Abstract:
:The antidiabetic agent metformin was shown to further possess chemopreventive and chemotherapeutic effects against cancer. Despite the advances, the underlying molecular mechanisms involved in decreasing tumor formation are still unclear. The understanding of the participation of oxidative stress in the action mechanism of metformin and its related effects on p53 and on DNA base excision repair (BER) system can help us to get closer to solve metformin puzzle in cancer. We investigated the effects of metformin in HepG2 and H2009 cells, verifying cytotoxicity, oxidative stress, antioxidant status, and DNA BER system. Our results showed metformin induced oxidative stress and reduced antioxidant capacity. Also, metformin treatment with hydrogen peroxide (H2O2) enhanced these effects. Although DNA BER enzyme activities were not changed accordantly together by metformin as a single agent or in combination with H2O2, activated p53 was decreased with increased oxidative stress in H2009 cells. Our study on the relationship between metformin/reactive oxygen species and DNA BER system in cancer cells would be helpful to understand the anticancer effects of metformin through cellular signal transduction pathways. These findings can be a model of the changes on oxidative stress that reflects p53's regulatory role on DNA repair systems in cancer for the future studies.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Dogan Turacli I,Candar T,Yuksel BE,Demirtas Sdoi
10.1177/0960327117737145subject
Has Abstractpub_date
2018-09-01 00:00:00pages
909-919issue
9eissn
0960-3271issn
1477-0903journal_volume
37pub_type
杂志文章abstract::Changes required for the explicit recognition of hormesis are outlined for both ecotoxicology and ecological risk assessment (ERA). A major research need is the extension of hormesis beyond chemical stressors to abiotic (e.g., habitat) and biotic stressors (e.g., species introductions, organism interactions). An overr...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1191/096032701718120337
更新日期:2001-10-01 00:00:00
abstract::A retrospective study was conducted on 269 patients with anticholinesterase poisoning who had been admitted to the Internal Medicine and Pediatric Clinics over the past 10 years. Their ages ranged from 17 d to 62 years. In adults, suicide was the most common means of intoxication. Miosis was the most frequent symptom ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719000900503
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abstract::Dimerized translationally controlled tumor protein (dTCTP) plays a role in allergic diseases. A 7-mer peptide, dimerized translationally binding protein 2 (dTBP2), binds to dTCTP and inhibits dTCTP, suggesting that the 7-mer peptide may have therapeutic potential. We assessed the safety of dTBP2 by examining its cytot...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113477873
更新日期:2013-11-01 00:00:00
abstract:INTRODUCTION:Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondial...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116661020
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:Calcium channel blockers (CCBs) were the most common agents associated with a significant morbidity and mortality rate. The main objective of this study was to examine the publication pattern related to CCBs poisoning at the global level using bibliometric analysis of articles published in SciVerse Scopus onlin...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115571768
更新日期:2015-11-01 00:00:00
abstract::Organic solvents can cause hearing loss themselves or promote noise-induced hearing loss. The objective of this study was to review the literature on the effects of low-level exposure to trichloroethylene on the auditory system and consider its relevance for the occupational settings. Both human and animal investigati...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108090267
更新日期:2008-03-01 00:00:00
abstract::Diazinon is one of the most widely used organophosphate insecticides (OPI) in agriculture and public health programs. The aim of this study was to investigate how an OPI, diazinon, affects lipid peroxidation (LPO) and the antioxidant defense system in vitro. For this purpose, two experiments were carried out. In exper...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327104ht408oa
更新日期:2004-01-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1177/0960327107070496
更新日期:2007-04-01 00:00:00
abstract::Sibutramine mesylate is a new anti-obesity drug. It is a crystalline salt of sibutramine developed to improve the solubility of sibutramine hydrochloride. Methanesulfonic acid was used as a salt-forming acid instead of hydrochloric acid, resulting in a greatly improved solubility of 1000 mg/mL in water. Sibutramine me...
journal_title:Human & experimental toxicology
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更新日期:2005-03-01 00:00:00
abstract::Pharmacological potential of curcumin was assessed in PC12 cells against hydrogen peroxide (H(2) O(2)) exposure. In MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and lactate dehydrogenase (LDH) assays, 24-hour exposure of H(2)O(2) (0.5 mM and above) was found to be cytotoxic. A significant (p < 0...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110371696
更新日期:2011-03-01 00:00:00
abstract::The aim of the study was to evaluate the effect of bisphenol A (BPA) on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression by neutrophils with regard to sex and nuclear factor-κB (NF-κB) pathway participation in this process. This study demonstrated that BPA intensifies the production o...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327118793188
更新日期:2019-02-01 00:00:00
abstract:INTRODUCTION:Poisoning from organophosphates and carbamates is a significant cause of morbidity and mortality worldwide. Concerns have been expressed over the safety and efficacy of the use of oximes such as pralidoxime (2-PAM) in patients with carbamate poisoning in general, and more so with carbaryl poisoning specifi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107070849
更新日期:2007-02-01 00:00:00
abstract::Experimental studies have shown that prenatal exposure to lead (Pb) produces morphological changes related to extracellular matrix remodelling. To analyse whether the matrix metalloproteinases (MMPs), particularly MMP-2, MMP-9, and the tissue inhibitor of metalloproteinases-2 (TIMP-2), are associated with morphologica...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111431706
更新日期:2012-07-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719801701007
更新日期:1998-10-01 00:00:00
abstract::Sibutramine is an antiobesity drug that inhibits the reuptake of serotonin and noradrenalin in the hypothalamus. A 37-year-old Korean man presented to the emergency room for the oral intake of 280 mg of sibutramine. The patient was in thyrotoxic state. The (99m)Technetium-pertechnetate thyroid scan showed irregular up...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327112468907
更新日期:2013-08-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112454891
更新日期:2013-03-01 00:00:00
abstract::Three patients admitted to the Accident and Emergency Unit of Lagos University Teaching Hospital (LUTH) after eating a cassava based meal 'Gari' died shortly after admission. The patients vomited and complained of abdominal pain immediately after the meal. They were unconscious with renal failure and died of cardiopul...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719201100107
更新日期:1992-01-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109348082
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327102ht224oa
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journal_title:Human & experimental toxicology
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doi:10.1177/0960327110388962
更新日期:2011-09-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109347048
更新日期:2009-09-01 00:00:00
abstract::This study was designed to evaluate the maternal toxicity and teratogenicity of fenproporex, one of the most widely-used anorectic drugs in many countries, including Brazil. Three periods of exposure were evaluated: (a) 30 days before mating; (b) from gestational day (GD) 0 to 14; and (c) 30 days before mating and dur...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327105ht545oa
更新日期:2005-08-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:Human & experimental toxicology
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更新日期:2006-05-01 00:00:00
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journal_title:Human & experimental toxicology
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更新日期:2001-04-01 00:00:00
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journal_title:Human & experimental toxicology
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更新日期:1996-02-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119828198
更新日期:2019-05-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719501400202
更新日期:1995-02-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719201100611
更新日期:1992-11-01 00:00:00