Association between blood aluminum and beta-2 receptor gene methylation with childhood asthma control.

abstract：:A number of novel serotonergic antidepressants have been introduced to clinical practice over the last decade. These medications are felt to be safe alternatives to the traditional tricyclic antidepressants and monoamine oxidase inhibitors, particularly in the overdose setting. Serious adverse reactions and drug inter...

journal_title：Human & experimental toxicology

authors： Hodgman MJ,Martin TG,Krenzelok EP

更新日期：1997-01-01 00:00:00

abstract：:The effect of Glycyrrhiza glabra extract (GgE) as a natural antioxidant and melatonin (MEL) on ochratoxin A (OTA)-induced histopathological damages on the testes and oxidative stress was evaluated in male rats. The animals were assigned into four groups (n = 8) including control and test groups. The rats in control gr...

journal_title：Human & experimental toxicology

authors： Malekinejad H,Mirzakhani N,Razi M,Cheraghi H,Alizadeh A,Dardmeh F

更新日期：2011-02-01 00:00:00

abstract：:Stem cell transplantation has indicated great promise for cell therapy in a wide range of diseases, but poor and insufficient viability of cells within damaged tissues has limited its potential therapeutic effects. 17 β-Estradiol (E2) is a steroid hormone that plays an important role in expression of many genes and re...

journal_title：Human & experimental toxicology

authors： Mirzamohammadi S,Mehrabani M,Tekiyehmaroof N,Sharifi AM

更新日期：2016-03-01 00:00:00

abstract：:1. Dettol liquid (chloroxylenol 4.8%, pine oil, isopropyl alcohol), a household disinfectant, has a corrosive action on the gastrointestinal mucosa when swallowed. The incidence of upper gastrointestinal haemorrhage and gastroscopic findings following Dettol poisoning was studied in 89 patients. 2. Five patients (5.6%...

journal_title：Human & experimental toxicology

authors： Chan TY,Sung JJ,Critchley JA

更新日期：1995-01-01 00:00:00

abstract：:Trichothecenes are mycotoxins produced by various species of fungi which can occur on various agricultural products. Among these compounds, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) and deoxynivalenol (DON) are the most naturally encountered and potent trichothecenes. Consumption of trichothecene contaminated fo...

journal_title：Human & experimental toxicology

authors： Rio B,Lautraite S,Parent-Massin D

更新日期：1997-11-01 00:00:00

abstract：:Oxidative stress has an important role in the pathophysiology of many occupational diseases. In this controlled exposure study, the intensity of oxidative stress biomarkers was assessed in the workers of natural sweet and sour gas refineries (SwGR and SoGR, respectively) and compared with controls. In addition, the ro...

journal_title：Human & experimental toxicology

authors： Mandegary A,Sezavar M,Saeedi A,Amirheidari B,Naghibi B

更新日期：2012-12-01 00:00:00

abstract：:As an input to dose assessments, measurements have been made of the clearance of Pu and Am after subcutaneous implantation in rats for six particulate materials and one dust from the Maralinga test sites. The tissue distribution of Pu and Am were measured in groups of six animals at one month and 6 months after implan...

journal_title：Human & experimental toxicology

authors： Harrison JD,Hodgson A,Haines JW,Stather JW

更新日期：1993-07-01 00:00:00

abstract：:Postoperative cognitive dysfunction, which is associated with a wide range of cognitive functions including working memory, long-term memory, information processing, attention, and cognitive flexibility, is a major clinical issue in geriatric surgical patients. The aim of the current study was to determine the protect...

journal_title：Human & experimental toxicology

authors： Liang L,Ma Z,Dong M,Ma J,Jiang A,Sun X

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:The present study was designed to highlight the toxic impact of baclofen on both biochemical and histopathological aspects in rats' liver, gastric, lung, kidney, and brain tissues. METHODS:The study was performed on 30 healthy adult male albino rats divided into four groups with 5 rats in each control group,...

journal_title：Human & experimental toxicology

authors： Issa SY,Hafez EM,El-Banna AS,Abdel Rahman SM,AlMazroua MK,El-Hamd MA

更新日期：2018-04-01 00:00:00

abstract：:The modulating effect of peroxisome proliferator-activated receptor α ligand on haemodynamic effects of phenylepherine (PE), angiotensin II (AII), endothelin 1 (ET1), acetylcholine (Ach), sodium nitroprusside (SNP) and isoproterenol (ISO) were evaluated in glycerol-induced acute kidney injury in rats. The effect of PE...

