Abstract:
:In this study, we aimed to investigate disulfide/thiol homeostasis in trichloroethylene (TCE) exposure. The study was carried out in 30 nonsmoker TCE-exposed workers with a variety of occupations. Additionally, 30 healthy nonsmoker volunteers were recruited as the control group. TCE exposure was determined by measuring urinary trichloroacetic acid (TCA) concentration. Median urinary TCA levels of exposed workers (20.5 mg/L) were significantly higher than control subjects (5 mg/L). Thiol and disulfide concentrations were determined using a novel automated method. Disulfide/thiol ratio was significantly higher in the exposed group (p < 0.001). Thiol/disulfide homeostasis was found to be disturbed in TCE-exposed workers. We predict that in TCE-exposed workers this disturbance can be a therapeutic target, and the efficiency of the treatment can easily be monitored by the novel method we used.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Bal C,Büyükşekerci M,Koca C,Ağış ER,Erdoğan S,Baran P,Gündüzöz M,Yilmaz Ödoi
10.1177/0960327115608928subject
Has Abstractpub_date
2016-09-01 00:00:00pages
915-20issue
9eissn
0960-3271issn
1477-0903pii
0960327115608928journal_volume
35pub_type
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