Baclofen systemic toxicity: Experimental histopathological and biochemical study.

abstract：:A retrospective study was conducted on 269 patients with anticholinesterase poisoning who had been admitted to the Internal Medicine and Pediatric Clinics over the past 10 years. Their ages ranged from 17 d to 62 years. In adults, suicide was the most common means of intoxication. Miosis was the most frequent symptom ...

journal_title：Human & experimental toxicology

authors： Oztürk MA,Keleştimur F,Kurtoğlu S,Güven K,Arslan D

更新日期：1990-09-01 00:00:00

abstract：:Information on the acute effects associated with the handling of 1,4-dioxane is sparse. Our aim was to evaluate the acute effects of 1,4-dioxane vapours. In a screening study, six healthy volunteers rated symptoms on a visual analogue scale (VAS), while exposed to stepwise increasing levels of 1,4-dioxane, from 1 to 2...

journal_title：Human & experimental toxicology

authors： Ernstgård L,Iregren A,Sjögren B,Johanson G

更新日期：2006-12-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) and dioxins are potentially toxic compounds which occur widely in the environment. Their effects on the growth and development of infants at the levels currently found in highly industrialised western countries is not well known. This Dutch multicenter study, combining animal and human...

journal_title：Human & experimental toxicology

authors： Sauer PJ,Huisman M,Koopman-Esseboom C,Morse DC,Smits-van Prooije AE,van de Berg KJ,Tuinstra LG,van der Paauw CG,Boersma ER,Weisglas-Kuperus N

更新日期：1994-12-01 00:00:00

abstract：:Lead exposure was assessed in a random cohort of 70 male papier mâché workers and compared with 35 age and sex matched controls. Blood-lead levels in workers were significantly higher than in controls (Mean 68.07 +/- 44.64 ug/dl vs 25.52 +/- 16.56 ug/dl respectively; P < 0.001). Urinary lead was also higher in workers...

journal_title：Human & experimental toxicology

authors： Wahid A,Koul PA,Shah SU,Khan AR,Bhat MS,Malik MA

更新日期：1997-05-01 00:00:00

abstract：:Dental amalgams are a commonly used dental restorative material, and amalgams are about 50% mercury (Hg). In our study, urinary Hg levels was examined in children of age 8-18 years, with and without dental amalgam fillings, from a completed clinical trial (parent study) that was designed to evaluate the potential heal...

journal_title：Human & experimental toxicology

authors： Geier DA,Carmody T,Kern JK,King PG,Geier MR

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Oxidative stress is one of the major mechanisms of cyclophosphamide (CPX)-induced toxicities. However, it is unknown how CPX induces oxidative stress. Based on the available information, we speculated that CPX could increase iron content in the tissues and then induce oxidative stress. METHOD:We tested this ...

journal_title：Human & experimental toxicology

authors： Sheng Y,Chen YJ,Qian ZM,Zheng J,Liu Y

更新日期：2020-07-01 00:00:00

abstract：:Comparisons on a linear and the Rozman logarithmic scale for dosage versus carcinogenicity in rodents are presented for methyl eugenol (ME), nitrosodiethylamine (NDEA), ethyl carbamate (EC) and 2-acetylaminofluorene (AAF). Each of these chemicals has been shown to be carcinogenic in experimental animals and, in additi...

journal_title：Human & experimental toxicology

authors： Waddell WJ

更新日期：2005-06-01 00:00:00

abstract：:Sibutramine mesylate is a new anti-obesity drug. It is a crystalline salt of sibutramine developed to improve the solubility of sibutramine hydrochloride. Methanesulfonic acid was used as a salt-forming acid instead of hydrochloric acid, resulting in a greatly improved solubility of 1000 mg/mL in water. Sibutramine me...

journal_title：Human & experimental toxicology

authors： Kim EJ,Park EK,Suh KH

更新日期：2005-03-01 00:00:00

abstract：:1. Polyvinyl chloride (PVC) cot mattress covers from SIDS cases were investigated as potential sources of soluble (potentially ingestable) antimony in the cot environment. 2. Body fluids (urine, saliva) and proprietary domestic detergents/sterilizing fluids markedly enhanced leaching of antimony from PVC. Release of a...

journal_title：Human & experimental toxicology

authors： Jenkins RO,Craig PJ,Goessler W,Irgolic KJ

更新日期：1998-03-01 00:00:00

abstract：:1. The influence of pharmacological pretreatment (pyridostigmine, benactyzine and trihexyphenidyle), designated PANPAL, on soman-induced cholinergic and stressogenic effects as well as on the efficacy of antidotal treatment (HI-6 plus obidoxime) in rats was studied. 2. PANPAL prophylaxis significantly decreased soman-...

