Combined therapy of gabapentin with pantoprazole exhibited better protective action against forestomach and pylorus ligation-induced gastric esophageal reflux disease in albino Wistar rats.

abstract：:1. This work examines the influence of age on some nephrotoxic signs of gentamicin in normal and diabetic rats (aged 1 and 24 months). 2. Gentamicin (80 mg-1 kg-1 day for 6 days, intramuscularly) produced the typical pattern of nephrotoxicity; significantly increasing the plasma concentrations of creatinine and urea, ...

journal_title：Human & experimental toxicology

authors： Ali BH,Bashir AK,Mugamer IT,Tanira MO

更新日期：1996-01-01 00:00:00

abstract：:Enterococcus faecalis is a facultative anaerobic gram-positive commensal bacterium common in the gastrointestinal tract of animals and humans. This study aimed to investigate the protective effects of heat-killed E. faecalis EF-2001 (EF-2001) on acute gastric ulcer using a murine model of ethanol (EtOH)-induced acute ...

journal_title：Human & experimental toxicology

authors： Jeon DB,Shin HG,Lee BW,Jeong SH,Kim JH,Ha JH,Park JY,Kwon HJ,Kim WJ,Ryu YB,Lee IC

更新日期：2020-05-01 00:00:00

abstract：:The aim of this study was to investigate the possible protective role of caffeic acid phenethyl ester on testicular toxicity of methotrexate in rats. Nineteen male rats were divided into three groups as follows: group I, control; group II, methotrexate-treated; group III, methotrexate + caffeic acid phenethyl ester-tr...

journal_title：Human & experimental toxicology

authors： Armagan A,Uzar E,Uz E,Yilmaz HR,Kutluhan S,Koyuncuoglu HR,Soyupek S,Cam H,Serel TA

更新日期：2008-07-01 00:00:00

abstract：:In this study, we aimed to investigate disulfide/thiol homeostasis in trichloroethylene (TCE) exposure. The study was carried out in 30 nonsmoker TCE-exposed workers with a variety of occupations. Additionally, 30 healthy nonsmoker volunteers were recruited as the control group. TCE exposure was determined by measurin...

journal_title：Human & experimental toxicology

authors： Bal C,Büyükşekerci M,Koca C,Ağış ER,Erdoğan S,Baran P,Gündüzöz M,Yilmaz Ö

更新日期：2016-09-01 00:00:00

abstract：:1. Blood lead levels were examined in 127 housepainters in North Carolina between April and September, 1993. Each participant filled out a questionnaire and gave a blood sample. The questionnaire covered the individual's work history, concentrating on paint-removal activities and personal protection, and also covered ...

journal_title：Human & experimental toxicology

authors： Ennever FK,Zaccaro DJ,Fernando RA,Jones BT

更新日期：1995-05-01 00:00:00

abstract：:Apoptosis induction in cancer cells is one of the most efficient ways to treat cancer and find anticancer compounds. The aim of this study was to evaluate the cytotoxic effects of heat-killed indigenous probiotic bacteria and apoptosis induction in the HT-29 human colon adenocarcinoma cell line. The growth-inhibitory ...

journal_title：Human & experimental toxicology

authors： Karimi Ardestani S,Tafvizi F,Tajabadi Ebrahimi M

更新日期：2019-09-01 00:00:00

abstract：:This study was focused on investigating the anticancer potential of indole-3-carbinol (I3C) against lung cancer H1299 cells via an increase in ROS levels. To investigate the induction of growth arrest and/or cell death in H1299 cells, a cell cycle arrest assay, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP...

journal_title：Human & experimental toxicology

authors： Lim HM,Park SH,Nam MJ

更新日期：2020-10-29 00:00:00

abstract：INTRODUCTION:Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondial...

journal_title：Human & experimental toxicology

authors： Karadas S,Aslan M,Ceylan MR,Sunnetcioglu M,Bozan N,Kara H,Demir H

更新日期：2017-07-01 00:00:00

abstract：:Exposure to quartz induces pulmonary inflammation and development of fibrosis. In order to study the fibrosing process, we investigated morphology, function and phenotype of alveolar (AMs) and interstitial (IMs) macrophages at an early stage of fibrosis in rats. Rats were exposed by intratracheal instillations of 10 m...

journal_title：Human & experimental toxicology

authors： Zetterberg G,Elmberger G,Johansson A,Lundahl J,Lundborg M,Sköld CM,Tornling G,Camner P,Eklund A

更新日期：2000-07-01 00:00:00

abstract：INTRODUCTION:Poisoning from organophosphates and carbamates is a significant cause of morbidity and mortality worldwide. Concerns have been expressed over the safety and efficacy of the use of oximes such as pralidoxime (2-PAM) in patients with carbamate poisoning in general, and more so with carbaryl poisoning specifi...

