A botulism outbreak from roasted canned mushrooms.

abstract：PURPOSE:Calcium channel blockers (CCBs) were the most common agents associated with a significant morbidity and mortality rate. The main objective of this study was to examine the publication pattern related to CCBs poisoning at the global level using bibliometric analysis of articles published in SciVerse Scopus onlin...

journal_title：Human & experimental toxicology

authors： Zyoud SH,Al-Jabi SW,Sweileh WM,Waring WS

更新日期：2015-11-01 00:00:00

abstract：:This paper presents the findings of a study of serum pseudocholinesterase activity in a group of 36 industrial workers chronically exposed to organophosphorus (OP) compounds. The mean pseudocholinesterase level of the workers was significantly lower than that of 36 other workers without a history of similar exposure. ...

journal_title：Human & experimental toxicology

authors： Peedicayil J,Ernest K,Thomas M,Kanagasabapathy AS,Stephen PM

更新日期：1991-07-01 00:00:00

abstract：:1. With DTPA as a comparison, the siderophore analogue 3,4,3-LIHOPO has been examined for its ability to remove 228Th nitrate from the rat after subcutaneous (sc) and intramuscular (im) injection to simulate wound contamination. The commencement of treatment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d...

journal_title：Human & experimental toxicology

authors： Stradling GN,Gray SA,Pearce MJ,Wilson I,Moody JC,Burgada R,Durbin PW,Raymond KN

更新日期：1995-02-01 00:00:00

abstract：:Sibutramine mesylate is a new anti-obesity drug. It is a crystalline salt of sibutramine developed to improve the solubility of sibutramine hydrochloride. Methanesulfonic acid was used as a salt-forming acid instead of hydrochloric acid, resulting in a greatly improved solubility of 1000 mg/mL in water. Sibutramine me...

journal_title：Human & experimental toxicology

authors： Kim EJ,Park EK,Suh KH

更新日期：2005-03-01 00:00:00

abstract：:Deregulated cancer cell metabolism plays an important role in cancer progression. Cancer cell metabolism has been in the centre of attention in therapeutical cancer cell targeting. Repurposed chemical agents, such as metformin and aspirin, have been studied extensively as preventive and therapeutic agents. Metformin i...

journal_title：Human & experimental toxicology

authors： Albayrak G,Konac E,Dikmen AU,Bilen CY

更新日期：2018-09-01 00:00:00

abstract：:A sound understanding of the mechanisms determining percutaneous absorption is necessary for toxicological risk assessment of chemicals contacting the skin. As part of a programme investigating these mechanisms we have developed a physiologically based mathematical model. The structure of the model parallels the multi...

journal_title：Human & experimental toxicology

authors： Auton TR,Westhead DR,Woollen BH,Scott RC,Wilks MF

更新日期：1994-01-01 00:00:00

abstract：:Levo-Carnitine (l-carnitine) is widely used in health and food. This study was to focus on the adverse effects of 8-week oral supplementation of l-carnitine (0.3 and 0.6 g/kg) in female and male Sprague Dawley rats. l-carnitine reduced body and fat weights, as well as serum, liver, and kidney lipid levels in rats. Sim...

journal_title：Human & experimental toxicology

authors： Liu L,Zhang DM,Wang MX,Fan CY,Zhou F,Wang SJ,Kong LD

更新日期：2015-11-01 00:00:00

abstract：:In this study, we aimed to investigate disulfide/thiol homeostasis in trichloroethylene (TCE) exposure. The study was carried out in 30 nonsmoker TCE-exposed workers with a variety of occupations. Additionally, 30 healthy nonsmoker volunteers were recruited as the control group. TCE exposure was determined by measurin...

journal_title：Human & experimental toxicology

authors： Bal C,Büyükşekerci M,Koca C,Ağış ER,Erdoğan S,Baran P,Gündüzöz M,Yilmaz Ö

更新日期：2016-09-01 00:00:00

abstract：:Information on the acute effects associated with the handling of 1,4-dioxane is sparse. Our aim was to evaluate the acute effects of 1,4-dioxane vapours. In a screening study, six healthy volunteers rated symptoms on a visual analogue scale (VAS), while exposed to stepwise increasing levels of 1,4-dioxane, from 1 to 2...

journal_title：Human & experimental toxicology

authors： Ernstgård L,Iregren A,Sjögren B,Johanson G

更新日期：2006-12-01 00:00:00

abstract：:Sibutramine is an antiobesity drug that inhibits the reuptake of serotonin and noradrenalin in the hypothalamus. A 37-year-old Korean man presented to the emergency room for the oral intake of 280 mg of sibutramine. The patient was in thyrotoxic state. The (99m)Technetium-pertechnetate thyroid scan showed irregular up...

