Abstract：
:This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetists (6 females and 7 males), surgeons (10 males), nurses (9 females), and technicians (8 males). The study revealed significantly increased comet parameters (mean comet tail length and mean percentage of DNA in the tail) in peripheral blood lymphocytes of OR personnel in comparison with control individuals. The maximum DNA damage was observed in anesthesia technicians, whereas the nurses showed the least DNA damage. Furthermore, significant difference was observed between smoker and nonsmokerOR personnel in relation to mean comet tail length. However, no significant difference was seen due to age, gender, or duration of exposure. Also, significant increase in mean percentage of tail DNA was observed in smoker individuals of both exposed and control groups. As a conclusion, this study points to the risk of DNA damage in personnel who are exposed to waste anesthetic gases.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
El-Ebiary AA,Abuelfadl AA,Sarhan NI,Othman MMdoi
10.1177/0960327111426584subject
Has Abstractpub_date
2013-06-01 00:00:00pages
563-70issue
6eissn
0960-3271issn
1477-0903pii
0960327111426584journal_volume
32pub_type
杂志文章abstract：OBJECTIVE:Chlorobenzylidene malononitrile (CS) is the tear gas used by the police. The aim was to evaluate an amphoteric, hypertonic, and chelating rinsing solution in CS exposure. METHODS:The first (CS) group of six police officers was exposed to CS only. The second (preexposure) group of eight sprayed their faces wi...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327115578866
更新日期：2016-02-01 00:00:00
abstract：:9-(4'-Aminophenyl)-9H-pyrido [3,4-b] indole (aminophenylnorharman, APNH) is a novel mutagenic heterocyclic amine, produced by the reaction of norharman with aniline in the presence of S9 mix. In the present study, the maternal and developmental toxicity of APNH were investigated in ICR mice administered oral doses of ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/0960327102ht227oa
更新日期：2002-03-01 00:00:00
abstract：:Teucrium polium L. (Lamiaceae) is a commonly used medicinal plant in folk medicine. Among several uses, T. polium is used to treat male fertility problems. This research was conducted to study the effect of T. polium on spermatogenesis, testosterone level, androgen receptor expression, and fertility in male rats. Admi...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327116688069
更新日期：2017-12-01 00:00:00
abstract：:Endogenous alcohol has been applied for spontaneous ethanol production via different metabolic pathways of the human body. Auto-brewery syndrome describes the patients with alcohol intoxication after ingesting carbohydrate-rich meals. The main objective of this study is to investigate the effect of diabetes mellitus (...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327116661400
更新日期：2017-05-01 00:00:00
abstract：:Silver nanoparticles are used in many commercial products in daily life. Exposure to nanosilver has hepatotoxic effects in animals. This study investigated the cytotoxicity associated with polyvinylpyrrolidone-coated nanosilver (23.44 ± 4.92 nm in diameter) exposure in the human hepatoma cell line (HepG2) and normal h...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327118769718
更新日期：2018-12-01 00:00:00
abstract：:Dimerized translationally controlled tumor protein (dTCTP) plays a role in allergic diseases. A 7-mer peptide, dimerized translationally binding protein 2 (dTBP2), binds to dTCTP and inhibits dTCTP, suggesting that the 7-mer peptide may have therapeutic potential. We assessed the safety of dTBP2 by examining its cytot...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327113477873
更新日期：2013-11-01 00:00:00
abstract：:1. Neonatal treatment of rats with vitamin D3 resulted in a change of sexual behavior in adulthood. 2. 2.5 mg vitamin D3 completely inhibited the ejaculation of males without any apparent influence on sexual desire. 250 mg vitamin D3 influenced both the desire and ejaculation. 3. Sexual activity of females was depress...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719601500704
更新日期：1996-07-01 00:00:00
abstract：:Paraquat poisoning was studied in 174 patients over a 12-month period when a new, low concentration paraquat product (4.5% w/v paraquat ion mixed with 4.5% w/v diquat ion; 63 cases) replaced the original high concentration paraquat product (20% w/v paraquat ion only; 111 cases). In both groups approximately 60% of the...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719201100401
更新日期：1992-07-01 00:00:00
abstract：:Occupational chronic solvent encephalopathy (CSE) is associated with a number of neurobehavioural disorders including defects of visual perception. The purpose of this study was to characterize colour vision defects in CSE patients. Colour vision was tested in bright illumination with the Farnsworth-Munsell 100-hue te...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327107076820
更新日期：2007-04-01 00:00:00
abstract：:From 1988 to 1991, 732 patients (91.1% Chinese) were admitted to four general medical wards at the Prince of Wales Hospital in Hong Kong with acute poisoning. The patients were predominantly female (68.9%) and relatively young (86.3% below the age of 40). Further analysis of 655 patients indicates that the vast majori...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719401300711
更新日期：1994-07-01 00:00:00
abstract：:1. The herbicide, paraquat, is accumulated by the energy-dependent polyamine uptake pathway of alveolar type II cells. There it undergoes redox cycling that results in an amplified production of toxic reactive oxygen species and depletion of NADPH and other reducing equivalents. These processes account for the lung be...
