Abstract:
AIM:Diazinon (DZN) is one of the most important organophosphorus compounds used to control pests in agriculture in many countries. Several studies have shown that exposure to DZN may alter protein expression in the liver. In order to further investigate the mechanism of DZN toxicity, differentially expressed ATP-interacting proteins, following subacute exposure to toxin, were separated and identified in rat liver. MAIN METHODS:Male rats were equally divided into four groups: control (corn oil) and DZN (15 mg/kg) by gavage once a day for 4 weeks. After homogenization of liver tissue, lysates were incubated ATP-sepharose beads. After several washes, ATP-interacting proteins were eluted and separated on 2-D polyacrylamide gels. Deferentially expressed proteins were cut and identified using matrix-assisted laser desorption/ionization/time-of-flight and Mascot database. Identified proteins were classified according to their biological process using protein analysis through evolutionary relationships (PANTHER) Web site. KEY FINDING:In this work, we showed that several key proteins involved in biological processes such as antioxidant system, oxidative stress, apoptosis, and metabolism were differentially expressed after subacute exposure to DZN.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Pourtaji A,Robati RY,Lari P,Hosseinzadeh H,Ramezani M,Abnous Kdoi
10.1177/0960327115619771subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1084-92issue
10eissn
0960-3271issn
1477-0903pii
0960327115619771journal_volume
35pub_type
杂志文章abstract::The polybrominated diphenyl ether flame retardants decabromodiphenyl ether (BDE-209) and bisphenol A (BPA) are environmental contaminants that can cross the placenta and exert toxicity in the developing fetal nervous system. Copy number variants (CNVs) play a role in a number of genetic disorders and may be implicated...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117710535
更新日期:2018-05-01 00:00:00
abstract::Pharmacological potential of curcumin was assessed in PC12 cells against hydrogen peroxide (H(2) O(2)) exposure. In MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and lactate dehydrogenase (LDH) assays, 24-hour exposure of H(2)O(2) (0.5 mM and above) was found to be cytotoxic. A significant (p < 0...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110371696
更新日期:2011-03-01 00:00:00
abstract::Gamma-hydroxybutyrate (GHB) is a compound used in the treatment of alcohol withdrawal, narcolepsy, and for induction of anaesthesia. It is also contained in many products illegally marketed as "dietary supplements" and is increasingly being recognised as a potential drug of abuse. We report the case of a 44-year-old m...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032701666142043
更新日期:2001-01-01 00:00:00
abstract::Exposure to quartz induces pulmonary inflammation and development of fibrosis. In order to study the fibrosing process, we investigated morphology, function and phenotype of alveolar (AMs) and interstitial (IMs) macrophages at an early stage of fibrosis in rats. Rats were exposed by intratracheal instillations of 10 m...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032700678816124
更新日期:2000-07-01 00:00:00
abstract::Severe carbon monoxide (CO) poisoning causes fulminant deaths in common environment as well as neurological sequelae to survivors. Prevention of delayed neurological syndrome (DNS) after exposure to CO, the most important sequela, is based up to date on hyperbaric oxygen administration. Nevertheless, its use remains c...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120901572
更新日期:2020-06-01 00:00:00
abstract::In this study, the effect of a combination of vitamin C, vitamin E and selenium on ethanol-induced duodenal mucosal damage in rats was investigated morphologically and biochemically. The duodenal mucosal injury was produced by oral administration of 1 mL of absolute ethanol to each rat. Animals received vitamin C (250...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327104ht468oa
更新日期:2004-08-01 00:00:00
abstract::The serial cognitive assessment of ten individuals made between 8 and 26 months after the water at Camelford in Cornwall was accidentally contaminated with aluminium sulphate, showed consistent evidence of impairment of information processing and memory. There was no obvious relationship between these impairments and ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719301200108
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:The objective of the present study was to determine oxidant and antioxidant status in infants with hyperbilirubinemia and/or kernicterus and to find whether there is a relationship between bilirubin level and oxidant/antioxidant status. PATIENTS:The study includes 69 full-term newborns (neonates with hyperbi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111401638
