Abstract:
:Until quite recently, pentabromodiphenyl ether (PentaBDE) was most commonly used as a flame retardant. Due to the considerably long atmospheric half-life of PentaBDE and its contribution to environmental pollution, it is categorized as a persistent organic pollutant (POP). As the data on the toxicity of PentaBDE is rather scarce, its potential acute toxicity was the subject of this study. PentaBDE was administered intragastrically to female rats, in a single dose (25, 200 or 2000 mg/kg b.w.). PentaBDE administered to rats disturbed redox homeostasis, which was manifested by lower total antioxidant status (TAS) in serum and by higher liver glutathione reduced (GSH) concentration. The toxic effect of PentaBDE intensified lipid peroxidation. On histopathological examination, administration of the highest PentaBDE dose (2000 mg/kg b.w.) was seen to induce symptoms of fatty liver. PentaBDE caused an increase in relative liver mass, cytochromes P-450 (after two highest doses), a dose-dependent increase in the activity of CYP lA (12-26 fold) and CYP 2B (5-6 fold) as well as the levels of CYP lAl (16-50 fold) and CYP 4A (2-3 fold) in liver.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Bruchajzer E,Frydrych B,Sporny S,Szymańska JAdoi
10.1177/0960327110371261subject
Has Abstractpub_date
2011-05-01 00:00:00pages
363-78issue
5eissn
0960-3271issn
1477-0903pii
0960327110371261journal_volume
30pub_type
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