Abstract:
:Kampo (Japanese traditional herbal) medicines have been produced by combining multiple crude drugs, almost all of plant origin but with some of animal or mineral origin, and contain a great many substances. Their effect is a combination of the various interactions of the constituent substances, whether they are enhancing, synergistic or suppressive. Kampo medicine has an overall effect that is different from the combined effects of individual crude drugs, and several side effects such as anorexia, slight fever and nausea have been reported in the treatment of certain disorders and disease states with Kampo medicines. Among 210 medical formulations used in Japan, some relevant information on the clinical uses, pharmacology and toxicology of six manufactured Kampo medical formulations, Shosaikoto, Daisaikoto, Saikokeishito, Hochuekkito, Saibokuto and Saireito, containing Bupleurum root are reviewed. Studies of some potential interactions between Kampo medicine and western drugs are also considered.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Ikegami F,Sumino M,Fujii Y,Akiba T,Satoh Tdoi
10.1191/0960327106het654oasubject
Has Abstractpub_date
2006-08-01 00:00:00pages
481-94issue
8eissn
0960-3271issn
1477-0903journal_volume
25pub_type
杂志文章,评审abstract::The pharmacokinetics of the herbicide fluazifop-butyl have been determined in female rats following oral and intravenous dosing, and described by a mathematical model. Penetration of fluazifop-butyl through epidermal membranes has been determined using three different receptor fluids. It is demonstrated how this in vi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719301200302
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVES:Pesticide poisoning stands as a major public health issue worldwide. The objective of this study was to examine the epidemiologic characteristics of pesticide-related hospitalizations in South Korea. METHODS:Data from the Korea National Hospital Discharge Survey were analyzed to describe the epidemiologic c...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111431709
更新日期:2012-08-01 00:00:00
abstract::Periodontitis is a common infectious disease associated with destruction of periodontal ligaments and alveolar bones. CD4(+) T cell-mediated immune response is involved in the progression of periodontitis. Tobacco consumption increases the risk of periodontal disease. However, the impact of nicotine on the interaction...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115614383
更新日期:2016-09-01 00:00:00
abstract::After acknowledging Renn's careful investigation and valuable insights, this paper expands on some issues that have been somewhat neglected in his account. It addresses the relationship between risk, uncertainity and ignorance in risk assessment, focusing in particular on the need to recognize that framing assumptions...
journal_title:Human & experimental toxicology
pub_type: 评论,杂志文章,评审
doi:10.1191/0960327103ht315oa
更新日期:2003-01-01 00:00:00
abstract::The effects of acute administration of dietary levels of ethanol and the garlic oil extract, diallyl sulphide (DAS), on cytochrome P450 2E1 (CYP2E1) activity in volunteers were studied using the selective probe substrate, chlorzoxazone (CZX). The ratio of the CZX metabolite 6- hydroxychlorzoxazone (6-OHCZX) to CZX was...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032701680350587
更新日期:2001-07-01 00:00:00
abstract::In this study, genotoxic activities of four halogenated anesthetics (halothane, isoflurane, sevoflurane and desflurane) were investigated in human peripheral blood lymphocytes (PBLs) and sperm cells in vitro by alkaline comet assay. For this purpose, sperm or lymphocyte suspension was exposed to different concentratio...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112446818
更新日期:2012-12-01 00:00:00
abstract::The use of Lucilia sericata larvae on the healing of wounds in diabetics has been reported. However, the role of the excretion/secretion (ES) products of the larvae in treatment of diabetic wounds remains unknown. This study investigated whether application of the ES products of L. sericata on the wound surface could ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117714041
更新日期:2018-05-01 00:00:00
abstract::Omeprazole is one of the most used acid-suppressing medications. This fact emphasizes the questions concerning the safety of this compound. Healthy volunteers (n=33) were included in this prospective study. All study subjects were analysed for their CYP2C19 genotype. Of the 33 individuals, 24 were homozygous for the w...
