Experimental studies on multiorgan toxicity of cyclosporine-A in rats using a radiopharmaceutical and comparison with histopathological findings.

abstract：:The aim of this study was to determine the safety of azelaic acid (AA) and its derivatives in nanovesicles for pharmaceutical and cosmetic uses. The hydrophilic property of AA was modified by complexing AA with hydroxypropyl-beta-cyclodextrin (AACD). The lipophilic property of AA was improved to diethyl azelate (DA) b...

journal_title：Human & experimental toxicology

authors： Panyosak A,Manosroi J,Rojanasakul Y,Manosroi A

更新日期：2009-06-01 00:00:00

abstract：:As an input to dose assessments, measurements have been made of the clearance of Pu and Am after subcutaneous implantation in rats for six particulate materials and one dust from the Maralinga test sites. The tissue distribution of Pu and Am were measured in groups of six animals at one month and 6 months after implan...

journal_title：Human & experimental toxicology

authors： Harrison JD,Hodgson A,Haines JW,Stather JW

更新日期：1993-07-01 00:00:00

abstract：:Predictive toxicology plays a critical role in reducing the failure rate of new drugs in pharmaceutical research and development. Despite recent gains in our understanding of drug-induced toxicity, however, it is urgent that the utility and limitations of our current predictive tools be determined in order to identify...

journal_title：Human & experimental toxicology

authors： Naven RT,Louise-May S

更新日期：2015-12-01 00:00:00

abstract：:1. The reactivating and therapeutic efficacy of a new acetylcholinesterase reactivator, designated BI-6 (1-/2-hydroxyiminomethylpyridinium/-4-/carbamoylpyridinium/- 2-butene dibromide), against organophosphate sarin was compared with presently used oximes (pralidoxime, obidoxime, methoxime) and H oximes (HI-6, HLö-7) ...

journal_title：Human & experimental toxicology

authors： Kassa J,Cabal J

更新日期：1999-09-01 00:00:00

abstract：:The aim of this study was focused on investigating the possible protective effect of erdosteine against gamma radiation-induced renal lesions in male albino rats. Twenty-eight albino rats were divided into four equal groups as follows: control group, irradiated group (animals subjected to whole-body gamma irradiation ...

journal_title：Human & experimental toxicology

authors： Elkady AA,Ibrahim IM

更新日期：2016-01-01 00:00:00

abstract：:Airborne mono-2-ethylhexyl phthalate (MEHP) was studied for acute airway effects using a bioassay with BALB/c mice. Concentration- and time-dependent effects were obtained by continuous monitoring of the breathing pattern during exposure to 0.3-43.6 mg/m3 MEHP for 60 min. Additionally, inflammatory effects of MEHP wer...

journal_title：Human & experimental toxicology

authors： Larsen ST,Hansen JS,Hammer M,Alarie Y,Nielsen GD

更新日期：2004-11-01 00:00:00

abstract：:Sulphur is an essential micronutrient required by the body in low concentrations, but its high intake can lead to a serious health hazard. Sulphur compounds are reported to induce several toxic responses in animals, but so far no reports are available on the toxic effects of elemental sulphur, following dietary supple...

journal_title：Human & experimental toxicology

authors： Arora A,Shukla Y

更新日期：2004-05-01 00:00:00

abstract：CONTEXT:Cardiac dysfunction is one of the most serious consequences of scorpion envenomation. The best tool to evaluate cardiac function is echocardiography, but it is not available at all emergency departments. Many studies aimed to describe biological predictive factors of cardiac dysfunction in scorpion envenomation...

journal_title：Human & experimental toxicology

authors： Chakroun-Walha O,Karray R,Jerbi M,Ben Rebeh A,Jammeli C,Bahloul M,Ammar R,Chabchoub I,Bouaziz M,Nasri A,Rekik N

更新日期：2018-06-01 00:00:00

abstract：:Pentavalent antimonial (Sb5+) drugs such as meglumine antimoniate (MA) are the mainstay treatment of leishmaniases in developing countries. The effects of these compounds on drug-metabolizing enzymes have not been characterized and their potential pharmacokinetic interactions with other drugs are therefore unknown. Th...

journal_title：Human & experimental toxicology

authors： Coelho DR,De-Oliveira A,Parente T,Leal BS,das Chagas LF,Oliveira TN,Saint'Pierre TD,Paumgartten F

更新日期：2017-01-01 00:00:00

abstract：:Substance misuse among street children is a significant problem in developing countries. Volatile substances are the most abused agents. According to case reports, chronic renal diseases are common among substance-abusing street children. In this study, we examined the renal findings of 42 volatile substance-abusing s...

journal_title：Human & experimental toxicology

authors： Olgar S,Oktem F,Dindar A,Kilbas A,Turkoglu UD,Cetin H,Altuntas I,Yilmaz R,Uz E,Ertugrul T,Omeroglu R,Aydogan U

