Dopamine and dobutamine reduce myocardial d-propoxyphene content in experimentally intoxicated rats.


:The effect of sympathomimetic intervention with dopamine or dobutamine on the myocardial uptake of d-propoxyphene was investigated experimentally in rats. The d-propoxyphene (19 mg kg-1 h-1) was continuously infused, intravenously, over 45 min. After 20 min of infusion the rats were given either dopamine (12.5 micrograms kg-1 min-1 or 25 micrograms kg-1 min-1), dobutamine (25 micrograms kg-1 min-1 or 45 micrograms kg-1 min-1) or normal saline (control). Each group consisted of eight rats. The myocardial d-propoxyphene content was significantly lower in the two groups given dopamine and in the group given dobutamine 45 micrograms kg-1 min-1 than in the control group (P less than 0.05). This finding indicates the benefit of early sympathomimetic intervention with either dopamine or dobutamine in d-propoxyphene intoxication.


Hum Exp Toxicol


Pedersen CB,Strøm J,Angelo HR,Munksgaard A,Høgskilde S,Bredgaard Sørensen M




Has Abstract


1991-03-01 00:00:00












  • Oxidative stress induced in the workers of natural gas refineries, no role for GSTM1 and GSTT1 polymorphisms.

    abstract::Oxidative stress has an important role in the pathophysiology of many occupational diseases. In this controlled exposure study, the intensity of oxidative stress biomarkers was assessed in the workers of natural sweet and sour gas refineries (SwGR and SoGR, respectively) and compared with controls. In addition, the ro...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Mandegary A,Sezavar M,Saeedi A,Amirheidari B,Naghibi B

    更新日期:2012-12-01 00:00:00

  • The biokinetics of plutonium-239 and americium-241 in the rat after subcutaneous deposition of contaminated particles from the former nuclear weapons site at Maralinga: implications for human exposure.

    abstract::As an input to dose assessments, measurements have been made of the clearance of Pu and Am after subcutaneous implantation in rats for six particulate materials and one dust from the Maralinga test sites. The tissue distribution of Pu and Am were measured in groups of six animals at one month and 6 months after implan...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Harrison JD,Hodgson A,Haines JW,Stather JW

    更新日期:1993-07-01 00:00:00

  • Chemical necrotizing fasciitis due to household insecticide injection: is immediate radical surgical debridement necessary?

    abstract::We describe two cases of chemical necrotizing fasciitis in the upper extremities, anterior chest wall and epigastric region of the abdominal wall caused by household insecticide injection. We suggest that surgical debridement can be successfully performed in the subacute period under close observation in hemodynamical...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Terzi C,Bacakoğlu A,Unek T,Ozkan MH

    更新日期:2002-12-01 00:00:00

  • Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat.

    abstract::The aim of this study was to investigate the possible protective role of caffeic acid phenethyl ester on testicular toxicity of methotrexate in rats. Nineteen male rats were divided into three groups as follows: group I, control; group II, methotrexate-treated; group III, methotrexate + caffeic acid phenethyl ester-tr...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Armagan A,Uzar E,Uz E,Yilmaz HR,Kutluhan S,Koyuncuoglu HR,Soyupek S,Cam H,Serel TA

    更新日期:2008-07-01 00:00:00

  • Metabolism of aspirin after therapeutic and toxic doses.

    abstract::1 The urinary recovery of metabolites of aspirin (ASA) was studied in 45 volunteers who took a therapeutic dose (600 mg) of ASA by mouth and in 37 patients who took ASA in overdose. 2 The main metabolite recovered from the volunteers was the glycine conjugate, salicyluric acid (SUA), which accounted for 75.01 +/- 1.19...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Patel DK,Hesse A,Ogunbona A,Notarianni LJ,Bennett PN

    更新日期:1990-05-01 00:00:00

  • Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus.