journal_title:Human & experimental toxicology
pub_type: 临床试验,杂志文章
doi:10.1191/0960327104ht431oa
更新日期:2004-03-01 00:00:00
abstract::Drugs containing 5-acetylsalicylic acid (5-ASA) have been commonly used for inflammatory bowel diseases for more than half a century, but no case about overdose of suppository form of mesalazine which was taken both orally and rectally has been reported in the related literature up to now. In the present case, a 20-ye...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110379249
更新日期:2011-07-01 00:00:00
abstract::This study investigated the main target sites of chlorpyrifos (CPF), its effect on biochemical indices, and the pathological changes observed in rat liver and kidney function using gas chromatography/mass spectrometry. Adult female Wistar rats (n = 12) were randomly assigned into two groups (one control and one test g...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115614384
更新日期:2016-09-01 00:00:00
abstract::Amyloid beta (Aβ) peptide aggregation and cholinergic neurodegeneration are involved in the development of cognitive impairment. Therefore, in this article, we examined rosuvastatin (RSV), an oral hypolipidemic drug, to determine its potential as a dual inhibitor of acetylcholinesterase (AChE) and Aβ peptide aggregati...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117705431
更新日期:2018-04-01 00:00:00
abstract::1. This study investigated whether the reactive organohalogen gases perfluoroisobutene (PFIB) and phosgene, which cause death by overwhelming pulmonary oedema, affect the surfactant system or type II pneumocytes of rat lung. 2. The progression and type of pulmonary injury in Porton Wistar-derived rats was monitored ov...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032799678839554
更新日期:1999-11-01 00:00:00
abstract:PURPOSE:Calcium channel blockers (CCBs) were the most common agents associated with a significant morbidity and mortality rate. The main objective of this study was to examine the publication pattern related to CCBs poisoning at the global level using bibliometric analysis of articles published in SciVerse Scopus onlin...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115571768
更新日期:2015-11-01 00:00:00
abstract::The aim of the present investigation was to check the fluctuation in essential elements, such as Na, K, Mg, Mn, Cu, Zn, Cr and Ni in the brain, spinal cord, liver and kidney of mice during methylmercury chloride (MMC) toxication and therapy with monothiols (N-acetyl-DL-homocysteine thiolactone and glutathione) and vit...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719401301201
更新日期:1994-12-01 00:00:00
abstract::Seafood is considered by nutritionists to be a high source of omega 3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) which are involved in prevention of cardiovascular diseases. The aim of the present study is firstly to detect the presence of organochlorine pesticides and heavy metals in some fresh seafood of ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110396535
更新日期:2011-10-01 00:00:00
abstract::1. Alveolar macrophages efficiently phagocytize particles deposited in the alveolar part of the lung. Phagolysosomal pH in alveolar macrophages from rabbits, dogs, baboons and guinea pigs is around 5 pH units. A low pH is of importance for clearance of inorganic particles and probably also for defence against bacteria...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719401300307
更新日期:1994-03-01 00:00:00
abstract::Organophosphorus compounds are known to cause the selective release of liver microsomal beta-glucuronidase into plasma. Organophophoruses may induce nitrosative stress leading to the generation of nitrogen free radicals and alterations in scavengers of free radicals in many biological systems. In this study, we invest...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107085349
更新日期:2007-12-01 00:00:00
abstract::Celecoxib has been shown to have antitumor effect in previous studies but the mechanisms are unclear. The effect of celecoxib on cytosolic Ca(2+) concentrations ([Ca(2+)]i) and viability in HA59T human hepatoma cells was explored. The Ca(2+)-sensitive fluorescent dye fura-2 was applied to measure [Ca(2+)]i. Celecoxib ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112472996
更新日期:2014-11-01 00:00:00
abstract::Hydrogen sulfide (H2S) is an endogenously produced gaseous messenger that participates in regulation of cardiovascular functions. This study evaluates the possible protective effect of H2S in cardiovascular dysfunction induced by cecal ligation and puncture (CLP) in rats. After 24 h of induction of CLP, heart rate (HR...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327114564794
