Selective inhibition of gastrointestinal beta-glucuronidase by polyvinylbenzyl D-glucaro(1,4)lactonate: attachment of D-glucaro(1,4)lactone to polyvinylbenzyl chloride.

Abstract:

:D-Glucaro(1,4)lactone, a potent beta-glucuronidase inhibitor was attached via the carboxylic acid moiety to polyvinylbenzyl chloride (PVBC) using a bimolecular nucleophilic displacement reaction. First, the caesium salt of D-glucaro(1,4)lactone was prepared by titrating the carboxylic acid to neutrality with aqueous caesium bicarbonate. The polyvinylbenzyl D-glucaro(1,4)lactonate was obtained in maximum yields of between 50 and 60% when caesium D-glucaro(1,4)lactonate was incubated with PVBC in DMF at 50 degrees C for 7 d in the presence of a catalyst, caesium iodide.

journal_name

Hum Exp Toxicol

authors

Sacco C,McEwen WE,Calabrese EJ

doi

10.1177/096032719301200216

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

181-4

issue

2

eissn

0960-3271

issn

1477-0903

journal_volume

12

pub_type

杂志文章
  • Vulpinic acid, a lichen metabolite, emerges as a potential drug candidate in the therapy of oxidative stress-related diseases, such as atherosclerosis.

    abstract::Vulpinic acid, a lichen compound, has been shown to have many beneficial effects and its medicinal value increases day by day. As in atherosclerosis, endothelial damage is the basis of many diseases. The aim of this study is to investigate the effects of vulpinic acid against oxidative stress damage induced by hydroge...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327119833745

    authors: Sahin E,Dabagoglu Psav S,Avan I,Candan M,Sahinturk V,Koparal AT

    更新日期:2019-06-01 00:00:00

  • Serum paraoxonase activity and oxidative stress levels in patients with cutaneous anthrax.

    abstract:INTRODUCTION:Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondial...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327116661020

    authors: Karadas S,Aslan M,Ceylan MR,Sunnetcioglu M,Bozan N,Kara H,Demir H

    更新日期:2017-07-01 00:00:00

  • Pharmacologic inhibition of the renin-angiotensin system did not attenuate hepatic toxicity induced by carbon tetrachloride in rats.

    abstract::The renin-angiotensin system (RAS) subserves vital physiological functions and also implicated in certain pathological states. Modulation of this system has been proposed in recent studies to be a promising strategy in treating liver fibrosis. We investigated the effect of the pharmacologic inhibition of RAS with angi...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327111401051

    authors: Ekor M,Odewabi AO,Kale OE,Oritogun KS,Adesanoye OA,Bamidele TO

    更新日期:2011-11-01 00:00:00

  • Oxidative stress induced in the workers of natural gas refineries, no role for GSTM1 and GSTT1 polymorphisms.

    abstract::Oxidative stress has an important role in the pathophysiology of many occupational diseases. In this controlled exposure study, the intensity of oxidative stress biomarkers was assessed in the workers of natural sweet and sour gas refineries (SwGR and SoGR, respectively) and compared with controls. In addition, the ro...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327112450898

    authors: Mandegary A,Sezavar M,Saeedi A,Amirheidari B,Naghibi B

    更新日期:2012-12-01 00:00:00

  • Statistical evaluation of the fixed concentration procedure for acute inhalation toxicity assessment.

    abstract::The conventional method for the assessment of acute inhalation toxicity (OECD Test Guideline 403, 1981) uses death of animals as an endpoint to identify the median lethal concentration (LC50). A new OECD Testing Guideline called the Fixed Concentration Procedure (FCP) is being prepared to provide an alternative to Tes...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1191/0960327103ht395oa

    authors: Stallard N,Whitehead A,Indans I

    更新日期:2003-11-01 00:00:00

  • Ototoxicity of trichloroethylene in concentrations relevant for the working environment.

    abstract::Organic solvents can cause hearing loss themselves or promote noise-induced hearing loss. The objective of this study was to review the literature on the effects of low-level exposure to trichloroethylene on the auditory system and consider its relevance for the occupational settings. Both human and animal investigati...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327108090267

    authors: Vyskocil A,Leroux T,Truchon G,Lemay F,Gagnon F,Gendron M,Viau C

    更新日期:2008-03-01 00:00:00

  • Impact of nicotine on the interplay between human periodontal ligament cells and CD4+ T cells.

