Effects of endothelin and nitric oxide on cardiac muscle functions in experimental septic shock model.

abstract：:A retrospective study was conducted on 269 patients with anticholinesterase poisoning who had been admitted to the Internal Medicine and Pediatric Clinics over the past 10 years. Their ages ranged from 17 d to 62 years. In adults, suicide was the most common means of intoxication. Miosis was the most frequent symptom ...

journal_title：Human & experimental toxicology

authors： Oztürk MA,Keleştimur F,Kurtoğlu S,Güven K,Arslan D

更新日期：1990-09-01 00:00:00

abstract：:Organic solvents can cause hearing loss themselves or promote noise-induced hearing loss. The objective of this study was to review the literature on the effects of low-level exposure to trichloroethylene on the auditory system and consider its relevance for the occupational settings. Both human and animal investigati...

journal_title：Human & experimental toxicology

authors： Vyskocil A,Leroux T,Truchon G,Lemay F,Gagnon F,Gendron M,Viau C

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:Mushroom poisoning is still a significant health-care problem, with the potential to affect blood parameters. The present study analyses the effect of mushroom poisoning on complete blood cell parameters, cell ratios, and cell volume indices and the effect of the mentioned parameters on prognosis/hospital len...

journal_title：Human & experimental toxicology

authors： Doğan M,Karahan I

更新日期：2019-10-01 00:00:00

abstract：:Puerarin, a potent free radicals scavenger, has been demonstrated to have protective efficacy in oxidative damage induced by nephrotoxins. In the present study, the attenuating effect of puerarin (PU) on lead (Pb)-induced apoptosis and oxidative stress was investigated in cultured primary rat proximal tubular (rPT) ce...

journal_title：Human & experimental toxicology

authors： Liu G,Li Z,Wang J,Wang H,Wang Z,Wang L

更新日期：2014-10-01 00:00:00

abstract：:Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenicity of many xenobiotics. In the present study, we investigated the possible induction of lipid peroxidation by aluminium in human foreskin fibroblast cultures by assayin...

journal_title：Human & experimental toxicology

authors： Anane R,Creppy EE

更新日期：2001-09-01 00:00:00

abstract：:A few landmarks in the development of dose response in toxicology are presented, with an explanation of why dose should only be considered on a logarithmic scale. Examples are shown, illustrating that the current practice of labeling dose-response curves for carcinogenesis as supralinear, linear or sublinear, is meani...

journal_title：Human & experimental toxicology

authors： Waddell WJ

更新日期：2006-07-01 00:00:00

abstract：:Exposure of Co631 cells to plutonium leads to increasing cell death depending on the dose and incubation time. The effects, however, are more pronounced with 239Pu, than with 238Pu. Uptake and binding of the two radionuclides during a 5-h incubation are about equal, but 238Pu is lost more rapidly from the cell. There ...

journal_title：Human & experimental toxicology

authors： Boxler C,Rau W,Planas-Bohne F

更新日期：1992-05-01 00:00:00

abstract：:1. The reactivating and therapeutic efficacy of a new acetylcholinesterase reactivator, designated BI-6 (1-/2-hydroxyiminomethylpyridinium/-4-/carbamoylpyridinium/- 2-butene dibromide), against organophosphate sarin was compared with presently used oximes (pralidoxime, obidoxime, methoxime) and H oximes (HI-6, HLö-7) ...

journal_title：Human & experimental toxicology

authors： Kassa J,Cabal J

更新日期：1999-09-01 00:00:00

abstract：:There are many discrepancies among the results of studies on the genotoxicity of lead. The aim of the study was to explore lead-induced DNA damage, including oxidative damage, in relation to oxidative stress intensity parameters and the antioxidant defense system in human leukocytes. The study population consisted of ...

journal_title：Human & experimental toxicology

authors： Dobrakowski M,Pawlas N,Kasperczyk A,Kozłowska A,Olewińska E,Machoń-Grecka A,Kasperczyk S

更新日期：2017-07-01 00:00:00

abstract：:Serrapeptase (SP) and nattokinase (NK) are proteolytic enzymes belonging to serine proteases. In this study, we hypothesized that SP and NK could modulate certain factors that are associated with Alzheimer's disease (AD) pathophysiology in the experimental model. Oral administration of aluminium chloride (AlCl3) in a ...