更新日期:2011-11-01 00:00:00
abstract::Lead exposure was assessed in a random cohort of 70 male papier mâché workers and compared with 35 age and sex matched controls. Blood-lead levels in workers were significantly higher than in controls (Mean 68.07 +/- 44.64 ug/dl vs 25.52 +/- 16.56 ug/dl respectively; P < 0.001). Urinary lead was also higher in workers...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719701600510
更新日期:1997-05-01 00:00:00
abstract::The present study was designed to evaluate the cardioprotective potential of lycopene (LCP) against isoproterenol (ISP)-induced myocardial infarction (MI), by assessing hemodynamic, biochemical and histopathological parameters. Wistar male albino rats were orally administered with LCP (0.5, 1.0 and 1.5 mg/kg) or with ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112454890
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:The present study was designed to highlight the toxic impact of baclofen on both biochemical and histopathological aspects in rats' liver, gastric, lung, kidney, and brain tissues. METHODS:The study was performed on 30 healthy adult male albino rats divided into four groups with 5 rats in each control group,...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117712369
更新日期:2018-04-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) and dioxins are potentially toxic compounds which occur widely in the environment. Their effects on the growth and development of infants at the levels currently found in highly industrialised western countries is not well known. This Dutch multicenter study, combining animal and human...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,多中心研究
doi:10.1177/096032719401301213
更新日期:1994-12-01 00:00:00
abstract::Benzydamine is a nonsteroidal anti-inflammatory drug, currently available as mouthwash, aerosol, dermal cream, vaginal douche preparation, pills and otic drops. Up to now no cases of poisoning due to this drug have been reported. A 6-year-old girl with an accidental poisoning with benzydamine is described. The episode...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032799678840264
更新日期:1999-07-01 00:00:00
abstract::Clobenpropit, an H( 3) receptor antagonist, has been reported to modulate both the release of neurotransmitters and also the activity of histidine decarboxylase (HDC). Therefore, a decarboxylase-positive modulator, namely pyridoxine, was taken for interaction studies with clobenpropit in the electroshock (ES) model of...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110372398
更新日期:2011-01-01 00:00:00
abstract::1. Groups of 60 male and 60 female B6C3F1 mice or HanIbm Wistar rats were exposed to HFA-134a using snout-only inhalation exposure techniques for periods of one hour daily for at least 104 weeks. HFA-134a was delivered directly from cylinders at vapour concentrations of 2500, 15,000 and 75,000ppm for mice and from met...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719501400902
更新日期:1995-09-01 00:00:00
abstract::Arsenic is a naturally occurring environmental toxicant, chronic exposure to arsenic can cause multiorgan damage, except for typical skin lesions, liver damage is the main problem for health concern in population with arsenic poisoning. Abnormal apoptosis is closely related to liver-related diseases, and p53 is one of...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120988880
更新日期:2021-01-27 00:00:00
abstract::We describe two cases of chemical necrotizing fasciitis in the upper extremities, anterior chest wall and epigastric region of the abdominal wall caused by household insecticide injection. We suggest that surgical debridement can be successfully performed in the subacute period under close observation in hemodynamical...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327102ht308cr
更新日期:2002-12-01 00:00:00
abstract::Cyfluthrin is a pyrethroid insecticide and common household pesticide. The effect of cyfluthrin on Ca2+-related physiology in human osteosarcoma is unclear. This study investigated the effect of cyfluthrin on cytosolic-free Ca2+ concentrations ([Ca2+]i) and viability in MG63 human osteosarcoma cells. Cyfluthrin concen...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120918298
更新日期:2020-09-01 00:00:00
abstract::Although ingestion of methyl ethyl ketone peroxide (MEKP) is rare, it carries a high risk of morbidity and mortality. This paper reports the first such case from Turkey in which a 70-year-old man unintentionally ingested MEKP in his kitchen. The patient was brought into the emergency department (ED) within 1 hour of i...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111407230
