Drug overdosage and other poisoning in Hong Kong--the Prince of Wales Hospital (Shatin) experience.

abstract：:1. Four different concentrations of quinalphos and methyl parathion were tested on human peripheral lymphocytes over different time periods, for the analysis of chromosomal aberrations and sister chromatid exchanges (SCEs). 2. A significant increase in chromosomal aberrations was observed when cells were treated with ...

journal_title：Human & experimental toxicology

authors： Rupa DS,Reddy PP,Reddi OS

更新日期：1990-11-01 00:00:00

abstract：:Iodine-125 HIPDM was evaluated as a screening agent for studying multiorgan toxicity due to Cyclosporine-A (CsA) and the results were compared to histopathological findings of the tissues. The rats were injected subcutaneously with 50 mg/kg (body weight) of CsA or with equal volume of the vehicle, Cremophor-EL, for 7 ...

journal_title：Human & experimental toxicology

authors： Shihab-Eldeen A,Owunwanne A,Junaid TA,Yacoub T

更新日期：1996-11-01 00:00:00

abstract：:In the 1980s, villages in the Kurdistan region of Iraq were exposed to chemical weapons (CWs), which killed and injured thousands of civilians. There has been no clinical assessment of the long-term effects of CWs exposure on those injured. We report the first such evaluation of CW effects on long-term health of child...

journal_title：Human & experimental toxicology

authors： Talabani JM,Ali AI,Kadir AM,Rashid R,Samin F,Greenwood D,Hay A

更新日期：2018-08-01 00:00:00

abstract：:Clinical and experimental studies have shown the adverse effects of excess glucocorticoid on testicular testosterone production. The NADPH co-enzyme has been recognized as an important factor that regulates several steps in steroidogenesis, while glucose oxidation acts as a limiting factor on testicular testosterone p...

journal_title：Human & experimental toxicology

authors： Kavitha TS,Parthasarathy C,Sivakumar R,Badrinarayanan R,Balasubramanian K

更新日期：2006-03-01 00:00:00

abstract：:9-(4'-Aminophenyl)-9H-pyrido [3,4-b] indole (aminophenylnorharman, APNH) is a novel mutagenic heterocyclic amine, produced by the reaction of norharman with aniline in the presence of S9 mix. In the present study, the maternal and developmental toxicity of APNH were investigated in ICR mice administered oral doses of ...

journal_title：Human & experimental toxicology

authors： Naga T,Yoshimura S,Totsuka Y,Wakabayashi K

更新日期：2002-03-01 00:00:00

abstract：:Severe carbon monoxide (CO) poisoning causes fulminant deaths in common environment as well as neurological sequelae to survivors. Prevention of delayed neurological syndrome (DNS) after exposure to CO, the most important sequela, is based up to date on hyperbaric oxygen administration. Nevertheless, its use remains c...

journal_title：Human & experimental toxicology

authors： Del Moral-Barbudo B,Blancas R,Ballesteros-Ortega D,Quintana-Díaz M,Martínez-González Ó

更新日期：2020-06-01 00:00:00

abstract：:This article explores the implications of hormesis on toxic tort litigation, in particular litigation regarding claims for medical monitoring or subclinical harm. In considering medical monitoring issues, courts have described medical monitoring both as a remedy and as an independent claim. If medical monitoring is up...

journal_title：Human & experimental toxicology

authors： Juni RL

更新日期：2008-02-01 00:00:00

abstract：:Cyfluthrin is a pyrethroid insecticide and common household pesticide. The effect of cyfluthrin on Ca2+-related physiology in human osteosarcoma is unclear. This study investigated the effect of cyfluthrin on cytosolic-free Ca2+ concentrations ([Ca2+]i) and viability in MG63 human osteosarcoma cells. Cyfluthrin concen...

journal_title：Human & experimental toxicology

authors： Lu YC,Liang WZ,Kuo CC,Hao LJ,Chou CT,Jan CR

更新日期：2020-09-01 00:00:00

abstract：:Pharmacological potential of curcumin was assessed in PC12 cells against hydrogen peroxide (H(2) O(2)) exposure. In MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and lactate dehydrogenase (LDH) assays, 24-hour exposure of H(2)O(2) (0.5 mM and above) was found to be cytotoxic. A significant (p < 0...

journal_title：Human & experimental toxicology

authors： Siddiqui MA,Kashyap MP,Kumar V,Tripathi VK,Khanna VK,Yadav S,Pant AB

更新日期：2011-03-01 00:00:00

abstract：:Until quite recently, pentabromodiphenyl ether (PentaBDE) was most commonly used as a flame retardant. Due to the considerably long atmospheric half-life of PentaBDE and its contribution to environmental pollution, it is categorized as a persistent organic pollutant (POP). As the data on the toxicity of PentaBDE is ra...

