Covert poisoning with difenacoum: clinical and toxicological observations.

abstract：:Acute and chronic arsenic exposure result in toxicity both in human and animal beings and cause many hepatic and renal manifestations. The present study stated that mushroom lectin prevents arsenic-induced apoptosis. Apoptosis was measured by morphological alterations, cell proliferation index (CPI), phagocytic activi...

journal_title：Human & experimental toxicology

authors： Rana T,Bera AK,Das S,Bhattacharya D,Pan D,Bandyopadhyay S,De S,Das SK

更新日期：2011-04-01 00:00:00

abstract：:Neutrophil functions were studied in 38 lead-exposed workers compared to 34 controls. Both groups were matched according to age, sex, drinking and smoking habits, ethnic origin and drug intake. Blood lead levels were found to be seven times higher in exposed workers than in controls. Phagocytosis assayed by chemilumin...

journal_title：Human & experimental toxicology

authors： Bergeret A,Pouget E,Tedone R,Meygret T,Cadot R,Descotes J

更新日期：1990-07-01 00:00:00

abstract：:Experimental studies have shown that prenatal exposure to lead (Pb) produces morphological changes related to extracellular matrix remodelling. To analyse whether the matrix metalloproteinases (MMPs), particularly MMP-2, MMP-9, and the tissue inhibitor of metalloproteinases-2 (TIMP-2), are associated with morphologica...

journal_title：Human & experimental toxicology

authors： González-Puebla E,González-Horta C,Infante-Ramírez R,Sanin LH,Levario-Carrillo M,Sánchez-Ramírez B

更新日期：2012-07-01 00:00:00

abstract：:In responding to Drs Calabrese and Baldwin's question, 'At what point, if ever, should hormesis be employed as the principal dose response default assumption in risk assessment?', we examined the benefits of replacing traditional dose-response with hormesis. In general, hormesis provides more complete useful informati...

journal_title：Human & experimental toxicology

authors： Pickrell JA,Oehme FW

更新日期：2005-05-01 00:00:00

abstract：:Sibutramine is an antiobesity drug that inhibits the reuptake of serotonin and noradrenalin in the hypothalamus. A 37-year-old Korean man presented to the emergency room for the oral intake of 280 mg of sibutramine. The patient was in thyrotoxic state. The (99m)Technetium-pertechnetate thyroid scan showed irregular up...

journal_title：Human & experimental toxicology

authors： Kim SK,Lee SM,Yoo SS,Hahm JR,Jung JH,Kim HS,Kim S,Chung SI,Jung TS

更新日期：2013-08-01 00:00:00

abstract：:The US Environmental Protection Agency (EPA) recently issued a Staff Paper that articulates current risk assessment practices. In section 4.1.3, EPA states, "... effects that appear to be adaptive, non-adverse, or beneficial may not be mentioned." This statement may be perceived as precluding risk assessments based on...

journal_title：Human & experimental toxicology

authors： Mundt KA

更新日期：2006-01-01 00:00:00

abstract：:Deregulated cancer cell metabolism plays an important role in cancer progression. Cancer cell metabolism has been in the centre of attention in therapeutical cancer cell targeting. Repurposed chemical agents, such as metformin and aspirin, have been studied extensively as preventive and therapeutic agents. Metformin i...

journal_title：Human & experimental toxicology

authors： Albayrak G,Konac E,Dikmen AU,Bilen CY

更新日期：2018-09-01 00:00:00

abstract：:Rosiglitazone is in the thiazolidinedione class of drugs used in the treatment of type 2 diabetes mellitus. It works as an insulin sensitizer by binding to the peroxisome proliferator-activated receptor gamma. We investigated the effects of prenatally administered rosiglitazone on pyramidal cell numbers and morphologi...

journal_title：Human & experimental toxicology

authors： Sağır D,Eren B,Yılmaz BD,Eren Z,Keleş ON,Gökçe AB

更新日期：2018-08-01 00:00:00

abstract：:Resveratrol, a grape skin and red wine-derived polyphenolic phytoalexin, exhibits hormetic action delivering numerous health benefits at lower doses while being detrimental at higher doses. Epidemiologic and clinical trials need to be based on the clear understanding of hormetic health benefits of resveratrol. ...

journal_title：Human & experimental toxicology

authors： Das DK

更新日期：2010-12-01 00:00:00

abstract：:1. The influence of pharmacological pretreatment (pyridostigmine, benactyzine and trihexyphenidyle), designated PANPAL, on soman-induced cholinergic and stressogenic effects as well as on the efficacy of antidotal treatment (HI-6 plus obidoxime) in rats was studied. 2. PANPAL prophylaxis significantly decreased soman-...