    abstract::Periodontitis is a common infectious disease associated with destruction of periodontal ligaments and alveolar bones. CD4(+) T cell-mediated immune response is involved in the progression of periodontitis. Tobacco consumption increases the risk of periodontal disease. However, the impact of nicotine on the interaction...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327115614383

    authors: Ge X,Liu YF,Wong Y,Wu LZ,Tan L,Liu F,Wang XJ

    更新日期:2016-09-01 00:00:00

  • An unusual case of mesalazine intoxication: oral and rectal overloading of the rectal suppository form.

    abstract::Drugs containing 5-acetylsalicylic acid (5-ASA) have been commonly used for inflammatory bowel diseases for more than half a century, but no case about overdose of suppository form of mesalazine which was taken both orally and rectally has been reported in the related literature up to now. In the present case, a 20-ye...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327110379249

    authors: Koseoglu Z,Satar S,Kara B,Sebe A,Kosenli O

    更新日期:2011-07-01 00:00:00

  • Hormesis in precautionary regulatory culture: models preferences and the advancement of science.

    abstract::The article focuses on flaws in the actual approaches of exposure to a chemical of recipient organisms. It demonstrates the excessive use of arguments based on adverse effects and underlines the necessity to take adaptive effects seriously. Regulators are invited to rethink their inclination to the 'When in doubt, kee...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327107083414

    authors: Hanekamp JC,Bast A

    更新日期:2007-11-01 00:00:00

  • Assessment of genotoxicity risk in operation room personnel by the alkaline comet assay.

    abstract::This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327111426584

    authors: El-Ebiary AA,Abuelfadl AA,Sarhan NI,Othman MM

    更新日期:2013-06-01 00:00:00

  • Effects of excess corticosterone on NADPH generating enzymes and glucose oxidation in Leydig cells of adult rats.

    abstract::Clinical and experimental studies have shown the adverse effects of excess glucocorticoid on testicular testosterone production. The NADPH co-enzyme has been recognized as an important factor that regulates several steps in steroidogenesis, while glucose oxidation acts as a limiting factor on testicular testosterone p...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1191/0960327106ht591oa

    authors: Kavitha TS,Parthasarathy C,Sivakumar R,Badrinarayanan R,Balasubramanian K

    更新日期:2006-03-01 00:00:00

  • Pyrvinium pamoate inhibits proliferation and invasion of human endometriotic stromal cells.

    abstract::Endometriosis is characterized by the presence of functional endometrial tissue in other pelvic organs. This gynecologic problem occurs in 35-50% of women with pain and infertility. Endometriotic cells share some characteristics such as proliferation, migration, and invasion with tumor cells. Pyrvinium pamoate, an ant...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327119896612

    authors: Karamian A,Nazarian H,Ziai SA,Zarnani AH,Salehpour S,Paktinat S,Novin MG

    更新日期:2020-05-01 00:00:00

  • In vivo inhibition of serum dopamine-beta-hydroxylase by CaNa2 EDTA injection.

    abstract::1. In humans CaNa2EDTA increases urinary excretion of lead as well as that of essential metals such as zinc, ferrum and manganese but not that of copper. 2. We studied the effect of CaNa2EDTA injection on serum dopamine-beta-hydroxylase, a copper-dependent enzyme, in three male lead welders hospitalized for suspected ...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/096032719401300405

    authors: De Paris P,Caroldi S

    更新日期:1994-04-01 00:00:00

  • A dose-dependent relationship between mercury exposure from dental amalgams and urinary mercury levels: a further assessment of the Casa Pia Children's Dental Amalgam Trial.

    abstract::Dental amalgams are a commonly used dental restorative material, and amalgams are about 50% mercury (Hg). In our study, urinary Hg levels was examined in children of age 8-18 years, with and without dental amalgam fillings, from a completed clinical trial (parent study) that was designed to evaluate the potential heal...

    journal_title:Human & experimental toxicology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1177/0960327111417264

    authors: Geier DA,Carmody T,Kern JK,King PG,Geier MR

    更新日期:2012-01-01 00:00:00

  • The effect of short-term intoxication of rats with pentabromodiphenyl ether (in mixture mimic commercial products).

