Abstract：
:A four-fold increase in the iron content of normal subjects was detected in plasma after 5 hours of iron administration. Iron supplementation had a surprisingly erratic effect on four patients with hepatomegaly secondary to heart insufficiency, since the increase in the iron content in the plasma after iron-dextran administration was either within the control range or significantly lower, independently of the initial values. Thiobarbituric acid reactive substances (TBARS) content was 2.5 +/- 0.2 and 4.3 +/- 0.4 microM for control and hepatomegalic subjects, respectively. The TBARS basal level was increased by iron supplementation. The difference between TBARS content in hepatomegalic and control subjects, after 5 hours of iron administration, was increased by 50% as compared to the difference in the basal content of TBARS. alpha-Tocopherol (alpha-T) content in plasma from subjects with hepatomegaly showed a significant decrease (-41%) as compared to control subjects. No significant difference over the basal level of alpha-T was measured after 5 hours of iron administration in any subject. The data presented here suggest that abnormal liver condition affects iron-dependent oxidative stress in plasma. Moreover, alpha-T does not seem to be the main antioxidant to control iron-dependent oxidative stress in plasma.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Galleano M,Lemberg A,Puntarulo Sdoi
10.1191/0960327103ht372oasubject
Has Abstractpub_date
2003-07-01 00:00:00pages
401-5issue
7eissn
0960-3271issn
1477-0903journal_volume
22pub_type
杂志文章abstract：:Hypofibrinogenemia is an important clinical consequence following envenomation by Lachesis muta muta, usually attenuated or prevented by administration of antivenom. The venom of L. m. muta contains both a metalloproteinase fibrinogenase and a serine protease thrombin-like enzyme, and exposure of fibrinogen to iron (F...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327116661401
更新日期：2017-07-01 00:00:00
abstract：:1. A study was carried out to find out if digoxin and acipimox interact. 2. Six elderly patients on digoxin were each given acipimox 150 mg three daily for a week, after informed consent. Digoxin and acipimox plasma concentrations and urinary excretion were measured after the first dose of acipimox and after a week of...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719201100509
更新日期：1992-09-01 00:00:00
abstract：:The majority of breast cancer patients are resistant to chemotherapy or radiotherapy due to the down-regulation or lack of caspase-3 expression. Capsaicin was found to inhibit cancer cell growth in caspase-3-deficient human breast cancer cells. This study aimed to investigate the growth-inhibitive effect of capsaicin ...
journal_title：Human & experimental toxicology
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doi：10.1177/0960327110396530
更新日期：2011-10-01 00:00:00
abstract：:A liquid alcoholic extract of Papaver somniferum named Elixir Paregorico is extensively used for diarrheal diseases in Brazil. Its increased popularity has brought concerns and fears over the safety of this herbal product. Given the lack of investigative clinical studies, in this regard, this study investigated whethe...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327108090274
更新日期：2008-10-01 00:00:00
abstract：:The aim of the present investigation was to check the fluctuation in essential elements, such as Na, K, Mg, Mn, Cu, Zn, Cr and Ni in the brain, spinal cord, liver and kidney of mice during methylmercury chloride (MMC) toxication and therapy with monothiols (N-acetyl-DL-homocysteine thiolactone and glutathione) and vit...
journal_title：Human & experimental toxicology
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abstract：:Formaldehyde is a physiological intermediary metabolite taking part in many biological process in the body. It is a constituent of many items of daily use, including foods. It is also used in medicine for treatment of some conditions. A 40% solution of formaldehyde in water is known as formalin. Formalin is irritating...
journal_title：Human & experimental toxicology
pub_type： 杂志文章,评审
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abstract：:In acute respiratory distress syndrome (ARDS), there is extensive overproduction of free radicals to the extent that endogenous anti-oxidants are overwhelmed, permitting oxidative cell damage. The present study examined the benefit of the anti-oxidant compound N-acetylcysteine (NAC) in the management of ARDS by measur...
journal_title：Human & experimental toxicology
pub_type： 杂志文章,随机对照试验
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更新日期：2007-09-01 00:00:00
abstract：:Brain tumors are often incurable despite current aggressive treatment modalities. Regional intracerebral administration of labeled monoclonal antibodies (Mabs) can maximize the radioisotope and Mab concentration to tumor sites while reducing systemic toxicity. h-R3 is a humanized antiepidermal growth factor receptor M...
journal_title：Human & experimental toxicology
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abstract：:Until quite recently, pentabromodiphenyl ether (PentaBDE) was most commonly used as a flame retardant. Due to the considerably long atmospheric half-life of PentaBDE and its contribution to environmental pollution, it is categorized as a persistent organic pollutant (POP). As the data on the toxicity of PentaBDE is ra...
