The effects of alcohol and diallyl sulphide on CYP2E1 activity in humans: a phenotyping study using chlorzoxazone.

abstract：:A retrospective review of medical records was carried out to determine the pattern of drug and chemical poisoning cases admitted to a teaching hospital in Malaysia. Medical records of patients admitted during the period January 1987 to December 1995 were reviewed. They accounted for 0.2% of total admissions during the...

journal_title：Human & experimental toxicology

authors： Ab Rahman AF

更新日期：2002-07-01 00:00:00

abstract：:Endogenous alcohol has been applied for spontaneous ethanol production via different metabolic pathways of the human body. Auto-brewery syndrome describes the patients with alcohol intoxication after ingesting carbohydrate-rich meals. The main objective of this study is to investigate the effect of diabetes mellitus (...

journal_title：Human & experimental toxicology

authors： Hafez EM,Hamad MA,Fouad M,Abdel-Lateff A

更新日期：2017-05-01 00:00:00

abstract：:Naringenin is a naturally occurring flavanones and has been found to exhibit free radical scavenging, enzyme inhibition, antioxidants, anti-inflammatory, and anticancer activities. Present study was designed to evaluate the protective role of naringenin against benzo[a]pyrene (B[a]P)-induced oxidative stress and pulmo...

journal_title：Human & experimental toxicology

authors： Ali R,Shahid A,Ali N,Hasan SK,Majed F,Sultana S

更新日期：2017-04-01 00:00:00

abstract：:Predictive toxicology plays a critical role in reducing the failure rate of new drugs in pharmaceutical research and development. Despite recent gains in our understanding of drug-induced toxicity, however, it is urgent that the utility and limitations of our current predictive tools be determined in order to identify...

journal_title：Human & experimental toxicology

authors： Naven RT,Louise-May S

更新日期：2015-12-01 00:00:00

abstract：:The aim of the present study was to investigate whether cognitive behavioral impairment, induced by nicotine in offspring rats, was associated with the alteration of hippocampal short-term potentiation (STP) and long-term potentiation (LTP) and to discuss the potential underlying mechanism. Young adult offspring rats ...

journal_title：Human & experimental toxicology

authors： Han G,An L,Yang B,Si L,Zhang T

更新日期：2014-02-01 00:00:00

abstract：:Silver nanoparticles are used in many commercial products in daily life. Exposure to nanosilver has hepatotoxic effects in animals. This study investigated the cytotoxicity associated with polyvinylpyrrolidone-coated nanosilver (23.44 ± 4.92 nm in diameter) exposure in the human hepatoma cell line (HepG2) and normal h...

journal_title：Human & experimental toxicology

authors： Xue Y,Wang J,Huang Y,Gao X,Kong L,Zhang T,Tang M

更新日期：2018-12-01 00:00:00

abstract：:In vivo antidotal efficacy of new bis- quaternary 2-(hydroxyimino)- N-(pyridin-3yl) acetamide derivatives (HNK series), to counter multiples of lethal doses of nerve agent sarin (GB) and reactivation of acetylcholinesterase (AChE), was evaluated in Swiss albino mice. [Protection index PI; median lethal dose (LD50) of ...

journal_title：Human & experimental toxicology

authors： Swami D,Karade HN,Acharya J,Kumar P

更新日期：2017-01-01 00:00:00

abstract：:Members of the transforming growth factor (TGF) family have emerged as critical contributors to the choreography of cellular and tissue interactions underlying morphogenesis of the orofacial region. The TGFs beta, and their downstream effector molecules, the Smads, play a pivotal role in normal as well as abnormal dev...

journal_title：Human & experimental toxicology

authors： Greene RM,Pisano MM

更新日期：2005-01-01 00:00:00

abstract：CONTEXT:Cardiac dysfunction is one of the most serious consequences of scorpion envenomation. The best tool to evaluate cardiac function is echocardiography, but it is not available at all emergency departments. Many studies aimed to describe biological predictive factors of cardiac dysfunction in scorpion envenomation...

journal_title：Human & experimental toxicology

authors： Chakroun-Walha O,Karray R,Jerbi M,Ben Rebeh A,Jammeli C,Bahloul M,Ammar R,Chabchoub I,Bouaziz M,Nasri A,Rekik N

更新日期：2018-06-01 00:00:00

abstract：:The serial cognitive assessment of ten individuals made between 8 and 26 months after the water at Camelford in Cornwall was accidentally contaminated with aluminium sulphate, showed consistent evidence of impairment of information processing and memory. There was no obvious relationship between these impairments and ...

journal_title：Human & experimental toxicology

authors： McMillan TM,Freemont AJ,Herxheimer A,Denton J,Taylor AP,Pazianas M,Cummin AR,Eastwood JB

更新日期：1993-01-01 00:00:00

abstract：:The pharmacokinetics of the herbicide fluazifop-butyl have been determined in female rats following oral and intravenous dosing, and described by a mathematical model. Penetration of fluazifop-butyl through epidermal membranes has been determined using three different receptor fluids. It is demonstrated how this in vi...

journal_title：Human & experimental toxicology

authors： Auton TR,Ramsey JD,Woollen BH

更新日期：1993-05-01 00:00:00

abstract：:Two previously healthy women developed nausea, vomiting, headache and dizziness for several days, a massive hair loss about 2 weeks later and a discoloration of the fingernails. Detailed diagnostic procedures did not reveal any pathological results. Therapeutic measures did not show any effect. Thallium and arsenic we...

