Prevention of paraquat toxicity in suspensions of alveolar type II cells by paraquat-specific antibodies.

abstract：:9-(4'-Aminophenyl)-9H-pyrido [3,4-b] indole (aminophenylnorharman, APNH) is a novel mutagenic heterocyclic amine, produced by the reaction of norharman with aniline in the presence of S9 mix. In the present study, the maternal and developmental toxicity of APNH were investigated in ICR mice administered oral doses of ...

journal_title：Human & experimental toxicology

authors： Naga T,Yoshimura S,Totsuka Y,Wakabayashi K

更新日期：2002-03-01 00:00:00

abstract：:The study of Jayjock and Lewis, 'Implication of Hormesis for Industrial Hygiene', represents a challenge for the scientific community to consider hormesis as a possible working hypothesis for redefining risk assessment strategy for low-dose exposures in the realm of industrial hygiene. This invited commentary aims at ...

journal_title：Human & experimental toxicology

authors： Carelli G,Iavicoli I,Castellino N

更新日期：2002-07-01 00:00:00

abstract：:A key aim of toxicology is the prevention of adverse effects due to toxic hazards. Therefore, the dissemination of toxicology research findings must confront two important challenges: one being the lack of information on the vast majority of potentially toxic industrial chemicals and the other being the strict criteri...

journal_title：Human & experimental toxicology

authors： Grandjean P

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:Pesticide poisoning stands as a major public health issue worldwide. The objective of this study was to examine the epidemiologic characteristics of pesticide-related hospitalizations in South Korea. METHODS:Data from the Korea National Hospital Discharge Survey were analyzed to describe the epidemiologic c...

journal_title：Human & experimental toxicology

authors： Kim HJ,Cha ES,Ko Y,Kim J,Kim SD,Lee WJ

更新日期：2012-08-01 00:00:00

abstract：:In carbon monoxide (CO) poisoning, CO affects the oxygen-carrying capacity of the hemoglobin molecule. Nucleolar-organizing regions (NORs) are genetic loci on chromosomes that are composed of ribosomal DNA and proteins. NORs can be stained with silver. A total of 18 rats were exposed to CO in three different concentra...

journal_title：Human & experimental toxicology

authors： Çolakoğlu S,Saritas A,Eroz R,Oktay M,Yaykasli KO,Akoz A,Kaya E,Kandis H

更新日期：2015-01-01 00:00:00

abstract：:HCH isomers, endosulfan, malathion, chlorpyrifos, and methyl-parathion were monitored in human milk samples from Bhopal, Madhya Pradesh. The endosulfan concentrations were highest and exceeded the sigma-HCH, chlorpyrifos, and malathion concentrations by 3.5-, 1.5-, and 8.4-fold, respectively. Through breast milk, infa...

journal_title：Human & experimental toxicology

authors： Sanghi R,Pillai MK,Jayalekshmi TR,Nair A

更新日期：2003-02-01 00:00:00

abstract：:Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Attenuation of fibrogenic process can significantly lower the mortality rate. However, pharmaceutical intervention at fibrogenesis stage remains a major task in medicine. So there is a need for a natural compound to treat hepatic fibrosis. This ...

journal_title：Human & experimental toxicology

authors： Thirupathi A,Silveira PC,Nesi RT,Pinho RA

更新日期：2017-02-01 00:00:00

abstract：:Coronary heart disease and in particular its most serious form - acute myocardial infarction (AMI) - represents the most common cause of mortality in developed countries. Better prognosis may be achieved by understanding the etiopathogenetic mechanisms of AMI. Therefore, a catecholamine model of myocardial injury, whi...

journal_title：Human & experimental toxicology

authors： Mladenka P,Hrdina R,Bobrovová Z,Semecky V,Vávrová J,Holecková M,Palicka V,Mazurová Y,Nachtigal P

更新日期：2009-10-01 00:00:00

abstract：:The phenomenon of subtoxic stimulation of organism response is not uncommon in aquatic toxicology experiments. We describe the presence of hormesis in both growth and reproduction experiments in aquatic toxicology where these responses are observed in both animals and plants and at different trophic levels of an ecosy...

journal_title：Human & experimental toxicology

authors： Bailer AJ,Oris JT

更新日期：1998-05-01 00:00:00

abstract：:Prolonged zidovudine (AZT) treatment in HIV-infected and AIDS patients is shown to induce liver toxicity leading to complications. Therapeutic regimen that could encounter this adverse effect is unavailable and management of toxicity is often symptomatic or is limited to withdrawal of therapy. In the present investiga...

