Abstract：
:This report highlights a rare presentation of vitamin B(12) deficiency (concurrent psychotic disorder, seizures and hypertension). A 16-year-old girl presented with nervousness that had been persisting for 2 weeks. She had stopped eating and there was decreased self-care and she could not walk and sleep. Two days prior to admission, generalized tonic-clonic convulsions were noted. On physical examination, vital signs were normal, except for hypertension (150/100 mm Hg). She did not respond to conversation; she could not answer the questions. Mood was depressive and hallucinations were noted. Laboratory analyses were normal, except for a low vitamin B(12) level (<150 pg mL(-1)). The patient was not given any treatment of hypertension, psychosis or seizures, except vitamin B(12) injections. After that, she showed improvement within 1 week. In the 7 days of hospitalization, the arterial blood pressure returned to normal, psychotic symptoms were resolved, the visual hallucinations and the depressive mood subsided, and she could eat and speak clearly. No hypertension or convulsions have been detected on the control examinations, and she has now been followed-up without any symptoms or findings. In conclusion, with this report we emphasized that psychosis, seizures and hypertension can be a rare manifestation of vitamin B(12) deficiency, which is reversible with therapy and serum vitamin B(12) level should be checked in patients who do not have an obvious cause for psychosis, seizures or hypertension.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Dogan M,Ariyuca S,Peker E,Akbayram S,Dogan ŞZ,Ozdemir O,Cesur Ydoi
10.1177/0960327111422404subject
Has Abstractpub_date
2012-04-01 00:00:00pages
410-3issue
4eissn
0960-3271issn
1477-0903pii
0960327111422404journal_volume
31pub_type
杂志文章abstract：:1. Six healthy male volunteers received intravenous injections of 26Al as citrate. Accelerator mass spectrometry and gamma-ray spectrometry were used to determine levels of the tracer in blood and excreta at times up to 5-6 d. 2. There was a rapid clearance from blood (mean 2% of injection remaining after 1 d) and maj...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719501400707
更新日期：1995-07-01 00:00:00
abstract：:Generation of reactive oxygen species (ROS) leads to serious tissue injuries. The effect of cyclopiazonic acid (CPA) on oxidative stress markers in the liver and kidneys of broiler chicks was studied. Ten-day-old male broiler chicks (Ross 308) were assigned into the control and test groups, which received normal salin...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327110384285
更新日期：2011-08-01 00:00:00
abstract：:The identification of biomarkers for toxicity prediction is crucial for drug development and safety evaluation. The selective and specific biomarkers for antihistamines-induced cardiotoxicity is not well identified yet. In order to evaluate the mechanism of the life-threatening effects caused by antihistamines, we use...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327114559988
更新日期：2015-08-01 00:00:00
abstract：:This article explores the implications of hormesis on toxic tort litigation, in particular litigation regarding claims for medical monitoring or subclinical harm. In considering medical monitoring issues, courts have described medical monitoring both as a remedy and as an independent claim. If medical monitoring is up...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327107086564
更新日期：2008-02-01 00:00:00
abstract：:1. This study examines the effect of treating rats with gentamicin (80 mg kg-1 day-1 intramuscularly (i.m.), for 6 days) alone or with either L-thyroxine or the anti-thyroid drug carbimazole. 2. Gentamicin produced significant increases in serum creatinine and urea concentrations, and significantly reduced the activit...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719501400103
更新日期：1995-01-01 00:00:00
abstract：:1 The concentrations of a range of organochlorine pesticide residues have been determined in 168 samples of human milk collected between January 1997 and May 1998 in the UK. 2 Of the 18 residues sought, only p,p'-DTT, p,p'-DDE, dieldrin, HCB, beta-HCH and gamma-HCH were detected. 3 The continuing trend of a reduction ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/096032799678839392
更新日期：1999-10-01 00:00:00
abstract：:Comparisons on a linear and the Rozman logarithmic scale for dosage versus carcinogenicity in rodents are presented for methyl eugenol (ME), nitrosodiethylamine (NDEA), ethyl carbamate (EC) and 2-acetylaminofluorene (AAF). Each of these chemicals has been shown to be carcinogenic in experimental animals and, in additi...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/0960327105ht525oa
更新日期：2005-06-01 00:00:00
abstract：:Phagocytes remove and store mercury (Hg) that enters the body. Macrophages and granulocytes respond in opposite ways to Hg: macrophages loose cell viability, and neutrophils become protected from apoptosis. We have investigated the cytology of early intake of Hg by macrophages and neutrophils after a short period (2-4...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/0960327104ht472oa
更新日期：2004-08-01 00:00:00
abstract：CONTEXT:Cardiac dysfunction is one of the most serious consequences of scorpion envenomation. The best tool to evaluate cardiac function is echocardiography, but it is not available at all emergency departments. Many studies aimed to describe biological predictive factors of cardiac dysfunction in scorpion envenomation...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327117722822
