Comparisons of thresholds for carcinogenicity on linear and logarithmic dosage scales.

abstract：:N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (PK1) is a novel polymeric anticancer agent containing doxorubicin (approximately 8 wt%) bound to the polymer backbone via a Gly-Phe-Leu-Gly peptidyl linker. The approximate LD50 of PK1 in MF1 mice after a single i.v. injection was 63 mg/kg (doxorubicin-eq...

journal_title：Human & experimental toxicology

authors： Duncan R,Coatsworth JK,Burtles S

更新日期：1998-02-01 00:00:00

abstract：:Predictive toxicology plays a critical role in reducing the failure rate of new drugs in pharmaceutical research and development. Despite recent gains in our understanding of drug-induced toxicity, however, it is urgent that the utility and limitations of our current predictive tools be determined in order to identify...

journal_title：Human & experimental toxicology

authors： Naven RT,Louise-May S

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Poisoning from organophosphates and carbamates is a significant cause of morbidity and mortality worldwide. Concerns have been expressed over the safety and efficacy of the use of oximes such as pralidoxime (2-PAM) in patients with carbamate poisoning in general, and more so with carbaryl poisoning specifi...

journal_title：Human & experimental toxicology

authors： Mercurio-Zappala M,Hack JB,Salvador A,Hoffman RS

更新日期：2007-02-01 00:00:00

abstract：:1. A study was carried out to find out if digoxin and acipimox interact. 2. Six elderly patients on digoxin were each given acipimox 150 mg three daily for a week, after informed consent. Digoxin and acipimox plasma concentrations and urinary excretion were measured after the first dose of acipimox and after a week of...

journal_title：Human & experimental toxicology

authors： Chijioke CP,Pearson RM,Benedetti S

更新日期：1992-09-01 00:00:00

abstract：:The antidiabetic agent metformin was shown to further possess chemopreventive and chemotherapeutic effects against cancer. Despite the advances, the underlying molecular mechanisms involved in decreasing tumor formation are still unclear. The understanding of the participation of oxidative stress in the action mechani...

journal_title：Human & experimental toxicology

authors： Dogan Turacli I,Candar T,Yuksel BE,Demirtas S

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:Pesticide poisoning stands as a major public health issue worldwide. The objective of this study was to examine the epidemiologic characteristics of pesticide-related hospitalizations in South Korea. METHODS:Data from the Korea National Hospital Discharge Survey were analyzed to describe the epidemiologic c...

journal_title：Human & experimental toxicology

authors： Kim HJ,Cha ES,Ko Y,Kim J,Kim SD,Lee WJ

更新日期：2012-08-01 00:00:00

abstract：:Exposure of Co631 cells to plutonium leads to increasing cell death depending on the dose and incubation time. The effects, however, are more pronounced with 239Pu, than with 238Pu. Uptake and binding of the two radionuclides during a 5-h incubation are about equal, but 238Pu is lost more rapidly from the cell. There ...

journal_title：Human & experimental toxicology

authors： Boxler C,Rau W,Planas-Bohne F

更新日期：1992-05-01 00:00:00

abstract：:The current study was undertaken to evaluate the effect of combined therapy of gabapentin and pantoprazole against forestomach and pylorus ligation-induced gastric esophageal reflux disease (GERD) in albino Wistar rats. Rats were randomly divided into five groups, each group consisting of six rats, fasted for 24 h, un...

journal_title：Human & experimental toxicology

authors： Arya P,Kaithwas G

更新日期：2020-04-01 00:00:00

abstract：:This study was designed to evaluate the maternal toxicity and teratogenicity of fenproporex, one of the most widely-used anorectic drugs in many countries, including Brazil. Three periods of exposure were evaluated: (a) 30 days before mating; (b) from gestational day (GD) 0 to 14; and (c) 30 days before mating and dur...

journal_title：Human & experimental toxicology

authors： Moreira CQ,Faria MJ,Baroneza JE,Oliveira RJ,Moreira EG

更新日期：2005-08-01 00:00:00

abstract：:1. Neonatal treatment of rats with vitamin D3 resulted in a change of sexual behavior in adulthood. 2. 2.5 mg vitamin D3 completely inhibited the ejaculation of males without any apparent influence on sexual desire. 250 mg vitamin D3 influenced both the desire and ejaculation. 3. Sexual activity of females was depress...

journal_title：Human & experimental toxicology

authors： Mirzahosseini S,Karabélyos C,Dobozy O,Csaba G

更新日期：1996-07-01 00:00:00

abstract：:Indomethacin, a non-steroidal anti-inflammatory drug is known to increase the efficacy and toxicity of methotrexate, the widely used anti-cancer drug in man. The mechanism for this interaction has not been clearly established. However, since these drugs bind with albumin, a possible displacement of methotrexate by ind...