journal_title：Human & experimental toxicology

authors： Bruchajzer E,Frydrych B,Sporny S,Szymańska JA

更新日期：2011-05-01 00:00:00

abstract：:Food-borne botulism is a rare disease that results from ingestion of the toxins produced by Clostridium botulinum. The most common cause of the disease is the consumption of home-canned foods prepared under inappropriate conditions, especially in rural environments. In this report, a food-borne botulism outbreak poten...

journal_title：Human & experimental toxicology

authors： Cengiz M,Yilmaz M,Dosemeci L,Ramazanoglu A

更新日期：2006-05-01 00:00:00

abstract：:1. This study investigated whether the reactive organohalogen gases perfluoroisobutene (PFIB) and phosgene, which cause death by overwhelming pulmonary oedema, affect the surfactant system or type II pneumocytes of rat lung. 2. The progression and type of pulmonary injury in Porton Wistar-derived rats was monitored ov...

journal_title：Human & experimental toxicology

authors： Jugg B,Jenner J,Rice P

更新日期：1999-11-01 00:00:00

abstract：:The effects of moderate lead exposure on testicular endocrine function were evaluated in a group of 90 males who were occupationally exposed to inorganic lead. Lead concentrations in blood and bone were measured as indices of short-term and long-term, cumulative exposure, respectively. The results of this study show t...

journal_title：Human & experimental toxicology

authors： McGregor AJ,Mason HJ

更新日期：1990-11-01 00:00:00

abstract：:1. Osmolal and anion gaps are helpful in the diagnosis and evaluation of intoxications with methanol and ethylene glycol. Reported reference values for osmolal gap and anion gap are -1 (+/- 6) mosm kg-1 H2O and 16 (+/- 2) mmol l-1, respectively. However, we have repeatedly found unexplained increased gaps in patients ...

journal_title：Human & experimental toxicology

authors： Aabakken L,Johansen KS,Rydningen EB,Bredesen JE,Ovrebø S,Jacobsen D

更新日期：1994-02-01 00:00:00

abstract：:Pharmaceutical research and new drug development rely extensively on animal research. The development of novel agents for intrathecal administration requires preclinical studies of toxic effects in an animal model. We have developed a nonrodent animal model for this purpose. Our sheep model: 1 Is an animal whose neura...

journal_title：Human & experimental toxicology

authors： Hassenbusch SJ,Satterfield WC,Gradert TL

更新日期：1999-02-01 00:00:00

abstract：:Okadaic acid (OA) is the main toxin produced by dinoflagellates, which can accumulate in the hepatopancreas of mussels and cause diarrhoetic shellfish poisoning in consumers. This toxin is also a tumour promoter and a specific potent inhibitor of protein phosphatases 1 and 2A. The results in this study show for the fi...

journal_title：Human & experimental toxicology

authors： Matias WG,Creppy EE

更新日期：1996-03-01 00:00:00

abstract：:Delta-aminolevulinate dehydratase (δ-ALA-D) enzyme is sensitive to pro-oxidant agents, including molecular oxygen. Here, we tested whether hyperoxygenation after total intravenous (i.v.) anesthesia could interact with the type of anesthesia (dexmedetomidine, continuous infusion; 0.5 μg/kg/h or remifentanil, continuous...

journal_title：Human & experimental toxicology

authors： Rocha JB,Heinzmann Bulow NM,Correa EF,Scholze C,Nogueira CW,Barbosa NB

更新日期：2011-04-01 00:00:00

abstract：:1. This study examines the effect of treating rats with gentamicin (80 mg kg-1 day-1 intramuscularly (i.m.), for 6 days) alone or with either L-thyroxine or the anti-thyroid drug carbimazole. 2. Gentamicin produced significant increases in serum creatinine and urea concentrations, and significantly reduced the activit...

journal_title：Human & experimental toxicology

authors： Ali BH,Bashir AA,Tanira MO

更新日期：1995-01-01 00:00:00

abstract：:In Southern Africa, the medicinal plant Warburgia salutaris is commonly used for the treatment of inflammatory and other diseases. The methanol extracts of W. salutaris were investigated with regard to a) production of proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma; b) a...

journal_title：Human & experimental toxicology

authors： Leshwedi M,Steenkamp V,Dutton M,Gulumian M

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:Mushroom poisoning is still a significant health-care problem, with the potential to affect blood parameters. The present study analyses the effect of mushroom poisoning on complete blood cell parameters, cell ratios, and cell volume indices and the effect of the mentioned parameters on prognosis/hospital len...

