Abstract:
:Acute exposure to systemic poisons represents an important challenge in clinical toxicology. We aimed to analyze the potential role of cardiac biomarkers, routine laboratory tests, and clinical scores as morbidity and in-hospital mortality predictors in patients intoxicated with various systemic poisons. We conducted a prospective study on adults acutely exposed to systemic poisons. We determined the PSS, Glasgow Coma Scale (GCS), and we performed electrocardiogram, laboratory tests, lactate and cardiac biomarkers (which were reassessed 4 h, respectively 6 h later). Of 120 patients included, 45% developed complications, 19.2% had a poor outcome, and 5% died. Multivariate logistic regression sustained lactate (odds ratio (OR) 1.58; confidence interval (CI) 95%: 0.97-2.59; p 0.066), MB isoenzyme of creatine kinase (6h-CKMB; OR 1.08; CI 95%: 1.02-1.16; p 0.018) as predictors for a poor outcome. A GCS < 10 (OR 0.113; CI 95%: 0.019-0.658; p 0.015) and 4h-lactate (OR 4.87; CI 95%: 0.79-29.82; p 0.087) predicted mortality after systemic poisons exposure. Receiver operating characteristic analysis showed that brain natriuretic peptide (area under the curve (AUC), 0.96; CI 95%: 0.92-0.99; p < 0.001), lactate (AUC, 0.91; CI 95%: 0.85-0.97; p < 0.001), and 6h-CKMB have good discriminatory capacity for predicting a poor outcome. In conclusion, these biomarkers, lactate, and GCS can be used to predict morbidity and mortality after systemic poisons exposure.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Lionte C,Sorodoc V,Tuchilus C,Cimpoiesu D,Jaba Edoi
10.1177/0960327116660866subject
Has Abstractpub_date
2017-07-01 00:00:00pages
651-662issue
7eissn
0960-3271issn
1477-0903pii
0960327116660866journal_volume
36pub_type
杂志文章abstract:OBJECTIVES:Pesticide poisoning stands as a major public health issue worldwide. The objective of this study was to examine the epidemiologic characteristics of pesticide-related hospitalizations in South Korea. METHODS:Data from the Korea National Hospital Discharge Survey were analyzed to describe the epidemiologic c...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111431709
更新日期:2012-08-01 00:00:00
abstract::To clarify the reproductive toxicity of polychlorinated biphenyl compounds through determination of testicular lipid peroxidation, reactive oxygen species and enzymatic and non-enzymatic antioxidants in rats exposed to Aroclor 1254. Adult male rats were administered Aroclor 1254 at a dose of 2 mg/kg per day ip for 30 ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327105ht500oa
更新日期:2005-02-01 00:00:00
abstract::Seafood is considered by nutritionists to be a high source of omega 3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) which are involved in prevention of cardiovascular diseases. The aim of the present study is firstly to detect the presence of organochlorine pesticides and heavy metals in some fresh seafood of ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110396535
更新日期:2011-10-01 00:00:00
abstract::We describe two cases of chemical necrotizing fasciitis in the upper extremities, anterior chest wall and epigastric region of the abdominal wall caused by household insecticide injection. We suggest that surgical debridement can be successfully performed in the subacute period under close observation in hemodynamical...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327102ht308cr
更新日期:2002-12-01 00:00:00
abstract:INTRODUCTION:Accidental toxicity by organophosphate (OP) agents may occur among farmers during spraying season due to improper use and handling. Plasma cholinesterase (ChE) activity measurement is recommended to monitor the extent of exposure to the OP agent. The aim of the current study was to measure plasma ChE activ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115584990
更新日期:2016-03-01 00:00:00
abstract::The Na+-taurocholate cotransporting polypeptide (NTCP) acts as the major hepatic basolateral uptake system, and plays a key role in balancing bile flow. The anti-tuberculosis drugs rifampin (RFP) can affect bile flow causing liver injury, while tanshinone IIA (TAN IIA) has the effect of protecting liver. This study ai...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120979030
更新日期:2020-12-14 00:00:00
abstract::A xenobiotic, well tolerated by the majority of treated patients, can cause serious complications in patients with individual susceptibility. Based on the hypothesis that such a phenomenon may occur in rare cases of rhabdomyolysis attributed to fenoverine (DCI), we designed a protocol to look for a genetic predisposit...
