Pharmacologic inhibition of the renin-angiotensin system did not attenuate hepatic toxicity induced by carbon tetrachloride in rats.


:The renin-angiotensin system (RAS) subserves vital physiological functions and also implicated in certain pathological states. Modulation of this system has been proposed in recent studies to be a promising strategy in treating liver fibrosis. We investigated the effect of the pharmacologic inhibition of RAS with angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in CCl(4)-induced liver injury with a view to ascertaining the chemopreventive benefit. Fifty-six Wistar albino rats were divided into eight experimental groups of seven rats/group. Groups 1-4 received normal saline (10 ml/kg), enalapril (0.6 mg/kg), losartan (1.4 mg/kg) and CCl(4) (80 mg/kg), respectively. Groups 5-8 were pretreated with enalapril (0.3 mg/kg), enalapril (0.6 mg/kg), losartan (0.7 mg/kg) and losartan (1.4 mg/kg) 1 hour before CCl(4) administration. Experiment lasted 11 days and dosing was via oral route. Rats were killed 24 hours after the last treatment. Serum activities of alkaline phosphatase, aspartate and alanine aminotransferases increased significantly (p < 0.05) by 46.0%, 90.6% and 122.3%, respectively, with severe hepatic centrilobular necrosis, fatty infiltration and increase in liver weight (p < 0.05) in the CCl(4)-treated rats. Enalapril (0.6 mg/kg) and losartan (1.4 mg/kg) significantly (p < 0.05) increased aspartate aminotransferase activity by 37.0% and 94.7% and produced mild centrilobular and periportal hepatic necrosis, respectively, with enalapril significantly (p < 0.05) increasing liver weight. Serum total cholesterol, triglyceride, albumin and total protein did not change significantly in these rats. Also, glutathione, malondialdehyde and uric acid levels were not significantly altered. Enalapril and losartan failed to attenuate liver injury associated with CCl(4) treatment. Although both drugs did not significantly alter serum biochemistry in the CCl(4)-treated rats, they however produced slight elevations in biomarkers of liver function and appear to worsen liver histopathology. Overall, the chemopreventive benefits of RAS inhibitors in liver disease remain doubtful and should be used with caution during hepatic dysfunction.


Hum Exp Toxicol


Ekor M,Odewabi AO,Kale OE,Oritogun KS,Adesanoye OA,Bamidele TO




Has Abstract


2011-11-01 00:00:00














  • Dose-dependent toxicity of diphenhydramine overdose.

    abstract:BACKGROUND:Diphenhydramine (DPHM) overdose is a frequent cause of acute poisoning. Although its clinical features are well known, information about the dose-dependent toxicity of DPHM is still scarce. The objective of this study was to investigate the dose-dependent toxicity of DPHM in patients with acute DPHM poisonin...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Radovanovic D,Meier PJ,Guirguis M,Lorent JP,Kupferschmidt H

    更新日期:2000-09-01 00:00:00

  • Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat.

    abstract::The aim of this study was to investigate the possible protective role of caffeic acid phenethyl ester on testicular toxicity of methotrexate in rats. Nineteen male rats were divided into three groups as follows: group I, control; group II, methotrexate-treated; group III, methotrexate + caffeic acid phenethyl ester-tr...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Armagan A,Uzar E,Uz E,Yilmaz HR,Kutluhan S,Koyuncuoglu HR,Soyupek S,Cam H,Serel TA

    更新日期:2008-07-01 00:00:00

  • The protective effect of vitamin C, vitamin E and selenium combination therapy on ethanol-induced duodenal mucosal injury.

    abstract::In this study, the effect of a combination of vitamin C, vitamin E and selenium on ethanol-induced duodenal mucosal damage in rats was investigated morphologically and biochemically. The duodenal mucosal injury was produced by oral administration of 1 mL of absolute ethanol to each rat. Animals received vitamin C (250...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Koyuturk M,Bolkent S,Ozdil S,Arbak S,Yanardag R

    更新日期:2004-08-01 00:00:00

  • Ellagic acid protects against arsenic trioxide-induced cardiotoxicity in rat.

    abstract::Arsenic trioxide (As2O3) is utilized for treating patients suffering from hematological malignancies particularly acute promyelocytic leukemia. Unfortunately, the extensive application of this chemotherapeutic agent has been limited due to its adverse effects such as cardiotoxicity. Ellagic acid, as a phenolic compoun...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Hemmati AA,Olapour S,Varzi HN,Khodayar MJ,Dianat M,Mohammadian B,Yaghooti H

    更新日期:2018-04-01 00:00:00

  • The effect of hexafluorocyclobutene on rat bronchoalveolar lavage fluid surfactant phospholipids and alveolar type II cells.

