Abstract:
INTRODUCTION:Accidental toxicity by organophosphate (OP) agents may occur among farmers during spraying season due to improper use and handling. Plasma cholinesterase (ChE) activity measurement is recommended to monitor the extent of exposure to the OP agent. The aim of the current study was to measure plasma ChE activity before and after exposure with OP pesticides. METHODS:This was a prospective study conducted on 36 farmers working in the farm field. The plasma ChE level was measured before spraying and 2 days and 8 weeks after spraying season and exposure to OP agent. Farmers were observed for clinical signs and symptoms of toxicity after exposure. RESULTS:Vertimac was the most common agent used by farmers followed by diazinon and chlorpyrifos. The plasma ChE level significantly decreased after exposure by over 50%. The level returned to preexposure level after 8 weeks. CONCLUSION:Exposure to OP pesticide is a major concern in the developing countries. More than 50% reduction in the plasma ChE activity after spraying is an alarming message for health-care system and policy makers. Furthermore, workplace evaluation, serial ChE monitoring, and appropriate training and education to exposed individuals would be initial important steps to avoid the toxicity or reduce the severity of poisoning.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Pakravan N,Shokrzadeh M,Bari MA,Shadboorestan Adoi
10.1177/0960327115584990subject
Has Abstractpub_date
2016-03-01 00:00:00pages
297-301issue
3eissn
0960-3271issn
1477-0903pii
0960327115584990journal_volume
35pub_type
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