Airway epithelial damage induced by sulfur mustard in guinea pigs, effects of glucocorticoids.

abstract：:Cyfluthrin is a pyrethroid insecticide and common household pesticide. The effect of cyfluthrin on Ca2+-related physiology in human osteosarcoma is unclear. This study investigated the effect of cyfluthrin on cytosolic-free Ca2+ concentrations ([Ca2+]i) and viability in MG63 human osteosarcoma cells. Cyfluthrin concen...

journal_title：Human & experimental toxicology

authors： Lu YC,Liang WZ,Kuo CC,Hao LJ,Chou CT,Jan CR

更新日期：2020-09-01 00:00:00

abstract：:In the 1980s, villages in the Kurdistan region of Iraq were exposed to chemical weapons (CWs), which killed and injured thousands of civilians. There has been no clinical assessment of the long-term effects of CWs exposure on those injured. We report the first such evaluation of CW effects on long-term health of child...

journal_title：Human & experimental toxicology

authors： Talabani JM,Ali AI,Kadir AM,Rashid R,Samin F,Greenwood D,Hay A

更新日期：2018-08-01 00:00:00

abstract：:Trichloroethylene (TCE) was exposed in the presence of the spin trap N-tert-butyl-alpha-phenyl nitrone (PBN, 0.1 M) to ionizing radiation from two different sources in an attempt to determine the origin of the spin-trapped radicals generating the EPR spectra in precision cut liver slices. TCE samples were irradiated w...

journal_title：Human & experimental toxicology

authors： Carmichael AJ,Steel-Goodwin L

更新日期：1997-06-01 00:00:00

abstract：PURPOSE:Calcium channel blockers (CCBs) were the most common agents associated with a significant morbidity and mortality rate. The main objective of this study was to examine the publication pattern related to CCBs poisoning at the global level using bibliometric analysis of articles published in SciVerse Scopus onlin...

journal_title：Human & experimental toxicology

authors： Zyoud SH,Al-Jabi SW,Sweileh WM,Waring WS

更新日期：2015-11-01 00:00:00

abstract：:We aimed to investigate the possible roles of nitric oxide (NO) and endothelin on the changes of cardiac muscle function in both hyper- and hypodynamic septic shock periods. Cecal ligation and puncture was performed in 50 Wistar albino rats to induce septic shock. Changes in atrium and right ventricle papillary muscle...

journal_title：Human & experimental toxicology

authors： Ozer EK,Iskit AB

更新日期：2016-03-01 00:00:00

abstract：:Pesticides are used in agriculture to protect crops from insects-pests. Most of the field workers of North Indian population are exposed to commonly used insecticides. In the present study, pesticides induced oxidative stress as well as alterations in the level of acetylcholinesterase (AChE) in a total of 70 male heal...

journal_title：Human & experimental toxicology

authors： Sharma RK,Upadhyay G,Siddiqi NJ,Sharma B

更新日期：2013-11-01 00:00:00

abstract：:1 The urinary recovery of metabolites of aspirin (ASA) was studied in 45 volunteers who took a therapeutic dose (600 mg) of ASA by mouth and in 37 patients who took ASA in overdose. 2 The main metabolite recovered from the volunteers was the glycine conjugate, salicyluric acid (SUA), which accounted for 75.01 +/- 1.19...

journal_title：Human & experimental toxicology

authors： Patel DK,Hesse A,Ogunbona A,Notarianni LJ,Bennett PN

更新日期：1990-05-01 00:00:00

abstract：:1. 26Al and 67Ga were given as citrates to a healthy male volunteer by intravenous injection. The retention of both tracers was studied by body radioactivity measurement. Levels in blood and excreta were determined by gamma-ray spectrometry and/or accelerator mass spectrometry. 2. More than half of the 26Al had left t...

journal_title：Human & experimental toxicology

authors： Priest ND,Newton D,Day JP,Talbot RJ,Warner AJ

更新日期：1995-03-01 00:00:00

abstract：:The aim of this study was to determine the safety of azelaic acid (AA) and its derivatives in nanovesicles for pharmaceutical and cosmetic uses. The hydrophilic property of AA was modified by complexing AA with hydroxypropyl-beta-cyclodextrin (AACD). The lipophilic property of AA was improved to diethyl azelate (DA) b...

journal_title：Human & experimental toxicology

authors： Panyosak A,Manosroi J,Rojanasakul Y,Manosroi A

更新日期：2009-06-01 00:00:00

abstract：:Diallyl sulfide, a sulfur-containing volatile compound present in garlic (Allium sativum), exerts anticarcinogenic activity in various rodent tumor models. In the present study, apoptosis-inhibiting effects of diallyl sulfide against a carcinogenic polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA...