    abstract::Until quite recently, pentabromodiphenyl ether (PentaBDE) was most commonly used as a flame retardant. Due to the considerably long atmospheric half-life of PentaBDE and its contribution to environmental pollution, it is categorized as a persistent organic pollutant (POP). As the data on the toxicity of PentaBDE is ra...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327110371261

    authors: Bruchajzer E,Frydrych B,Sporny S,Szymańska JA

    更新日期:2011-05-01 00:00:00

  • HFA-134a (1,1,1,2-tetrafluoroethane); lack of oncogenicity in rodents after inhalation.

    abstract::1. Groups of 60 male and 60 female B6C3F1 mice or HanIbm Wistar rats were exposed to HFA-134a using snout-only inhalation exposure techniques for periods of one hour daily for at least 104 weeks. HFA-134a was delivered directly from cylinders at vapour concentrations of 2500, 15,000 and 75,000ppm for mice and from met...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/096032719501400902

    authors: Alexander DJ,Libretto SE,Chevalier HJ,Imamura T,Pappritz G,Wilson J

    更新日期:1995-09-01 00:00:00

  • Evaluation and comparison of cytotoxicity, genotoxicity, and apoptotic effects of poly-l-lysine/plasmid DNA micro- and nanoparticles.

    abstract::The principal impediment to gene therapy is the development of efficient, nontoxic gene carriers that can handle and deliver foreign genetic materials into various cell types, including healthy and cancerous cells. Poly-l-lysine (PLL) polymers are one of the most favorable gene carriers among nonviral vectors, and PLL...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327119846924

    authors: Alinejad-Mofrad E,Malaekeh-Nikouei B,Gholami L,Mousavi SH,Sadeghnia HR,Mohajeri M,Darroudi M,Oskuee RK

    更新日期:2019-08-01 00:00:00

  • Protective effect of 17β-estradiol on serum deprivation-induced apoptosis and oxidative stress in bone marrow-derived mesenchymal stem cells.

    abstract::Stem cell transplantation has indicated great promise for cell therapy in a wide range of diseases, but poor and insufficient viability of cells within damaged tissues has limited its potential therapeutic effects. 17 β-Estradiol (E2) is a steroid hormone that plays an important role in expression of many genes and re...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327115586208

    authors: Mirzamohammadi S,Mehrabani M,Tekiyehmaroof N,Sharifi AM

    更新日期:2016-03-01 00:00:00

  • Neutrophil functions in lead-exposed workers.

    abstract::Neutrophil functions were studied in 38 lead-exposed workers compared to 34 controls. Both groups were matched according to age, sex, drinking and smoking habits, ethnic origin and drug intake. Blood lead levels were found to be seven times higher in exposed workers than in controls. Phagocytosis assayed by chemilumin...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/096032719000900405

    authors: Bergeret A,Pouget E,Tedone R,Meygret T,Cadot R,Descotes J

    更新日期:1990-07-01 00:00:00

  • Pharmacology and toxicology of Bupleurum root-containing Kampo medicines in clinical use.

    abstract::Kampo (Japanese traditional herbal) medicines have been produced by combining multiple crude drugs, almost all of plant origin but with some of animal or mineral origin, and contain a great many substances. Their effect is a combination of the various interactions of the constituent substances, whether they are enhanc...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章,评审

    doi:10.1191/0960327106het654oa

    authors: Ikegami F,Sumino M,Fujii Y,Akiba T,Satoh T

    更新日期:2006-08-01 00:00:00

  • Ellagic acid protects against arsenic trioxide-induced cardiotoxicity in rat.

    abstract::Arsenic trioxide (As2O3) is utilized for treating patients suffering from hematological malignancies particularly acute promyelocytic leukemia. Unfortunately, the extensive application of this chemotherapeutic agent has been limited due to its adverse effects such as cardiotoxicity. Ellagic acid, as a phenolic compoun...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327117701986

    authors: Hemmati AA,Olapour S,Varzi HN,Khodayar MJ,Dianat M,Mohammadian B,Yaghooti H

    更新日期:2018-04-01 00:00:00

  • Cytogeneticity of quinalphos and methyl parathion in human peripheral lymphocytes.

    abstract::1. Four different concentrations of quinalphos and methyl parathion were tested on human peripheral lymphocytes over different time periods, for the analysis of chromosomal aberrations and sister chromatid exchanges (SCEs). 2. A significant increase in chromosomal aberrations was observed when cells were treated with ...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/096032719000900605

    authors: Rupa DS,Reddy PP,Reddi OS

    更新日期:1990-11-01 00:00:00

  • Effects of fenofibrate, a PPAR-α ligand, on the haemodynamics of glycerol-induced renal failure in rats.

