Abstract:
:1. Multiple low doses of the direct acting organophosphates, ecothiopate, paraoxon and mipafox produced persistent and additive inhibition of diaphragm acetylcholinesterase. Paraoxon and mipafox had similar effects on brain acetylcholinesterase. There was greater recovery from inhibition between doses for paraoxon and ecothiopate than for mipafox. 2. Ecothiopate did not inhibit brain acetylcholinesterase but there was a small increase in activity. 3. Mipafox also had a cumulative inhibitory effect on brain neuropathy target esterase. 4. These results have particular implication for the use of multiple low doses of organophosphates occupationally by man.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Williams FM,Charlton C,de Blaquière GE,Mutch E,Kelly SS,Blain PGdoi
10.1177/096032719701600201subject
Has Abstractpub_date
1997-02-01 00:00:00pages
67-71issue
2eissn
0960-3271issn
1477-0903journal_volume
16pub_type
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