Quercetin protects rat hepatocytes from oxidative damage induced by ethanol and iron by maintaining intercellular liable iron pool.

abstract：:Oxidative stress has an important role in the pathophysiology of many occupational diseases. In this controlled exposure study, the intensity of oxidative stress biomarkers was assessed in the workers of natural sweet and sour gas refineries (SwGR and SoGR, respectively) and compared with controls. In addition, the ro...

journal_title：Human & experimental toxicology

authors： Mandegary A,Sezavar M,Saeedi A,Amirheidari B,Naghibi B

更新日期：2012-12-01 00:00:00

abstract：:Pharmacological potential of curcumin was assessed in PC12 cells against hydrogen peroxide (H(2) O(2)) exposure. In MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and lactate dehydrogenase (LDH) assays, 24-hour exposure of H(2)O(2) (0.5 mM and above) was found to be cytotoxic. A significant (p < 0...

journal_title：Human & experimental toxicology

authors： Siddiqui MA,Kashyap MP,Kumar V,Tripathi VK,Khanna VK,Yadav S,Pant AB

更新日期：2011-03-01 00:00:00

abstract：:There is compelling evidence in support of positive associations between zinc (Zn) deficiency and high accumulation of cadmium (Cd) in biological samples of different cancerous patients. The incidence of mouth cancer has been increased among people who possess habit of drinking alcohol, tobacco smoking and chewing wit...

journal_title：Human & experimental toxicology

authors： Kazi TG,Wadhwa SK,Afridi HI,Kazi N,Kandhro GA,Baig JA,Shah AQ,Kolachi NF,Khan S

更新日期：2010-03-01 00:00:00

abstract：:3,4-Methylenedioxyphenol (sesamol) is effective against acetaminophen-induced liver injury in rats. Whether sesamol's anti-hepatotoxic effect is comparable to that of N-acetylcysteine has never been studied. We investigated the anti-hepatotoxic effects of sesamol and N-acetylcysteine on acetaminophen-induced hepatotox...

journal_title：Human & experimental toxicology

authors： Chandrasekaran VR,Chien SP,Hsu DZ,Liu MY

更新日期：2011-10-01 00:00:00

abstract：:In this study, genotoxic activities of four halogenated anesthetics (halothane, isoflurane, sevoflurane and desflurane) were investigated in human peripheral blood lymphocytes (PBLs) and sperm cells in vitro by alkaline comet assay. For this purpose, sperm or lymphocyte suspension was exposed to different concentratio...

journal_title：Human & experimental toxicology

authors： Kaymak C,Kadioglu E,Coskun E,Basar H,Basar M

更新日期：2012-12-01 00:00:00

abstract：:Silver nanoparticles are used in many commercial products in daily life. Exposure to nanosilver has hepatotoxic effects in animals. This study investigated the cytotoxicity associated with polyvinylpyrrolidone-coated nanosilver (23.44 ± 4.92 nm in diameter) exposure in the human hepatoma cell line (HepG2) and normal h...

journal_title：Human & experimental toxicology

authors： Xue Y,Wang J,Huang Y,Gao X,Kong L,Zhang T,Tang M

更新日期：2018-12-01 00:00:00

abstract：:This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...

journal_title：Human & experimental toxicology

authors： El-Ebiary AA,Abuelfadl AA,Sarhan NI,Othman MM

更新日期：2013-06-01 00:00:00

abstract：:Occupational chronic solvent encephalopathy (CSE) is associated with a number of neurobehavioural disorders including defects of visual perception. The purpose of this study was to characterize colour vision defects in CSE patients. Colour vision was tested in bright illumination with the Farnsworth-Munsell 100-hue te...

journal_title：Human & experimental toxicology

authors： Päällysaho J,Näsänen R,Mäntyjärvi M,Kaukiainen A,Sainio M

更新日期：2007-04-01 00:00:00

abstract：:Dermal exposure is an important factor in risk characterization. In occupational settings it becomes relatively more important because of the continuous reduction in inhalation exposure. In the public health arena, dermal exposure may also form a significant contribution to the total exposure. Dermal exposure, however...

journal_title：Human & experimental toxicology

authors： Boogaard PJ

更新日期：2008-04-01 00:00:00

abstract：:The effects of low lead exposure were investigated in 96 children (7-12 years old) living and studying within a 1 km radius of a lead smelter (exposed population) located in Torreón, Coahuila, México, and compared with 30 children living and studying 4.5 km from the same smelter (control population). Both populations ...

journal_title：Human & experimental toxicology

authors： Calderón-Salinas JV,Valdéz-Anaya B,Mazúñiga-Charles,Albores-Medina A

更新日期：1996-04-01 00:00:00

abstract：:The color of the teeth is an important topic for many people and can be influenced by intrinsic and extrinsic stains. There is an increasing demand for whitening of the teeth year by year. The most popular way of whitening is "bleaching," which is the result of the breakdown of pigments located in the enamel and/or th...