journal_title：Human & experimental toxicology

authors： Prasad S,Kalra N,Srivastava S,Shukla Y

更新日期：2008-01-01 00:00:00

abstract：:The renin-angiotensin system (RAS) subserves vital physiological functions and also implicated in certain pathological states. Modulation of this system has been proposed in recent studies to be a promising strategy in treating liver fibrosis. We investigated the effect of the pharmacologic inhibition of RAS with angi...

journal_title：Human & experimental toxicology

authors： Ekor M,Odewabi AO,Kale OE,Oritogun KS,Adesanoye OA,Bamidele TO

更新日期：2011-11-01 00:00:00

abstract：:A number of xenobiotics require redox reactions to form the reactive intermediates involved in the ultimate toxic events (e.g., adduct formation). The same mechanisms lead to the formation of reactive oxygen species (ROS), which can themselves exert direct toxicity including, e.g., DNA oxidative damage or glutathione ...

journal_title：Human & experimental toxicology

authors： Pagano G

更新日期：2002-02-01 00:00:00

abstract：:1. Four different concentrations of quinalphos and methyl parathion were tested on human peripheral lymphocytes over different time periods, for the analysis of chromosomal aberrations and sister chromatid exchanges (SCEs). 2. A significant increase in chromosomal aberrations was observed when cells were treated with ...

journal_title：Human & experimental toxicology

authors： Rupa DS,Reddy PP,Reddi OS

更新日期：1990-11-01 00:00:00

abstract：:The principal impediment to gene therapy is the development of efficient, nontoxic gene carriers that can handle and deliver foreign genetic materials into various cell types, including healthy and cancerous cells. Poly-l-lysine (PLL) polymers are one of the most favorable gene carriers among nonviral vectors, and PLL...

journal_title：Human & experimental toxicology

authors： Alinejad-Mofrad E,Malaekeh-Nikouei B,Gholami L,Mousavi SH,Sadeghnia HR,Mohajeri M,Darroudi M,Oskuee RK

更新日期：2019-08-01 00:00:00

abstract：:Occupational chronic solvent encephalopathy (CSE) is associated with a number of neurobehavioural disorders including defects of visual perception. The purpose of this study was to characterize colour vision defects in CSE patients. Colour vision was tested in bright illumination with the Farnsworth-Munsell 100-hue te...

journal_title：Human & experimental toxicology

authors： Päällysaho J,Näsänen R,Mäntyjärvi M,Kaukiainen A,Sainio M

更新日期：2007-04-01 00:00:00

abstract：:Methyl salicylate (oil of wintergreen) is widely available in many over-the-counter liniments, ointments, lotions or medicated oils for the relief of musculoskeletal aches and pains. Ingestion of methyl salicylate poses the threat of severe, rapid-onset salicylate poisoning because of its liquid, concentrated form and...

journal_title：Human & experimental toxicology

authors： Chan TY

更新日期：1996-09-01 00:00:00

abstract：:Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenicity of many xenobiotics. In the present study, we investigated the possible induction of lipid peroxidation by aluminium in human foreskin fibroblast cultures by assayin...

journal_title：Human & experimental toxicology

authors： Anane R,Creppy EE

更新日期：2001-09-01 00:00:00

abstract：:1. The coumarin anticoagulant difenacoum was detected by high performance liquid chromatography (HPLC) with multi-wavelength UV detection in plasma from a 41 years old man who presented with a severe deficiency of vitamin K-dependent clotting factors of unknown aetiology. A longitudinal toxicological study of the cons...

journal_title：Human & experimental toxicology

authors： McCarthy PT,Cox AD,Harrington DJ,Evely RS,Hampton E,al-Sabah AI,Massey E,Jackson H,Ferguson T

更新日期：1997-03-01 00:00:00

abstract：:The National Toxicology Program (NTP) Technical Reports online database was reviewed to find chemicals that were reported to show clear evidence of carcinogenicity in the NTP rodent studies and for which data on human exposure could be found. Six representative compounds were selected. Three volatile compounds: ethyl ...

journal_title：Human & experimental toxicology

authors： Waddell WJ

更新日期：2003-09-01 00:00:00

abstract：:Endometriosis is characterized by the presence of functional endometrial tissue in other pelvic organs. This gynecologic problem occurs in 35-50% of women with pain and infertility. Endometriotic cells share some characteristics such as proliferation, migration, and invasion with tumor cells. Pyrvinium pamoate, an ant...

journal_title：Human & experimental toxicology

authors： Karamian A,Nazarian H,Ziai SA,Zarnani AH,Salehpour S,Paktinat S,Novin MG