journal_title：Human & experimental toxicology

authors： Raghu R,Jesudas B,Bhavani G,Ezhilarasan D,Karthikeyan S

更新日期：2015-11-01 00:00:00

abstract：:Two studies were performed in order to evaluate cytochrome P450 1A2 mediated caffeine metabolism during different nutritional conditions. 1. In the first study, 23 healthy male non-smokers, mean age 25, changed from a customary mixed diet to a standard diet in 6 days. The 6 day's standard diet was based on bread, pota...

journal_title：Human & experimental toxicology

authors： Kall MA,Clausen J

更新日期：1995-10-01 00:00:00

abstract：:The regulation of osteoblast proliferation is a key factor in maintaining bone mass. The enhancement of this process can be achieved by stimulating the proliferation of these cells. Mechanical stimulation is one of the important enhancing factors, but the exact cellular mechanisms of mechanical stimulation, i.e., mech...

journal_title：Human & experimental toxicology

authors： Rosenberg N

更新日期：2003-05-01 00:00:00

abstract：:1. Multiple low doses of the direct acting organophosphates, ecothiopate, paraoxon and mipafox produced persistent and additive inhibition of diaphragm acetylcholinesterase. Paraoxon and mipafox had similar effects on brain acetylcholinesterase. There was greater recovery from inhibition between doses for paraoxon and...

journal_title：Human & experimental toxicology

authors： Williams FM,Charlton C,de Blaquière GE,Mutch E,Kelly SS,Blain PG

更新日期：1997-02-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA) is a powerfully addictive psychostimulant with pronounced effects on the central nervous system, but the precise mechanism of MDMA-induced toxicity remains unclear, specifically on the retina. This study was performed to investigate the effects of MDMA treatment on the retina a...

journal_title：Human & experimental toxicology

authors： Ma Y,Bian C,Song D,Yao G,Nie R

更新日期：2020-11-01 00:00:00

abstract：:To evaluate in vitro inhibitory effects of four types of histamine H2-receptor antagonist (H2-receptor antagonists), famotidine, roxatidine, cimetidine and ranitidine, on platelet function, we examined aggregating potency and P-selectin levels with agonist-induced aggregation. Ranitidine and cimetidine inhibited, in c...

journal_title：Human & experimental toxicology

authors： Nakamura K,Kariyazono H,Shinkawa T,Yamaguchi T,Yamashita T,Ayukawa O,Moriyama Y,Yotsumoto G,Toyohira H,Taira A,Yamada K

更新日期：1999-08-01 00:00:00

abstract：:The second-generation selective 5-HT2 receptor antagonists and reuptake inhibitors (SARIs) class antidepressants are known to have fewer cardiovascular side effects than the older ones. However, several case reports showed that trazodone, one of the second-generation SARIs, induces QT prolongation, cardiac arrhythmia,...

journal_title：Human & experimental toxicology

authors： Lee S,Lee HA,Kim SJ,Kim KS

更新日期：2016-05-01 00:00:00

abstract：:A liquid alcoholic extract of Papaver somniferum named Elixir Paregorico is extensively used for diarrheal diseases in Brazil. Its increased popularity has brought concerns and fears over the safety of this herbal product. Given the lack of investigative clinical studies, in this regard, this study investigated whethe...

journal_title：Human & experimental toxicology

authors： de Moraes M,Bezerra M,Bezerra F,de Moraes R,Cavalcanti P,Uchoa C,Lima F,Odorico de Moraes M

更新日期：2008-10-01 00:00:00

abstract：:Pharmacological potential of curcumin was assessed in PC12 cells against hydrogen peroxide (H(2) O(2)) exposure. In MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and lactate dehydrogenase (LDH) assays, 24-hour exposure of H(2)O(2) (0.5 mM and above) was found to be cytotoxic. A significant (p < 0...

journal_title：Human & experimental toxicology

authors： Siddiqui MA,Kashyap MP,Kumar V,Tripathi VK,Khanna VK,Yadav S,Pant AB

更新日期：2011-03-01 00:00:00

abstract：:Food-borne botulism is a rare disease that results from ingestion of the toxins produced by Clostridium botulinum. The most common cause of the disease is the consumption of home-canned foods prepared under inappropriate conditions, especially in rural environments. In this report, a food-borne botulism outbreak poten...

journal_title：Human & experimental toxicology

authors： Cengiz M,Yilmaz M,Dosemeci L,Ramazanoglu A

更新日期：2006-05-01 00:00:00

abstract：UNLABELLED:We present the first ever case of homicidal poisoning due to injection of methidathion, an organophosphate insecticide. CASE:A 4-month-old baby presented to the emergency department with chief complaints of unconsciousness and irregular respiration. A bitter odour and an injection site with a greenish blue ...