更新日期：2008-06-01 00:00:00

abstract：:The antidiabetic agent metformin was shown to further possess chemopreventive and chemotherapeutic effects against cancer. Despite the advances, the underlying molecular mechanisms involved in decreasing tumor formation are still unclear. The understanding of the participation of oxidative stress in the action mechani...

journal_title：Human & experimental toxicology

authors： Dogan Turacli I,Candar T,Yuksel BE,Demirtas S

更新日期：2018-09-01 00:00:00

abstract：:Pharmacological potential of curcumin was assessed in PC12 cells against hydrogen peroxide (H(2) O(2)) exposure. In MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and lactate dehydrogenase (LDH) assays, 24-hour exposure of H(2)O(2) (0.5 mM and above) was found to be cytotoxic. A significant (p < 0...

journal_title：Human & experimental toxicology

authors： Siddiqui MA,Kashyap MP,Kumar V,Tripathi VK,Khanna VK,Yadav S,Pant AB

更新日期：2011-03-01 00:00:00

abstract：:Morphine-6-glucuronide, the active metabolite of morphine, and to a lesser extent morphine itself are known to accumulate in patients with renal failure. A number of cases on non-lethal morphine toxicity in patients with renal impairment report high plasma concentrations of morphine-6-glucuronide, suggesting that this...

journal_title：Human & experimental toxicology

authors： Lagas JS,Wagenaar JF,Huitema AD,Hillebrand MJ,Koks CH,Gerdes VE,Brandjes DP,Beijnen JH

更新日期：2011-09-01 00:00:00

abstract：:Cisplatin is an effective anticancer drug used against a variety of cancers. The full therapeutic potential of cisplatin is often hampered due to concurrent development of various side effects in the hosts. Rutin, a naturally occurring bioflavonoid shows several pharmacological activities. It has been earlier reported...

journal_title：Human & experimental toxicology

authors： Prasad R,Prasad SB

更新日期：2020-08-13 00:00:00

abstract：:Pityriasis rosea (PR) is a common, acute, and self-limited inflammatory skin disease. The typical clinical presentation includes the appearance of a primary "herald" patch followed within days to weeks by the onset of secondary scaly skin eruptions distributed along the skin tension line in most cases. Although PR is ...

journal_title：Human & experimental toxicology

authors： Polat M,Uzun Ö,Örs I,Boran Ç

更新日期：2014-12-01 00:00:00

abstract：:The aim of this study was to compare simultaneously obtained arterial and capillary blood gas (CBG) values in comatose-poisoned patients presented with stable vital signs. Forty-five adult patients with a diagnosis of coma because of poisoning and stable vital signs were included in this prospective study. With respec...

journal_title：Human & experimental toxicology

authors： Eizadi-Mood N,Alfred S,Yaraghi A,Huynh C,Moghadam AS

更新日期：2009-10-01 00:00:00

abstract：:The majority of households in rural India still rely on unprocessed solid biomass for domestic energy. The aim of this study was to investigate whether chronic exposure to biomass smoke causes activation of leukocytes and the formation of leukocyte-platelet aggregates. We conducted flow cytometric analysis of beta2 Ma...

journal_title：Human & experimental toxicology

authors： Ray MR,Mukherjee S,Roychoudhury S,Bhattacharya P,Banerjee M,Siddique S,Chakraborty S,Lahiri T

更新日期：2006-11-01 00:00:00

abstract：:Serrapeptase (SP) and nattokinase (NK) are proteolytic enzymes belonging to serine proteases. In this study, we hypothesized that SP and NK could modulate certain factors that are associated with Alzheimer's disease (AD) pathophysiology in the experimental model. Oral administration of aluminium chloride (AlCl3) in a ...

journal_title：Human & experimental toxicology

authors： Fadl NN,Ahmed HH,Booles HF,Sayed AH

更新日期：2013-07-01 00:00:00

abstract：:In this study, genotoxic activities of four halogenated anesthetics (halothane, isoflurane, sevoflurane and desflurane) were investigated in human peripheral blood lymphocytes (PBLs) and sperm cells in vitro by alkaline comet assay. For this purpose, sperm or lymphocyte suspension was exposed to different concentratio...

journal_title：Human & experimental toxicology

authors： Kaymak C,Kadioglu E,Coskun E,Basar H,Basar M

更新日期：2012-12-01 00:00:00

abstract：:Generation of reactive oxygen species (ROS) leads to serious tissue injuries. The effect of cyclopiazonic acid (CPA) on oxidative stress markers in the liver and kidneys of broiler chicks was studied. Ten-day-old male broiler chicks (Ross 308) were assigned into the control and test groups, which received normal salin...

