Abstract:
:Exposure of Co631 cells to plutonium leads to increasing cell death depending on the dose and incubation time. The effects, however, are more pronounced with 239Pu, than with 238Pu. Uptake and binding of the two radionuclides during a 5-h incubation are about equal, but 238Pu is lost more rapidly from the cell. There are also differences in the subcellular distribution which lead to a pronounced difference in the distribution of radioactivity. The influence of these differences in the handling of 238Pu and 239Pu by the cell and of the mass difference on the radiotoxicity of the radionuclides is discussed.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Boxler C,Rau W,Planas-Bohne Fdoi
10.1177/096032719201100303subject
Has Abstractpub_date
1992-05-01 00:00:00pages
163-6issue
3eissn
0960-3271issn
1477-0903journal_volume
11pub_type
杂志文章abstract::Methyl salicylate (oil of wintergreen) is widely available in many over-the-counter liniments, ointments, lotions or medicated oils for the relief of musculoskeletal aches and pains. Ingestion of methyl salicylate poses the threat of severe, rapid-onset salicylate poisoning because of its liquid, concentrated form and...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1177/096032719601500905
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) is the main clinical concern resulted from ischemia-reperfusion injury (IRI). Ample clinical data indicates that AKI is associated with distant organ dysfunctions and poor patients' outcomes. Oxidative stress and inflammation have a critical role in the pathogenesis of organ injurie...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120979014
更新日期:2020-12-16 00:00:00
abstract::The objective of this study was to evaluate data retrospectively on accidental ingestion of ethylene glycol (EG), based on calls to the Czech Toxicological Information Centre and from toxicological laboratories, in the years 2000-2004. All patients who ingested a known amount of EG and/or subjects with measured serum ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107073831
更新日期:2007-01-01 00:00:00
abstract::Naringenin is a naturally occurring flavanones and has been found to exhibit free radical scavenging, enzyme inhibition, antioxidants, anti-inflammatory, and anticancer activities. Present study was designed to evaluate the protective role of naringenin against benzo[a]pyrene (B[a]P)-induced oxidative stress and pulmo...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116650009
更新日期:2017-04-01 00:00:00
abstract::The malignancy of non-small cell lung cancer (NSCLC) largely results from its invasive manner. Secreted frizzled-related proteins (SFRPs) have been recently found to suppress the invasiveness of some cancers. On the other hand, the methylation of SFRPs increases protein degradation to reduce the activity of SFRPs, res...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117693071
更新日期:2018-02-01 00:00:00
abstract::This study presents the findings of free radical scavenging and antigenotoxic effect of hydroalcoholic extract of Cymbopogon citratus (CCE). The CCE at a concentration of 60 microg/mL resulted in a significant scavenging ability of 2,2-diphenyl-2-picryl hydrazyl (DPPH; (85%), 2,2-azinobis (3-ethyl benzothiazoline-6-su...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109104822
更新日期:2009-04-01 00:00:00
abstract::Inhalation of zinc fumes may lead to the acute respiratory distress syndrome. The mechanisms of pulmonary zinc toxicity are not yet understood. Therefore we investigated zinc-dependent depression of protein and RNA synthesis in rat and human lung cell lines. 1. After exposure to 120 or 150 micromol/l zinc, RNA synthes...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719801701203
更新日期:1998-12-01 00:00:00
abstract::The current study was undertaken to evaluate the effect of combined therapy of gabapentin and pantoprazole against forestomach and pylorus ligation-induced gastric esophageal reflux disease (GERD) in albino Wistar rats. Rats were randomly divided into five groups, each group consisting of six rats, fasted for 24 h, un...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119893409
更新日期:2020-04-01 00:00:00
abstract::Persistent organochlorine pollutants (POPs), such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dichloro diphenyl trichloroethane (DDT) and its major metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p' -DDE) have been associated with type 2 diabetes mellitus (T2DM) in rece...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,多中心研究
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更新日期:2007-05-01 00:00:00
abstract::Acute and chronic arsenic exposure result in toxicity both in human and animal beings and cause many hepatic and renal manifestations. The present study stated that mushroom lectin prevents arsenic-induced apoptosis. Apoptosis was measured by morphological alterations, cell proliferation index (CPI), phagocytic activi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110372642
更新日期:2011-04-01 00:00:00
abstract::Nicotinamide riboside (NR) is a naturally occurring form of vitamin B3 present in trace amounts in some foods. Like niacin, it has been shown to be a precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). The safety of Niagen™, a synthetic form of NR, was determined using a bacterial reverse mutage...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115626254
更新日期:2016-11-01 00:00:00
abstract::This paper presents the findings of a study of serum pseudocholinesterase activity in a group of 36 industrial workers chronically exposed to organophosphorus (OP) compounds. The mean pseudocholinesterase level of the workers was significantly lower than that of 36 other workers without a history of similar exposure. ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719101000406
更新日期:1991-07-01 00:00:00
abstract::Accidental ingestion of electrical batteries occurs commonly in children. This rarely is associated with severe morbidity and mortality. Significant symptoms can arise due to leakage of alkali or heavy metals from the battery after degradation in the gastrointestinal tract. The main heavy metal of concern in electrica...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327104ht433oa