journal_title：Human & experimental toxicology

authors： Mercurio-Zappala M,Hack JB,Salvador A,Hoffman RS

更新日期：2007-02-01 00:00:00

abstract：:Drugs intended for use in preventing allograft rejection in transplant patients are likely to be administered chronically; thus, it is normally expected that sponsors would conduct nonclinical studies to determine the carcinogenic potential of candidate compounds. For pharmaceuticals other than biologic agents, this w...

journal_title：Human & experimental toxicology

authors： Hastings KL

更新日期：2000-04-01 00:00:00

abstract：:A few landmarks in the development of dose response in toxicology are presented, with an explanation of why dose should only be considered on a logarithmic scale. Examples are shown, illustrating that the current practice of labeling dose-response curves for carcinogenesis as supralinear, linear or sublinear, is meani...

journal_title：Human & experimental toxicology

authors： Waddell WJ

更新日期：2006-07-01 00:00:00

abstract：:The pharmacokinetics of the herbicide fluazifop-butyl have been determined in female rats following oral and intravenous dosing, and described by a mathematical model. Penetration of fluazifop-butyl through epidermal membranes has been determined using three different receptor fluids. It is demonstrated how this in vi...

journal_title：Human & experimental toxicology

authors： Auton TR,Ramsey JD,Woollen BH

更新日期：1993-05-01 00:00:00

abstract：:The second-generation selective 5-HT2 receptor antagonists and reuptake inhibitors (SARIs) class antidepressants are known to have fewer cardiovascular side effects than the older ones. However, several case reports showed that trazodone, one of the second-generation SARIs, induces QT prolongation, cardiac arrhythmia,...

journal_title：Human & experimental toxicology

authors： Lee S,Lee HA,Kim SJ,Kim KS

更新日期：2016-05-01 00:00:00

abstract：:Arsenic is a naturally occurring environmental toxicant, chronic exposure to arsenic can cause multiorgan damage, except for typical skin lesions, liver damage is the main problem for health concern in population with arsenic poisoning. Abnormal apoptosis is closely related to liver-related diseases, and p53 is one of...

journal_title：Human & experimental toxicology

authors： Yang Y,Liu C,Xie T,Wang D,Chen X,Ma L,Zhang A

更新日期：2021-01-27 00:00:00

abstract：:1. The reactivating and therapeutic efficacy of a new acetylcholinesterase reactivator, designated BI-6 (1-/2-hydroxyiminomethylpyridinium/-4-/carbamoylpyridinium/- 2-butene dibromide), against organophosphate sarin was compared with presently used oximes (pralidoxime, obidoxime, methoxime) and H oximes (HI-6, HLö-7) ...

journal_title：Human & experimental toxicology

authors： Kassa J,Cabal J

更新日期：1999-09-01 00:00:00

abstract：:Postoperative cognitive dysfunction, which is associated with a wide range of cognitive functions including working memory, long-term memory, information processing, attention, and cognitive flexibility, is a major clinical issue in geriatric surgical patients. The aim of the current study was to determine the protect...

journal_title：Human & experimental toxicology

authors： Liang L,Ma Z,Dong M,Ma J,Jiang A,Sun X

更新日期：2017-12-01 00:00:00

abstract：:1. This study investigated whether the reactive organohalogen gases perfluoroisobutene (PFIB) and phosgene, which cause death by overwhelming pulmonary oedema, affect the surfactant system or type II pneumocytes of rat lung. 2. The progression and type of pulmonary injury in Porton Wistar-derived rats was monitored ov...

journal_title：Human & experimental toxicology

authors： Jugg B,Jenner J,Rice P

更新日期：1999-11-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is an endogenously produced gaseous messenger that participates in regulation of cardiovascular functions. This study evaluates the possible protective effect of H2S in cardiovascular dysfunction induced by cecal ligation and puncture (CLP) in rats. After 24 h of induction of CLP, heart rate (HR...

journal_title：Human & experimental toxicology

authors： Abdelrahman RS,El-Awady MS,Nader MA,Ammar EM

更新日期：2015-10-01 00:00:00

abstract：:Indomethacin, a non-steroidal anti-inflammatory drug is known to increase the efficacy and toxicity of methotrexate, the widely used anti-cancer drug in man. The mechanism for this interaction has not been clearly established. However, since these drugs bind with albumin, a possible displacement of methotrexate by ind...

journal_title：Human & experimental toxicology

authors： Raveendran R,Heybroek W,Caulfield M,Lawson M,Abrams SM,Wrigley PF,Slevin M,Turner P