journal_title：Human & experimental toxicology

authors： Fadl NN,Ahmed HH,Booles HF,Sayed AH

更新日期：2013-07-01 00:00:00

abstract：:Sibutramine is an antiobesity drug that inhibits the reuptake of serotonin and noradrenalin in the hypothalamus. A 37-year-old Korean man presented to the emergency room for the oral intake of 280 mg of sibutramine. The patient was in thyrotoxic state. The (99m)Technetium-pertechnetate thyroid scan showed irregular up...

journal_title：Human & experimental toxicology

authors： Kim SK,Lee SM,Yoo SS,Hahm JR,Jung JH,Kim HS,Kim S,Chung SI,Jung TS

更新日期：2013-08-01 00:00:00

abstract：:Exposure to quartz induces pulmonary inflammation and development of fibrosis. In order to study the fibrosing process, we investigated morphology, function and phenotype of alveolar (AMs) and interstitial (IMs) macrophages at an early stage of fibrosis in rats. Rats were exposed by intratracheal instillations of 10 m...

journal_title：Human & experimental toxicology

authors： Zetterberg G,Elmberger G,Johansson A,Lundahl J,Lundborg M,Sköld CM,Tornling G,Camner P,Eklund A

更新日期：2000-07-01 00:00:00

abstract：:Stem cell transplantation has indicated great promise for cell therapy in a wide range of diseases, but poor and insufficient viability of cells within damaged tissues has limited its potential therapeutic effects. 17 β-Estradiol (E2) is a steroid hormone that plays an important role in expression of many genes and re...

journal_title：Human & experimental toxicology

authors： Mirzamohammadi S,Mehrabani M,Tekiyehmaroof N,Sharifi AM

更新日期：2016-03-01 00:00:00

abstract：:The purpose of this study was to characterize the zinc oxide nanoparticles (ZnO-NPs) and their bulk counterpart in suspensions and to access the impact of their acute oral toxicity at doses of 300 and 2000 mg/kg in healthy female Wistar rats. The hematological, biochemical, and urine parameters were accessed at 24 and...

journal_title：Human & experimental toxicology

authors： Srivastav AK,Kumar M,Ansari NG,Jain AK,Shankar J,Arjaria N,Jagdale P,Singh D

更新日期：2016-12-01 00:00:00

abstract：:Progressive renal dysfunction in 5/6 nephrectomized (NX) rats can be physiologically divided into three stages, coinciding with morphological stages, after definition of physiological parameters for identification of stage. Now, for the establishment of a toxicity screening approach using 5/6 NX rats, our concept, "Di...

journal_title：Human & experimental toxicology

authors： Barata K,Yoshida M,Hokao R,Imai S,Takahashi S,Harada E,Maekawa A

更新日期：2001-02-01 00:00:00

abstract：:The US Environmental Protection Agency (EPA) recently issued a Staff Paper that articulates current risk assessment practices. In section 4.1.3, EPA states, "... effects that appear to be adaptive, non-adverse, or beneficial may not be mentioned." This statement may be perceived as precluding risk assessments based on...

journal_title：Human & experimental toxicology

authors： Mundt KA

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:The present work aimed to investigate the relationship between occupational exposure to airborne molds, serum aflatoxin B1 (AFB1), and liver enzymes of workers handling wheat flour. METHODS:The study included 90 bakers, 100 flour milling workers, and 100 controls with no exposure to flour dust. Workplace asp...

journal_title：Human & experimental toxicology

authors： Saad-Hussein A,Taha MM,Fadl NN,Awad AH,Mahdy-Abdallah H,Moubarz G,Aziz H,El-Shamy KA

更新日期：2016-01-01 00:00:00

abstract：:Pesticides are used in agriculture to protect crops from insects-pests. Most of the field workers of North Indian population are exposed to commonly used insecticides. In the present study, pesticides induced oxidative stress as well as alterations in the level of acetylcholinesterase (AChE) in a total of 70 male heal...

journal_title：Human & experimental toxicology

authors： Sharma RK,Upadhyay G,Siddiqi NJ,Sharma B

更新日期：2013-11-01 00:00:00

abstract：:Sibutramine mesylate is a new anti-obesity drug. It is a crystalline salt of sibutramine developed to improve the solubility of sibutramine hydrochloride. Methanesulfonic acid was used as a salt-forming acid instead of hydrochloric acid, resulting in a greatly improved solubility of 1000 mg/mL in water. Sibutramine me...

journal_title：Human & experimental toxicology

authors： Kim EJ,Park EK,Suh KH

更新日期：2005-03-01 00:00:00

abstract：:Formaldehyde is a physiological intermediary metabolite taking part in many biological process in the body. It is a constituent of many items of daily use, including foods. It is also used in medicine for treatment of some conditions. A 40% solution of formaldehyde in water is known as formalin. Formalin is irritating...