journal_title：Human & experimental toxicology
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doi：10.1177/096032719401300808
更新日期：1994-08-01 00:00:00
abstract：:Cisplatin is an effective anticancer drug used against a variety of cancers. The full therapeutic potential of cisplatin is often hampered due to concurrent development of various side effects in the hosts. Rutin, a naturally occurring bioflavonoid shows several pharmacological activities. It has been earlier reported...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327120947793
更新日期：2020-08-13 00:00:00
abstract：:1. Six healthy male volunteers received intravenous injections of 26Al as citrate. Accelerator mass spectrometry and gamma-ray spectrometry were used to determine levels of the tracer in blood and excreta at times up to 5-6 d. 2. There was a rapid clearance from blood (mean 2% of injection remaining after 1 d) and maj...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719501400707
更新日期：1995-07-01 00:00:00
abstract：:The Organization for Economic Cooperation and Development (OECD) has promoted Good Laboratory Practice (GLP) since the mid 1970s. This paper describes the development of the concept through international harmonisation, Quality Assurance (QA), and compliance monitoring. Ultimately this process permits Mutual Acceptance...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719301200611
更新日期：1993-11-01 00:00:00
abstract：:The second-generation selective 5-HT2 receptor antagonists and reuptake inhibitors (SARIs) class antidepressants are known to have fewer cardiovascular side effects than the older ones. However, several case reports showed that trazodone, one of the second-generation SARIs, induces QT prolongation, cardiac arrhythmia,...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327115595683
更新日期：2016-05-01 00:00:00
abstract：:The serial cognitive assessment of ten individuals made between 8 and 26 months after the water at Camelford in Cornwall was accidentally contaminated with aluminium sulphate, showed consistent evidence of impairment of information processing and memory. There was no obvious relationship between these impairments and ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719301200108
更新日期：1993-01-01 00:00:00
abstract：:This descriptive and retrospective study was conducted at the poisoning ward of Imam teaching hospital, Sari, Iran, with the aim of evaluating the pattern of poisoning. Hence, the medical profiles of 2057 patients, who were admitted, were carefully reviewed during the period from April 2006 to March 2008 for 2 years. ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327110361501
更新日期：2010-09-01 00:00:00
abstract：:In this study, we aimed to investigate disulfide/thiol homeostasis in trichloroethylene (TCE) exposure. The study was carried out in 30 nonsmoker TCE-exposed workers with a variety of occupations. Additionally, 30 healthy nonsmoker volunteers were recruited as the control group. TCE exposure was determined by measurin...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327115608928
更新日期：2016-09-01 00:00:00
abstract：:The color of the teeth is an important topic for many people and can be influenced by intrinsic and extrinsic stains. There is an increasing demand for whitening of the teeth year by year. The most popular way of whitening is "bleaching," which is the result of the breakdown of pigments located in the enamel and/or th...