更新日期：2018-06-01 00:00:00
abstract：:Sulfur dioxide (SO2) is a common exogenous atmospheric pollutant. Studies have shown that SO2 can cause vasodilation as a gas signaling molecule, but the specific signaling pathways are not well understood. This study aimed to explore the underlying mechanism behind the effects of SO2 on vasodilation of isolated rat a...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327120911428
更新日期：2020-08-01 00:00:00
abstract：:In acute respiratory distress syndrome (ARDS), there is extensive overproduction of free radicals to the extent that endogenous anti-oxidants are overwhelmed, permitting oxidative cell damage. The present study examined the benefit of the anti-oxidant compound N-acetylcysteine (NAC) in the management of ARDS by measur...
journal_title：Human & experimental toxicology
pub_type： 杂志文章,随机对照试验
doi：10.1177/0960327107083452
更新日期：2007-09-01 00:00:00
abstract：:Previous studies have shown that environmental exposure to heavy metals has been related to epigenetic changes, such as DNA methylation in receptors involved in pathogenesis of asthma. One of these receptors is beta-2 adrenergic receptor (ADRB2). We conducted this study to examine the association between blood aluminu...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327120921436
更新日期：2020-10-01 00:00:00
abstract：:Dermal exposure is an important factor in risk characterization. In occupational settings it becomes relatively more important because of the continuous reduction in inhalation exposure. In the public health arena, dermal exposure may also form a significant contribution to the total exposure. Dermal exposure, however...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327107085830
更新日期：2008-04-01 00:00:00
abstract：:1 The cytotoxicity of dichlorobenzenes in cultured rat liver slices has previously been shown to be strain specific and biotransformation related. 2 In order to extrapolate animal models to humans, the dichlorobenzenes were incubated with human liver slices to try to clarify their hepatotoxic potential in man. 3 The d...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719101000510
更新日期：1991-09-01 00:00:00
abstract：:N-nitrosodimethylamine (NDMA) is a xenobiotic widespread in human environment capable of regulating the lifespan of immune cells. In this study, we examined the roles of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor 5 (DR5) complex and the Fas molecule in the induction of the extri...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327114551391
更新日期：2015-06-01 00:00:00
abstract：AIM:Diazinon (DZN) is one of the most important organophosphorus compounds used to control pests in agriculture in many countries. Several studies have shown that exposure to DZN may alter protein expression in the liver. In order to further investigate the mechanism of DZN toxicity, differentially expressed ATP-intera...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327115619771
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVES:Pesticide poisoning stands as a major public health issue worldwide. The objective of this study was to examine the epidemiologic characteristics of pesticide-related hospitalizations in South Korea. METHODS:Data from the Korea National Hospital Discharge Survey were analyzed to describe the epidemiologic c...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327111431709
更新日期：2012-08-01 00:00:00
abstract：:Progressive renal dysfunction in 5/6 nephrectomized (NX) rats can be physiologically divided into three stages, coinciding with morphological stages, after definition of physiological parameters for identification of stage. Now, for the establishment of a toxicity screening approach using 5/6 NX rats, our concept, "Di...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/096032701666840048
更新日期：2001-02-01 00:00:00
abstract：:Morphine-6-glucuronide, the active metabolite of morphine, and to a lesser extent morphine itself are known to accumulate in patients with renal failure. A number of cases on non-lethal morphine toxicity in patients with renal impairment report high plasma concentrations of morphine-6-glucuronide, suggesting that this...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327110388962
更新日期：2011-09-01 00:00:00
abstract：:1. This work examines the influence of age on some nephrotoxic signs of gentamicin in normal and diabetic rats (aged 1 and 24 months). 2. Gentamicin (80 mg-1 kg-1 day for 6 days, intramuscularly) produced the typical pattern of nephrotoxicity; significantly increasing the plasma concentrations of creatinine and urea, ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719601500109
更新日期：1996-01-01 00:00:00
abstract：:The modulating effect of peroxisome proliferator-activated receptor α ligand on haemodynamic effects of phenylepherine (PE), angiotensin II (AII), endothelin 1 (ET1), acetylcholine (Ach), sodium nitroprusside (SNP) and isoproterenol (ISO) were evaluated in glycerol-induced acute kidney injury in rats. The effect of PE...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327112454891
更新日期：2013-03-01 00:00:00
abstract：:Manganese (Mn) is an essential nutrient required for proper growth and maintenance of numerous biological systems. At high levels it is known to be neurotoxic. While focused research concerning the transport of Mn across the blood-brain barrier (BBB) is on-going, the exact identity of the transporter(s) responsible is...
