Abstract:
:Sulfur dioxide (SO2) is a common exogenous atmospheric pollutant. Studies have shown that SO2 can cause vasodilation as a gas signaling molecule, but the specific signaling pathways are not well understood. This study aimed to explore the underlying mechanism behind the effects of SO2 on vasodilation of isolated rat aorta. The results showed that when the dose of SO2 was 30 μM, the vasodilation of endothelium-intact rings was partially suppressed by LY294002 and NG-nitro-l-arginine methyl ester, and the protein levels of phosphoinositide 3-kinase (PI3K), p-Akt, and p-endothelial nitric oxide synthase (p-eNOS) were significantly increased. When the dose of SO2 was 300 μM or 1500 μM, the vasodilation of endothelium-denuded rings did not change after application of the inhibitor, but the protein levels of PI3K, p-Akt, and p-eNOS were significantly decreased, and the activity of NOS and the level of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) were significantly increased. We speculate that the mechanism of SO2-induced vasodilatation likely involved the endothelial PI3K/Akt/eNOS and NO/cGMP signal pathways. In addition, at the concentration of 1500 μM, SO2 markedly increased the level of caspase-3 and caspase-9. The results suggest that high concentrations of SO2 may cause damage to blood vessels. This study will help to further inform the etiologies of SO2-related cardiovascular disease.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Zhang Q,Lyu W,Yu M,Niu Ydoi
10.1177/0960327120911428subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1108-1117issue
8eissn
0960-3271issn
1477-0903journal_volume
39pub_type
杂志文章abstract::This study evaluated the protective potential of curcumin on the possible side effects of bortezomib (Bt) therapy on normal cells in mice. The mice were segregated into three groups (n = 10) that included normal control, Bt-treated, and Bt + curcumin-treated groups. The Bt treatment resulted in significant decrease in...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327114555928
更新日期:2015-07-01 00:00:00
abstract::1. In humans morphine is metabolised to morphine-3-glucuronide (M3G) which possess no opioid activity, and morphine-6-glucuronide (M6G) which is a potent opioid receptor agonist that probably contribute to the desired as well as toxic effects of morphine. 2. In order to investigate the possible effect of ranitidine on...
journal_title:Human & experimental toxicology
pub_type: 临床试验,杂志文章
doi:10.1177/096032719801700611
更新日期:1998-06-01 00:00:00
abstract::A liquid alcoholic extract of Papaver somniferum named Elixir Paregorico is extensively used for diarrheal diseases in Brazil. Its increased popularity has brought concerns and fears over the safety of this herbal product. Given the lack of investigative clinical studies, in this regard, this study investigated whethe...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108090274
更新日期:2008-10-01 00:00:00
abstract::Persistent organochlorine pollutants (POPs), such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dichloro diphenyl trichloroethane (DDT) and its major metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p' -DDE) have been associated with type 2 diabetes mellitus (T2DM) in rece...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,多中心研究
doi:10.1177/0960327107076886
更新日期:2007-05-01 00:00:00
abstract::Pyrazinamide (PYZ)-an essential component of primary drug regimen used for the treatment and management of multidrug resistant or latent tuberculosis-is well known for its hepatoxicity. However, the mechanism of PYZ-induced hepatotoxicity is still unknown to researchers. Studies have shown that the drug is metabolized...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117705426
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109354311
更新日期:2009-12-01 00:00:00
abstract::This study was carried out on rodents, to explore the neurobehavioral effects of acrylonitrile (AN) administered in drinking water. Thirty, male, Sprague-Dawley rats were randomly divided into three groups: two exposure groups (50 and 200 ppm AN), and one control group (tap water without AN). Three tests, including th...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107070563
更新日期:2007-03-01 00:00:00
abstract::The Organization for Economic Cooperation and Development (OECD) has promoted Good Laboratory Practice (GLP) since the mid 1970s. This paper describes the development of the concept through international harmonisation, Quality Assurance (QA), and compliance monitoring. Ultimately this process permits Mutual Acceptance...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719301200611