journal_title：Human & experimental toxicology

authors： Kassa J,Bajgar J

更新日期：1996-05-01 00:00:00

abstract：:Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenicity of many xenobiotics. In the present study, we investigated the possible induction of lipid peroxidation by aluminium in human foreskin fibroblast cultures by assayin...

journal_title：Human & experimental toxicology

authors： Anane R,Creppy EE

更新日期：2001-09-01 00:00:00

abstract：:Cultures of bovine pulmonary endothelial (BPE) cells were exposed to LC70 doses of ricin or abrin (15.5 and 4.5 pM respectively) over a period of up to 40 h. The viability of the cultures (as determined by the neutral red (NR) dye retention assay) declined after 6 h exposure to the toxins. From 15 h onwards, cellular ...

journal_title：Human & experimental toxicology

authors： Hughes JN,Lindsay CD,Griffiths GD

更新日期：1996-05-01 00:00:00

abstract：:The number of definite and probable human chemical carcinogens identified by IARC approaches between 1987 and June 2004 is reported to be 50 agents. However, overall, given the rapid expansion in the number of chemicals in use, the throughput of the current approach to identifying potential environmental carcinogens i...

journal_title：Human & experimental toxicology

authors： Battershill JM

更新日期：2005-11-01 00:00:00

abstract：:Substance misuse among street children is a significant problem in developing countries. Volatile substances are the most abused agents. According to case reports, chronic renal diseases are common among substance-abusing street children. In this study, we examined the renal findings of 42 volatile substance-abusing s...

journal_title：Human & experimental toxicology

authors： Olgar S,Oktem F,Dindar A,Kilbas A,Turkoglu UD,Cetin H,Altuntas I,Yilmaz R,Uz E,Ertugrul T,Omeroglu R,Aydogan U

更新日期：2008-06-01 00:00:00

abstract：:1. The herbicide, paraquat, is accumulated by the energy-dependent polyamine uptake pathway of alveolar type II cells. There it undergoes redox cycling that results in an amplified production of toxic reactive oxygen species and depletion of NADPH and other reducing equivalents. These processes account for the lung be...

journal_title：Human & experimental toxicology

authors： Chen N,Bowles MR,Pond SM

更新日期：1994-08-01 00:00:00

abstract：:1. A modified mouse liver slice culture technique was established and the viability of the system was assessed on the basis of leakage of cytosolic enzymes viz. lactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartic aminotransferase (AST) and slice histology. 2. This system w...

journal_title：Human & experimental toxicology

authors： Bhattacharya R,Rao PV,Bhaskar AS,Pant SC,Dube SN

更新日期：1996-02-01 00:00:00

abstract：:This report highlights a rare presentation of vitamin B(12) deficiency (concurrent psychotic disorder, seizures and hypertension). A 16-year-old girl presented with nervousness that had been persisting for 2 weeks. She had stopped eating and there was decreased self-care and she could not walk and sleep. Two days prio...

journal_title：Human & experimental toxicology

authors： Dogan M,Ariyuca S,Peker E,Akbayram S,Dogan ŞZ,Ozdemir O,Cesur Y

更新日期：2012-04-01 00:00:00

abstract：:1. 26Al and 67Ga were given as citrates to a healthy male volunteer by intravenous injection. The retention of both tracers was studied by body radioactivity measurement. Levels in blood and excreta were determined by gamma-ray spectrometry and/or accelerator mass spectrometry. 2. More than half of the 26Al had left t...

journal_title：Human & experimental toxicology

authors： Priest ND,Newton D,Day JP,Talbot RJ,Warner AJ

更新日期：1995-03-01 00:00:00

abstract：:The National Toxicology Program (NTP) Technical Reports online database was reviewed to find chemicals that were reported to show clear evidence of carcinogenicity in the NTP rodent studies and for which data on human exposure could be found. Six representative compounds were selected. Three volatile compounds: ethyl ...

journal_title：Human & experimental toxicology

authors： Waddell WJ

更新日期：2003-09-01 00:00:00

abstract：:D-Glucaro(1,4)lactone, a potent beta-glucuronidase inhibitor was attached via the carboxylic acid moiety to polyvinylbenzyl chloride (PVBC) using a bimolecular nucleophilic displacement reaction. First, the caesium salt of D-glucaro(1,4)lactone was prepared by titrating the carboxylic acid to neutrality with aqueous c...