更新日期:2011-12-01 00:00:00
abstract::The purpose of this study was to characterize the zinc oxide nanoparticles (ZnO-NPs) and their bulk counterpart in suspensions and to access the impact of their acute oral toxicity at doses of 300 and 2000 mg/kg in healthy female Wistar rats. The hematological, biochemical, and urine parameters were accessed at 24 and...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116629530
更新日期:2016-12-01 00:00:00
abstract::Seafood is considered by nutritionists to be a high source of omega 3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) which are involved in prevention of cardiovascular diseases. The aim of the present study is firstly to detect the presence of organochlorine pesticides and heavy metals in some fresh seafood of ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110396535
更新日期:2011-10-01 00:00:00
abstract::The aim of this study was to investigate the possible protective role of caffeic acid phenethyl ester on testicular toxicity of methotrexate in rats. Nineteen male rats were divided into three groups as follows: group I, control; group II, methotrexate-treated; group III, methotrexate + caffeic acid phenethyl ester-tr...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108092293
更新日期:2008-07-01 00:00:00
abstract::Chronic mercury exposure impairs vascular function, leading to the depression of endothelium-dependent vasodilatation. Loss of the nitric oxide (NO) pathway has been implicated, but little is known about effects on other endothelial mediators. This study investigated the mechanisms of endothelial dysfunction in rats s...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110391389
更新日期:2011-11-01 00:00:00
abstract::The aim of this study was to compare simultaneously obtained arterial and capillary blood gas (CBG) values in comatose-poisoned patients presented with stable vital signs. Forty-five adult patients with a diagnosis of coma because of poisoning and stable vital signs were included in this prospective study. With respec...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109107001
更新日期:2009-10-01 00:00:00
abstract::Boophone disticha (B. disticha) has been used systemically in traditional medical practice in Zimbabwe and neighbouring countries for the management of various central nervous system conditions including hysteria. Abuse of the plant by teenagers in Zimbabwe for its claimed hallucinogenic effects has also been reported...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110384524
更新日期:2011-08-01 00:00:00
abstract::Indomethacin, a non-steroidal anti-inflammatory drug is known to increase the efficacy and toxicity of methotrexate, the widely used anti-cancer drug in man. The mechanism for this interaction has not been clearly established. However, since these drugs bind with albumin, a possible displacement of methotrexate by ind...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719201100411
更新日期:1992-07-01 00:00:00
abstract::The current study was undertaken to evaluate the effect of combined therapy of gabapentin and pantoprazole against forestomach and pylorus ligation-induced gastric esophageal reflux disease (GERD) in albino Wistar rats. Rats were randomly divided into five groups, each group consisting of six rats, fasted for 24 h, un...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119893409
更新日期:2020-04-01 00:00:00
abstract::Generation of reactive oxygen species (ROS) leads to serious tissue injuries. The effect of cyclopiazonic acid (CPA) on oxidative stress markers in the liver and kidneys of broiler chicks was studied. Ten-day-old male broiler chicks (Ross 308) were assigned into the control and test groups, which received normal salin...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110384285
更新日期:2011-08-01 00:00:00
abstract::Resveratrol, a grape skin and red wine-derived polyphenolic phytoalexin, exhibits hormetic action delivering numerous health benefits at lower doses while being detrimental at higher doses. Epidemiologic and clinical trials need to be based on the clear understanding of hormetic health benefits of resveratrol. ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110383626
更新日期:2010-12-01 00:00:00
abstract::Hormesis can be considered as a parameter which has a non-monotonic relationship with some endpoint. Since caloric intake is such a parameter, and the impact of this parameter on risk assessment has been fairly well characterized, it can provide clues as to how to integrate the information from a hormetic parameter in...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719801700810
更新日期:1998-08-01 00:00:00