The effect of uremic toxin cyanate (OCN–) on anaerobic sulfur metabolism and prooxidative processes in the rat kidney: a protective role of lipoate.

abstract：:A key aim of toxicology is the prevention of adverse effects due to toxic hazards. Therefore, the dissemination of toxicology research findings must confront two important challenges: one being the lack of information on the vast majority of potentially toxic industrial chemicals and the other being the strict criteri...

journal_title：Human & experimental toxicology

authors： Grandjean P

更新日期：2015-12-01 00:00:00

abstract：:Sulfur dioxide (SO2) is a common exogenous atmospheric pollutant. Studies have shown that SO2 can cause vasodilation as a gas signaling molecule, but the specific signaling pathways are not well understood. This study aimed to explore the underlying mechanism behind the effects of SO2 on vasodilation of isolated rat a...

journal_title：Human & experimental toxicology

authors： Zhang Q,Lyu W,Yu M,Niu Y

更新日期：2020-08-01 00:00:00

abstract：:Seafood is considered by nutritionists to be a high source of omega 3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) which are involved in prevention of cardiovascular diseases. The aim of the present study is firstly to detect the presence of organochlorine pesticides and heavy metals in some fresh seafood of ...

journal_title：Human & experimental toxicology

authors： Al-Malki AL,Moselhy SS

更新日期：2011-10-01 00:00:00

abstract：:Dimerized translationally controlled tumor protein (dTCTP) plays a role in allergic diseases. A 7-mer peptide, dimerized translationally binding protein 2 (dTBP2), binds to dTCTP and inhibits dTCTP, suggesting that the 7-mer peptide may have therapeutic potential. We assessed the safety of dTBP2 by examining its cytot...

journal_title：Human & experimental toxicology

authors： Kim M,Jin YB,Lee K,Lee YS

更新日期：2013-11-01 00:00:00

abstract：:The Na+-taurocholate cotransporting polypeptide (NTCP) acts as the major hepatic basolateral uptake system, and plays a key role in balancing bile flow. The anti-tuberculosis drugs rifampin (RFP) can affect bile flow causing liver injury, while tanshinone IIA (TAN IIA) has the effect of protecting liver. This study ai...

journal_title：Human & experimental toxicology

authors： Yang Y,Liu L,Xu M,Zhang X,Wang L,He Q,Xu M,Jiang X

更新日期：2020-12-14 00:00:00

abstract：:3,4-Methylenedioxyphenol (sesamol) is effective against acetaminophen-induced liver injury in rats. Whether sesamol's anti-hepatotoxic effect is comparable to that of N-acetylcysteine has never been studied. We investigated the anti-hepatotoxic effects of sesamol and N-acetylcysteine on acetaminophen-induced hepatotox...

journal_title：Human & experimental toxicology

authors： Chandrasekaran VR,Chien SP,Hsu DZ,Liu MY

更新日期：2011-10-01 00:00:00

abstract：:Morphine-6-glucuronide, the active metabolite of morphine, and to a lesser extent morphine itself are known to accumulate in patients with renal failure. A number of cases on non-lethal morphine toxicity in patients with renal impairment report high plasma concentrations of morphine-6-glucuronide, suggesting that this...

journal_title：Human & experimental toxicology

authors： Lagas JS,Wagenaar JF,Huitema AD,Hillebrand MJ,Koks CH,Gerdes VE,Brandjes DP,Beijnen JH

更新日期：2011-09-01 00:00:00

abstract：:N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (PK1) is a novel polymeric anticancer agent containing doxorubicin (approximately 8 wt%) bound to the polymer backbone via a Gly-Phe-Leu-Gly peptidyl linker. The approximate LD50 of PK1 in MF1 mice after a single i.v. injection was 63 mg/kg (doxorubicin-eq...

journal_title：Human & experimental toxicology

authors： Duncan R,Coatsworth JK,Burtles S

更新日期：1998-02-01 00:00:00

abstract：:1. Groups of 60 male and 60 female B6C3F1 mice or HanIbm Wistar rats were exposed to HFA-134a using snout-only inhalation exposure techniques for periods of one hour daily for at least 104 weeks. HFA-134a was delivered directly from cylinders at vapour concentrations of 2500, 15,000 and 75,000ppm for mice and from met...

journal_title：Human & experimental toxicology

authors： Alexander DJ,Libretto SE,Chevalier HJ,Imamura T,Pappritz G,Wilson J

更新日期：1995-09-01 00:00:00

abstract：:Okadaic acid (OA) is the main toxin produced by dinoflagellates, which can accumulate in the hepatopancreas of mussels and cause diarrhoetic shellfish poisoning in consumers. This toxin is also a tumour promoter and a specific potent inhibitor of protein phosphatases 1 and 2A. The results in this study show for the fi...