journal_title：Human & experimental toxicology

authors： Kim SK,Lee SM,Yoo SS,Hahm JR,Jung JH,Kim HS,Kim S,Chung SI,Jung TS

更新日期：2013-08-01 00:00:00

abstract：:Teucrium polium L. (Lamiaceae) is a commonly used medicinal plant in folk medicine. Among several uses, T. polium is used to treat male fertility problems. This research was conducted to study the effect of T. polium on spermatogenesis, testosterone level, androgen receptor expression, and fertility in male rats. Admi...

journal_title：Human & experimental toxicology

authors： Al-Tikriti A,Al-Khateeb E,Abbas MA

更新日期：2017-12-01 00:00:00

abstract：:In this study, genotoxic activities of four halogenated anesthetics (halothane, isoflurane, sevoflurane and desflurane) were investigated in human peripheral blood lymphocytes (PBLs) and sperm cells in vitro by alkaline comet assay. For this purpose, sperm or lymphocyte suspension was exposed to different concentratio...

journal_title：Human & experimental toxicology

authors： Kaymak C,Kadioglu E,Coskun E,Basar H,Basar M

更新日期：2012-12-01 00:00:00

abstract：:Drugs containing 5-acetylsalicylic acid (5-ASA) have been commonly used for inflammatory bowel diseases for more than half a century, but no case about overdose of suppository form of mesalazine which was taken both orally and rectally has been reported in the related literature up to now. In the present case, a 20-ye...

journal_title：Human & experimental toxicology

authors： Koseoglu Z,Satar S,Kara B,Sebe A,Kosenli O

更新日期：2011-07-01 00:00:00

abstract：:Formaldehyde is a physiological intermediary metabolite taking part in many biological process in the body. It is a constituent of many items of daily use, including foods. It is also used in medicine for treatment of some conditions. A 40% solution of formaldehyde in water is known as formalin. Formalin is irritating...

journal_title：Human & experimental toxicology

authors： Pandey CK,Agarwal A,Baronia A,Singh N

更新日期：2000-06-01 00:00:00

abstract：:Prolonged zidovudine (AZT) treatment in HIV-infected and AIDS patients is shown to induce liver toxicity leading to complications. Therapeutic regimen that could encounter this adverse effect is unavailable and management of toxicity is often symptomatic or is limited to withdrawal of therapy. In the present investiga...

journal_title：Human & experimental toxicology

authors： Raghu R,Jesudas B,Bhavani G,Ezhilarasan D,Karthikeyan S

更新日期：2015-11-01 00:00:00

abstract：:Hypofibrinogenemia is an important clinical consequence following envenomation by Lachesis muta muta, usually attenuated or prevented by administration of antivenom. The venom of L. m. muta contains both a metalloproteinase fibrinogenase and a serine protease thrombin-like enzyme, and exposure of fibrinogen to iron (F...

journal_title：Human & experimental toxicology

authors： Nielsen VG,Matika RW

更新日期：2017-07-01 00:00:00

abstract：:1. This work examines the influence of age on some nephrotoxic signs of gentamicin in normal and diabetic rats (aged 1 and 24 months). 2. Gentamicin (80 mg-1 kg-1 day for 6 days, intramuscularly) produced the typical pattern of nephrotoxicity; significantly increasing the plasma concentrations of creatinine and urea, ...

journal_title：Human & experimental toxicology

authors： Ali BH,Bashir AK,Mugamer IT,Tanira MO

更新日期：1996-01-01 00:00:00

abstract：:1. Tobacco smoke contains around 4000 substances, most of which are described as toxic, and they may have an influence on the development of progeny. 2. The present studies concentrate on the measurement and calculation of indices describing the new-born's survival, rearing of pups, weight of foetuses, young animals, ...

journal_title：Human & experimental toxicology

authors： Florek E,Marszalek A,Biczysko W,Szymanowski K

更新日期：1999-04-01 00:00:00

abstract：:Accumulating evidence has shown that ethanol-induced iron overload plays a crucial role in the development and progression of alcoholic liver disease. We designed the present study to investigate the potential protective effect of quercetin, a naturally occurring iron-chelating antioxidant on alcoholic iron overload a...

journal_title：Human & experimental toxicology

authors： Li Y,Deng Y,Tang Y,Yu H,Gao C,Liu L,Liu L,Yao P

更新日期：2014-05-01 00:00:00

abstract：:The synthetic catecholamine isoprenaline (ISO) has been used as an inductor in the acute myocardial infarction model for more than a half century. Despite the fact that many articles were published on this topic, precise early haemodynamic pathology remains unknown. Acute haemodynamic changes were measured in rats; fi...

journal_title：Human & experimental toxicology

authors： Filipský T,Zatloukalová L,Mladěnka P,Hrdina R

更新日期：2012-08-01 00:00:00

abstract：:A liquid alcoholic extract of Papaver somniferum named Elixir Paregorico is extensively used for diarrheal diseases in Brazil. Its increased popularity has brought concerns and fears over the safety of this herbal product. Given the lack of investigative clinical studies, in this regard, this study investigated whethe...

