Pesticides-induced biochemical alterations in occupational North Indian suburban population.

abstract：INTRODUCTION:Accidental toxicity by organophosphate (OP) agents may occur among farmers during spraying season due to improper use and handling. Plasma cholinesterase (ChE) activity measurement is recommended to monitor the extent of exposure to the OP agent. The aim of the current study was to measure plasma ChE activ...

journal_title：Human & experimental toxicology

authors： Pakravan N,Shokrzadeh M,Bari MA,Shadboorestan A

更新日期：2016-03-01 00:00:00

abstract：:The objective of the present study was to perform histological and stereological examination of alcohol-induced changes in the optic nerve, considered an extension of white matter of the brain, in rats. This study included 20 male Wistar albino rats aged 60 days and weighing 190-220 g. The rats were divided into three...

journal_title：Human & experimental toxicology

authors： Igit T,Colcimen N

更新日期：2019-05-01 00:00:00

abstract：:Coronary heart disease and in particular its most serious form - acute myocardial infarction (AMI) - represents the most common cause of mortality in developed countries. Better prognosis may be achieved by understanding the etiopathogenetic mechanisms of AMI. Therefore, a catecholamine model of myocardial injury, whi...

journal_title：Human & experimental toxicology

authors： Mladenka P,Hrdina R,Bobrovová Z,Semecky V,Vávrová J,Holecková M,Palicka V,Mazurová Y,Nachtigal P

更新日期：2009-10-01 00:00:00

abstract：:1. A study was carried out to find out if digoxin and acipimox interact. 2. Six elderly patients on digoxin were each given acipimox 150 mg three daily for a week, after informed consent. Digoxin and acipimox plasma concentrations and urinary excretion were measured after the first dose of acipimox and after a week of...

journal_title：Human & experimental toxicology

authors： Chijioke CP,Pearson RM,Benedetti S

更新日期：1992-09-01 00:00:00

abstract：:This study was designed to evaluate the maternal toxicity and teratogenicity of fenproporex, one of the most widely-used anorectic drugs in many countries, including Brazil. Three periods of exposure were evaluated: (a) 30 days before mating; (b) from gestational day (GD) 0 to 14; and (c) 30 days before mating and dur...

journal_title：Human & experimental toxicology

authors： Moreira CQ,Faria MJ,Baroneza JE,Oliveira RJ,Moreira EG

更新日期：2005-08-01 00:00:00

abstract：:A few landmarks in the development of dose response in toxicology are presented, with an explanation of why dose should only be considered on a logarithmic scale. Examples are shown, illustrating that the current practice of labeling dose-response curves for carcinogenesis as supralinear, linear or sublinear, is meani...

journal_title：Human & experimental toxicology

authors： Waddell WJ

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:Chlorobenzylidene malononitrile (CS) is the tear gas used by the police. The aim was to evaluate an amphoteric, hypertonic, and chelating rinsing solution in CS exposure. METHODS:The first (CS) group of six police officers was exposed to CS only. The second (preexposure) group of eight sprayed their faces wi...

journal_title：Human & experimental toxicology

authors： Brvar M

更新日期：2016-02-01 00:00:00

abstract：:This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...

journal_title：Human & experimental toxicology

authors： El-Ebiary AA,Abuelfadl AA,Sarhan NI,Othman MM

更新日期：2013-06-01 00:00:00

abstract：:1. Polyvinyl chloride (PVC) cot mattress covers from SIDS cases were investigated as potential sources of soluble (potentially ingestable) antimony in the cot environment. 2. Body fluids (urine, saliva) and proprietary domestic detergents/sterilizing fluids markedly enhanced leaching of antimony from PVC. Release of a...

journal_title：Human & experimental toxicology

authors： Jenkins RO,Craig PJ,Goessler W,Irgolic KJ

更新日期：1998-03-01 00:00:00

abstract：:Inhalation of zinc fumes may lead to the acute respiratory distress syndrome. The mechanisms of pulmonary zinc toxicity are not yet understood. Therefore we investigated zinc-dependent depression of protein and RNA synthesis in rat and human lung cell lines. 1. After exposure to 120 or 150 micromol/l zinc, RNA synthes...

journal_title：Human & experimental toxicology

authors： Walther UI,Schulze J,Forth W

更新日期：1998-12-01 00:00:00

abstract：:A retrospective review of medical records was carried out to determine the pattern of drug and chemical poisoning cases admitted to a teaching hospital in Malaysia. Medical records of patients admitted during the period January 1987 to December 1995 were reviewed. They accounted for 0.2% of total admissions during the...