journal_title：Human & experimental toxicology

authors： Ozdemir C,Kar H,Bilge Y,Batuk G,Batuk HI

更新日期：2009-08-01 00:00:00

abstract：:Benzydamine is a nonsteroidal anti-inflammatory drug, currently available as mouthwash, aerosol, dermal cream, vaginal douche preparation, pills and otic drops. Up to now no cases of poisoning due to this drug have been reported. A 6-year-old girl with an accidental poisoning with benzydamine is described. The episode...

journal_title：Human & experimental toxicology

authors： Gómez-López L,Hernández-Rodríguez J,Pou J,Nogué S

更新日期：1999-07-01 00:00:00

abstract：:Postoperative cognitive dysfunction, which is associated with a wide range of cognitive functions including working memory, long-term memory, information processing, attention, and cognitive flexibility, is a major clinical issue in geriatric surgical patients. The aim of the current study was to determine the protect...

journal_title：Human & experimental toxicology

authors： Liang L,Ma Z,Dong M,Ma J,Jiang A,Sun X

更新日期：2017-12-01 00:00:00

abstract：:1. The reactivating and therapeutic efficacy of a new acetylcholinesterase reactivator, designated BI-6 (1-/2-hydroxyiminomethylpyridinium/-4-/carbamoylpyridinium/- 2-butene dibromide), against organophosphate sarin was compared with presently used oximes (pralidoxime, obidoxime, methoxime) and H oximes (HI-6, HLö-7) ...

journal_title：Human & experimental toxicology

authors： Kassa J,Cabal J

更新日期：1999-09-01 00:00:00

abstract：:1. Following the establishment, in the USA, of the first poisons information centre, in 1953, the movement has grown globally. Originally, such a service was intended to meet an emergency need. Its efficacy has still not been objectively audited. 2. The suggestion now is that clinical toxicology has become such a dive...

journal_title：Human & experimental toxicology

authors： Goulding R

更新日期：1991-11-01 00:00:00

abstract：:Paraquat poisoning was studied in 174 patients over a 12-month period when a new, low concentration paraquat product (4.5% w/v paraquat ion mixed with 4.5% w/v diquat ion; 63 cases) replaced the original high concentration paraquat product (20% w/v paraquat ion only; 111 cases). In both groups approximately 60% of the...

journal_title：Human & experimental toxicology

authors： Yoshioka T,Sugimoto T,Kinoshita N,Shimazu T,Hiraide A,Kuwagata Y

更新日期：1992-07-01 00:00:00

abstract：:As an input to dose assessments, measurements have been made of the clearance of Pu and Am after subcutaneous implantation in rats for six particulate materials and one dust from the Maralinga test sites. The tissue distribution of Pu and Am were measured in groups of six animals at one month and 6 months after implan...

journal_title：Human & experimental toxicology

authors： Harrison JD,Hodgson A,Haines JW,Stather JW

更新日期：1993-07-01 00:00:00

abstract：:Levo-Carnitine (l-carnitine) is widely used in health and food. This study was to focus on the adverse effects of 8-week oral supplementation of l-carnitine (0.3 and 0.6 g/kg) in female and male Sprague Dawley rats. l-carnitine reduced body and fat weights, as well as serum, liver, and kidney lipid levels in rats. Sim...

journal_title：Human & experimental toxicology

authors： Liu L,Zhang DM,Wang MX,Fan CY,Zhou F,Wang SJ,Kong LD

更新日期：2015-11-01 00:00:00

abstract：:Information on the acute effects associated with the handling of 1,4-dioxane is sparse. Our aim was to evaluate the acute effects of 1,4-dioxane vapours. In a screening study, six healthy volunteers rated symptoms on a visual analogue scale (VAS), while exposed to stepwise increasing levels of 1,4-dioxane, from 1 to 2...

journal_title：Human & experimental toxicology

authors： Ernstgård L,Iregren A,Sjögren B,Johanson G

更新日期：2006-12-01 00:00:00

abstract：:1. Tobacco smoke contains around 4000 substances, most of which are described as toxic, and they may have an influence on the development of progeny. 2. The present studies concentrate on the measurement and calculation of indices describing the new-born's survival, rearing of pups, weight of foetuses, young animals, ...

journal_title：Human & experimental toxicology

authors： Florek E,Marszalek A,Biczysko W,Szymanowski K

更新日期：1999-04-01 00:00:00

abstract：:The renin-angiotensin system (RAS) subserves vital physiological functions and also implicated in certain pathological states. Modulation of this system has been proposed in recent studies to be a promising strategy in treating liver fibrosis. We investigated the effect of the pharmacologic inhibition of RAS with angi...

journal_title：Human & experimental toxicology

authors： Ekor M,Odewabi AO,Kale OE,Oritogun KS,Adesanoye OA,Bamidele TO

更新日期：2011-11-01 00:00:00