Abstract:
:The Organization for Economic Cooperation and Development (OECD) has promoted Good Laboratory Practice (GLP) since the mid 1970s. This paper describes the development of the concept through international harmonisation, Quality Assurance (QA), and compliance monitoring. Ultimately this process permits Mutual Acceptance of Data (MAD). An important aspect of the OECD's programme is the promotion of related training and information exchange.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Turnheim Ddoi
10.1177/096032719301200611subject
Has Abstractpub_date
1993-11-01 00:00:00pages
528-32issue
6eissn
0960-3271issn
1477-0903journal_volume
12pub_type
杂志文章abstract::Omeprazole is one of the most used acid-suppressing medications. This fact emphasizes the questions concerning the safety of this compound. Healthy volunteers (n=33) were included in this prospective study. All study subjects were analysed for their CYP2C19 genotype. Of the 33 individuals, 24 were homozygous for the w...
journal_title:Human & experimental toxicology
pub_type: 临床试验,杂志文章
doi:10.1191/0960327104ht431oa
更新日期:2004-03-01 00:00:00
abstract::Evidence-based guidelines do not exist for the treatment of patients with chronic mild-moderate digoxin toxicity. We sought to evaluate differences among specialists in the use of digoxin-specific antibody fragments and the decision to admit these patients. A sample of cardiologists, emergency physicians, and medical ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109105405
更新日期:2009-05-01 00:00:00
abstract::In this study, we aimed to investigate disulfide/thiol homeostasis in trichloroethylene (TCE) exposure. The study was carried out in 30 nonsmoker TCE-exposed workers with a variety of occupations. Additionally, 30 healthy nonsmoker volunteers were recruited as the control group. TCE exposure was determined by measurin...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115608928
更新日期:2016-09-01 00:00:00
abstract::Drugs containing 5-acetylsalicylic acid (5-ASA) have been commonly used for inflammatory bowel diseases for more than half a century, but no case about overdose of suppository form of mesalazine which was taken both orally and rectally has been reported in the related literature up to now. In the present case, a 20-ye...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110379249
更新日期:2011-07-01 00:00:00
abstract::The article focuses on flaws in the actual approaches of exposure to a chemical of recipient organisms. It demonstrates the excessive use of arguments based on adverse effects and underlines the necessity to take adaptive effects seriously. Regulators are invited to rethink their inclination to the 'When in doubt, kee...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107083414
更新日期:2007-11-01 00:00:00
abstract::The effect of fendiline on cytosolic free Ca(2+) concentrations ([Ca(2+)](i)) and proliferation has not been explored in human oral cancer cells. This study examined whether fendiline altered Ca(2+) levels and caused cell death in OC2 human oral cancer cells. [Ca(2+)](i) and cell viability were measured using the fluo...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108097436
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The mortality rate associated with human glufosinate poisoning is high. We evaluated the usefulness of serum ammonia and sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation II (APACHE II) scores for early prediction of in-hospital mortality in glufosinate ammonium po...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119855124
更新日期:2019-09-01 00:00:00
abstract::Manganese (Mn) is an essential nutrient required for proper growth and maintenance of numerous biological systems. At high levels it is known to be neurotoxic. While focused research concerning the transport of Mn across the blood-brain barrier (BBB) is on-going, the exact identity of the transporter(s) responsible is...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1177/0960327107070496
更新日期:2007-04-01 00:00:00
abstract::Vigabatrin (VGB) is an antiepileptic drug thatincreases brain γ-aminobutyric acid (GABA) levels through irreversible inhibition of GABA transaminase. The aim of this study was to evaluate neurotoxicological effects of VGB measuring motor activity and genotoxic and mutagenic effects after a single and repeated administ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115611970
更新日期:2016-09-01 00:00:00
abstract::Enterococcus faecalis is a facultative anaerobic gram-positive commensal bacterium common in the gastrointestinal tract of animals and humans. This study aimed to investigate the protective effects of heat-killed E. faecalis EF-2001 (EF-2001) on acute gastric ulcer using a murine model of ethanol (EtOH)-induced acute ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119899987
更新日期:2020-05-01 00:00:00
abstract::Dimethylacetamide (DMAc) is a skin-penetrating solvent able to induce hepatic damage after chronic exposure. Previous research has indicated that metabolism may be saturated at its present TLV/TWA (10 ppm). Biological monitoring of monomethylacetamide (MMAc), the primary metabolite of DMAc, might therefore underestima...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719301200206
更新日期:1993-03-01 00:00:00
abstract::1. The reactivating and therapeutic efficacy of a new acetylcholinesterase reactivator, designated BI-6 (1-/2-hydroxyiminomethylpyridinium/-4-/carbamoylpyridinium/- 2-butene dibromide), against organophosphate sarin was compared with presently used oximes (pralidoxime, obidoxime, methoxime) and H oximes (HI-6, HLö-7) ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032799678845106
更新日期:1999-09-01 00:00:00
abstract::The aim of this study was to compare the number of inactivated-influenza vaccine-related spontaneous abortion and stillbirth (SB) reports in the Vaccine Adverse Event Reporting System (VAERS) database during three consecutive flu seasons beginning 2008/2009 and assess the relative fetal death reports associated with t...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112455067
更新日期:2013-05-01 00:00:00
abstract::The modulating effect of peroxisome proliferator-activated receptor α ligand on haemodynamic effects of phenylepherine (PE), angiotensin II (AII), endothelin 1 (ET1), acetylcholine (Ach), sodium nitroprusside (SNP) and isoproterenol (ISO) were evaluated in glycerol-induced acute kidney injury in rats. The effect of PE...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112454891
更新日期:2013-03-01 00:00:00
abstract::A number of novel serotonergic antidepressants have been introduced to clinical practice over the last decade. These medications are felt to be safe alternatives to the traditional tricyclic antidepressants and monoamine oxidase inhibitors, particularly in the overdose setting. Serious adverse reactions and drug inter...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327197016001031
更新日期:1997-01-01 00:00:00
abstract::The study of Jayjock and Lewis, 'Implication of Hormesis for Industrial Hygiene', represents a challenge for the scientific community to consider hormesis as a possible working hypothesis for redefining risk assessment strategy for low-dose exposures in the realm of industrial hygiene. This invited commentary aims at ...