journal_title：Human & experimental toxicology
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更新日期：2011-05-01 00:00:00
abstract：:The conventional method for the assessment of acute inhalation toxicity (OECD Test Guideline 403, 1981) uses death of animals as an endpoint to identify the median lethal concentration (LC50). A new OECD Testing Guideline called the Fixed Concentration Procedure (FCP) is being prepared to provide an alternative to Tes...
journal_title：Human & experimental toxicology
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abstract：:The renin-angiotensin system (RAS) subserves vital physiological functions and also implicated in certain pathological states. Modulation of this system has been proposed in recent studies to be a promising strategy in treating liver fibrosis. We investigated the effect of the pharmacologic inhibition of RAS with angi...
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更新日期：2011-11-01 00:00:00
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journal_title：Human & experimental toxicology
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doi：10.1177/096032719601500406
更新日期：1996-04-01 00:00:00
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journal_title：Human & experimental toxicology
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doi：10.1177/096032719501400902
更新日期：1995-09-01 00:00:00
abstract：:In responding to Drs Calabrese and Baldwin's question, 'At what point, if ever, should hormesis be employed as the principal dose response default assumption in risk assessment?', we examined the benefits of replacing traditional dose-response with hormesis. In general, hormesis provides more complete useful informati...
journal_title：Human & experimental toxicology
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更新日期：2005-05-01 00:00:00
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doi：10.1177/0960327109105164
更新日期：2009-06-01 00:00:00
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journal_title：Human & experimental toxicology
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doi：10.1177/0960327116660866
更新日期：2017-07-01 00:00:00
abstract：:Gamma-hydroxybutyrate (GHB) is a compound used in the treatment of alcohol withdrawal, narcolepsy, and for induction of anaesthesia. It is also contained in many products illegally marketed as "dietary supplements" and is increasingly being recognised as a potential drug of abuse. We report the case of a 44-year-old m...
journal_title：Human & experimental toxicology
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更新日期：2001-01-01 00:00:00
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更新日期：2016-11-01 00:00:00
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journal_title：Human & experimental toxicology
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更新日期：2019-02-01 00:00:00
abstract：:1. Blood lead levels were examined in 127 housepainters in North Carolina between April and September, 1993. Each participant filled out a questionnaire and gave a blood sample. The questionnaire covered the individual's work history, concentrating on paint-removal activities and personal protection, and also covered ...
journal_title：Human & experimental toxicology
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abstract：:Sulfur dioxide (SO2) is a common exogenous atmospheric pollutant. Studies have shown that SO2 can cause vasodilation as a gas signaling molecule, but the specific signaling pathways are not well understood. This study aimed to explore the underlying mechanism behind the effects of SO2 on vasodilation of isolated rat a...
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abstract：:Paracetamol overdose is common and microRNA (miR)-122 expression is increased with liver injury. We aimed to measure miR-122 in the setting of an abbreviated paracetamol overdose treatment regimen. We compared miRNA expression in patients treated for paracetamol poisoning with an abbreviated 12-h intravenous acetylcys...
journal_title：Human & experimental toxicology
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journal_title：Human & experimental toxicology
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abstract：:Pesticides are used in agriculture to protect crops from insects-pests. Most of the field workers of North Indian population are exposed to commonly used insecticides. In the present study, pesticides induced oxidative stress as well as alterations in the level of acetylcholinesterase (AChE) in a total of 70 male heal...
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更新日期：2013-11-01 00:00:00
abstract：:Potassium bromate (KBrO3) is a potent nephrotoxic agent. In this paper, we report the chemopreventive effect of Nigella sativa (black cumin) on KBrO3-mediated renal oxidative stress, toxicity and tumor promotion response in rats. KBrO3 (125 mg/kg body weight, intraperitoneally) enhances lipid peroxidation, gamma-gluta...
journal_title：Human & experimental toxicology
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更新日期：2003-04-01 00:00:00
abstract：:1 The cytotoxicity of dichlorobenzenes in cultured rat liver slices has previously been shown to be strain specific and biotransformation related. 2 In order to extrapolate animal models to humans, the dichlorobenzenes were incubated with human liver slices to try to clarify their hepatotoxic potential in man. 3 The d...
journal_title：Human & experimental toxicology
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更新日期：1991-09-01 00:00:00
abstract：:Severe carbon monoxide (CO) poisoning causes fulminant deaths in common environment as well as neurological sequelae to survivors. Prevention of delayed neurological syndrome (DNS) after exposure to CO, the most important sequela, is based up to date on hyperbaric oxygen administration. Nevertheless, its use remains c...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327120901572
更新日期：2020-06-01 00:00:00