journal_title：Human & experimental toxicology

authors： Adedapo AA,Oyekan AO

更新日期：2013-03-01 00:00:00

abstract：:Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenicity of many xenobiotics. In the present study, we investigated the possible induction of lipid peroxidation by aluminium in human foreskin fibroblast cultures by assayin...

journal_title：Human & experimental toxicology

authors： Anane R,Creppy EE

更新日期：2001-09-01 00:00:00

abstract：:The time-dependent changes in lead (Pb) concentrations in major tissues, serum and urine, and the Pb biomarker delta-aminolevulinic acid (ALA) concentration in urine were studied in rats after sub-chronic Pb exposure. Female Sprague-Dawley (SD) rats were exposed to Pb in drinking water at concentrations of 100 ppm and...

journal_title：Human & experimental toxicology

authors： Kang HG,Jeong SH,Cho MR,Cho JH,Bischoff K

更新日期：2009-10-01 00:00:00

abstract：:In our study, rats were exposed to sarin vapors for 240 min at four different concentrations (0.30, 0.43, 0.58 and 0.82 microg/L) in a whole-body inhalation chamber. The acetylcholinesterase activity (AChE, EC 3.1.1.7) was measured in the whole blood, frontal cortex (FC), pontomedullar area (PM) and basal ganglia (BG)...

journal_title：Human & experimental toxicology

authors： Bartosova-Sevelova L,Bajgar J

更新日期：2005-07-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA) is a powerfully addictive psychostimulant with pronounced effects on the central nervous system, but the precise mechanism of MDMA-induced toxicity remains unclear, specifically on the retina. This study was performed to investigate the effects of MDMA treatment on the retina a...

journal_title：Human & experimental toxicology

authors： Ma Y,Bian C,Song D,Yao G,Nie R

更新日期：2020-11-01 00:00:00

abstract：:This study was designed to evaluate the maternal toxicity and teratogenicity of fenproporex, one of the most widely-used anorectic drugs in many countries, including Brazil. Three periods of exposure were evaluated: (a) 30 days before mating; (b) from gestational day (GD) 0 to 14; and (c) 30 days before mating and dur...

journal_title：Human & experimental toxicology

authors： Moreira CQ,Faria MJ,Baroneza JE,Oliveira RJ,Moreira EG

更新日期：2005-08-01 00:00:00

abstract：:Cisplatin is an effective anticancer drug used against a variety of cancers. The full therapeutic potential of cisplatin is often hampered due to concurrent development of various side effects in the hosts. Rutin, a naturally occurring bioflavonoid shows several pharmacological activities. It has been earlier reported...

journal_title：Human & experimental toxicology

authors： Prasad R,Prasad SB

更新日期：2020-08-13 00:00:00

abstract：:The synthetic catecholamine isoprenaline (ISO) has been used as an inductor in the acute myocardial infarction model for more than a half century. Despite the fact that many articles were published on this topic, precise early haemodynamic pathology remains unknown. Acute haemodynamic changes were measured in rats; fi...

journal_title：Human & experimental toxicology

authors： Filipský T,Zatloukalová L,Mladěnka P,Hrdina R

更新日期：2012-08-01 00:00:00

abstract：:Recent years have seen substantial shifts in cultural attitudes towards cannabis for medical and recreational use. However, legalizing recreational marijuana may have adverse effects on individual and public health. As the most widely used illicit agent, cannabis is commonly reported to disrupt learning and memory. Un...

journal_title：Human & experimental toxicology

authors： Zhang Z,Li R,Lu H,Zhang X

更新日期：2020-03-01 00:00:00

abstract：:9-(4'-Aminophenyl)-9H-pyrido [3,4-b] indole (aminophenylnorharman, APNH) is a novel mutagenic heterocyclic amine, produced by the reaction of norharman with aniline in the presence of S9 mix. In the present study, the maternal and developmental toxicity of APNH were investigated in ICR mice administered oral doses of ...

journal_title：Human & experimental toxicology

authors： Naga T,Yoshimura S,Totsuka Y,Wakabayashi K

更新日期：2002-03-01 00:00:00

abstract：:The effects of moderate lead exposure on testicular endocrine function were evaluated in a group of 90 males who were occupationally exposed to inorganic lead. Lead concentrations in blood and bone were measured as indices of short-term and long-term, cumulative exposure, respectively. The results of this study show t...