    abstract::Hexafluorocyclobutene (HFCB), a reactive organohalogen gas, causes overwhelming pulmonary oedema. We investigated its effect on the rat lung surfactant system, comparing its action on type II pneumocytes with air-exposed rats. The inflammatory cell population and protein content of bronchoalveolar lavage fluid was ana...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Jugg B,Jenner J,Hughes JN,Rice P

    更新日期:2001-05-01 00:00:00

  • Evaluation of biochemical changes in dental tissues after different office bleaching methods.

    abstract::The color of the teeth is an important topic for many people and can be influenced by intrinsic and extrinsic stains. There is an increasing demand for whitening of the teeth year by year. The most popular way of whitening is "bleaching," which is the result of the breakdown of pigments located in the enamel and/or th...

    journal_title:Human & experimental toxicology

    pub_type: 临床试验,杂志文章


    authors: Karaarslan ES,Özmen ZC,Aytac F,Bicakci AA,Buldur M,Aydogan L,Hologlu F,Özkocak B

    更新日期:2019-04-01 00:00:00

  • P38-β/SAPK-inhibiting and apoptosis-inducing activities of (E)-4-chloro-2-((3-ethoxy-2-hydroxybenzylidene) amino)phenol.

    abstract::The present study has three purposes; first evaluating cytotoxicity of (E)-4-chloro-2-((3-ethoxy-2-hydroxybenzylidene)amino)phenol (ACES), second deciphering ACES-mediated cellular death mechanism, and third estimating ACES-mediated alterations in the expressions of mitogen-activated protein kinase (MAPK) pathway-rela...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Karaosmanoğlu O

    更新日期:2020-10-01 00:00:00

  • Venous thrombosis following intravenous injection of household bleach.

    abstract::Sodium hypochlorite (NaClO) is used extensively as a disinfectant or bleaching agent. Most studies describe ingestion or inhalation route of this product with rare complication and fatalities. Despite global daily exposures, data about bleach injection is limited. Here we report intentional infusion of 20 mL, sodium h...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Rahmani SH,Ahmadi S,Vahdati SS,Moghaddam HH

    更新日期:2012-06-01 00:00:00

  • Cyclophosphamide induces a significant increase in iron content in the liver and spleen of mice.

    abstract:OBJECTIVE:Oxidative stress is one of the major mechanisms of cyclophosphamide (CPX)-induced toxicities. However, it is unknown how CPX induces oxidative stress. Based on the available information, we speculated that CPX could increase iron content in the tissues and then induce oxidative stress. METHOD:We tested this ...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Sheng Y,Chen YJ,Qian ZM,Zheng J,Liu Y

    更新日期:2020-07-01 00:00:00

  • Cardiac biomarkers in a model of acute catecholamine cardiotoxicity.

    abstract::Coronary heart disease and in particular its most serious form - acute myocardial infarction (AMI) - represents the most common cause of mortality in developed countries. Better prognosis may be achieved by understanding the etiopathogenetic mechanisms of AMI. Therefore, a catecholamine model of myocardial injury, whi...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Mladenka P,Hrdina R,Bobrovová Z,Semecky V,Vávrová J,Holecková M,Palicka V,Mazurová Y,Nachtigal P

    更新日期:2009-10-01 00:00:00

  • The serum levels of adiponectin and leptin in mustard lung patients.

    abstract:INTRODUCTION:Chronic obstructive pulmonary disease (COPD) due to sulfur mustard (SM), known as mustard lung, is an important late pulmonary complication of SM poisoning. Due to the possible role of systemic inflammation in mustard lung, we evaluated the serum levels of adiponectin and leptin in these patients. MATERIA...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Rokni Yazdi H,Lari SM,Attaran D,Ayatollahi H,Mohsenizadeh A

    更新日期:2014-06-01 00:00:00

  • Hormesis--implications for risk assessment caloric intake (body weight) as an exemplar.

    abstract::Hormesis can be considered as a parameter which has a non-monotonic relationship with some endpoint. Since caloric intake is such a parameter, and the impact of this parameter on risk assessment has been fairly well characterized, it can provide clues as to how to integrate the information from a hormetic parameter in...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Turturro A,Hass B,Hart RW

    更新日期:1998-08-01 00:00:00

  • The compromise of dynamic disulfide/thiol homeostasis as a biomarker of oxidative stress in trichloroethylene exposure.

    abstract::In this study, we aimed to investigate disulfide/thiol homeostasis in trichloroethylene (TCE) exposure. The study was carried out in 30 nonsmoker TCE-exposed workers with a variety of occupations. Additionally, 30 healthy nonsmoker volunteers were recruited as the control group. TCE exposure was determined by measurin...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Bal C,Büyükşekerci M,Koca C,Ağış ER,Erdoğan S,Baran P,Gündüzöz M,Yilmaz Ö