journal_title:Human & experimental toxicology
pub_type: 评论,杂志文章
doi:10.1191/0960327102ht269xx
更新日期:2002-07-01 00:00:00
abstract::Clobenpropit, an H( 3) receptor antagonist, has been reported to modulate both the release of neurotransmitters and also the activity of histidine decarboxylase (HDC). Therefore, a decarboxylase-positive modulator, namely pyridoxine, was taken for interaction studies with clobenpropit in the electroshock (ES) model of...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110372398
更新日期:2011-01-01 00:00:00
abstract::Organophosphate-induced delayed neuropathy (OPIDN) is a progressive neuropathic disorder that manifests in days to weeks following exposure to an acute dose of organophosphates. The precise mechanism involved in the development of OPIDN is not clear as it develops after many days of the cessation of cholinergic crisis...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112446842
更新日期:2012-12-01 00:00:00
abstract::Sibutramine is an antiobesity drug that inhibits the reuptake of serotonin and noradrenalin in the hypothalamus. A 37-year-old Korean man presented to the emergency room for the oral intake of 280 mg of sibutramine. The patient was in thyrotoxic state. The (99m)Technetium-pertechnetate thyroid scan showed irregular up...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112468907
更新日期:2013-08-01 00:00:00
abstract::The color of the teeth is an important topic for many people and can be influenced by intrinsic and extrinsic stains. There is an increasing demand for whitening of the teeth year by year. The most popular way of whitening is "bleaching," which is the result of the breakdown of pigments located in the enamel and/or th...
journal_title:Human & experimental toxicology
pub_type: 临床试验,杂志文章
doi:10.1177/0960327118817103
更新日期:2019-04-01 00:00:00
abstract::D-Glucaro(1,4)lactone, a potent beta-glucuronidase inhibitor was attached via the carboxylic acid moiety to polyvinylbenzyl chloride (PVBC) using a bimolecular nucleophilic displacement reaction. First, the caesium salt of D-glucaro(1,4)lactone was prepared by titrating the carboxylic acid to neutrality with aqueous c...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719301200216
更新日期:1993-03-01 00:00:00
abstract::Occupational chronic solvent encephalopathy (CSE) is associated with a number of neurobehavioural disorders including defects of visual perception. The purpose of this study was to characterize colour vision defects in CSE patients. Colour vision was tested in bright illumination with the Farnsworth-Munsell 100-hue te...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107076820
更新日期:2007-04-01 00:00:00
abstract::Pyrazinamide (PYZ)-an essential component of primary drug regimen used for the treatment and management of multidrug resistant or latent tuberculosis-is well known for its hepatoxicity. However, the mechanism of PYZ-induced hepatotoxicity is still unknown to researchers. Studies have shown that the drug is metabolized...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117705426
更新日期:2018-04-01 00:00:00
abstract::Although ingestion of methyl ethyl ketone peroxide (MEKP) is rare, it carries a high risk of morbidity and mortality. This paper reports the first such case from Turkey in which a 70-year-old man unintentionally ingested MEKP in his kitchen. The patient was brought into the emergency department (ED) within 1 hour of i...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111407230
更新日期:2011-12-01 00:00:00
abstract::Epichlorohydrin (ECH) is an antifertility agent that acts both as an epididymal toxicant and an agent capable of directly affecting sperm motility. This study identified the time course of apoptotic cell death in rat epididymides after ECH treatment. Rats were administrated with a single oral dose of ECH (50 mg/kg). E...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112467042
更新日期:2013-06-01 00:00:00
abstract::The present study was designed to evaluate the cardioprotective potential of lycopene (LCP) against isoproterenol (ISP)-induced myocardial infarction (MI), by assessing hemodynamic, biochemical and histopathological parameters. Wistar male albino rats were orally administered with LCP (0.5, 1.0 and 1.5 mg/kg) or with ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112454890
更新日期:2013-05-01 00:00:00
abstract::Nicotinamide riboside (NR) is a naturally occurring form of vitamin B3 present in trace amounts in some foods. Like niacin, it has been shown to be a precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). The safety of Niagen™, a synthetic form of NR, was determined using a bacterial reverse mutage...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115626254
更新日期:2016-11-01 00:00:00
abstract::The objective of this study was to evaluate data retrospectively on accidental ingestion of ethylene glycol (EG), based on calls to the Czech Toxicological Information Centre and from toxicological laboratories, in the years 2000-2004. All patients who ingested a known amount of EG and/or subjects with measured serum ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107073831
更新日期:2007-01-01 00:00:00
abstract::Dermal exposure is an important factor in risk characterization. In occupational settings it becomes relatively more important because of the continuous reduction in inhalation exposure. In the public health arena, dermal exposure may also form a significant contribution to the total exposure. Dermal exposure, however...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107085830
更新日期:2008-04-01 00:00:00
abstract::The use of Lucilia sericata larvae on the healing of wounds in diabetics has been reported. However, the role of the excretion/secretion (ES) products of the larvae in treatment of diabetic wounds remains unknown. This study investigated whether application of the ES products of L. sericata on the wound surface could ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117714041
更新日期:2018-05-01 00:00:00