journal_title：Human & experimental toxicology
pub_type： 杂志文章,评审
doi：10.1177/0960327107070496
更新日期：2007-04-01 00:00:00
abstract：:The purpose of this study was to characterize the zinc oxide nanoparticles (ZnO-NPs) and their bulk counterpart in suspensions and to access the impact of their acute oral toxicity at doses of 300 and 2000 mg/kg in healthy female Wistar rats. The hematological, biochemical, and urine parameters were accessed at 24 and...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327116629530
更新日期：2016-12-01 00:00:00
abstract：:Epichlorohydrin (ECH) is an antifertility agent that acts both as an epididymal toxicant and an agent capable of directly affecting sperm motility. This study identified the time course of apoptotic cell death in rat epididymides after ECH treatment. Rats were administrated with a single oral dose of ECH (50 mg/kg). E...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327112467042
更新日期：2013-06-01 00:00:00
abstract：:Pesticides are used in agriculture to protect crops from insects-pests. Most of the field workers of North Indian population are exposed to commonly used insecticides. In the present study, pesticides induced oxidative stress as well as alterations in the level of acetylcholinesterase (AChE) in a total of 70 male heal...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327112474835
更新日期：2013-11-01 00:00:00
abstract：:Airborne mono-2-ethylhexyl phthalate (MEHP) was studied for acute airway effects using a bioassay with BALB/c mice. Concentration- and time-dependent effects were obtained by continuous monitoring of the breathing pattern during exposure to 0.3-43.6 mg/m3 MEHP for 60 min. Additionally, inflammatory effects of MEHP wer...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/0960327104ht486oa
更新日期：2004-11-01 00:00:00
abstract：:This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327111426584
更新日期：2013-06-01 00:00:00
abstract：:Derivatives of dehydrocrotonin (DHC; Compound I) with different anti-ulcerogenic properties but less toxicity were produced by reducing the cyclohexenone moiety of DHC with NaBH4 (Compound II), reducing the cyclohexenone and lactone moieties with LiAlH4 (Compound III) and transforming the lactone moiety into an amide ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/0960327102ht246oa
更新日期：2002-05-01 00:00:00
abstract：:The aim of this study was to determine the safety of azelaic acid (AA) and its derivatives in nanovesicles for pharmaceutical and cosmetic uses. The hydrophilic property of AA was modified by complexing AA with hydroxypropyl-beta-cyclodextrin (AACD). The lipophilic property of AA was improved to diethyl azelate (DA) b...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327109105164
更新日期：2009-06-01 00:00:00
abstract：:The color of the teeth is an important topic for many people and can be influenced by intrinsic and extrinsic stains. There is an increasing demand for whitening of the teeth year by year. The most popular way of whitening is "bleaching," which is the result of the breakdown of pigments located in the enamel and/or th...
journal_title：Human & experimental toxicology
pub_type： 临床试验,杂志文章
doi：10.1177/0960327118817103
更新日期：2019-04-01 00:00:00