journal_title：Human & experimental toxicology

authors： McGregor AJ,Mason HJ

更新日期：1990-11-01 00:00:00

abstract：:1. Multiple low doses of the direct acting organophosphates, ecothiopate, paraoxon and mipafox produced persistent and additive inhibition of diaphragm acetylcholinesterase. Paraoxon and mipafox had similar effects on brain acetylcholinesterase. There was greater recovery from inhibition between doses for paraoxon and...

journal_title：Human & experimental toxicology

authors： Williams FM,Charlton C,de Blaquière GE,Mutch E,Kelly SS,Blain PG

更新日期：1997-02-01 00:00:00

abstract：:The study of Jayjock and Lewis, 'Implication of Hormesis for Industrial Hygiene', represents a challenge for the scientific community to consider hormesis as a possible working hypothesis for redefining risk assessment strategy for low-dose exposures in the realm of industrial hygiene. This invited commentary aims at ...

journal_title：Human & experimental toxicology

authors： Carelli G,Iavicoli I,Castellino N

更新日期：2002-07-01 00:00:00

abstract：:Dermal exposure is an important factor in risk characterization. In occupational settings it becomes relatively more important because of the continuous reduction in inhalation exposure. In the public health arena, dermal exposure may also form a significant contribution to the total exposure. Dermal exposure, however...

journal_title：Human & experimental toxicology

authors： Boogaard PJ

更新日期：2008-04-01 00:00:00

abstract：:Two previously healthy women developed nausea, vomiting, headache and dizziness for several days, a massive hair loss about 2 weeks later and a discoloration of the fingernails. Detailed diagnostic procedures did not reveal any pathological results. Therapeutic measures did not show any effect. Thallium and arsenic we...

journal_title：Human & experimental toxicology

authors： Müller D,Desel H

更新日期：2010-05-01 00:00:00

abstract：:1. Human volunteer studies are an essential part of drug development but their use in the area of non-pharmaceutical chemicals has so far been very limited. Such studies can have considerable value in the assessment and improvement of the safe use of chemicals. 2. Once metabolic pathways and target metabolites have be...

journal_title：Human & experimental toxicology

authors： Wilks MF,Woollen BH

更新日期：1994-06-01 00:00:00

abstract：:Diallyl sulfide, a sulfur-containing volatile compound present in garlic (Allium sativum), exerts anticarcinogenic activity in various rodent tumor models. In the present study, apoptosis-inhibiting effects of diallyl sulfide against a carcinogenic polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA...

journal_title：Human & experimental toxicology

authors： Prasad S,Kalra N,Srivastava S,Shukla Y

更新日期：2008-01-01 00:00:00

abstract：:1. With DTPA as a comparison, the siderophore analogue 3,4,3-LIHOPO has been examined for its ability to remove 228Th nitrate from the rat after subcutaneous (sc) and intramuscular (im) injection to simulate wound contamination. The commencement of treatment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d...

journal_title：Human & experimental toxicology

authors： Stradling GN,Gray SA,Pearce MJ,Wilson I,Moody JC,Burgada R,Durbin PW,Raymond KN

更新日期：1995-02-01 00:00:00

abstract：:Sterigmatocystin (Stg), a major secondary metabolite of Aspergillus versicolor and A. nidulans, is the precursor of aflatoxin B1. In this study, male albino rats were treated with Stg-contaminated diet for 30 days, resulting in reduced levels of glutathione, ascorbic acid, and alpha-tocopherol. The activity of catalas...

journal_title：Human & experimental toxicology

authors： Sivakumar V,Thanislass J,Niranjali S,Devaraj H

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to determine oxidant and antioxidant status in infants with hyperbilirubinemia and/or kernicterus and to find whether there is a relationship between bilirubin level and oxidant/antioxidant status. PATIENTS:The study includes 69 full-term newborns (neonates with hyperbi...

journal_title：Human & experimental toxicology

authors： Doğan M,Peker E,Kirimi E,Sal E,Akbayram S,Erel O,Ocak AR,Tuncer O

更新日期：2011-11-01 00:00:00

abstract：:The effect of fendiline on cytosolic free Ca(2+) concentrations ([Ca(2+)](i)) and proliferation has not been explored in human oral cancer cells. This study examined whether fendiline altered Ca(2+) levels and caused cell death in OC2 human oral cancer cells. [Ca(2+)](i) and cell viability were measured using the fluo...

journal_title：Human & experimental toxicology

authors： Huang C,Huang C,Cheng J,Liu S,Chen I,Tsai J,Chou C,Tseng P,Jan C

更新日期：2009-01-01 00:00:00