    abstract::Persistent organochlorine pollutants (POPs), such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dichloro diphenyl trichloroethane (DDT) and its major metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p' -DDE) have been associated with type 2 diabetes mellitus (T2DM) in rece...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章,多中心研究


    authors: Rignell-Hydbom A,Rylander L,Hagmar L

    更新日期:2007-05-01 00:00:00

  • The experimental investigations of the toxic influence of tobacco smoke affecting progeny during pregnancy.

    abstract::1. Tobacco smoke contains around 4000 substances, most of which are described as toxic, and they may have an influence on the development of progeny. 2. The present studies concentrate on the measurement and calculation of indices describing the new-born's survival, rearing of pups, weight of foetuses, young animals, ...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Florek E,Marszalek A,Biczysko W,Szymanowski K

    更新日期:1999-04-01 00:00:00

  • Cyclophosphamide induces a significant increase in iron content in the liver and spleen of mice.

    abstract:OBJECTIVE:Oxidative stress is one of the major mechanisms of cyclophosphamide (CPX)-induced toxicities. However, it is unknown how CPX induces oxidative stress. Based on the available information, we speculated that CPX could increase iron content in the tissues and then induce oxidative stress. METHOD:We tested this ...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Sheng Y,Chen YJ,Qian ZM,Zheng J,Liu Y

    更新日期:2020-07-01 00:00:00

  • Histoprotective effect of rutin against cisplatin-induced toxicities in tumor-bearing mice: Rutin lessens cisplatin-induced toxicities.

    abstract::Cisplatin is an effective anticancer drug used against a variety of cancers. The full therapeutic potential of cisplatin is often hampered due to concurrent development of various side effects in the hosts. Rutin, a naturally occurring bioflavonoid shows several pharmacological activities. It has been earlier reported...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Prasad R,Prasad SB

    更新日期:2020-08-13 00:00:00

  • Safety evaluation of Elixir Paregorico in healthy volunteers: a phase I study.

    abstract::A liquid alcoholic extract of Papaver somniferum named Elixir Paregorico is extensively used for diarrheal diseases in Brazil. Its increased popularity has brought concerns and fears over the safety of this herbal product. Given the lack of investigative clinical studies, in this regard, this study investigated whethe...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: de Moraes M,Bezerra M,Bezerra F,de Moraes R,Cavalcanti P,Uchoa C,Lima F,Odorico de Moraes M

    更新日期:2008-10-01 00:00:00

  • Differences in the radiotoxicity of two plutonium isotopes in cells in vitro: can they be ascribed to different handling by the cells?

    abstract::Exposure of Co631 cells to plutonium leads to increasing cell death depending on the dose and incubation time. The effects, however, are more pronounced with 239Pu, than with 238Pu. Uptake and binding of the two radionuclides during a 5-h incubation are about equal, but 238Pu is lost more rapidly from the cell. There ...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Boxler C,Rau W,Planas-Bohne F

    更新日期:1992-05-01 00:00:00

  • Liver slice culture for assessing hepatotoxicity of freshwater cyanobacteria.

    abstract::1. A modified mouse liver slice culture technique was established and the viability of the system was assessed on the basis of leakage of cytosolic enzymes viz. lactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartic aminotransferase (AST) and slice histology. 2. This system w...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Bhattacharya R,Rao PV,Bhaskar AS,Pant SC,Dube SN

    更新日期:1996-02-01 00:00:00

  • Severe metabolic acidosis in the alcoholic: differential diagnosis and management.

    abstract::1. A chronic alcoholic with severe metabolic acidosis presents a difficult diagnostic problem. The most common cause is alcoholic ketoacidosis, a syndrome with a typical history but often misleading laboratory findings. This paper will focus on this important and probably underdiagnosed syndrome. 2. The disorder occur...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章,评审


    authors: Höjer J

    更新日期:1996-06-01 00:00:00

  • Hormesis in precautionary regulatory culture: models preferences and the advancement of science.

    abstract::The article focuses on flaws in the actual approaches of exposure to a chemical of recipient organisms. It demonstrates the excessive use of arguments based on adverse effects and underlines the necessity to take adaptive effects seriously. Regulators are invited to rethink their inclination to the 'When in doubt, kee...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Hanekamp JC,Bast A