更新日期:1993-11-01 00:00:00
abstract::Epichlorohydrin (ECH) is an antifertility agent that acts both as an epididymal toxicant and an agent capable of directly affecting sperm motility. This study identified the time course of apoptotic cell death in rat epididymides after ECH treatment. Rats were administrated with a single oral dose of ECH (50 mg/kg). E...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112467042
更新日期:2013-06-01 00:00:00
abstract::1. Tobacco smoke contains around 4000 substances, most of which are described as toxic, and they may have an influence on the development of progeny. 2. The present studies concentrate on the measurement and calculation of indices describing the new-born's survival, rearing of pups, weight of foetuses, young animals, ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032799678839996
更新日期:1999-04-01 00:00:00
abstract::A number of novel serotonergic antidepressants have been introduced to clinical practice over the last decade. These medications are felt to be safe alternatives to the traditional tricyclic antidepressants and monoamine oxidase inhibitors, particularly in the overdose setting. Serious adverse reactions and drug inter...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327197016001031
更新日期:1997-01-01 00:00:00
abstract::The aim of this study was to investigate the possible protective role of caffeic acid phenethyl ester on testicular toxicity of methotrexate in rats. Nineteen male rats were divided into three groups as follows: group I, control; group II, methotrexate-treated; group III, methotrexate + caffeic acid phenethyl ester-tr...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108092293
更新日期:2008-07-01 00:00:00
abstract::Paraquat poisoning was studied in 174 patients over a 12-month period when a new, low concentration paraquat product (4.5% w/v paraquat ion mixed with 4.5% w/v diquat ion; 63 cases) replaced the original high concentration paraquat product (20% w/v paraquat ion only; 111 cases). In both groups approximately 60% of the...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719201100401
更新日期:1992-07-01 00:00:00
abstract::Dimerized translationally controlled tumor protein (dTCTP) plays a role in allergic diseases. A 7-mer peptide, dimerized translationally binding protein 2 (dTBP2), binds to dTCTP and inhibits dTCTP, suggesting that the 7-mer peptide may have therapeutic potential. We assessed the safety of dTBP2 by examining its cytot...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113477873
更新日期:2013-11-01 00:00:00
abstract::Enterococcus faecalis is a facultative anaerobic gram-positive commensal bacterium common in the gastrointestinal tract of animals and humans. This study aimed to investigate the protective effects of heat-killed E. faecalis EF-2001 (EF-2001) on acute gastric ulcer using a murine model of ethanol (EtOH)-induced acute ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119899987
更新日期:2020-05-01 00:00:00
abstract::N-nitrosodimethylamine (NDMA) is a xenobiotic widespread in human environment capable of regulating the lifespan of immune cells. In this study, we examined the roles of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor 5 (DR5) complex and the Fas molecule in the induction of the extri...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327114551391
更新日期:2015-06-01 00:00:00
abstract:CONTEXT:Cardiac dysfunction is one of the most serious consequences of scorpion envenomation. The best tool to evaluate cardiac function is echocardiography, but it is not available at all emergency departments. Many studies aimed to describe biological predictive factors of cardiac dysfunction in scorpion envenomation...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117722822
更新日期:2018-06-01 00:00:00
abstract::In the 1980s, villages in the Kurdistan region of Iraq were exposed to chemical weapons (CWs), which killed and injured thousands of civilians. There has been no clinical assessment of the long-term effects of CWs exposure on those injured. We report the first such evaluation of CW effects on long-term health of child...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117734620
更新日期:2018-08-01 00:00:00
abstract::Manganese (Mn) is an essential nutrient required for proper growth and maintenance of numerous biological systems. At high levels it is known to be neurotoxic. While focused research concerning the transport of Mn across the blood-brain barrier (BBB) is on-going, the exact identity of the transporter(s) responsible is...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1177/0960327107070496
更新日期:2007-04-01 00:00:00