更新日期:2004-04-01 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with high morbidity and mortality. miR-182-5p is overexpressed in several fibrosis-related diseases but its effect in pulmonary fibrosis has not been reported yet. To investigate the function of miR-182-5p in pulmonary fibrosis, we establish...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119895549
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:The widespread use of synthetic cannabinoids (SCs) among youth has become an important public health problem. Several life-threatening side effects of SC have been reported, including cardiovascular, gastrointestinal, neurological, renal, metabolic, ophthalmologic, and pulmonary effects, besides skin toxicit...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120930057
更新日期:2020-11-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719201100411
更新日期:1992-07-01 00:00:00
abstract::The synthetic catecholamine isoprenaline (ISO) has been used as an inductor in the acute myocardial infarction model for more than a half century. Despite the fact that many articles were published on this topic, precise early haemodynamic pathology remains unknown. Acute haemodynamic changes were measured in rats; fi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112438927
更新日期:2012-08-01 00:00:00
abstract::Phagocytes remove and store mercury (Hg) that enters the body. Macrophages and granulocytes respond in opposite ways to Hg: macrophages loose cell viability, and neutrophils become protected from apoptosis. We have investigated the cytology of early intake of Hg by macrophages and neutrophils after a short period (2-4...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327104ht472oa
更新日期:2004-08-01 00:00:00
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journal_title:Human & experimental toxicology
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doi:10.1177/0960327120947793
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journal_title:Human & experimental toxicology
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doi:10.1177/0960327120938845
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abstract::The aim of this study was to determine the safety of azelaic acid (AA) and its derivatives in nanovesicles for pharmaceutical and cosmetic uses. The hydrophilic property of AA was modified by complexing AA with hydroxypropyl-beta-cyclodextrin (AACD). The lipophilic property of AA was improved to diethyl azelate (DA) b...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
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更新日期:2009-06-01 00:00:00
abstract::1. Human volunteer studies are an essential part of drug development but their use in the area of non-pharmaceutical chemicals has so far been very limited. Such studies can have considerable value in the assessment and improvement of the safe use of chemicals. 2. Once metabolic pathways and target metabolites have be...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1177/096032719401300604
更新日期:1994-06-01 00:00:00
abstract::4-hydroxynonenal (4-HNE) and 6-hydroxydopamine (6-OHDA)-mediated damage in dopaminergic neurons is well documented. Protective potential of steroidal hormone (17β-estradiol) has also been suggested. However, therapeutic potential of such promising hormone is hampered due to complex brain anatomy and physiology. Thus, ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110382130
更新日期:2011-08-01 00:00:00
abstract::The effect of Glycyrrhiza glabra extract (GgE) as a natural antioxidant and melatonin (MEL) on ochratoxin A (OTA)-induced histopathological damages on the testes and oxidative stress was evaluated in male rats. The animals were assigned into four groups (n = 8) including control and test groups. The rats in control gr...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110368416
更新日期:2011-02-01 00:00:00
abstract::Members of the transforming growth factor (TGF) family have emerged as critical contributors to the choreography of cellular and tissue interactions underlying morphogenesis of the orofacial region. The TGFs beta, and their downstream effector molecules, the Smads, play a pivotal role in normal as well as abnormal dev...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1191/0960327105ht492oa
更新日期:2005-01-01 00:00:00
abstract::Osteosarcoma is characterized by high malignancy and high metastasis rate, resulting in high mortality and disability. MiR-663a has been reported in a variety of tumors to promote tumorigenesis. However, miR-663a has not been reported in the pathogenesis of osteosarcoma. Bioinformatics analysis and experiments includi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120937330
更新日期:2020-12-01 00:00:00
abstract::Serrapeptase (SP) and nattokinase (NK) are proteolytic enzymes belonging to serine proteases. In this study, we hypothesized that SP and NK could modulate certain factors that are associated with Alzheimer's disease (AD) pathophysiology in the experimental model. Oral administration of aluminium chloride (AlCl3) in a ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112467040
更新日期:2013-07-01 00:00:00
abstract::The principal impediment to gene therapy is the development of efficient, nontoxic gene carriers that can handle and deliver foreign genetic materials into various cell types, including healthy and cancerous cells. Poly-l-lysine (PLL) polymers are one of the most favorable gene carriers among nonviral vectors, and PLL...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119846924
更新日期:2019-08-01 00:00:00
abstract::The conventional method for the assessment of acute inhalation toxicity (OECD Test Guideline 403, 1981) uses death of animals as an endpoint to identify the median lethal concentration (LC50). A new OECD Testing Guideline called the Fixed Concentration Procedure (FCP) is being prepared to provide an alternative to Tes...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327103ht395oa
更新日期:2003-11-01 00:00:00
abstract:UNLABELLED:A single dose of monocrotaline, a pyrrolizidine alkaloid, was injected into rats in order to produce 25 (Group I) and 45 (Group II) days later a progressive and so called delayed liver injury. The present study investigated the prostanoid production of Kupffer cells and endothelial cells separated from Monoc...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719801701007
更新日期:1998-10-01 00:00:00