    更新日期:2007-11-01 00:00:00

  • Benefits of Good Laboratory Practice as a tool to improve testing.

    abstract::The Organization for Economic Cooperation and Development (OECD) has promoted Good Laboratory Practice (GLP) since the mid 1970s. This paper describes the development of the concept through international harmonisation, Quality Assurance (QA), and compliance monitoring. Ultimately this process permits Mutual Acceptance...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Turnheim D

    更新日期:1993-11-01 00:00:00

  • Preventive efficacy of hydroalcoholic extract of Cymbopogon citratus against radiation-induced DNA damage on V79 cells and free radical scavenging ability against radicals generated in vitro.

    abstract::This study presents the findings of free radical scavenging and antigenotoxic effect of hydroalcoholic extract of Cymbopogon citratus (CCE). The CCE at a concentration of 60 microg/mL resulted in a significant scavenging ability of 2,2-diphenyl-2-picryl hydrazyl (DPPH; (85%), 2,2-azinobis (3-ethyl benzothiazoline-6-su...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Rao BS,Shanbhoge R,Rao BN,Adiga SK,Upadhya D,Aithal BK,Kumar MR

    更新日期:2009-04-01 00:00:00

  • Assessment of genotoxicity risk in operation room personnel by the alkaline comet assay.

    abstract::This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: El-Ebiary AA,Abuelfadl AA,Sarhan NI,Othman MM

    更新日期:2013-06-01 00:00:00

  • A botulism outbreak from roasted canned mushrooms.

    abstract::Food-borne botulism is a rare disease that results from ingestion of the toxins produced by Clostridium botulinum. The most common cause of the disease is the consumption of home-canned foods prepared under inappropriate conditions, especially in rural environments. In this report, a food-borne botulism outbreak poten...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Cengiz M,Yilmaz M,Dosemeci L,Ramazanoglu A

    更新日期:2006-05-01 00:00:00

  • Acute overdose due to benzydamine.

    abstract::Benzydamine is a nonsteroidal anti-inflammatory drug, currently available as mouthwash, aerosol, dermal cream, vaginal douche preparation, pills and otic drops. Up to now no cases of poisoning due to this drug have been reported. A 6-year-old girl with an accidental poisoning with benzydamine is described. The episode...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Gómez-López L,Hernández-Rodríguez J,Pou J,Nogué S

    更新日期:1999-07-01 00:00:00

  • Diepoxybutane and mitomycin C toxicity is associated with the induction of oxidative DNA damage in sea urchin embryos.

    abstract::Diepoxybutane (DEB)- and mitomycin C (MMC)-associated toxicity was investigated in embryos from the sea urchin (SU) species Sphaerechinus granularis. DEB- and MMC-induced toxicity resulted in S. granularis embryos and larvae at concentrations ranging 10(-5) to 10(-4) M DEB, and 3 x 10(-6) to 3 x 10(-5) M MMC, in terms...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Pagano G,Degan P,De Biase A,Iaccarino M,Warnau M

    更新日期:2001-12-01 00:00:00

  • Corticosterone does not cause testicular toxicopathology in the rat: relevance to methylxanthines, ACTH and stress.

    abstract::1. Methylxanthines, ACTH and stress are well known to produce testicular pathology (e.g. seminiferous tubule atrophy). Methylxanthines, ACTH and stress alter hormone secretion, particularly from the pituitary-adrenocortical system. Consequently, it has recently been suggested that there may be a causal relationship be...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Harvey PW,Er J,Fernandes C,Rush KC,Major IR,Cockburn A

    更新日期:1992-11-01 00:00:00

  • An assessment of the in vitro toxicology of Clostridium perfringens type D epsilon-toxin in human and animal cells.

    abstract::The epithelial Madin Darby canine kidney (MDCK) cell line and 17 human cell lines were examined for sensitivity to Clostridium perfringens type D epsilon-toxin. MDCK cells were confirmed as being sensitive to the toxin. In addition, the Caucasian renal leiomyoblastoma (G-402) human cell line was identified as being ep...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Shortt SJ,Titball RW,Lindsay CD