journal_title：Human & experimental toxicology

authors： Karaarslan ES,Özmen ZC,Aytac F,Bicakci AA,Buldur M,Aydogan L,Hologlu F,Özkocak B

更新日期：2019-04-01 00:00:00

abstract：:Exposure of Co631 cells to plutonium leads to increasing cell death depending on the dose and incubation time. The effects, however, are more pronounced with 239Pu, than with 238Pu. Uptake and binding of the two radionuclides during a 5-h incubation are about equal, but 238Pu is lost more rapidly from the cell. There ...

journal_title：Human & experimental toxicology

authors： Boxler C,Rau W,Planas-Bohne F

更新日期：1992-05-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) and dioxins are potentially toxic compounds which occur widely in the environment. Their effects on the growth and development of infants at the levels currently found in highly industrialised western countries is not well known. This Dutch multicenter study, combining animal and human...

journal_title：Human & experimental toxicology

authors： Sauer PJ,Huisman M,Koopman-Esseboom C,Morse DC,Smits-van Prooije AE,van de Berg KJ,Tuinstra LG,van der Paauw CG,Boersma ER,Weisglas-Kuperus N

更新日期：1994-12-01 00:00:00

abstract：:In this study, we aimed to investigate disulfide/thiol homeostasis in trichloroethylene (TCE) exposure. The study was carried out in 30 nonsmoker TCE-exposed workers with a variety of occupations. Additionally, 30 healthy nonsmoker volunteers were recruited as the control group. TCE exposure was determined by measurin...

journal_title：Human & experimental toxicology

authors： Bal C,Büyükşekerci M,Koca C,Ağış ER,Erdoğan S,Baran P,Gündüzöz M,Yilmaz Ö

更新日期：2016-09-01 00:00:00

abstract：:The aim of the present study was to investigate whether cognitive behavioral impairment, induced by nicotine in offspring rats, was associated with the alteration of hippocampal short-term potentiation (STP) and long-term potentiation (LTP) and to discuss the potential underlying mechanism. Young adult offspring rats ...

journal_title：Human & experimental toxicology

authors： Han G,An L,Yang B,Si L,Zhang T

更新日期：2014-02-01 00:00:00

abstract：:Formaldehyde is a physiological intermediary metabolite taking part in many biological process in the body. It is a constituent of many items of daily use, including foods. It is also used in medicine for treatment of some conditions. A 40% solution of formaldehyde in water is known as formalin. Formalin is irritating...

journal_title：Human & experimental toxicology

authors： Pandey CK,Agarwal A,Baronia A,Singh N

更新日期：2000-06-01 00:00:00

abstract：:The time-dependent changes in lead (Pb) concentrations in major tissues, serum and urine, and the Pb biomarker delta-aminolevulinic acid (ALA) concentration in urine were studied in rats after sub-chronic Pb exposure. Female Sprague-Dawley (SD) rats were exposed to Pb in drinking water at concentrations of 100 ppm and...

journal_title：Human & experimental toxicology

authors： Kang HG,Jeong SH,Cho MR,Cho JH,Bischoff K

更新日期：2009-10-01 00:00:00

abstract：:Sibutramine is an antiobesity drug that inhibits the reuptake of serotonin and noradrenalin in the hypothalamus. A 37-year-old Korean man presented to the emergency room for the oral intake of 280 mg of sibutramine. The patient was in thyrotoxic state. The (99m)Technetium-pertechnetate thyroid scan showed irregular up...

journal_title：Human & experimental toxicology

authors： Kim SK,Lee SM,Yoo SS,Hahm JR,Jung JH,Kim HS,Kim S,Chung SI,Jung TS

更新日期：2013-08-01 00:00:00

abstract：:The effects of the environmental toxicant, triethyltin, on Ca2+ mobilization in Madin-Darby canine kidney (MDCK) cells have been examined. Triethyltin induced an increase in cytosolic free Ca2+ levels ([Ca2+]i) at concentrations larger than 2 microM in a concentration-dependent manner. Within 5 min, the [Ca2+]i signal...

journal_title：Human & experimental toxicology

authors： Jiann BP,Chou KJ,Chang HT,Chen WC,Huang JK,Jan CR

更新日期：2002-08-01 00:00:00

abstract：:The effect of Glycyrrhiza glabra extract (GgE) as a natural antioxidant and melatonin (MEL) on ochratoxin A (OTA)-induced histopathological damages on the testes and oxidative stress was evaluated in male rats. The animals were assigned into four groups (n = 8) including control and test groups. The rats in control gr...