更新日期：2020-05-01 00:00:00

abstract：:The aim of this study was to evaluate the scores of the Acute Physiology and Chronic Health Evaluation (APACHE) II and a modified APACHE II system (MAS), without parameters of biochemical tests; and to find prognostic value of individual elements of the APACHE II and MAS in predicting outcomes in organophosphate (OP) ...

journal_title：Human & experimental toxicology

authors： Eizadi-Mood N,Saghaei M,Jabalameli M

更新日期：2007-07-01 00:00:00

abstract：:The serial cognitive assessment of ten individuals made between 8 and 26 months after the water at Camelford in Cornwall was accidentally contaminated with aluminium sulphate, showed consistent evidence of impairment of information processing and memory. There was no obvious relationship between these impairments and ...

journal_title：Human & experimental toxicology

authors： McMillan TM,Freemont AJ,Herxheimer A,Denton J,Taylor AP,Pazianas M,Cummin AR,Eastwood JB

更新日期：1993-01-01 00:00:00

abstract：:The present study was undertaken to investigate the effects of maternal lead (Pb) exposure on the expression of interleukin (IL) 1β, IL 6, and glial fibrillary acidic protein (GFAP) in hippocampus of mice offspring. Pb exposure initiated from the beginning of gestation to weaning. Lead acetate (PbAc) administered in d...

journal_title：Human & experimental toxicology

authors： Li N,Liu X,Zhang P,Qiao M,Li H,Li X,Zhang H,Yu Z

更新日期：2015-04-01 00:00:00

abstract：:This study was focused on investigating the anticancer potential of indole-3-carbinol (I3C) against lung cancer H1299 cells via an increase in ROS levels. To investigate the induction of growth arrest and/or cell death in H1299 cells, a cell cycle arrest assay, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP...

journal_title：Human & experimental toxicology

authors： Lim HM,Park SH,Nam MJ

更新日期：2020-10-29 00:00:00

abstract：:Cisplatin is an effective anticancer drug used against a variety of cancers. The full therapeutic potential of cisplatin is often hampered due to concurrent development of various side effects in the hosts. Rutin, a naturally occurring bioflavonoid shows several pharmacological activities. It has been earlier reported...

journal_title：Human & experimental toxicology

authors： Prasad R,Prasad SB

更新日期：2020-08-13 00:00:00

abstract：:Genotoxicants can be identified as aneugens and clastogens through a micronucleus (MN) assay. The current high-content screening-based MN assays usually discriminate an aneugen from a clastogen based on only one parameter, such as the MN size, intensity, or morphology, which yields low accuracies (70-84%) because each...

journal_title：Human & experimental toxicology

authors： Huang ZH,Li N,Rao KF,Liu CT,Huang Y,Ma M,Wang ZJ

更新日期：2018-03-01 00:00:00

abstract：:Diepoxybutane (DEB)- and mitomycin C (MMC)-associated toxicity was investigated in embryos from the sea urchin (SU) species Sphaerechinus granularis. DEB- and MMC-induced toxicity resulted in S. granularis embryos and larvae at concentrations ranging 10(-5) to 10(-4) M DEB, and 3 x 10(-6) to 3 x 10(-5) M MMC, in terms...

journal_title：Human & experimental toxicology

authors： Pagano G,Degan P,De Biase A,Iaccarino M,Warnau M

更新日期：2001-12-01 00:00:00

abstract：:Nickel nanoparticles (Ni-NPs) have been widely used in various industries related to electronics, ceramics, textiles, and nanomedicine. Ambient and occupational exposure to Ni-NPs may bring about potential detrimental effects on animals and humans. Thus, there is a growing effort to identify compounds that can amelior...

journal_title：Human & experimental toxicology

authors： Iqbal S,Jabeen F,Peng C,Ijaz MU,Chaudhry AS

更新日期：2020-11-01 00:00:00

abstract：:A xenobiotic, well tolerated by the majority of treated patients, can cause serious complications in patients with individual susceptibility. Based on the hypothesis that such a phenomenon may occur in rare cases of rhabdomyolysis attributed to fenoverine (DCI), we designed a protocol to look for a genetic predisposit...

journal_title：Human & experimental toxicology

authors： Jouglard J,Kozak-Ribbens G,de Haro L,Cozzone PJ

更新日期：1996-10-01 00:00:00

abstract：:To clarify the reproductive toxicity of polychlorinated biphenyl compounds through determination of testicular lipid peroxidation, reactive oxygen species and enzymatic and non-enzymatic antioxidants in rats exposed to Aroclor 1254. Adult male rats were administered Aroclor 1254 at a dose of 2 mg/kg per day ip for 30 ...

journal_title：Human & experimental toxicology

authors： Murugesan P,Senthilkumar J,Balasubramanian K,Aruldhas MM,Arunakaran J

更新日期：2005-02-01 00:00:00