    更新日期:2000-02-01 00:00:00

  • Highly sensitive C-reactive protein levels in Iranian patients with pulmonary complication of sulfur mustard poisoning and its correlation with severity of airway diseases.

    abstract:BACKGROUND:Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due ...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Attaran D,Lari SM,Khajehdaluee M,Ayatollahi H,Towhidi M,Asnaashari A,Marallu HG,Mazloomi M,Mood MB

    更新日期:2009-12-01 00:00:00

  • The effects of multiple low doses of organophosphates on target enzymes in brain and diaphragm in the mouse.

    abstract::1. Multiple low doses of the direct acting organophosphates, ecothiopate, paraoxon and mipafox produced persistent and additive inhibition of diaphragm acetylcholinesterase. Paraoxon and mipafox had similar effects on brain acetylcholinesterase. There was greater recovery from inhibition between doses for paraoxon and...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Williams FM,Charlton C,de Blaquière GE,Mutch E,Kelly SS,Blain PG

    更新日期:1997-02-01 00:00:00

  • Review of the safety assessment of polychlorinated biphenyls (PCBs) with particular reference to reproductive toxicity.

    abstract::1. The methods used to evaluate the toxicological effects of PCBs in animals have been reviewed. 2. The data show that Toxic Equivalency Factors (TEFs) could be developed to assess the potential toxicity of PCB mixtures for certain specific target organ effects (such as the liver and immune system) but would be inappr...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章,评审


    authors: Battershill JM

    更新日期:1994-09-01 00:00:00

  • Incorporating hormesis in the routine testing of hazards.

    abstract::The phenomenon of subtoxic stimulation of organism response is not uncommon in aquatic toxicology experiments. We describe the presence of hormesis in both growth and reproduction experiments in aquatic toxicology where these responses are observed in both animals and plants and at different trophic levels of an ecosy...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章,评审


    authors: Bailer AJ,Oris JT

    更新日期:1998-05-01 00:00:00

  • Reliability of history of acetaminophen ingestion in intentional drug overdose patients.

    abstract::The objective of this study was to determine the reliability of denial of acetaminophen ingestion in intentional drug overdose patients. All intentional drug overdose patients admitted to an emergency department who were able to provide a history were included. A detailed history was obtained on names, timing and numb...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Bentur Y,Lurie Y,Tamir A,Keyes DC,Basis F

    更新日期:2011-01-01 00:00:00

  • Human metabolism of aluminium-26 and gallium-67 injected as citrates.

    abstract::1. 26Al and 67Ga were given as citrates to a healthy male volunteer by intravenous injection. The retention of both tracers was studied by body radioactivity measurement. Levels in blood and excreta were determined by gamma-ray spectrometry and/or accelerator mass spectrometry. 2. More than half of the 26Al had left t...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Priest ND,Newton D,Day JP,Talbot RJ,Warner AJ

    更新日期:1995-03-01 00:00:00

  • Effects of lutein and chlorophyll b on GSH depletion and DNA damage induced by cisplatin in vivo.

    abstract::Recent studies have proposed the use of low concentrations of phytochemicals and combinations of phytochemicals in chemoprevention to reduce cytotoxicity and simulate normal ingestion through diet. The purpose of the present study was to evaluate whether the DNA damage, chromosome instability, and oxidative stress ind...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Serpeloni JM,Almeida MR,Mercadante AZ,Bianchi ML,Antunes LM

    更新日期:2013-08-01 00:00:00

  • In vivo inhibition of serum dopamine-beta-hydroxylase by CaNa2 EDTA injection.

    abstract::1. In humans CaNa2EDTA increases urinary excretion of lead as well as that of essential metals such as zinc, ferrum and manganese but not that of copper. 2. We studied the effect of CaNa2EDTA injection on serum dopamine-beta-hydroxylase, a copper-dependent enzyme, in three male lead welders hospitalized for suspected ...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: De Paris P,Caroldi S

    更新日期:1994-04-01 00:00:00