journal_title：Human & experimental toxicology
pub_type： 临床试验,杂志文章
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abstract：:Phosphorus flame retardants are a group of chemicals that are used to slow or prevent the spread of fire. These compounds have been detected in different environments including human organism. In the present study, we have investigated DNA-damaging potential and effect on DNA methylation of tris(2-chloroethyl) phospha...
journal_title：Human & experimental toxicology
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journal_title：Human & experimental toxicology
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doi：10.1177/096032719000900111
更新日期：1990-01-01 00:00:00
abstract：:As an input to dose assessments, measurements have been made of the clearance of Pu and Am after subcutaneous implantation in rats for six particulate materials and one dust from the Maralinga test sites. The tissue distribution of Pu and Am were measured in groups of six animals at one month and 6 months after implan...
journal_title：Human & experimental toxicology
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doi：10.1177/096032719301200410
更新日期：1993-07-01 00:00:00
abstract：:1. The methods used to evaluate the toxicological effects of PCBs in animals have been reviewed. 2. The data show that Toxic Equivalency Factors (TEFs) could be developed to assess the potential toxicity of PCB mixtures for certain specific target organ effects (such as the liver and immune system) but would be inappr...
journal_title：Human & experimental toxicology
pub_type： 杂志文章,评审
doi：10.1177/096032719401300901
更新日期：1994-09-01 00:00:00
abstract：:Puerarin, a potent free radicals scavenger, has been demonstrated to have protective efficacy in oxidative damage induced by nephrotoxins. In the present study, the attenuating effect of puerarin (PU) on lead (Pb)-induced apoptosis and oxidative stress was investigated in cultured primary rat proximal tubular (rPT) ce...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327114521048
更新日期：2014-10-01 00:00:00
abstract：:Deregulated cancer cell metabolism plays an important role in cancer progression. Cancer cell metabolism has been in the centre of attention in therapeutical cancer cell targeting. Repurposed chemical agents, such as metformin and aspirin, have been studied extensively as preventive and therapeutic agents. Metformin i...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327117747025
更新日期：2018-09-01 00:00:00
abstract：:Accidental ingestion of electrical batteries occurs commonly in children. This rarely is associated with severe morbidity and mortality. Significant symptoms can arise due to leakage of alkali or heavy metals from the battery after degradation in the gastrointestinal tract. The main heavy metal of concern in electrica...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/0960327104ht433oa
更新日期：2004-04-01 00:00:00
abstract：:Periodontitis is a common infectious disease associated with destruction of periodontal ligaments and alveolar bones. CD4(+) T cell-mediated immune response is involved in the progression of periodontitis. Tobacco consumption increases the risk of periodontal disease. However, the impact of nicotine on the interaction...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327115614383
更新日期：2016-09-01 00:00:00
abstract：:1. The reactivating and therapeutic efficacy of a new acetylcholinesterase reactivator, designated BI-6 (1-/2-hydroxyiminomethylpyridinium/-4-/carbamoylpyridinium/- 2-butene dibromide), against organophosphate sarin was compared with presently used oximes (pralidoxime, obidoxime, methoxime) and H oximes (HI-6, HLö-7) ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/096032799678845106
更新日期：1999-09-01 00:00:00
abstract：:1. Dettol liquid (chloroxylenol 4.8%, pine oil, isopropyl alcohol), a household disinfectant, has a corrosive action on the gastrointestinal mucosa when swallowed. The incidence of upper gastrointestinal haemorrhage and gastroscopic findings following Dettol poisoning was studied in 89 patients. 2. Five patients (5.6%...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719501400104
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:Mushroom poisoning is still a significant health-care problem, with the potential to affect blood parameters. The present study analyses the effect of mushroom poisoning on complete blood cell parameters, cell ratios, and cell volume indices and the effect of the mentioned parameters on prognosis/hospital len...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327119855131
更新日期：2019-10-01 00:00:00