journal_title：Human & experimental toxicology

authors： Raveendran R,Heybroek W,Caulfield M,Lawson M,Abrams SM,Wrigley PF,Slevin M,Turner P

更新日期：1992-07-01 00:00:00

abstract：:The mechanism of doxorubicin (DOX)-induced cardiotoxicity remains controversial. Wistar rats (n = 66) received DOX injections intraperitoneally and were randomly assigned to 2 experimental protocols: (1) rats were killed before (-24 h, n = 8) and 24 h after (+24 h, n = 8) a single dose of DOX (4 mg/kg body weight) to ...

journal_title：Human & experimental toxicology

authors： Segredo MP,Salvadori DM,Rocha NS,Moretto FC,Correa CR,Camargo EA,de Almeida DC,Reis RA,Freire CM,Braz MG,Tang G,Matsubara LS,Matsubara BB,Yeum KJ,Ferreira AL

更新日期：2014-07-01 00:00:00

abstract：:Oxidative stress has an important role in the pathophysiology of many occupational diseases. In this controlled exposure study, the intensity of oxidative stress biomarkers was assessed in the workers of natural sweet and sour gas refineries (SwGR and SoGR, respectively) and compared with controls. In addition, the ro...

journal_title：Human & experimental toxicology

authors： Mandegary A,Sezavar M,Saeedi A,Amirheidari B,Naghibi B

更新日期：2012-12-01 00:00:00

abstract：:To evaluate in vitro inhibitory effects of four types of histamine H2-receptor antagonist (H2-receptor antagonists), famotidine, roxatidine, cimetidine and ranitidine, on platelet function, we examined aggregating potency and P-selectin levels with agonist-induced aggregation. Ranitidine and cimetidine inhibited, in c...

journal_title：Human & experimental toxicology

authors： Nakamura K,Kariyazono H,Shinkawa T,Yamaguchi T,Yamashita T,Ayukawa O,Moriyama Y,Yotsumoto G,Toyohira H,Taira A,Yamada K

更新日期：1999-08-01 00:00:00

abstract：:A liquid alcoholic extract of Papaver somniferum named Elixir Paregorico is extensively used for diarrheal diseases in Brazil. Its increased popularity has brought concerns and fears over the safety of this herbal product. Given the lack of investigative clinical studies, in this regard, this study investigated whethe...

journal_title：Human & experimental toxicology

authors： de Moraes M,Bezerra M,Bezerra F,de Moraes R,Cavalcanti P,Uchoa C,Lima F,Odorico de Moraes M

更新日期：2008-10-01 00:00:00

abstract：:Derivatives of dehydrocrotonin (DHC; Compound I) with different anti-ulcerogenic properties but less toxicity were produced by reducing the cyclohexenone moiety of DHC with NaBH4 (Compound II), reducing the cyclohexenone and lactone moieties with LiAlH4 (Compound III) and transforming the lactone moiety into an amide ...

journal_title：Human & experimental toxicology

authors： Melo PS,Durán N,Haun M

更新日期：2002-05-01 00:00:00

abstract：:A retrospective review of medical records was carried out to determine the pattern of drug and chemical poisoning cases admitted to a teaching hospital in Malaysia. Medical records of patients admitted during the period January 1987 to December 1995 were reviewed. They accounted for 0.2% of total admissions during the...

journal_title：Human & experimental toxicology

authors： Ab Rahman AF

更新日期：2002-07-01 00:00:00

abstract：:The polybrominated diphenyl ether flame retardants decabromodiphenyl ether (BDE-209) and bisphenol A (BPA) are environmental contaminants that can cross the placenta and exert toxicity in the developing fetal nervous system. Copy number variants (CNVs) play a role in a number of genetic disorders and may be implicated...

journal_title：Human & experimental toxicology

authors： Du L,Sun W,Li XM,Li XY,Liu W,Chen D

更新日期：2018-05-01 00:00:00

abstract：:Nickel nanoparticles (Ni-NPs) have been widely used in various industries related to electronics, ceramics, textiles, and nanomedicine. Ambient and occupational exposure to Ni-NPs may bring about potential detrimental effects on animals and humans. Thus, there is a growing effort to identify compounds that can amelior...