journal_title：Human & experimental toxicology

authors： Ab Rahman AF

更新日期：2002-07-01 00:00:00

abstract：:Resveratrol, a grape skin and red wine-derived polyphenolic phytoalexin, exhibits hormetic action delivering numerous health benefits at lower doses while being detrimental at higher doses. Epidemiologic and clinical trials need to be based on the clear understanding of hormetic health benefits of resveratrol. ...

journal_title：Human & experimental toxicology

authors： Das DK

更新日期：2010-12-01 00:00:00

abstract：:In the 1980s, villages in the Kurdistan region of Iraq were exposed to chemical weapons (CWs), which killed and injured thousands of civilians. There has been no clinical assessment of the long-term effects of CWs exposure on those injured. We report the first such evaluation of CW effects on long-term health of child...

journal_title：Human & experimental toxicology

authors： Talabani JM,Ali AI,Kadir AM,Rashid R,Samin F,Greenwood D,Hay A

更新日期：2018-08-01 00:00:00

abstract：:A four-fold increase in the iron content of normal subjects was detected in plasma after 5 hours of iron administration. Iron supplementation had a surprisingly erratic effect on four patients with hepatomegaly secondary to heart insufficiency, since the increase in the iron content in the plasma after iron-dextran ad...

journal_title：Human & experimental toxicology

authors： Galleano M,Lemberg A,Puntarulo S

更新日期：2003-07-01 00:00:00

abstract：INTRODUCTION:Poisoning from organophosphates and carbamates is a significant cause of morbidity and mortality worldwide. Concerns have been expressed over the safety and efficacy of the use of oximes such as pralidoxime (2-PAM) in patients with carbamate poisoning in general, and more so with carbaryl poisoning specifi...

journal_title：Human & experimental toxicology

authors： Mercurio-Zappala M,Hack JB,Salvador A,Hoffman RS

更新日期：2007-02-01 00:00:00

abstract：:The phenomenon of subtoxic stimulation of organism response is not uncommon in aquatic toxicology experiments. We describe the presence of hormesis in both growth and reproduction experiments in aquatic toxicology where these responses are observed in both animals and plants and at different trophic levels of an ecosy...

journal_title：Human & experimental toxicology

authors： Bailer AJ,Oris JT

更新日期：1998-05-01 00:00:00

abstract：:Nicotinamide riboside (NR) is a naturally occurring form of vitamin B3 present in trace amounts in some foods. Like niacin, it has been shown to be a precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). The safety of Niagen™, a synthetic form of NR, was determined using a bacterial reverse mutage...

journal_title：Human & experimental toxicology

authors： Conze DB,Crespo-Barreto J,Kruger CL

更新日期：2016-11-01 00:00:00

abstract：:Deregulated cancer cell metabolism plays an important role in cancer progression. Cancer cell metabolism has been in the centre of attention in therapeutical cancer cell targeting. Repurposed chemical agents, such as metformin and aspirin, have been studied extensively as preventive and therapeutic agents. Metformin i...

journal_title：Human & experimental toxicology

authors： Albayrak G,Konac E,Dikmen AU,Bilen CY

更新日期：2018-09-01 00:00:00

abstract：:Three patients admitted to the Accident and Emergency Unit of Lagos University Teaching Hospital (LUTH) after eating a cassava based meal 'Gari' died shortly after admission. The patients vomited and complained of abdominal pain immediately after the meal. They were unconscious with renal failure and died of cardiopul...

journal_title：Human & experimental toxicology

authors： Akintonwa A,Tunwashe OL

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The widespread use of synthetic cannabinoids (SCs) among youth has become an important public health problem. Several life-threatening side effects of SC have been reported, including cardiovascular, gastrointestinal, neurological, renal, metabolic, ophthalmologic, and pulmonary effects, besides skin toxicit...

journal_title：Human & experimental toxicology

authors： Guler EM,Bektay MY,Akyildiz AG,Sisman BH,Izzettin FV,Kocyigit A

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due ...

journal_title：Human & experimental toxicology

authors： Attaran D,Lari SM,Khajehdaluee M,Ayatollahi H,Towhidi M,Asnaashari A,Marallu HG,Mazloomi M,Mood MB