journal_title：Human & experimental toxicology

authors： Matias WG,Creppy EE

更新日期：1996-03-01 00:00:00

abstract：:N-nitrosodimethylamine (NDMA) is a xenobiotic widespread in human environment capable of regulating the lifespan of immune cells. In this study, we examined the roles of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor 5 (DR5) complex and the Fas molecule in the induction of the extri...

journal_title：Human & experimental toxicology

authors： Iwaniuk A,Jabłońska E,Jabłoński J,Ratajczak-Wrona W,Garley M

更新日期：2015-06-01 00:00:00

abstract：:Acrylamide is oxidized by cytochrome P450 2E1 (CYP2E1) to its epoxide form, glycidamide, which is believed to be responsible for the mutagenic and carcinogenic activities. This study was carried out to investigate the early changes that may be related to the carcinogenic activity of acrylamide in thyroid, adrenal glan...

journal_title：Human & experimental toxicology

authors： Hamdy SM,Bakeer HM,Eskander EF,Sayed ON

更新日期：2012-05-01 00:00:00

abstract：:Apoptosis induction in cancer cells is one of the most efficient ways to treat cancer and find anticancer compounds. The aim of this study was to evaluate the cytotoxic effects of heat-killed indigenous probiotic bacteria and apoptosis induction in the HT-29 human colon adenocarcinoma cell line. The growth-inhibitory ...

journal_title：Human & experimental toxicology

authors： Karimi Ardestani S,Tafvizi F,Tajabadi Ebrahimi M

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:Pesticide poisoning stands as a major public health issue worldwide. The objective of this study was to examine the epidemiologic characteristics of pesticide-related hospitalizations in South Korea. METHODS:Data from the Korea National Hospital Discharge Survey were analyzed to describe the epidemiologic c...

journal_title：Human & experimental toxicology

authors： Kim HJ,Cha ES,Ko Y,Kim J,Kim SD,Lee WJ

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Chronic obstructive pulmonary disease (COPD) due to sulfur mustard (SM), known as mustard lung, is an important late pulmonary complication of SM poisoning. Due to the possible role of systemic inflammation in mustard lung, we evaluated the serum levels of adiponectin and leptin in these patients. MATERIA...

journal_title：Human & experimental toxicology

authors： Rokni Yazdi H,Lari SM,Attaran D,Ayatollahi H,Mohsenizadeh A

更新日期：2014-06-01 00:00:00

abstract：:The US Environmental Protection Agency (EPA) recently issued a Staff Paper that articulates current risk assessment practices. In section 4.1.3, EPA states, "... effects that appear to be adaptive, non-adverse, or beneficial may not be mentioned." This statement may be perceived as precluding risk assessments based on...

journal_title：Human & experimental toxicology

authors： Mundt KA

更新日期：2006-01-01 00:00:00

abstract：:The effect of sympathomimetic intervention with dopamine or dobutamine on the myocardial uptake of d-propoxyphene was investigated experimentally in rats. The d-propoxyphene (19 mg kg-1 h-1) was continuously infused, intravenously, over 45 min. After 20 min of infusion the rats were given either dopamine (12.5 microgr...

journal_title：Human & experimental toxicology

authors： Pedersen CB,Strøm J,Angelo HR,Munksgaard A,Høgskilde S,Bredgaard Sørensen M

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVE:To investigate the mechanism of apoptosis dependent on the Fas/FasL (Fas ligand) complex in the presence of N-nitrosodimethylamine (NDMA) in human leukocytes. METHODS:Polymorphonuclear neutrophils (PMNs) and peripheral blood mononuclear cells (PBMCs) were isolated form whole blood by density centrifugation. ...

journal_title：Human & experimental toxicology

authors： Iwaniuk A,Grubczak K,Ratajczak-Wrona W,Garley M,Nowak K,Jabłońska E

更新日期：2019-05-01 00:00:00

abstract：:Public health issues have been raised regarding fructose toxicity and its serious metabolic disorders. Deleterious effects of high fructose intake on insulin sensitivity, body weight, lipid homeostasis have been identified. The new millennium has witnessed the emergence of a modern epidemic, the metabolic syndrome (MS...

journal_title：Human & experimental toxicology

authors： Abdelhamid YA,Elyamany MF,Al-Shorbagy MY,Badary OA

更新日期：2020-10-29 00:00:00

abstract：:Formaldehyde is a physiological intermediary metabolite taking part in many biological process in the body. It is a constituent of many items of daily use, including foods. It is also used in medicine for treatment of some conditions. A 40% solution of formaldehyde in water is known as formalin. Formalin is irritating...

journal_title：Human & experimental toxicology

authors： Pandey CK,Agarwal A,Baronia A,Singh N

更新日期：2000-06-01 00:00:00

abstract：:There is compelling evidence in support of positive associations between zinc (Zn) deficiency and high accumulation of cadmium (Cd) in biological samples of different cancerous patients. The incidence of mouth cancer has been increased among people who possess habit of drinking alcohol, tobacco smoking and chewing wit...