journal_title：Human & experimental toxicology

authors： Sacco C,McEwen WE,Calabrese EJ

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Deliberate self-poisoning (DSP) is a major health problem with increasing incidence mainly among young people. OBJECTIVE:To examine the clinical and toxicological characteristics of DSP, it is compared to unintentional (non-DSP) exposures and those characteristics which might be associated with increased to...

journal_title：Human & experimental toxicology

authors： Bentur Y,Raikhlin-Eisenkraft B,Lavee M

更新日期：2004-07-01 00:00:00

abstract：:N-nitrosodimethylamine (NDMA) is a xenobiotic widespread in human environment capable of regulating the lifespan of immune cells. In this study, we examined the roles of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor 5 (DR5) complex and the Fas molecule in the induction of the extri...

journal_title：Human & experimental toxicology

authors： Iwaniuk A,Jabłońska E,Jabłoński J,Ratajczak-Wrona W,Garley M

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present investigation was to check the fluctuation in essential elements, such as Na, K, Mg, Mn, Cu, Zn, Cr and Ni in the brain, spinal cord, liver and kidney of mice during methylmercury chloride (MMC) toxication and therapy with monothiols (N-acetyl-DL-homocysteine thiolactone and glutathione) and vit...

journal_title：Human & experimental toxicology

authors： Bapu C,Purohit RC,Sood PP

更新日期：1994-12-01 00:00:00

abstract：:The principal impediment to gene therapy is the development of efficient, nontoxic gene carriers that can handle and deliver foreign genetic materials into various cell types, including healthy and cancerous cells. Poly-l-lysine (PLL) polymers are one of the most favorable gene carriers among nonviral vectors, and PLL...

journal_title：Human & experimental toxicology

authors： Alinejad-Mofrad E,Malaekeh-Nikouei B,Gholami L,Mousavi SH,Sadeghnia HR,Mohajeri M,Darroudi M,Oskuee RK

更新日期：2019-08-01 00:00:00

abstract：:A number of xenobiotics require redox reactions to form the reactive intermediates involved in the ultimate toxic events (e.g., adduct formation). The same mechanisms lead to the formation of reactive oxygen species (ROS), which can themselves exert direct toxicity including, e.g., DNA oxidative damage or glutathione ...

journal_title：Human & experimental toxicology

authors： Pagano G

更新日期：2002-02-01 00:00:00

abstract：:1. A chronic alcoholic with severe metabolic acidosis presents a difficult diagnostic problem. The most common cause is alcoholic ketoacidosis, a syndrome with a typical history but often misleading laboratory findings. This paper will focus on this important and probably underdiagnosed syndrome. 2. The disorder occur...

journal_title：Human & experimental toxicology

authors： Höjer J

更新日期：1996-06-01 00:00:00

abstract：CONTEXT:Cardiac dysfunction is one of the most serious consequences of scorpion envenomation. The best tool to evaluate cardiac function is echocardiography, but it is not available at all emergency departments. Many studies aimed to describe biological predictive factors of cardiac dysfunction in scorpion envenomation...

journal_title：Human & experimental toxicology

authors： Chakroun-Walha O,Karray R,Jerbi M,Ben Rebeh A,Jammeli C,Bahloul M,Ammar R,Chabchoub I,Bouaziz M,Nasri A,Rekik N

更新日期：2018-06-01 00:00:00

abstract：:A sound understanding of the mechanisms determining percutaneous absorption is necessary for toxicological risk assessment of chemicals contacting the skin. As part of a programme investigating these mechanisms we have developed a physiologically based mathematical model. The structure of the model parallels the multi...

journal_title：Human & experimental toxicology

authors： Auton TR,Westhead DR,Woollen BH,Scott RC,Wilks MF

更新日期：1994-01-01 00:00:00

abstract：:This article explores the implications of hormesis on toxic tort litigation, in particular litigation regarding claims for medical monitoring or subclinical harm. In considering medical monitoring issues, courts have described medical monitoring both as a remedy and as an independent claim. If medical monitoring is up...

journal_title：Human & experimental toxicology

authors： Juni RL

更新日期：2008-02-01 00:00:00

abstract：:Arsenic trioxide (As2O3) is utilized for treating patients suffering from hematological malignancies particularly acute promyelocytic leukemia. Unfortunately, the extensive application of this chemotherapeutic agent has been limited due to its adverse effects such as cardiotoxicity. Ellagic acid, as a phenolic compoun...

journal_title：Human & experimental toxicology

authors： Hemmati AA,Olapour S,Varzi HN,Khodayar MJ,Dianat M,Mohammadian B,Yaghooti H

更新日期：2018-04-01 00:00:00