journal_title：Human & experimental toxicology

authors： de Moraes M,Bezerra M,Bezerra F,de Moraes R,Cavalcanti P,Uchoa C,Lima F,Odorico de Moraes M

更新日期：2008-10-01 00:00:00

abstract：:Fructus Psoraleae (FP), widely used in traditional medicine, is increasingly reported to cause serious hepatotoxicity in recent years. However, the main toxic constituents responsible for hepatotoxicity and the underlying mechanisms are poorly understood. In the present study, psoralen, a main and quality-control cons...

journal_title：Human & experimental toxicology

authors： Huang J,Wang Q,Chen M,Bi Y,Shi H,Zhou K

更新日期：2020-12-15 00:00:00

abstract：:This study was designed to investigate the effect of agmatine sulfate (AG, CAS2482-00-0) in nicotine (NIC)-induced vascular endothelial dysfunction (VED) in rabbits. NIC was administered to produce VED in rabbits with or without AG for 6 weeks. Serum lipid profile, serum thiobarbituric acid reactive substances, reduce...

journal_title：Human & experimental toxicology

authors： Nader MA,Gamiel NM,El-Kashef H,Zaghloul MS

更新日期：2016-05-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with high morbidity and mortality. miR-182-5p is overexpressed in several fibrosis-related diseases but its effect in pulmonary fibrosis has not been reported yet. To investigate the function of miR-182-5p in pulmonary fibrosis, we establish...

journal_title：Human & experimental toxicology

authors： Chen Y,Zhang Q,Zhou Y,Yang Z,Tan M

更新日期：2020-05-01 00:00:00

abstract：:Resveratrol, a grape skin and red wine-derived polyphenolic phytoalexin, exhibits hormetic action delivering numerous health benefits at lower doses while being detrimental at higher doses. Epidemiologic and clinical trials need to be based on the clear understanding of hormetic health benefits of resveratrol. ...

journal_title：Human & experimental toxicology

authors： Das DK

更新日期：2010-12-01 00:00:00

abstract：:Pyrazinamide (PYZ)-an essential component of primary drug regimen used for the treatment and management of multidrug resistant or latent tuberculosis-is well known for its hepatoxicity. However, the mechanism of PYZ-induced hepatotoxicity is still unknown to researchers. Studies have shown that the drug is metabolized...

journal_title：Human & experimental toxicology

authors： Rawat A,Chaturvedi S,Singh AK,Guleria A,Dubey D,Keshari AK,Raj V,Rai A,Prakash A,Kumar U,Kumar D,Saha S

更新日期：2018-04-01 00:00:00

abstract：:The aim of the present study was to investigate whether cognitive behavioral impairment, induced by nicotine in offspring rats, was associated with the alteration of hippocampal short-term potentiation (STP) and long-term potentiation (LTP) and to discuss the potential underlying mechanism. Young adult offspring rats ...

journal_title：Human & experimental toxicology

authors： Han G,An L,Yang B,Si L,Zhang T

更新日期：2014-02-01 00:00:00

abstract：:In this study we examined the effect of the aqueous extract of Thonningia sanguinea (T.S.) on 7-ethoxyresorufin O-deethylase (EROD, CYP1A1), 7-pentoxyresorufin O-dealkylase (PROD, CYP2B1/2), 7-methoxyresorufin O-demethylase (MROD, CYP1A2), aniline hydroxylase (aniline, CYP2E1), p-nitrophenol hydroxylase (PNPH, CYP2E1)...

journal_title：Human & experimental toxicology

authors： Gyamfi MA,Hokama N,Oppong-Boachie K,Aniya Y

更新日期：2000-11-01 00:00:00

abstract：:Celecoxib has been shown to have antitumor effect in previous studies but the mechanisms are unclear. The effect of celecoxib on cytosolic Ca(2+) concentrations ([Ca(2+)]i) and viability in HA59T human hepatoma cells was explored. The Ca(2+)-sensitive fluorescent dye fura-2 was applied to measure [Ca(2+)]i. Celecoxib ...

journal_title：Human & experimental toxicology

authors： Cheng HH,Chou CT,Lu YC,Lu T,Chi CC,Tseng LL,Liu SI,Cheng JS,Kuo CC,Liang WZ,Jan CR

更新日期：2014-11-01 00:00:00

abstract：:1. Three indexes for evaluating the severity of paraquat poisoning based on plasma-paraquat concentration are presently in use; the curves of Proudfood et al. and Scherrmann et al. and the SIPP. Their effectiveness in determining the prognosis of patients with paraquat poisoning was evaluated. 2. To determine which in...

journal_title：Human & experimental toxicology

authors： Suzuki K,Takasu N,Arita S,Ueda A,Okabe T,Ishimatsu S,Tanaka S,Kohama A

更新日期：1991-01-01 00:00:00