journal_title：Human & experimental toxicology

authors： Malekinejad H,Mirzakhani N,Razi M,Cheraghi H,Alizadeh A,Dardmeh F

更新日期：2011-02-01 00:00:00

abstract：:D-Glucaro(1,4)lactone, a potent beta-glucuronidase inhibitor was attached via the carboxylic acid moiety to polyvinylbenzyl chloride (PVBC) using a bimolecular nucleophilic displacement reaction. First, the caesium salt of D-glucaro(1,4)lactone was prepared by titrating the carboxylic acid to neutrality with aqueous c...

journal_title：Human & experimental toxicology

authors： Sacco C,McEwen WE,Calabrese EJ

更新日期：1993-03-01 00:00:00

abstract：:Male rats were exposed to manganese sulphate i.p. daily for a period of four weeks to see its effects on tissue levels and urinary excretion of total nicotinamide nucleotides (TNN). Increased levels of TNN were observed in blood and brain while the levels were found to be decreased in liver. There was a progressive in...

journal_title：Human & experimental toxicology

authors： Patel AB,Pandya AA

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is the main clinical concern resulted from ischemia-reperfusion injury (IRI). Ample clinical data indicates that AKI is associated with distant organ dysfunctions and poor patients' outcomes. Oxidative stress and inflammation have a critical role in the pathogenesis of organ injurie...

journal_title：Human & experimental toxicology

authors： Bagheri Y,Aghajani S,Hosseinzadeh M,Hoshmandan F,Abdollahpour A,Vahed SZ

更新日期：2020-12-16 00:00:00

abstract：:Brain tumors are often incurable despite current aggressive treatment modalities. Regional intracerebral administration of labeled monoclonal antibodies (Mabs) can maximize the radioisotope and Mab concentration to tumor sites while reducing systemic toxicity. h-R3 is a humanized antiepidermal growth factor receptor M...

journal_title：Human & experimental toxicology

authors： Gonzalez B,Casaco A,Alvarez P,Leon M,Arteaga M,Leon A,Santana E,Bada A,Figueredo R,Hernández R,Iznaga-Escobar N,González F,Perez R

更新日期：2000-12-01 00:00:00

abstract：:Hypofibrinogenemia is an important clinical consequence following envenomation by Lachesis muta muta, usually attenuated or prevented by administration of antivenom. The venom of L. m. muta contains both a metalloproteinase fibrinogenase and a serine protease thrombin-like enzyme, and exposure of fibrinogen to iron (F...

journal_title：Human & experimental toxicology

authors： Nielsen VG,Matika RW

更新日期：2017-07-01 00:00:00

abstract：:1. Groups of 60 male and 60 female B6C3F1 mice or HanIbm Wistar rats were exposed to HFA-134a using snout-only inhalation exposure techniques for periods of one hour daily for at least 104 weeks. HFA-134a was delivered directly from cylinders at vapour concentrations of 2500, 15,000 and 75,000ppm for mice and from met...

journal_title：Human & experimental toxicology

authors： Alexander DJ,Libretto SE,Chevalier HJ,Imamura T,Pappritz G,Wilson J

更新日期：1995-09-01 00:00:00

abstract：:A 20-year-old male who attempted suicide by injecting subcutaneously 10 ml of Sistemin 40 (40% dimethoate) was admitted 16 h later. General weakness, muscular fibrillations and a marked inhibition of red blood cell and serum cholinesterases were the prominent signs of intoxication. The antidotal treatment of intermitt...

journal_title：Human & experimental toxicology

authors： Jovanović D,Randjelović S,Joksović D

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:Automatic dishwashing rinse aids are drying aids which contain non-ionic surfactants, usually ethoxylated alcohols, typically at concentrations of ≤30%. OBJECTIVE:To assess the reported toxicity of rinse aids. METHODS:Telephone enquiries to the UK National Poisons Information Service were analysed from J...

journal_title：Human & experimental toxicology

authors： Day R,Bradberry SM,Sandilands EA,Thomas S,Thompson JP,Vale JA

更新日期：2020-06-01 00:00:00

abstract：:The Na+-taurocholate cotransporting polypeptide (NTCP) acts as the major hepatic basolateral uptake system, and plays a key role in balancing bile flow. The anti-tuberculosis drugs rifampin (RFP) can affect bile flow causing liver injury, while tanshinone IIA (TAN IIA) has the effect of protecting liver. This study ai...

journal_title：Human & experimental toxicology

authors： Yang Y,Liu L,Xu M,Zhang X,Wang L,He Q,Xu M,Jiang X

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND:The widespread use of synthetic cannabinoids (SCs) among youth has become an important public health problem. Several life-threatening side effects of SC have been reported, including cardiovascular, gastrointestinal, neurological, renal, metabolic, ophthalmologic, and pulmonary effects, besides skin toxicit...

journal_title：Human & experimental toxicology

authors： Guler EM,Bektay MY,Akyildiz AG,Sisman BH,Izzettin FV,Kocyigit A

更新日期：2020-11-01 00:00:00