更新日期：2009-12-01 00:00:00

abstract：:The effect of Glycyrrhiza glabra extract (GgE) as a natural antioxidant and melatonin (MEL) on ochratoxin A (OTA)-induced histopathological damages on the testes and oxidative stress was evaluated in male rats. The animals were assigned into four groups (n = 8) including control and test groups. The rats in control gr...

journal_title：Human & experimental toxicology

authors： Malekinejad H,Mirzakhani N,Razi M,Cheraghi H,Alizadeh A,Dardmeh F

更新日期：2011-02-01 00:00:00

abstract：:A sound understanding of the mechanisms determining percutaneous absorption is necessary for toxicological risk assessment of chemicals contacting the skin. As part of a programme investigating these mechanisms we have developed a physiologically based mathematical model. The structure of the model parallels the multi...

journal_title：Human & experimental toxicology

authors： Auton TR,Westhead DR,Woollen BH,Scott RC,Wilks MF

更新日期：1994-01-01 00:00:00

abstract：:4-hydroxynonenal (4-HNE) and 6-hydroxydopamine (6-OHDA)-mediated damage in dopaminergic neurons is well documented. Protective potential of steroidal hormone (17β-estradiol) has also been suggested. However, therapeutic potential of such promising hormone is hampered due to complex brain anatomy and physiology. Thus, ...

journal_title：Human & experimental toxicology

authors： Siddiqui MA,Kashyap MP,Al-Khedhairy AA,Musarrat J,Khanna VK,Yadav S,Pant AB

更新日期：2011-08-01 00:00:00

abstract：:Iodine-125 HIPDM was evaluated as a screening agent for studying multiorgan toxicity due to Cyclosporine-A (CsA) and the results were compared to histopathological findings of the tissues. The rats were injected subcutaneously with 50 mg/kg (body weight) of CsA or with equal volume of the vehicle, Cremophor-EL, for 7 ...

journal_title：Human & experimental toxicology

authors： Shihab-Eldeen A,Owunwanne A,Junaid TA,Yacoub T

更新日期：1996-11-01 00:00:00

abstract：:Drugs containing 5-acetylsalicylic acid (5-ASA) have been commonly used for inflammatory bowel diseases for more than half a century, but no case about overdose of suppository form of mesalazine which was taken both orally and rectally has been reported in the related literature up to now. In the present case, a 20-ye...

journal_title：Human & experimental toxicology

authors： Koseoglu Z,Satar S,Kara B,Sebe A,Kosenli O

更新日期：2011-07-01 00:00:00

abstract：:Prolonged zidovudine (AZT) treatment in HIV-infected and AIDS patients is shown to induce liver toxicity leading to complications. Therapeutic regimen that could encounter this adverse effect is unavailable and management of toxicity is often symptomatic or is limited to withdrawal of therapy. In the present investiga...

journal_title：Human & experimental toxicology

authors： Raghu R,Jesudas B,Bhavani G,Ezhilarasan D,Karthikeyan S

更新日期：2015-11-01 00:00:00

abstract：:Neutrophil functions were studied in 38 lead-exposed workers compared to 34 controls. Both groups were matched according to age, sex, drinking and smoking habits, ethnic origin and drug intake. Blood lead levels were found to be seven times higher in exposed workers than in controls. Phagocytosis assayed by chemilumin...

journal_title：Human & experimental toxicology

authors： Bergeret A,Pouget E,Tedone R,Meygret T,Cadot R,Descotes J

更新日期：1990-07-01 00:00:00

abstract：:The present study was undertaken to investigate the effects of maternal lead (Pb) exposure on the expression of interleukin (IL) 1β, IL 6, and glial fibrillary acidic protein (GFAP) in hippocampus of mice offspring. Pb exposure initiated from the beginning of gestation to weaning. Lead acetate (PbAc) administered in d...

journal_title：Human & experimental toxicology

authors： Li N,Liu X,Zhang P,Qiao M,Li H,Li X,Zhang H,Yu Z

更新日期：2015-04-01 00:00:00

abstract：:1 The cytotoxicity of dichlorobenzenes in cultured rat liver slices has previously been shown to be strain specific and biotransformation related. 2 In order to extrapolate animal models to humans, the dichlorobenzenes were incubated with human liver slices to try to clarify their hepatotoxic potential in man. 3 The d...

journal_title：Human & experimental toxicology

authors： Fisher R,Barr J,Zukoski CF,Putnam CW,Sipes IG,Gandolfi AJ,Brendel K

更新日期：1991-09-01 00:00:00