journal_title：Human & experimental toxicology

authors： Kassa J,Bajgar J

更新日期：1996-05-01 00:00:00

abstract：:In vivo antidotal efficacy of new bis- quaternary 2-(hydroxyimino)- N-(pyridin-3yl) acetamide derivatives (HNK series), to counter multiples of lethal doses of nerve agent sarin (GB) and reactivation of acetylcholinesterase (AChE), was evaluated in Swiss albino mice. [Protection index PI; median lethal dose (LD50) of ...

journal_title：Human & experimental toxicology

authors： Swami D,Karade HN,Acharya J,Kumar P

更新日期：2017-01-01 00:00:00

abstract：:In order to assess the effect of arsenic on the male reproductive impairment in mice, 7-week-old animals were exposed to 7.5 mg sodium arsenite (NaAsO(2))/kg body weight, during 35 days (one spermatogenic cycle). One group of animals was sacrificed after exposure, while another group received distilled water for an ad...

journal_title：Human & experimental toxicology

authors： Ferreira M,Matos RC,Oliveira H,Nunes B,Pereira Mde L

更新日期：2012-03-01 00:00:00

abstract：:1. Blood lead levels were examined in 127 housepainters in North Carolina between April and September, 1993. Each participant filled out a questionnaire and gave a blood sample. The questionnaire covered the individual's work history, concentrating on paint-removal activities and personal protection, and also covered ...

journal_title：Human & experimental toxicology

authors： Ennever FK,Zaccaro DJ,Fernando RA,Jones BT

更新日期：1995-05-01 00:00:00

abstract：:Accumulating evidence has shown that ethanol-induced iron overload plays a crucial role in the development and progression of alcoholic liver disease. We designed the present study to investigate the potential protective effect of quercetin, a naturally occurring iron-chelating antioxidant on alcoholic iron overload a...

journal_title：Human & experimental toxicology

authors： Li Y,Deng Y,Tang Y,Yu H,Gao C,Liu L,Liu L,Yao P

更新日期：2014-05-01 00:00:00

abstract：:A four-fold increase in the iron content of normal subjects was detected in plasma after 5 hours of iron administration. Iron supplementation had a surprisingly erratic effect on four patients with hepatomegaly secondary to heart insufficiency, since the increase in the iron content in the plasma after iron-dextran ad...

journal_title：Human & experimental toxicology

authors： Galleano M,Lemberg A,Puntarulo S

更新日期：2003-07-01 00:00:00

abstract：:Chronic mercury exposure impairs vascular function, leading to the depression of endothelium-dependent vasodilatation. Loss of the nitric oxide (NO) pathway has been implicated, but little is known about effects on other endothelial mediators. This study investigated the mechanisms of endothelial dysfunction in rats s...

journal_title：Human & experimental toxicology

authors： Omanwar S,Ravi K,Fahim M

更新日期：2011-11-01 00:00:00

abstract：:1. Tobacco smoke contains around 4000 substances, most of which are described as toxic, and they may have an influence on the development of progeny. 2. The present studies concentrate on the measurement and calculation of indices describing the new-born's survival, rearing of pups, weight of foetuses, young animals, ...

journal_title：Human & experimental toxicology

authors： Florek E,Marszalek A,Biczysko W,Szymanowski K

更新日期：1999-04-01 00:00:00

abstract：:Postoperative cognitive dysfunction, which is associated with a wide range of cognitive functions including working memory, long-term memory, information processing, attention, and cognitive flexibility, is a major clinical issue in geriatric surgical patients. The aim of the current study was to determine the protect...

journal_title：Human & experimental toxicology

authors： Liang L,Ma Z,Dong M,Ma J,Jiang A,Sun X

更新日期：2017-12-01 00:00:00

abstract：:1. This work examines the influence of age on some nephrotoxic signs of gentamicin in normal and diabetic rats (aged 1 and 24 months). 2. Gentamicin (80 mg-1 kg-1 day for 6 days, intramuscularly) produced the typical pattern of nephrotoxicity; significantly increasing the plasma concentrations of creatinine and urea, ...

journal_title：Human & experimental toxicology

authors： Ali BH,Bashir AK,Mugamer IT,Tanira MO

更新日期：1996-01-01 00:00:00

abstract：:Cytochrome P450 4B1 (CYP4B1) plays crucial roles in biotransforming of xenobiotics. Its predominant extrahepatic expression has been associated with certain tissue-specific toxicities. However, the expressions of CYP4B1 in various cancers and hence their potential roles in cancer development were inclusive. In this wo...