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:Calcium channel blockers (CCBs) were the most common agents associated with a significant morbidity and mortality rate. The main objective of this study was to examine the publication pattern related to CCBs poisoning at the global level using bibliometric analysis of articles published in SciVerse Scopus onlin...

journal_title：Human & experimental toxicology

authors： Zyoud SH,Al-Jabi SW,Sweileh WM,Waring WS

更新日期：2015-11-01 00:00:00

abstract：:Comparisons on a linear and the Rozman logarithmic scale for dosage versus carcinogenicity in rodents are presented for methyl eugenol (ME), nitrosodiethylamine (NDEA), ethyl carbamate (EC) and 2-acetylaminofluorene (AAF). Each of these chemicals has been shown to be carcinogenic in experimental animals and, in additi...

journal_title：Human & experimental toxicology

authors： Waddell WJ

更新日期：2005-06-01 00:00:00

abstract：:The present study was undertaken to investigate the effects of maternal lead (Pb) exposure on the expression of interleukin (IL) 1β, IL 6, and glial fibrillary acidic protein (GFAP) in hippocampus of mice offspring. Pb exposure initiated from the beginning of gestation to weaning. Lead acetate (PbAc) administered in d...

journal_title：Human & experimental toxicology

authors： Li N,Liu X,Zhang P,Qiao M,Li H,Li X,Zhang H,Yu Z

更新日期：2015-04-01 00:00:00

abstract：:Sulfur mustard (SM) represents a potential chemical warfare agent. In order to characterize SM-induced airway epithelial damage, we studied the effects of an intratracheal injection of 0.3 mg/kg of SM in guinea pigs, 5 h, 24 h, 14 days and 35 days after exposure. During the acute period, lesions prevailed in tracheal ...

journal_title：Human & experimental toxicology

authors： Calvet JH,Coste A,Levame M,Harf A,Macquin-Mavier I,Escudier E

更新日期：1996-12-01 00:00:00

abstract：:As an input to dose assessments, measurements have been made of the clearance of Pu and Am after subcutaneous implantation in rats for six particulate materials and one dust from the Maralinga test sites. The tissue distribution of Pu and Am were measured in groups of six animals at one month and 6 months after implan...

journal_title：Human & experimental toxicology

authors： Harrison JD,Hodgson A,Haines JW,Stather JW

更新日期：1993-07-01 00:00:00

abstract：:Dental amalgams are a commonly used dental restorative material, and amalgams are about 50% mercury (Hg). In our study, urinary Hg levels was examined in children of age 8-18 years, with and without dental amalgam fillings, from a completed clinical trial (parent study) that was designed to evaluate the potential heal...

journal_title：Human & experimental toxicology

authors： Geier DA,Carmody T,Kern JK,King PG,Geier MR

更新日期：2012-01-01 00:00:00

abstract：:Pityriasis rosea (PR) is a common, acute, and self-limited inflammatory skin disease. The typical clinical presentation includes the appearance of a primary "herald" patch followed within days to weeks by the onset of secondary scaly skin eruptions distributed along the skin tension line in most cases. Although PR is ...

journal_title：Human & experimental toxicology

authors： Polat M,Uzun Ö,Örs I,Boran Ç

更新日期：2014-12-01 00:00:00

abstract：:Neutrophil functions were studied in 38 lead-exposed workers compared to 34 controls. Both groups were matched according to age, sex, drinking and smoking habits, ethnic origin and drug intake. Blood lead levels were found to be seven times higher in exposed workers than in controls. Phagocytosis assayed by chemilumin...

journal_title：Human & experimental toxicology

authors： Bergeret A,Pouget E,Tedone R,Meygret T,Cadot R,Descotes J

更新日期：1990-07-01 00:00:00

abstract：:The aim of this study was to compare the number of inactivated-influenza vaccine-related spontaneous abortion and stillbirth (SB) reports in the Vaccine Adverse Event Reporting System (VAERS) database during three consecutive flu seasons beginning 2008/2009 and assess the relative fetal death reports associated with t...

journal_title：Human & experimental toxicology

authors： Goldman GS

更新日期：2013-05-01 00:00:00

abstract：:The present study was designed to evaluate the protective effects of Juglans regia kernel extract against cigarette smoke extract (CSE)-induced lung toxicities in Wistar rats. Prophylactic treatment of methanolic extract of J. regia kernel at the doses of 50 mg/kg b.wt. and 100 mg/kg b.wt was given by gavage to Wistar...

journal_title：Human & experimental toxicology

authors： Qamar W,Sultana S

更新日期：2011-06-01 00:00:00