Abstract:
:1. The influence of pharmacological pretreatment (pyridostigmine, benactyzine and trihexyphenidyle), designated PANPAL, on soman-induced cholinergic and stressogenic effects as well as on the efficacy of antidotal treatment (HI-6 plus obidoxime) in rats was studied. 2. PANPAL prophylaxis significantly decreased soman-induced cholinesterase inhibition in blood, brain and diaphragm as well as stressogenic effects of soman (an increase in plasma corticosterone level and liver tyrosine aminotransferase activity). 3. PANPAL pretreatment did not improve the efficacy of HI-6 in combination with benactyzine on soman-induced anticholinesterase and stressogenic effects. 4. These findings confirm that PANPAL prophylaxis can improve prognosis of soman poisoning especially by protection of cholinesterases.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Kassa J,Bajgar Jdoi
10.1177/096032719601500503subject
Has Abstractpub_date
1996-05-01 00:00:00pages
383-8issue
5eissn
0960-3271issn
1477-0903journal_volume
15pub_type
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