journal_title：Human & experimental toxicology

authors： Lim S,Alshagga M,Ong CE,Chieng JY,Pan Y

更新日期：2020-06-01 00:00:00

abstract：:Sterigmatocystin (Stg), a major secondary metabolite of Aspergillus versicolor and A. nidulans, is the precursor of aflatoxin B1. In this study, male albino rats were treated with Stg-contaminated diet for 30 days, resulting in reduced levels of glutathione, ascorbic acid, and alpha-tocopherol. The activity of catalas...

journal_title：Human & experimental toxicology

authors： Sivakumar V,Thanislass J,Niranjali S,Devaraj H

更新日期：2001-08-01 00:00:00

abstract：:This descriptive and retrospective study was conducted at the poisoning ward of Imam teaching hospital, Sari, Iran, with the aim of evaluating the pattern of poisoning. Hence, the medical profiles of 2057 patients, who were admitted, were carefully reviewed during the period from April 2006 to March 2008 for 2 years. ...

journal_title：Human & experimental toxicology

authors： Ahmadi A,Pakravan N,Ghazizadeh Z

更新日期：2010-09-01 00:00:00

abstract：:The common effects of acetaminophen (paracetamol), isopropylantipyrine (propyphenazone) and caffeine on fetal development were examined in rats. The mixture was given in Tween 80 solution once daily, in a constant proportion of 5:3:1, during days 8-14 of gestation in three different doses. Dose S1 - 3.5 mg/kg acetamin...

journal_title：Human & experimental toxicology

authors： Burdan F

更新日期：2002-01-01 00:00:00

abstract：:The aim of the present study was to investigate whether cognitive behavioral impairment, induced by nicotine in offspring rats, was associated with the alteration of hippocampal short-term potentiation (STP) and long-term potentiation (LTP) and to discuss the potential underlying mechanism. Young adult offspring rats ...

journal_title：Human & experimental toxicology

authors： Han G,An L,Yang B,Si L,Zhang T

更新日期：2014-02-01 00:00:00

abstract：:This study investigated the main target sites of chlorpyrifos (CPF), its effect on biochemical indices, and the pathological changes observed in rat liver and kidney function using gas chromatography/mass spectrometry. Adult female Wistar rats (n = 12) were randomly assigned into two groups (one control and one test g...

journal_title：Human & experimental toxicology

authors： Tanvir EM,Afroz R,Chowdhury M,Gan SH,Karim N,Islam MN,Khalil MI

更新日期：2016-09-01 00:00:00

abstract：:The Na+-taurocholate cotransporting polypeptide (NTCP) acts as the major hepatic basolateral uptake system, and plays a key role in balancing bile flow. The anti-tuberculosis drugs rifampin (RFP) can affect bile flow causing liver injury, while tanshinone IIA (TAN IIA) has the effect of protecting liver. This study ai...

journal_title：Human & experimental toxicology

authors： Yang Y,Liu L,Xu M,Zhang X,Wang L,He Q,Xu M,Jiang X

更新日期：2020-12-14 00:00:00

abstract：:Drugs intended for use in preventing allograft rejection in transplant patients are likely to be administered chronically; thus, it is normally expected that sponsors would conduct nonclinical studies to determine the carcinogenic potential of candidate compounds. For pharmaceuticals other than biologic agents, this w...

journal_title：Human & experimental toxicology

authors： Hastings KL

更新日期：2000-04-01 00:00:00

abstract：:Fructus Psoraleae (FP), widely used in traditional medicine, is increasingly reported to cause serious hepatotoxicity in recent years. However, the main toxic constituents responsible for hepatotoxicity and the underlying mechanisms are poorly understood. In the present study, psoralen, a main and quality-control cons...

journal_title：Human & experimental toxicology

authors： Huang J,Wang Q,Chen M,Bi Y,Shi H,Zhou K

更新日期：2020-12-15 00:00:00

abstract：:The article focuses on flaws in the actual approaches of exposure to a chemical of recipient organisms. It demonstrates the excessive use of arguments based on adverse effects and underlines the necessity to take adaptive effects seriously. Regulators are invited to rethink their inclination to the 'When in doubt, kee...

journal_title：Human & experimental toxicology

authors： Hanekamp JC,Bast A

更新日期：2007-11-01 00:00:00

abstract：:Paracetamol overdose is common and microRNA (miR)-122 expression is increased with liver injury. We aimed to measure miR-122 in the setting of an abbreviated paracetamol overdose treatment regimen. We compared miRNA expression in patients treated for paracetamol poisoning with an abbreviated 12-h intravenous acetylcys...

journal_title：Human & experimental toxicology

authors： Wong A,Nejad C,Gantier M,Choy KW,Doery J,Graudins A

更新日期：2019-06-01 00:00:00