    更新日期:2016-09-01 00:00:00

  • Lipid peroxidation as a possible secondary mechanism of sterigmatocystin toxicity.

    abstract::Sterigmatocystin (Stg), a major secondary metabolite of Aspergillus versicolor and A. nidulans, is the precursor of aflatoxin B1. In this study, male albino rats were treated with Stg-contaminated diet for 30 days, resulting in reduced levels of glutathione, ascorbic acid, and alpha-tocopherol. The activity of catalas...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Sivakumar V,Thanislass J,Niranjali S,Devaraj H

    更新日期:2001-08-01 00:00:00

  • Fendiline-evoked [Ca2+]i rises and non-Ca2+-triggered cell death in human oral cancer cells.

    abstract::The effect of fendiline on cytosolic free Ca(2+) concentrations ([Ca(2+)](i)) and proliferation has not been explored in human oral cancer cells. This study examined whether fendiline altered Ca(2+) levels and caused cell death in OC2 human oral cancer cells. [Ca(2+)](i) and cell viability were measured using the fluo...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Huang C,Huang C,Cheng J,Liu S,Chen I,Tsai J,Chou C,Tseng P,Jan C

    更新日期:2009-01-01 00:00:00

  • Large-scale label-free proteomics analysis of occupational poisoned patients of 1-bromopropane, workers exposed to 1-bromopropane and healthy individuals.

    abstract::1-Bromopropane (1-BP) is an increasingly used chemical solvent for cleaning metals and gradually replacing spraying adhesives. Workers exposed to 1-BP (WBP) showed nervous system dysfunction and other symptoms. This study focused on the proteomic change between healthy individuals (HIs), WBP and poisoned patients with...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Miao R,Ding B,Zhang Y,Zhao R,Li Y,Zhu B

    更新日期:2018-01-01 00:00:00

  • A case of unusual suicidal poisoning by the organophosphorus insecticide dimethoate.

    abstract::A 20-year-old male who attempted suicide by injecting subcutaneously 10 ml of Sistemin 40 (40% dimethoate) was admitted 16 h later. General weakness, muscular fibrillations and a marked inhibition of red blood cell and serum cholinesterases were the prominent signs of intoxication. The antidotal treatment of intermitt...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Jovanović D,Randjelović S,Joksović D

    更新日期:1990-01-01 00:00:00

  • Acute overdose due to benzydamine.

    abstract::Benzydamine is a nonsteroidal anti-inflammatory drug, currently available as mouthwash, aerosol, dermal cream, vaginal douche preparation, pills and otic drops. Up to now no cases of poisoning due to this drug have been reported. A 6-year-old girl with an accidental poisoning with benzydamine is described. The episode...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Gómez-López L,Hernández-Rodríguez J,Pou J,Nogué S

    更新日期:1999-07-01 00:00:00

  • Safrole-modulated immune response is mediated through enhancing the CD11b surface marker and stimulating the phagocytosis by macrophages in BALB/c mice.

    abstract::Safrole, a component of piper betle inflorescence, is a documented rodent hepatocarcinogen and inhibits bactericidal activity and the release of superoxide anion (O(2-)) by polymorphonuclear leukocytes (PMNs). In the present study, we investigated the effects of safrole on immune responses, including natural killer (N...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Fan MJ,Lin SY,Yu CC,Tang NY,Ho HC,Chung HK,Yang JS,Huang YP,Ip SW,Chung JG

    更新日期:2012-09-01 00:00:00

  • Severe metabolic acidosis in the alcoholic: differential diagnosis and management.

    abstract::1. A chronic alcoholic with severe metabolic acidosis presents a difficult diagnostic problem. The most common cause is alcoholic ketoacidosis, a syndrome with a typical history but often misleading laboratory findings. This paper will focus on this important and probably underdiagnosed syndrome. 2. The disorder occur...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章,评审


    authors: Höjer J

    更新日期:1996-06-01 00:00:00

  • Transient thyrotoxicosis from thyroiditis induced by sibutramine overdose: a case report.

    abstract::Sibutramine is an antiobesity drug that inhibits the reuptake of serotonin and noradrenalin in the hypothalamus. A 37-year-old Korean man presented to the emergency room for the oral intake of 280 mg of sibutramine. The patient was in thyrotoxic state. The (99m)Technetium-pertechnetate thyroid scan showed irregular up...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Kim SK,Lee SM,Yoo SS,Hahm JR,Jung JH,Kim HS,Kim S,Chung SI,Jung TS

    更新日期:2013-08-01 00:00:00

  • Chronic occupational lead exposure and testicular endocrine function.

