Commentary on 'resveratrol commonly displays hormesis: occurrence and biomedical significance' by Calabrese et al.

abstract：:Paracetamol overdose is common and microRNA (miR)-122 expression is increased with liver injury. We aimed to measure miR-122 in the setting of an abbreviated paracetamol overdose treatment regimen. We compared miRNA expression in patients treated for paracetamol poisoning with an abbreviated 12-h intravenous acetylcys...

journal_title：Human & experimental toxicology

authors： Wong A,Nejad C,Gantier M,Choy KW,Doery J,Graudins A

更新日期：2019-06-01 00:00:00

abstract：:The malignancy of non-small cell lung cancer (NSCLC) largely results from its invasive manner. Secreted frizzled-related proteins (SFRPs) have been recently found to suppress the invasiveness of some cancers. On the other hand, the methylation of SFRPs increases protein degradation to reduce the activity of SFRPs, res...

journal_title：Human & experimental toxicology

authors： Zhang X,Rong X,Chen Y,Su L

更新日期：2018-02-01 00:00:00

abstract：:Endogenous alcohol has been applied for spontaneous ethanol production via different metabolic pathways of the human body. Auto-brewery syndrome describes the patients with alcohol intoxication after ingesting carbohydrate-rich meals. The main objective of this study is to investigate the effect of diabetes mellitus (...

journal_title：Human & experimental toxicology

authors： Hafez EM,Hamad MA,Fouad M,Abdel-Lateff A

更新日期：2017-05-01 00:00:00

abstract：:Silver nanoparticles are used in many commercial products in daily life. Exposure to nanosilver has hepatotoxic effects in animals. This study investigated the cytotoxicity associated with polyvinylpyrrolidone-coated nanosilver (23.44 ± 4.92 nm in diameter) exposure in the human hepatoma cell line (HepG2) and normal h...

journal_title：Human & experimental toxicology

authors： Xue Y,Wang J,Huang Y,Gao X,Kong L,Zhang T,Tang M

更新日期：2018-12-01 00:00:00

abstract：:Cisplatin is an effective anticancer drug used against a variety of cancers. The full therapeutic potential of cisplatin is often hampered due to concurrent development of various side effects in the hosts. Rutin, a naturally occurring bioflavonoid shows several pharmacological activities. It has been earlier reported...

journal_title：Human & experimental toxicology

authors： Prasad R,Prasad SB

更新日期：2020-08-13 00:00:00

abstract：:A few landmarks in the development of dose response in toxicology are presented, with an explanation of why dose should only be considered on a logarithmic scale. Examples are shown, illustrating that the current practice of labeling dose-response curves for carcinogenesis as supralinear, linear or sublinear, is meani...

journal_title：Human & experimental toxicology

authors： Waddell WJ

更新日期：2006-07-01 00:00:00

abstract：:Drugs containing 5-acetylsalicylic acid (5-ASA) have been commonly used for inflammatory bowel diseases for more than half a century, but no case about overdose of suppository form of mesalazine which was taken both orally and rectally has been reported in the related literature up to now. In the present case, a 20-ye...

journal_title：Human & experimental toxicology

authors： Koseoglu Z,Satar S,Kara B,Sebe A,Kosenli O

更新日期：2011-07-01 00:00:00

abstract：:The Na+-taurocholate cotransporting polypeptide (NTCP) acts as the major hepatic basolateral uptake system, and plays a key role in balancing bile flow. The anti-tuberculosis drugs rifampin (RFP) can affect bile flow causing liver injury, while tanshinone IIA (TAN IIA) has the effect of protecting liver. This study ai...

journal_title：Human & experimental toxicology

authors： Yang Y,Liu L,Xu M,Zhang X,Wang L,He Q,Xu M,Jiang X

更新日期：2020-12-14 00:00:00

abstract：:The serial cognitive assessment of ten individuals made between 8 and 26 months after the water at Camelford in Cornwall was accidentally contaminated with aluminium sulphate, showed consistent evidence of impairment of information processing and memory. There was no obvious relationship between these impairments and ...

journal_title：Human & experimental toxicology

authors： McMillan TM,Freemont AJ,Herxheimer A,Denton J,Taylor AP,Pazianas M,Cummin AR,Eastwood JB

更新日期：1993-01-01 00:00:00

abstract：:Boophone disticha (B. disticha) has been used systemically in traditional medical practice in Zimbabwe and neighbouring countries for the management of various central nervous system conditions including hysteria. Abuse of the plant by teenagers in Zimbabwe for its claimed hallucinogenic effects has also been reported...