journal_title：Human & experimental toxicology

authors： Iqbal S,Jabeen F,Peng C,Ijaz MU,Chaudhry AS

更新日期：2020-11-01 00:00:00

abstract：:The objective of the present study was to perform histological and stereological examination of alcohol-induced changes in the optic nerve, considered an extension of white matter of the brain, in rats. This study included 20 male Wistar albino rats aged 60 days and weighing 190-220 g. The rats were divided into three...

journal_title：Human & experimental toxicology

authors： Igit T,Colcimen N

更新日期：2019-05-01 00:00:00

abstract：:The color of the teeth is an important topic for many people and can be influenced by intrinsic and extrinsic stains. There is an increasing demand for whitening of the teeth year by year. The most popular way of whitening is "bleaching," which is the result of the breakdown of pigments located in the enamel and/or th...

journal_title：Human & experimental toxicology

authors： Karaarslan ES,Özmen ZC,Aytac F,Bicakci AA,Buldur M,Aydogan L,Hologlu F,Özkocak B

更新日期：2019-04-01 00:00:00

abstract：:Personal reflections on radiation hormesis for the past 50 years are presented. The causes of ignoring and rejections of this phenomenon by international and national bodies and by radiation protection establishment are analyzed. The opposition against nuclear weapons and preparations for nuclear war was probably the ...

journal_title：Human & experimental toxicology

authors： Jaworowski Z

更新日期：2010-04-01 00:00:00

abstract：:The objective of this study was to determine the reliability of denial of acetaminophen ingestion in intentional drug overdose patients. All intentional drug overdose patients admitted to an emergency department who were able to provide a history were included. A detailed history was obtained on names, timing and numb...

journal_title：Human & experimental toxicology

authors： Bentur Y,Lurie Y,Tamir A,Keyes DC,Basis F

更新日期：2011-01-01 00:00:00

abstract：:Cisplatin is an effective anticancer drug used against a variety of cancers. The full therapeutic potential of cisplatin is often hampered due to concurrent development of various side effects in the hosts. Rutin, a naturally occurring bioflavonoid shows several pharmacological activities. It has been earlier reported...

journal_title：Human & experimental toxicology

authors： Prasad R,Prasad SB

更新日期：2020-08-13 00:00:00

abstract：:Methyl salicylate (oil of wintergreen) is widely available in many over-the-counter liniments, ointments, lotions or medicated oils for the relief of musculoskeletal aches and pains. Ingestion of methyl salicylate poses the threat of severe, rapid-onset salicylate poisoning because of its liquid, concentrated form and...

journal_title：Human & experimental toxicology

authors： Chan TY

更新日期：1996-09-01 00:00:00

abstract：:This study was designed to evaluate the hepato and neuroprotective activity of Daflon and low-dose γ radiation on thioacetamide (TAA)-induced liver damage and hepatic encephalopathy (HE) in rats. Effect of daily Daflon treatment (100 mg/kg body weight, Per OS (p.o.) for consecutive 3 days) and/or fractionated low-dose...

journal_title：Human & experimental toxicology

authors： Abdel-Rafei M,Amin MM,Hasan HF

更新日期：2017-01-01 00:00:00

abstract：:In responding to Drs Calabrese and Baldwin's question, 'At what point, if ever, should hormesis be employed as the principal dose response default assumption in risk assessment?', we examined the benefits of replacing traditional dose-response with hormesis. In general, hormesis provides more complete useful informati...

journal_title：Human & experimental toxicology

authors： Pickrell JA,Oehme FW

更新日期：2005-05-01 00:00:00

abstract：:Boophone disticha (B. disticha) has been used systemically in traditional medical practice in Zimbabwe and neighbouring countries for the management of various central nervous system conditions including hysteria. Abuse of the plant by teenagers in Zimbabwe for its claimed hallucinogenic effects has also been reported...

journal_title：Human & experimental toxicology

authors： Gadaga LL,Tagwireyi D,Dzangare J,Nhachi CF

更新日期：2011-08-01 00:00:00

abstract：:Nicotinamide riboside (NR) is a naturally occurring form of vitamin B3 present in trace amounts in some foods. Like niacin, it has been shown to be a precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). The safety of Niagen™, a synthetic form of NR, was determined using a bacterial reverse mutage...

journal_title：Human & experimental toxicology

authors： Conze DB,Crespo-Barreto J,Kruger CL

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The mortality rate associated with human glufosinate poisoning is high. We evaluated the usefulness of serum ammonia and sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation II (APACHE II) scores for early prediction of in-hospital mortality in glufosinate ammonium po...

journal_title：Human & experimental toxicology

authors： Lee J,Lee Y,Kim YS,Choi JG,Go TH,Kim H,Cha YS

更新日期：2019-09-01 00:00:00