journal_title:Human & experimental toxicology
pub_type: 临床试验,杂志文章
doi:10.1177/096032719601501004
更新日期:1996-10-01 00:00:00
abstract:AIM:To assess the systemic inflammatory response (SIR) and the multi-organ damage after large-volume liver radiofrequency ablation (RFA) with or without concurrent Pringle maneuver. METHODS:Wistar rats were subjected to 30% liver RFA (group RFA), liver RFA under 30-min Pringle maneuver (group RFA + P), Pringle only (g...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111401438
更新日期:2011-11-01 00:00:00
abstract:CONTEXT:Cardiac dysfunction is one of the most serious consequences of scorpion envenomation. The best tool to evaluate cardiac function is echocardiography, but it is not available at all emergency departments. Many studies aimed to describe biological predictive factors of cardiac dysfunction in scorpion envenomation...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117722822
更新日期:2018-06-01 00:00:00
abstract::Pyrazinamide (PYZ)-an essential component of primary drug regimen used for the treatment and management of multidrug resistant or latent tuberculosis-is well known for its hepatoxicity. However, the mechanism of PYZ-induced hepatotoxicity is still unknown to researchers. Studies have shown that the drug is metabolized...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117705426
更新日期:2018-04-01 00:00:00
abstract::Arsenic is a naturally occurring environmental toxicant, chronic exposure to arsenic can cause multiorgan damage, except for typical skin lesions, liver damage is the main problem for health concern in population with arsenic poisoning. Abnormal apoptosis is closely related to liver-related diseases, and p53 is one of...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120988880
更新日期:2021-01-27 00:00:00
abstract::Methyl salicylate (oil of wintergreen) is widely available in many over-the-counter liniments, ointments, lotions or medicated oils for the relief of musculoskeletal aches and pains. Ingestion of methyl salicylate poses the threat of severe, rapid-onset salicylate poisoning because of its liquid, concentrated form and...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1177/096032719601500905
更新日期:1996-09-01 00:00:00
abstract:UNLABELLED:We present the first ever case of homicidal poisoning due to injection of methidathion, an organophosphate insecticide. CASE:A 4-month-old baby presented to the emergency department with chief complaints of unconsciousness and irregular respiration. A bitter odour and an injection site with a greenish blue ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109348082
更新日期:2009-08-01 00:00:00
abstract::Morphine-6-glucuronide, the active metabolite of morphine, and to a lesser extent morphine itself are known to accumulate in patients with renal failure. A number of cases on non-lethal morphine toxicity in patients with renal impairment report high plasma concentrations of morphine-6-glucuronide, suggesting that this...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110388962
更新日期:2011-09-01 00:00:00
abstract::The objective of this study is to analyze exposures concerning analgesics that were reported to Dokuz Eylul University Drug and Poison Information Center (DPIC) and admitted to the Department of Emergency Medicine in Dokuz Eylul University Hospital (EMDEU) between 1993 and 2004. Demographics of the patients, character...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107076836
更新日期:2007-08-01 00:00:00
abstract::Brain tumors are often incurable despite current aggressive treatment modalities. Regional intracerebral administration of labeled monoclonal antibodies (Mabs) can maximize the radioisotope and Mab concentration to tumor sites while reducing systemic toxicity. h-R3 is a humanized antiepidermal growth factor receptor M...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032700675323269
更新日期:2000-12-01 00:00:00
abstract::Potassium bromate (KBrO3) is a potent nephrotoxic agent. In this paper, we report the chemopreventive effect of Nigella sativa (black cumin) on KBrO3-mediated renal oxidative stress, toxicity and tumor promotion response in rats. KBrO3 (125 mg/kg body weight, intraperitoneally) enhances lipid peroxidation, gamma-gluta...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327103ht349oa
更新日期:2003-04-01 00:00:00
abstract::Three patients admitted to the Accident and Emergency Unit of Lagos University Teaching Hospital (LUTH) after eating a cassava based meal 'Gari' died shortly after admission. The patients vomited and complained of abdominal pain immediately after the meal. They were unconscious with renal failure and died of cardiopul...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719201100107
更新日期:1992-01-01 00:00:00
abstract::1. In humans morphine is metabolised to morphine-3-glucuronide (M3G) which possess no opioid activity, and morphine-6-glucuronide (M6G) which is a potent opioid receptor agonist that probably contribute to the desired as well as toxic effects of morphine. 2. In order to investigate the possible effect of ranitidine on...