abstract::Vulpinic acid, a lichen compound, has been shown to have many beneficial effects and its medicinal value increases day by day. As in atherosclerosis, endothelial damage is the basis of many diseases. The aim of this study is to investigate the effects of vulpinic acid against oxidative stress damage induced by hydroge...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119833745
更新日期:2019-06-01 00:00:00
abstract::Airborne mono-2-ethylhexyl phthalate (MEHP) was studied for acute airway effects using a bioassay with BALB/c mice. Concentration- and time-dependent effects were obtained by continuous monitoring of the breathing pattern during exposure to 0.3-43.6 mg/m3 MEHP for 60 min. Additionally, inflammatory effects of MEHP wer...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327104ht486oa
更新日期:2004-11-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) and dioxins are potentially toxic compounds which occur widely in the environment. Their effects on the growth and development of infants at the levels currently found in highly industrialised western countries is not well known. This Dutch multicenter study, combining animal and human...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,多中心研究
doi:10.1177/096032719401301213
更新日期:1994-12-01 00:00:00
abstract::Sulfur mustard (SM) represents a potential chemical warfare agent. In order to characterize SM-induced airway epithelial damage, we studied the effects of an intratracheal injection of 0.3 mg/kg of SM in guinea pigs, 5 h, 24 h, 14 days and 35 days after exposure. During the acute period, lesions prevailed in tracheal ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719601501204
更新日期:1996-12-01 00:00:00
abstract::We describe two cases of chemical necrotizing fasciitis in the upper extremities, anterior chest wall and epigastric region of the abdominal wall caused by household insecticide injection. We suggest that surgical debridement can be successfully performed in the subacute period under close observation in hemodynamical...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327102ht308cr
更新日期:2002-12-01 00:00:00
abstract::The time-dependent changes in lead (Pb) concentrations in major tissues, serum and urine, and the Pb biomarker delta-aminolevulinic acid (ALA) concentration in urine were studied in rats after sub-chronic Pb exposure. Female Sprague-Dawley (SD) rats were exposed to Pb in drinking water at concentrations of 100 ppm and...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109107046
更新日期:2009-10-01 00:00:00
abstract::4-hydroxynonenal (4-HNE) and 6-hydroxydopamine (6-OHDA)-mediated damage in dopaminergic neurons is well documented. Protective potential of steroidal hormone (17β-estradiol) has also been suggested. However, therapeutic potential of such promising hormone is hampered due to complex brain anatomy and physiology. Thus, ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110382130
更新日期:2011-08-01 00:00:00
abstract::This study was designed to determine the levels of prolactin, leptin, osteopontin, and follistatin in workers chronically and subacutely exposed to lead compounds. The examined population consisted of three groups. The first group was composed of 56 male workers who were chronically exposed to lead for 13.38 ± 10.38 y...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116658106
更新日期:2017-06-01 00:00:00
abstract::In order to assess the effect of arsenic on the male reproductive impairment in mice, 7-week-old animals were exposed to 7.5 mg sodium arsenite (NaAsO(2))/kg body weight, during 35 days (one spermatogenic cycle). One group of animals was sacrificed after exposure, while another group received distilled water for an ad...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111405862
更新日期:2012-03-01 00:00:00
abstract::In carbon monoxide (CO) poisoning, CO affects the oxygen-carrying capacity of the hemoglobin molecule. Nucleolar-organizing regions (NORs) are genetic loci on chromosomes that are composed of ribosomal DNA and proteins. NORs can be stained with silver. A total of 18 rats were exposed to CO in three different concentra...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327114531994
更新日期:2015-01-01 00:00:00
abstract::1 The concentrations of a range of organochlorine pesticide residues have been determined in 168 samples of human milk collected between January 1997 and May 1998 in the UK. 2 Of the 18 residues sought, only p,p'-DTT, p,p'-DDE, dieldrin, HCB, beta-HCH and gamma-HCH were detected. 3 The continuing trend of a reduction ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032799678839392
更新日期:1999-10-01 00:00:00