journal_title：Human & experimental toxicology

authors： Gadaga LL,Tagwireyi D,Dzangare J,Nhachi CF

更新日期：2011-08-01 00:00:00

abstract：:Neutrophil functions were studied in 38 lead-exposed workers compared to 34 controls. Both groups were matched according to age, sex, drinking and smoking habits, ethnic origin and drug intake. Blood lead levels were found to be seven times higher in exposed workers than in controls. Phagocytosis assayed by chemilumin...

journal_title：Human & experimental toxicology

authors： Bergeret A,Pouget E,Tedone R,Meygret T,Cadot R,Descotes J

更新日期：1990-07-01 00:00:00

abstract：:Hexafluorocyclobutene (HFCB), a reactive organohalogen gas, causes overwhelming pulmonary oedema. We investigated its effect on the rat lung surfactant system, comparing its action on type II pneumocytes with air-exposed rats. The inflammatory cell population and protein content of bronchoalveolar lavage fluid was ana...

journal_title：Human & experimental toxicology

authors： Jugg B,Jenner J,Hughes JN,Rice P

更新日期：2001-05-01 00:00:00

abstract：:Recent years have seen substantial shifts in cultural attitudes towards cannabis for medical and recreational use. However, legalizing recreational marijuana may have adverse effects on individual and public health. As the most widely used illicit agent, cannabis is commonly reported to disrupt learning and memory. Un...

journal_title：Human & experimental toxicology

authors： Zhang Z,Li R,Lu H,Zhang X

更新日期：2020-03-01 00:00:00

abstract：:Pharmaceutical research and new drug development rely extensively on animal research. The development of novel agents for intrathecal administration requires preclinical studies of toxic effects in an animal model. We have developed a nonrodent animal model for this purpose. Our sheep model: 1 Is an animal whose neura...

journal_title：Human & experimental toxicology

authors： Hassenbusch SJ,Satterfield WC,Gradert TL

更新日期：1999-02-01 00:00:00

abstract：:Okadaic acid (OA) is the main toxin produced by dinoflagellates, which can accumulate in the hepatopancreas of mussels and cause diarrhoetic shellfish poisoning in consumers. This toxin is also a tumour promoter and a specific potent inhibitor of protein phosphatases 1 and 2A. The results in this study show for the fi...

journal_title：Human & experimental toxicology

authors： Matias WG,Creppy EE

更新日期：1996-03-01 00:00:00

abstract：:1. Three indexes for evaluating the severity of paraquat poisoning based on plasma-paraquat concentration are presently in use; the curves of Proudfood et al. and Scherrmann et al. and the SIPP. Their effectiveness in determining the prognosis of patients with paraquat poisoning was evaluated. 2. To determine which in...

journal_title：Human & experimental toxicology

authors： Suzuki K,Takasu N,Arita S,Ueda A,Okabe T,Ishimatsu S,Tanaka S,Kohama A

更新日期：1991-01-01 00:00:00

abstract：:This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...

journal_title：Human & experimental toxicology

authors： El-Ebiary AA,Abuelfadl AA,Sarhan NI,Othman MM

更新日期：2013-06-01 00:00:00

abstract：:1. 26Al and 67Ga were given as citrates to a healthy male volunteer by intravenous injection. The retention of both tracers was studied by body radioactivity measurement. Levels in blood and excreta were determined by gamma-ray spectrometry and/or accelerator mass spectrometry. 2. More than half of the 26Al had left t...

journal_title：Human & experimental toxicology

authors： Priest ND,Newton D,Day JP,Talbot RJ,Warner AJ

更新日期：1995-03-01 00:00:00

abstract：:D-Glucaro(1,4)lactone, a potent beta-glucuronidase inhibitor was attached via the carboxylic acid moiety to polyvinylbenzyl chloride (PVBC) using a bimolecular nucleophilic displacement reaction. First, the caesium salt of D-glucaro(1,4)lactone was prepared by titrating the carboxylic acid to neutrality with aqueous c...

journal_title：Human & experimental toxicology

authors： Sacco C,McEwen WE,Calabrese EJ

更新日期：1993-03-01 00:00:00

abstract：:The present study has three purposes; first evaluating cytotoxicity of (E)-4-chloro-2-((3-ethoxy-2-hydroxybenzylidene)amino)phenol (ACES), second deciphering ACES-mediated cellular death mechanism, and third estimating ACES-mediated alterations in the expressions of mitogen-activated protein kinase (MAPK) pathway-rela...