journal_title：Human & experimental toxicology

authors： Malekinejad H,Akbari P,Allymehr M,Hobbenaghi R,Rezaie A

更新日期：2011-08-01 00:00:00

abstract：:Sulfur mustard (SM) represents a potential chemical warfare agent. In order to characterize SM-induced airway epithelial damage, we studied the effects of an intratracheal injection of 0.3 mg/kg of SM in guinea pigs, 5 h, 24 h, 14 days and 35 days after exposure. During the acute period, lesions prevailed in tracheal ...

journal_title：Human & experimental toxicology

authors： Calvet JH,Coste A,Levame M,Harf A,Macquin-Mavier I,Escudier E

更新日期：1996-12-01 00:00:00

abstract：:The aim of the study was to evaluate the effect of bisphenol A (BPA) on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression by neutrophils with regard to sex and nuclear factor-κB (NF-κB) pathway participation in this process. This study demonstrated that BPA intensifies the production o...

journal_title：Human & experimental toxicology

authors： Ratajczak-Wrona W,Nowak K,Garley M,Tynecka M,Jablonska E

更新日期：2019-02-01 00:00:00

abstract：:1. Four different concentrations of quinalphos and methyl parathion were tested on human peripheral lymphocytes over different time periods, for the analysis of chromosomal aberrations and sister chromatid exchanges (SCEs). 2. A significant increase in chromosomal aberrations was observed when cells were treated with ...

journal_title：Human & experimental toxicology

authors： Rupa DS,Reddy PP,Reddi OS

更新日期：1990-11-01 00:00:00

abstract：:Sulfur dioxide (SO2) is a common exogenous atmospheric pollutant. Studies have shown that SO2 can cause vasodilation as a gas signaling molecule, but the specific signaling pathways are not well understood. This study aimed to explore the underlying mechanism behind the effects of SO2 on vasodilation of isolated rat a...

journal_title：Human & experimental toxicology

authors： Zhang Q,Lyu W,Yu M,Niu Y

更新日期：2020-08-01 00:00:00

abstract：:Sibutramine mesylate is a new anti-obesity drug. It is a crystalline salt of sibutramine developed to improve the solubility of sibutramine hydrochloride. Methanesulfonic acid was used as a salt-forming acid instead of hydrochloric acid, resulting in a greatly improved solubility of 1000 mg/mL in water. Sibutramine me...

journal_title：Human & experimental toxicology

authors： Kim EJ,Park EK,Suh KH

更新日期：2005-03-01 00:00:00

abstract：:Deregulated cancer cell metabolism plays an important role in cancer progression. Cancer cell metabolism has been in the centre of attention in therapeutical cancer cell targeting. Repurposed chemical agents, such as metformin and aspirin, have been studied extensively as preventive and therapeutic agents. Metformin i...

journal_title：Human & experimental toxicology

authors： Albayrak G,Konac E,Dikmen AU,Bilen CY

更新日期：2018-09-01 00:00:00

abstract：:Neutrophil functions were studied in 38 lead-exposed workers compared to 34 controls. Both groups were matched according to age, sex, drinking and smoking habits, ethnic origin and drug intake. Blood lead levels were found to be seven times higher in exposed workers than in controls. Phagocytosis assayed by chemilumin...

journal_title：Human & experimental toxicology

authors： Bergeret A,Pouget E,Tedone R,Meygret T,Cadot R,Descotes J

更新日期：1990-07-01 00:00:00

abstract：:Although ingestion of methyl ethyl ketone peroxide (MEKP) is rare, it carries a high risk of morbidity and mortality. This paper reports the first such case from Turkey in which a 70-year-old man unintentionally ingested MEKP in his kitchen. The patient was brought into the emergency department (ED) within 1 hour of i...

journal_title：Human & experimental toxicology

authors： Bozdemir MN,Yildiz M,Seyhanli ES,Gurbuz S,Kilicaslan I,Karlidag T

更新日期：2011-12-01 00:00:00

abstract：:Progesterone (a neurosteroid) is an important modulator of the nervous system functioning. Organophosphorus pesticides like phosphamidon have been shown to adversely affect memory and induce oxidative stress on both acute and chronic exposure. The present study was therefore designed to investigate the effects of prog...

journal_title：Human & experimental toxicology

authors： Sharma AK,Bhattacharya SK,Khanna N,Tripathi AK,Arora T,Mehta AK,Mehta KD,Joshi V

更新日期：2011-10-01 00:00:00

abstract：:Cytochrome P450 4B1 (CYP4B1) plays crucial roles in biotransforming of xenobiotics. Its predominant extrahepatic expression has been associated with certain tissue-specific toxicities. However, the expressions of CYP4B1 in various cancers and hence their potential roles in cancer development were inclusive. In this wo...

journal_title：Human & experimental toxicology

authors： Lim S,Alshagga M,Ong CE,Chieng JY,Pan Y

更新日期：2020-06-01 00:00:00