更新日期:2015-10-01 00:00:00
abstract::1. Four different concentrations of quinalphos and methyl parathion were tested on human peripheral lymphocytes over different time periods, for the analysis of chromosomal aberrations and sister chromatid exchanges (SCEs). 2. A significant increase in chromosomal aberrations was observed when cells were treated with ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719000900605
更新日期:1990-11-01 00:00:00
abstract::Evidence-based guidelines do not exist for the treatment of patients with chronic mild-moderate digoxin toxicity. We sought to evaluate differences among specialists in the use of digoxin-specific antibody fragments and the decision to admit these patients. A sample of cardiologists, emergency physicians, and medical ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109105405
更新日期:2009-05-01 00:00:00
abstract:INTRODUCTION:Accidental toxicity by organophosphate (OP) agents may occur among farmers during spraying season due to improper use and handling. Plasma cholinesterase (ChE) activity measurement is recommended to monitor the extent of exposure to the OP agent. The aim of the current study was to measure plasma ChE activ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115584990
更新日期:2016-03-01 00:00:00
abstract::Okadaic acid (OA) is the main toxin produced by dinoflagellates, which can accumulate in the hepatopancreas of mussels and cause diarrhoetic shellfish poisoning in consumers. This toxin is also a tumour promoter and a specific potent inhibitor of protein phosphatases 1 and 2A. The results in this study show for the fi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719601500307
更新日期:1996-03-01 00:00:00
abstract::In vivo antidotal efficacy of new bis- quaternary 2-(hydroxyimino)- N-(pyridin-3yl) acetamide derivatives (HNK series), to counter multiples of lethal doses of nerve agent sarin (GB) and reactivation of acetylcholinesterase (AChE), was evaluated in Swiss albino mice. [Protection index PI; median lethal dose (LD50) of ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116637109
更新日期:2017-01-01 00:00:00
abstract::The effect of fendiline on cytosolic free Ca(2+) concentrations ([Ca(2+)](i)) and proliferation has not been explored in human oral cancer cells. This study examined whether fendiline altered Ca(2+) levels and caused cell death in OC2 human oral cancer cells. [Ca(2+)](i) and cell viability were measured using the fluo...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108097436
更新日期:2009-01-01 00:00:00
abstract::The objective of this study is to analyze exposures concerning analgesics that were reported to Dokuz Eylul University Drug and Poison Information Center (DPIC) and admitted to the Department of Emergency Medicine in Dokuz Eylul University Hospital (EMDEU) between 1993 and 2004. Demographics of the patients, character...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107076836
更新日期:2007-08-01 00:00:00
abstract::Endogenous alcohol has been applied for spontaneous ethanol production via different metabolic pathways of the human body. Auto-brewery syndrome describes the patients with alcohol intoxication after ingesting carbohydrate-rich meals. The main objective of this study is to investigate the effect of diabetes mellitus (...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116661400
更新日期:2017-05-01 00:00:00
abstract::Diazinon is one of the most widely used organophosphate insecticides (OPI) in agriculture and public health programs. The aim of this study was to investigate how an OPI, diazinon, affects lipid peroxidation (LPO) and the antioxidant defense system in vitro. For this purpose, two experiments were carried out. In exper...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327104ht408oa
更新日期:2004-01-01 00:00:00
abstract::Results obtained in long-term carcinogenicity studies with animals should be evaluated, first and foremost, by statistical comparisons of the data obtained from the treated group with that from the concurrent control group. Often the results are compared with data from so-called historical control groups in order to t...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1191/0960327103ht394oa
更新日期:2003-10-01 00:00:00
abstract::The study was done to find out whether subacute exposure to supercypermethrin forte (SCM) affected cellular and humoral immunity. Groups of 10 male Wistar rats were given SCM by gavage for 28 days at 12.5 mg kg-1 day-1 (1/14 LD50), 8.75 mg kg-1 day-1 (1/20 LD50) and 4.38 mg kg-1 day-1 (1/40 LD50) and the response of s...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719501400502
更新日期:1995-05-01 00:00:00