journal_title：Human & experimental toxicology

authors： Karaosmanoğlu O

更新日期：2020-10-01 00:00:00

abstract：:Cytochrome P450 4B1 (CYP4B1) plays crucial roles in biotransforming of xenobiotics. Its predominant extrahepatic expression has been associated with certain tissue-specific toxicities. However, the expressions of CYP4B1 in various cancers and hence their potential roles in cancer development were inclusive. In this wo...

journal_title：Human & experimental toxicology

authors： Lim S,Alshagga M,Ong CE,Chieng JY,Pan Y

更新日期：2020-06-01 00:00:00

abstract：:1. The herbicide, paraquat, is accumulated by the energy-dependent polyamine uptake pathway of alveolar type II cells. There it undergoes redox cycling that results in an amplified production of toxic reactive oxygen species and depletion of NADPH and other reducing equivalents. These processes account for the lung be...

journal_title：Human & experimental toxicology

authors： Chen N,Bowles MR,Pond SM

更新日期：1994-08-01 00:00:00

abstract：:The aim of the study was to evaluate the effect of bisphenol A (BPA) on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression by neutrophils with regard to sex and nuclear factor-κB (NF-κB) pathway participation in this process. This study demonstrated that BPA intensifies the production o...

journal_title：Human & experimental toxicology

authors： Ratajczak-Wrona W,Nowak K,Garley M,Tynecka M,Jablonska E

更新日期：2019-02-01 00:00:00

abstract：:It has been argued that the phenomenon of hormesis should prompt us to revise current regulatory policy in order to take beneficial effects of small doses of various agents into account. I argue that three problems--the comparative smallness of hormetic effects, the fine-tuning problem, and the problem of aggregated a...

journal_title：Human & experimental toxicology

authors： Sandin P

更新日期：2008-08-01 00:00:00

abstract：:Methyl salicylate (oil of wintergreen) is widely available in many over-the-counter liniments, ointments, lotions or medicated oils for the relief of musculoskeletal aches and pains. Ingestion of methyl salicylate poses the threat of severe, rapid-onset salicylate poisoning because of its liquid, concentrated form and...

journal_title：Human & experimental toxicology

authors： Chan TY

更新日期：1996-09-01 00:00:00

abstract：:Comparisons on a linear and the Rozman logarithmic scale for dosage versus carcinogenicity in rodents are presented for methyl eugenol (ME), nitrosodiethylamine (NDEA), ethyl carbamate (EC) and 2-acetylaminofluorene (AAF). Each of these chemicals has been shown to be carcinogenic in experimental animals and, in additi...

journal_title：Human & experimental toxicology

authors： Waddell WJ

更新日期：2005-06-01 00:00:00

abstract：:Until quite recently, pentabromodiphenyl ether (PentaBDE) was most commonly used as a flame retardant. Due to the considerably long atmospheric half-life of PentaBDE and its contribution to environmental pollution, it is categorized as a persistent organic pollutant (POP). As the data on the toxicity of PentaBDE is ra...

journal_title：Human & experimental toxicology

authors： Bruchajzer E,Frydrych B,Sporny S,Szymańska JA

更新日期：2011-05-01 00:00:00

abstract：:This study deals with pesticide exposure profile in some European countries with a specific focus on ethylenebisdithiocarbamates (EBDC). In all, 55 Bulgarian greenhouse workers, 51 Finnish potato farmers, 48 Italian vineyard workers, 42 Dutch floriculture farmers, and 52 Bulgarian zineb producers entered the study. Ea...

journal_title：Human & experimental toxicology

authors： Fustinoni S,Campo L,Liesivuori J,Pennanen S,Vergieva T,van Amelsvoort L,Bosetti C,Van Loveren H,Colosio C

更新日期：2008-09-01 00:00:00

abstract：:Periodontitis is a common infectious disease associated with destruction of periodontal ligaments and alveolar bones. CD4(+) T cell-mediated immune response is involved in the progression of periodontitis. Tobacco consumption increases the risk of periodontal disease. However, the impact of nicotine on the interaction...

journal_title：Human & experimental toxicology

authors： Ge X,Liu YF,Wong Y,Wu LZ,Tan L,Liu F,Wang XJ

更新日期：2016-09-01 00:00:00

abstract：:A sound understanding of the mechanisms determining percutaneous absorption is necessary for toxicological risk assessment of chemicals contacting the skin. As part of a programme investigating these mechanisms we have developed a physiologically based mathematical model. The structure of the model parallels the multi...

journal_title：Human & experimental toxicology

authors： Auton TR,Westhead DR,Woollen BH,Scott RC,Wilks MF

更新日期：1994-01-01 00:00:00