-09-01 00:00:00
abstract::Pharmacological potential of curcumin was assessed in PC12 cells against hydrogen peroxide (H(2) O(2)) exposure. In MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and lactate dehydrogenase (LDH) assays, 24-hour exposure of H(2)O(2) (0.5 mM and above) was found to be cytotoxic. A significant (p < 0...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110371696
更新日期:2011-03-01 00:00:00
abstract::In this study, genotoxic activities of four halogenated anesthetics (halothane, isoflurane, sevoflurane and desflurane) were investigated in human peripheral blood lymphocytes (PBLs) and sperm cells in vitro by alkaline comet assay. For this purpose, sperm or lymphocyte suspension was exposed to different concentratio...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112446818
更新日期:2012-12-01 00:00:00
abstract::1. The effect of pyridostigmine on cardiorespiratory function after oxime + atropine injection was investigated in tabun poisoned guinea-pigs and without tabun poisoning. 2. The trachea, a carotid artery and jugular vein were cannulated in female urethane-anaesthetised Pirbright-white guinea-pigs. After baseline measu...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719501400803
更新日期:1995-08-01 00:00:00
abstract::Paracetamol overdose is common and microRNA (miR)-122 expression is increased with liver injury. We aimed to measure miR-122 in the setting of an abbreviated paracetamol overdose treatment regimen. We compared miRNA expression in patients treated for paracetamol poisoning with an abbreviated 12-h intravenous acetylcys...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119833740
更新日期:2019-06-01 00:00:00