    abstract::The effects of moderate lead exposure on testicular endocrine function were evaluated in a group of 90 males who were occupationally exposed to inorganic lead. Lead concentrations in blood and bone were measured as indices of short-term and long-term, cumulative exposure, respectively. The results of this study show t...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: McGregor AJ,Mason HJ

    更新日期:1990-11-01 00:00:00

  • Detection of germ cell genotoxic potential of carbon disulphide using sperm head shape abnormality test.

    abstract::1. Adult male albino rats (CF Strain) were administered i.p. CS2 dissolved in cotton seed oil at doses of 25, 50, 100 and 200 mg/kg b. wt. for a period of 60 days. Effect of CS2 on epididymis, adrenal weight, sperm count and sperm head shape abnormality was studied. 2. Epididymal weight remained unaltered in 25, 50 an...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Kumar S,Patel KG,Gautam AK,Agarwal K,Shah BA,Saiyed HN

    更新日期:1999-12-01 00:00:00

  • Differential protection of pre-, co- and post-treatment of curcumin against hydrogen peroxide in PC12 cells.

    abstract::Pharmacological potential of curcumin was assessed in PC12 cells against hydrogen peroxide (H(2) O(2)) exposure. In MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and lactate dehydrogenase (LDH) assays, 24-hour exposure of H(2)O(2) (0.5 mM and above) was found to be cytotoxic. A significant (p < 0...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Siddiqui MA,Kashyap MP,Kumar V,Tripathi VK,Khanna VK,Yadav S,Pant AB

    更新日期:2011-03-01 00:00:00

  • MicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose.

    abstract::Paracetamol overdose is common and microRNA (miR)-122 expression is increased with liver injury. We aimed to measure miR-122 in the setting of an abbreviated paracetamol overdose treatment regimen. We compared miRNA expression in patients treated for paracetamol poisoning with an abbreviated 12-h intravenous acetylcys...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Wong A,Nejad C,Gantier M,Choy KW,Doery J,Graudins A

    更新日期:2019-06-01 00:00:00

  • Organochlorine and organophosphorus pesticide residues in breast milk from Bhopal, Madhya Pradesh, India.

    abstract::HCH isomers, endosulfan, malathion, chlorpyrifos, and methyl-parathion were monitored in human milk samples from Bhopal, Madhya Pradesh. The endosulfan concentrations were highest and exceeded the sigma-HCH, chlorpyrifos, and malathion concentrations by 3.5-, 1.5-, and 8.4-fold, respectively. Through breast milk, infa...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Sanghi R,Pillai MK,Jayalekshmi TR,Nair A

    更新日期:2003-02-01 00:00:00

  • Effects of fenofibrate, a PPAR-α ligand, on the haemodynamics of glycerol-induced renal failure in rats.

    abstract::The modulating effect of peroxisome proliferator-activated receptor α ligand on haemodynamic effects of phenylepherine (PE), angiotensin II (AII), endothelin 1 (ET1), acetylcholine (Ach), sodium nitroprusside (SNP) and isoproterenol (ISO) were evaluated in glycerol-induced acute kidney injury in rats. The effect of PE...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Adedapo AA,Oyekan AO

    更新日期:2013-03-01 00:00:00

  • The influence of chronic and subacute exposure to lead on the levels of prolactin, leptin, osteopontin, and follistatin in humans.

    abstract::This study was designed to determine the levels of prolactin, leptin, osteopontin, and follistatin in workers chronically and subacutely exposed to lead compounds. The examined population consisted of three groups. The first group was composed of 56 male workers who were chronically exposed to lead for 13.38 ± 10.38 y...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Dobrakowski M,Kasperczyk A,Czuba ZP,Machoń-Grecka A,Szlacheta Z,Kasperczyk S

    更新日期:2017-06-01 00:00:00

  • Commentary on 'resveratrol commonly displays hormesis: occurrence and biomedical significance' by Calabrese et al.

    abstract::Resveratrol, a grape skin and red wine-derived polyphenolic phytoalexin, exhibits hormetic action delivering numerous health benefits at lower doses while being detrimental at higher doses. Epidemiologic and clinical trials need to be based on the clear understanding of hormetic health benefits of resveratrol. ...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Das DK

    更新日期:2010-12-01 00:00:00

  • Effect of progesterone on phosphamidon-induced impairment of memory and oxidative stress in rats.

    abstract::Progesterone (a neurosteroid) is an important modulator of the nervous system functioning. Organophosphorus pesticides like phosphamidon have been shown to adversely affect memory and induce oxidative stress on both acute and chronic exposure. The present study was therefore designed to investigate the effects of prog...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Sharma AK,Bhattacharya SK,Khanna N,Tripathi AK,Arora T,Mehta AK,Mehta KD,Joshi V

    更新日期:2011-10-01 00:00:00