journal_title：Human & experimental toxicology

authors： Doğan M,Karahan I

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondial...

journal_title：Human & experimental toxicology

authors： Karadas S,Aslan M,Ceylan MR,Sunnetcioglu M,Bozan N,Kara H,Demir H

更新日期：2017-07-01 00:00:00

abstract：:The present study was undertaken to investigate the effects of maternal lead (Pb) exposure on the expression of interleukin (IL) 1β, IL 6, and glial fibrillary acidic protein (GFAP) in hippocampus of mice offspring. Pb exposure initiated from the beginning of gestation to weaning. Lead acetate (PbAc) administered in d...

journal_title：Human & experimental toxicology

authors： Li N,Liu X,Zhang P,Qiao M,Li H,Li X,Zhang H,Yu Z

更新日期：2015-04-01 00:00:00

abstract：:Occupational chronic solvent encephalopathy (CSE) is associated with a number of neurobehavioural disorders including defects of visual perception. The purpose of this study was to characterize colour vision defects in CSE patients. Colour vision was tested in bright illumination with the Farnsworth-Munsell 100-hue te...

journal_title：Human & experimental toxicology

authors： Päällysaho J,Näsänen R,Mäntyjärvi M,Kaukiainen A,Sainio M

更新日期：2007-04-01 00:00:00

abstract：:Tripartite motif-containing protein 24 (TRIM24) has currently emerged as a crucial cancer-related gene present in a wide range of human cancer types. However, the involvement of TRIM24 in acute myeloid leukemia (AML) has not been well investigated. The present study aims to investigate the significance, cellular funct...

journal_title：Human & experimental toxicology

authors： Li C,Xin H,Shi Y,Mu J

更新日期：2020-12-01 00:00:00

abstract：:Brain tumors are often incurable despite current aggressive treatment modalities. Regional intracerebral administration of labeled monoclonal antibodies (Mabs) can maximize the radioisotope and Mab concentration to tumor sites while reducing systemic toxicity. h-R3 is a humanized antiepidermal growth factor receptor M...

journal_title：Human & experimental toxicology

authors： Gonzalez B,Casaco A,Alvarez P,Leon M,Arteaga M,Leon A,Santana E,Bada A,Figueredo R,Hernández R,Iznaga-Escobar N,González F,Perez R

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:Calcium channel blockers (CCBs) were the most common agents associated with a significant morbidity and mortality rate. The main objective of this study was to examine the publication pattern related to CCBs poisoning at the global level using bibliometric analysis of articles published in SciVerse Scopus onlin...

journal_title：Human & experimental toxicology

authors： Zyoud SH,Al-Jabi SW,Sweileh WM,Waring WS

更新日期：2015-11-01 00:00:00

abstract：:The color of the teeth is an important topic for many people and can be influenced by intrinsic and extrinsic stains. There is an increasing demand for whitening of the teeth year by year. The most popular way of whitening is "bleaching," which is the result of the breakdown of pigments located in the enamel and/or th...

journal_title：Human & experimental toxicology

authors： Karaarslan ES,Özmen ZC,Aytac F,Bicakci AA,Buldur M,Aydogan L,Hologlu F,Özkocak B

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:Oxidative stress is one of the major mechanisms of cyclophosphamide (CPX)-induced toxicities. However, it is unknown how CPX induces oxidative stress. Based on the available information, we speculated that CPX could increase iron content in the tissues and then induce oxidative stress. METHOD:We tested this ...

journal_title：Human & experimental toxicology

authors： Sheng Y,Chen YJ,Qian ZM,Zheng J,Liu Y

更新日期：2020-07-01 00:00:00

abstract：:We aimed to investigate the possible roles of nitric oxide (NO) and endothelin on the changes of cardiac muscle function in both hyper- and hypodynamic septic shock periods. Cecal ligation and puncture was performed in 50 Wistar albino rats to induce septic shock. Changes in atrium and right ventricle papillary muscle...

journal_title：Human & experimental toxicology

authors： Ozer EK,Iskit AB

更新日期：2016-03-01 00:00:00

abstract：:1. Adult male albino rats (CF Strain) were administered i.p. CS2 dissolved in cotton seed oil at doses of 25, 50, 100 and 200 mg/kg b. wt. for a period of 60 days. Effect of CS2 on epididymis, adrenal weight, sperm count and sperm head shape abnormality was studied. 2. Epididymal weight remained unaltered in 25, 50 an...

journal_title：Human & experimental toxicology

authors： Kumar S,Patel KG,Gautam AK,Agarwal K,Shah BA,Saiyed HN

更新日期：1999-12-01 00:00:00