    abstract::The modulating effect of peroxisome proliferator-activated receptor α ligand on haemodynamic effects of phenylepherine (PE), angiotensin II (AII), endothelin 1 (ET1), acetylcholine (Ach), sodium nitroprusside (SNP) and isoproterenol (ISO) were evaluated in glycerol-induced acute kidney injury in rats. The effect of PE...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327112454891

    authors: Adedapo AA,Oyekan AO

    更新日期:2013-03-01 00:00:00

  • Radiation hormesis--a remedy for fear.

    abstract::Personal reflections on radiation hormesis for the past 50 years are presented. The causes of ignoring and rejections of this phenomenon by international and national bodies and by radiation protection establishment are analyzed. The opposition against nuclear weapons and preparations for nuclear war was probably the ...

    journal_title:Human & experimental toxicology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1177/0960327110363974

    authors: Jaworowski Z

    更新日期:2010-04-01 00:00:00

  • Comparisons of thresholds for carcinogenicity on linear and logarithmic dosage scales.

    abstract::Comparisons on a linear and the Rozman logarithmic scale for dosage versus carcinogenicity in rodents are presented for methyl eugenol (ME), nitrosodiethylamine (NDEA), ethyl carbamate (EC) and 2-acetylaminofluorene (AAF). Each of these chemicals has been shown to be carcinogenic in experimental animals and, in additi...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1191/0960327105ht525oa

    authors: Waddell WJ

    更新日期:2005-06-01 00:00:00

  • Features reported after exposure to automatic dishwashing rinse aids.

    abstract:INTRODUCTION:Automatic dishwashing rinse aids are drying aids which contain non-ionic surfactants, usually ethoxylated alcohols, typically at concentrations of ≤30%. OBJECTIVE:To assess the reported toxicity of rinse aids. METHODS:Telephone enquiries to the UK National Poisons Information Service were analysed from J...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327120901580

    authors: Day R,Bradberry SM,Sandilands EA,Thomas S,Thompson JP,Vale JA

    更新日期:2020-06-01 00:00:00

  • Analysis of single hair by XRF discloses mercury intake.

    abstract::Utilizing information obtained from the X-ray fluorescence linear scanning along a single strand of hair in a recent fatal exposure to dimethylmercury, it was possible to determine the circumstances leading to the fatal result. When the Dartmouth chemistry professor displayed symptoms of mercury toxicity, samples of h...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1191/096032701678766813

    authors: Toribara TY

    更新日期:2001-04-01 00:00:00

  • Effect of progesterone on phosphamidon-induced impairment of memory and oxidative stress in rats.

    abstract::Progesterone (a neurosteroid) is an important modulator of the nervous system functioning. Organophosphorus pesticides like phosphamidon have been shown to adversely affect memory and induce oxidative stress on both acute and chronic exposure. The present study was therefore designed to investigate the effects of prog...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327110396522

    authors: Sharma AK,Bhattacharya SK,Khanna N,Tripathi AK,Arora T,Mehta AK,Mehta KD,Joshi V

    更新日期:2011-10-01 00:00:00

  • Inhibition of miR-182-5p attenuates pulmonary fibrosis via TGF-β/Smad pathway.

    abstract::Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with high morbidity and mortality. miR-182-5p is overexpressed in several fibrosis-related diseases but its effect in pulmonary fibrosis has not been reported yet. To investigate the function of miR-182-5p in pulmonary fibrosis, we establish...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327119895549

    authors: Chen Y,Zhang Q,Zhou Y,Yang Z,Tan M

    更新日期:2020-05-01 00:00:00

  • Novel effect of Daflon and low-dose γ-radiation in modulation of thioacetamide-induced hepatic encephalopathy in male albino rats.

    abstract::This study was designed to evaluate the hepato and neuroprotective activity of Daflon and low-dose γ radiation on thioacetamide (TAA)-induced liver damage and hepatic encephalopathy (HE) in rats. Effect of daily Daflon treatment (100 mg/kg body weight, Per OS (p.o.) for consecutive 3 days) and/or fractionated low-dose...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章

    doi:10.1177/0960327116637657

    authors: Abdel-Rafei M,Amin MM,Hasan HF

    更新日期:2017-01-01 00:00:00