journal_title：Human & experimental toxicology

authors： Kazi TG,Wadhwa SK,Afridi HI,Kazi N,Kandhro GA,Baig JA,Shah AQ,Kolachi NF,Khan S

更新日期：2010-03-01 00:00:00

abstract：:Occupational chronic solvent encephalopathy (CSE) is associated with a number of neurobehavioural disorders including defects of visual perception. The purpose of this study was to characterize colour vision defects in CSE patients. Colour vision was tested in bright illumination with the Farnsworth-Munsell 100-hue te...

journal_title：Human & experimental toxicology

authors： Päällysaho J,Näsänen R,Mäntyjärvi M,Kaukiainen A,Sainio M

更新日期：2007-04-01 00:00:00

abstract：:The aim of this study was to evaluate the scores of the Acute Physiology and Chronic Health Evaluation (APACHE) II and a modified APACHE II system (MAS), without parameters of biochemical tests; and to find prognostic value of individual elements of the APACHE II and MAS in predicting outcomes in organophosphate (OP) ...

journal_title：Human & experimental toxicology

authors： Eizadi-Mood N,Saghaei M,Jabalameli M

更新日期：2007-07-01 00:00:00

abstract：:The aim of this study was to compare simultaneously obtained arterial and capillary blood gas (CBG) values in comatose-poisoned patients presented with stable vital signs. Forty-five adult patients with a diagnosis of coma because of poisoning and stable vital signs were included in this prospective study. With respec...

journal_title：Human & experimental toxicology

authors： Eizadi-Mood N,Alfred S,Yaraghi A,Huynh C,Moghadam AS

更新日期：2009-10-01 00:00:00

abstract：:This study was designed to determine the levels of prolactin, leptin, osteopontin, and follistatin in workers chronically and subacutely exposed to lead compounds. The examined population consisted of three groups. The first group was composed of 56 male workers who were chronically exposed to lead for 13.38 ± 10.38 y...

journal_title：Human & experimental toxicology

authors： Dobrakowski M,Kasperczyk A,Czuba ZP,Machoń-Grecka A,Szlacheta Z,Kasperczyk S

更新日期：2017-06-01 00:00:00

abstract：:The renin-angiotensin system (RAS) subserves vital physiological functions and also implicated in certain pathological states. Modulation of this system has been proposed in recent studies to be a promising strategy in treating liver fibrosis. We investigated the effect of the pharmacologic inhibition of RAS with angi...

journal_title：Human & experimental toxicology

authors： Ekor M,Odewabi AO,Kale OE,Oritogun KS,Adesanoye OA,Bamidele TO

更新日期：2011-11-01 00:00:00

abstract：:In the 1980s, villages in the Kurdistan region of Iraq were exposed to chemical weapons (CWs), which killed and injured thousands of civilians. There has been no clinical assessment of the long-term effects of CWs exposure on those injured. We report the first such evaluation of CW effects on long-term health of child...

journal_title：Human & experimental toxicology

authors： Talabani JM,Ali AI,Kadir AM,Rashid R,Samin F,Greenwood D,Hay A

更新日期：2018-08-01 00:00:00

abstract：:The color of the teeth is an important topic for many people and can be influenced by intrinsic and extrinsic stains. There is an increasing demand for whitening of the teeth year by year. The most popular way of whitening is "bleaching," which is the result of the breakdown of pigments located in the enamel and/or th...

journal_title：Human & experimental toxicology

authors： Karaarslan ES,Özmen ZC,Aytac F,Bicakci AA,Buldur M,Aydogan L,Hologlu F,Özkocak B

更新日期：2019-04-01 00:00:00

abstract：:The mechanism of doxorubicin (DOX)-induced cardiotoxicity remains controversial. Wistar rats (n = 66) received DOX injections intraperitoneally and were randomly assigned to 2 experimental protocols: (1) rats were killed before (-24 h, n = 8) and 24 h after (+24 h, n = 8) a single dose of DOX (4 mg/kg body weight) to ...

journal_title：Human & experimental toxicology

authors： Segredo MP,Salvadori DM,Rocha NS,Moretto FC,Correa CR,Camargo EA,de Almeida DC,Reis RA,Freire CM,Braz MG,Tang G,Matsubara LS,Matsubara BB,Yeum KJ,Ferreira AL

更新日期：2014-07-01 00:00:00

abstract：:Food-borne botulism is a rare disease that results from ingestion of the toxins produced by Clostridium botulinum. The most common cause of the disease is the consumption of home-canned foods prepared under inappropriate conditions, especially in rural environments. In this report, a food-borne botulism outbreak poten...

journal_title：Human & experimental toxicology

authors： Cengiz M,Yilmaz M,Dosemeci L,Ramazanoglu A

更新日期：2006-05-01 00:00:00