journal_title:Human & experimental toxicology
pub_type: 临床试验,杂志文章
doi:10.1177/096032719801700611
更新日期:1998-06-01 00:00:00
abstract::Nickel nanoparticles (Ni-NPs) have been widely used in various industries related to electronics, ceramics, textiles, and nanomedicine. Ambient and occupational exposure to Ni-NPs may bring about potential detrimental effects on animals and humans. Thus, there is a growing effort to identify compounds that can amelior...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120930125
更新日期:2020-11-01 00:00:00
abstract::Enterococcus faecalis is a facultative anaerobic gram-positive commensal bacterium common in the gastrointestinal tract of animals and humans. This study aimed to investigate the protective effects of heat-killed E. faecalis EF-2001 (EF-2001) on acute gastric ulcer using a murine model of ethanol (EtOH)-induced acute ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119899987
更新日期:2020-05-01 00:00:00
abstract::Phagocytes remove and store mercury (Hg) that enters the body. Macrophages and granulocytes respond in opposite ways to Hg: macrophages loose cell viability, and neutrophils become protected from apoptosis. We have investigated the cytology of early intake of Hg by macrophages and neutrophils after a short period (2-4...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327104ht472oa
更新日期:2004-08-01 00:00:00
abstract::Information on the acute effects associated with the handling of 1,4-dioxane is sparse. Our aim was to evaluate the acute effects of 1,4-dioxane vapours. In a screening study, six healthy volunteers rated symptoms on a visual analogue scale (VAS), while exposed to stepwise increasing levels of 1,4-dioxane, from 1 to 2...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327106073805
更新日期:2006-12-01 00:00:00
abstract::Dimethylacetamide (DMAc) is a skin-penetrating solvent able to induce hepatic damage after chronic exposure. Previous research has indicated that metabolism may be saturated at its present TLV/TWA (10 ppm). Biological monitoring of monomethylacetamide (MMAc), the primary metabolite of DMAc, might therefore underestima...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719301200206
更新日期:1993-03-01 00:00:00
abstract::The effects of acute administration of dietary levels of ethanol and the garlic oil extract, diallyl sulphide (DAS), on cytochrome P450 2E1 (CYP2E1) activity in volunteers were studied using the selective probe substrate, chlorzoxazone (CZX). The ratio of the CZX metabolite 6- hydroxychlorzoxazone (6-OHCZX) to CZX was...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032701680350587
更新日期:2001-07-01 00:00:00
abstract::9-(4'-Aminophenyl)-9H-pyrido [3,4-b] indole (aminophenylnorharman, APNH) is a novel mutagenic heterocyclic amine, produced by the reaction of norharman with aniline in the presence of S9 mix. In the present study, the maternal and developmental toxicity of APNH were investigated in ICR mice administered oral doses of ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327102ht227oa
更新日期:2002-03-01 00:00:00
abstract::The aim of this study was to compare the number of inactivated-influenza vaccine-related spontaneous abortion and stillbirth (SB) reports in the Vaccine Adverse Event Reporting System (VAERS) database during three consecutive flu seasons beginning 2008/2009 and assess the relative fetal death reports associated with t...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112455067
更新日期:2013-05-01 00:00:00
abstract::The benefits and costs are discussed for the possibility of using pups generated in breeding studies for additional assessments, such as evaluating immunotoxicity. Such an approach is logistically challenging, but not overwhelming. ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327102ht291oa
更新日期:2002-09-01 00:00:00
abstract::N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (PK1) is a novel polymeric anticancer agent containing doxorubicin (approximately 8 wt%) bound to the polymer backbone via a Gly-Phe-Leu-Gly peptidyl linker. The approximate LD50 of PK1 in MF1 mice after a single i.v. injection was 63 mg/kg (doxorubicin-eq...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719801700204
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:Oxidative stress is one of the major mechanisms of cyclophosphamide (CPX)-induced toxicities. However, it is unknown how CPX induces oxidative stress. Based on the available information, we speculated that CPX could increase iron content in the tissues and then induce oxidative stress. METHOD:We tested this ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120909880
更新日期:2020-07-01 00:00:00