journal_title：Human & experimental toxicology

authors： Pandey CK,Agarwal A,Baronia A,Singh N

更新日期：2000-06-01 00:00:00

abstract：:A retrospective review of medical records was carried out to determine the pattern of drug and chemical poisoning cases admitted to a teaching hospital in Malaysia. Medical records of patients admitted during the period January 1987 to December 1995 were reviewed. They accounted for 0.2% of total admissions during the...

journal_title：Human & experimental toxicology

authors： Ab Rahman AF

更新日期：2002-07-01 00:00:00

abstract：:The objective of this study was to determine the reliability of denial of acetaminophen ingestion in intentional drug overdose patients. All intentional drug overdose patients admitted to an emergency department who were able to provide a history were included. A detailed history was obtained on names, timing and numb...

journal_title：Human & experimental toxicology

authors： Bentur Y,Lurie Y,Tamir A,Keyes DC,Basis F

更新日期：2011-01-01 00:00:00

abstract：AIM:Diazinon (DZN) is one of the most important organophosphorus compounds used to control pests in agriculture in many countries. Several studies have shown that exposure to DZN may alter protein expression in the liver. In order to further investigate the mechanism of DZN toxicity, differentially expressed ATP-intera...

journal_title：Human & experimental toxicology

authors： Pourtaji A,Robati RY,Lari P,Hosseinzadeh H,Ramezani M,Abnous K

更新日期：2016-10-01 00:00:00

abstract：:Public health issues have been raised regarding fructose toxicity and its serious metabolic disorders. Deleterious effects of high fructose intake on insulin sensitivity, body weight, lipid homeostasis have been identified. The new millennium has witnessed the emergence of a modern epidemic, the metabolic syndrome (MS...

journal_title：Human & experimental toxicology

authors： Abdelhamid YA,Elyamany MF,Al-Shorbagy MY,Badary OA

更新日期：2020-10-29 00:00:00

abstract：:Persistent organochlorine pollutants (POPs), such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dichloro diphenyl trichloroethane (DDT) and its major metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p' -DDE) have been associated with type 2 diabetes mellitus (T2DM) in rece...

journal_title：Human & experimental toxicology

authors： Rignell-Hydbom A,Rylander L,Hagmar L

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:The present study was designed to highlight the toxic impact of baclofen on both biochemical and histopathological aspects in rats' liver, gastric, lung, kidney, and brain tissues. METHODS:The study was performed on 30 healthy adult male albino rats divided into four groups with 5 rats in each control group,...

journal_title：Human & experimental toxicology

authors： Issa SY,Hafez EM,El-Banna AS,Abdel Rahman SM,AlMazroua MK,El-Hamd MA

更新日期：2018-04-01 00:00:00

abstract：:The malignancy of non-small cell lung cancer (NSCLC) largely results from its invasive manner. Secreted frizzled-related proteins (SFRPs) have been recently found to suppress the invasiveness of some cancers. On the other hand, the methylation of SFRPs increases protein degradation to reduce the activity of SFRPs, res...

journal_title：Human & experimental toxicology

authors： Zhang X,Rong X,Chen Y,Su L

更新日期：2018-02-01 00:00:00

abstract：:1. The herbicide, paraquat, is accumulated by the energy-dependent polyamine uptake pathway of alveolar type II cells. There it undergoes redox cycling that results in an amplified production of toxic reactive oxygen species and depletion of NADPH and other reducing equivalents. These processes account for the lung be...

journal_title：Human & experimental toxicology

authors： Chen N,Bowles MR,Pond SM

更新日期：1994-08-01 00:00:00

abstract：:Morphine-6-glucuronide, the active metabolite of morphine, and to a lesser extent morphine itself are known to accumulate in patients with renal failure. A number of cases on non-lethal morphine toxicity in patients with renal impairment report high plasma concentrations of morphine-6-glucuronide, suggesting that this...

journal_title：Human & experimental toxicology

authors： Lagas JS,Wagenaar JF,Huitema AD,Hillebrand MJ,Koks CH,Gerdes VE,Brandjes DP,Beijnen JH

更新日期：2011-09-01 00:00:00

abstract：:Drugs intended for use in preventing allograft rejection in transplant patients are likely to be administered chronically; thus, it is normally expected that sponsors would conduct nonclinical studies to determine the carcinogenic potential of candidate compounds. For pharmaceuticals other than biologic agents, this w...

journal_title：Human & experimental toxicology

authors： Hastings KL

更新日期：2000-04-01 00:00:00