journal_title：Human & experimental toxicology

authors： Müller D,Desel H

更新日期：2010-05-01 00:00:00

abstract：:Airborne mono-2-ethylhexyl phthalate (MEHP) was studied for acute airway effects using a bioassay with BALB/c mice. Concentration- and time-dependent effects were obtained by continuous monitoring of the breathing pattern during exposure to 0.3-43.6 mg/m3 MEHP for 60 min. Additionally, inflammatory effects of MEHP wer...

journal_title：Human & experimental toxicology

authors： Larsen ST,Hansen JS,Hammer M,Alarie Y,Nielsen GD

更新日期：2004-11-01 00:00:00

abstract：:The effects of low lead exposure were investigated in 96 children (7-12 years old) living and studying within a 1 km radius of a lead smelter (exposed population) located in Torreón, Coahuila, México, and compared with 30 children living and studying 4.5 km from the same smelter (control population). Both populations ...

journal_title：Human & experimental toxicology

authors： Calderón-Salinas JV,Valdéz-Anaya B,Mazúñiga-Charles,Albores-Medina A

更新日期：1996-04-01 00:00:00

abstract：:Dimethylacetamide (DMAc) is a skin-penetrating solvent able to induce hepatic damage after chronic exposure. Previous research has indicated that metabolism may be saturated at its present TLV/TWA (10 ppm). Biological monitoring of monomethylacetamide (MMAc), the primary metabolite of DMAc, might therefore underestima...

journal_title：Human & experimental toxicology

authors： Palmen NG,Evelo CT,Borm PJ,Henderson PT

更新日期：1993-03-01 00:00:00

abstract：:1 The concentrations of a range of organochlorine pesticide residues have been determined in 168 samples of human milk collected between January 1997 and May 1998 in the UK. 2 Of the 18 residues sought, only p,p'-DTT, p,p'-DDE, dieldrin, HCB, beta-HCH and gamma-HCH were detected. 3 The continuing trend of a reduction ...

journal_title：Human & experimental toxicology

authors： Harris CA,O'Hagan S,Merson GH

更新日期：1999-10-01 00:00:00

abstract：:We aimed to investigate the possible roles of nitric oxide (NO) and endothelin on the changes of cardiac muscle function in both hyper- and hypodynamic septic shock periods. Cecal ligation and puncture was performed in 50 Wistar albino rats to induce septic shock. Changes in atrium and right ventricle papillary muscle...

journal_title：Human & experimental toxicology

authors： Ozer EK,Iskit AB

更新日期：2016-03-01 00:00:00

abstract：:1. Carbofuran was administered orally to adult male rats at dose levels of 0.1, 0.2, 0.4 or 0.8 mg kg-1 body weight, 5 d wk-1 for 60 days. A dose dependent decrease was observed in body weight of rats treated with 0.2-0.8 mg carbofuran kg-1 body weight. 2. A significant decrease in the weight of epididymides, seminal ...

journal_title：Human & experimental toxicology

authors： Pant N,Prasad AK,Srivastava SC,Shankar R,Srivastava SP

更新日期：1995-11-01 00:00:00

abstract：:1. Following the establishment, in the USA, of the first poisons information centre, in 1953, the movement has grown globally. Originally, such a service was intended to meet an emergency need. Its efficacy has still not been objectively audited. 2. The suggestion now is that clinical toxicology has become such a dive...

journal_title：Human & experimental toxicology

authors： Goulding R

更新日期：1991-11-01 00:00:00

abstract：:Generation of reactive oxygen species (ROS) leads to serious tissue injuries. The effect of cyclopiazonic acid (CPA) on oxidative stress markers in the liver and kidneys of broiler chicks was studied. Ten-day-old male broiler chicks (Ross 308) were assigned into the control and test groups, which received normal salin...

journal_title：Human & experimental toxicology

authors： Malekinejad H,Akbari P,Allymehr M,Hobbenaghi R,Rezaie A

更新日期：2011-08-01 00:00:00

abstract：:1. A chronic alcoholic with severe metabolic acidosis presents a difficult diagnostic problem. The most common cause is alcoholic ketoacidosis, a syndrome with a typical history but often misleading laboratory findings. This paper will focus on this important and probably underdiagnosed syndrome. 2. The disorder occur...

journal_title：Human & experimental toxicology

authors： Höjer J

更新日期：1996-06-01 00:00:00

abstract：:The effects of the environmental toxicant, triethyltin, on Ca2+ mobilization in Madin-Darby canine kidney (MDCK) cells have been examined. Triethyltin induced an increase in cytosolic free Ca2+ levels ([Ca2+]i) at concentrations larger than 2 microM in a concentration-dependent manner. Within 5 min, the [Ca2+]i signal...

journal_title：Human & experimental toxicology

authors： Jiann BP,Chou KJ,Chang HT,Chen WC,Huang JK,Jan CR

更新日期：2002-08-01 00:00:00

abstract：:Sepsis, often initiated by an infection, is a state of disrupted inflammatory homeostasis. There is increasing evidence that oxidative stress has an important role in the development of sepsis-induced multiorgan failure. Resveratrol (RV) is a polyphenolic compound found in the skin of red fruits, such as mulberries an...

journal_title：Human & experimental toxicology

authors： Aydin S,Bacanli M,Taner G,Şahin T,Başaran AA,Başaran N

更新日期：2013-10-01 00:00:00

abstract：:Dermal exposure is an important factor in risk characterization. In occupational settings it becomes relatively more important because of the continuous reduction in inhalation exposure. In the public health arena, dermal exposure may also form a significant contribution to the total exposure. Dermal exposure, however...

journal_title：Human & experimental toxicology

authors： Boogaard PJ

更新日期：2008-04-01 00:00:00

abstract：:The fixed-dose procedure (FDP) was introduced as OECD Test Guideline 420 in 1992, as an alternative to the conventional median lethal dose (LD50) test for the assessment of acute oral toxicity (OECD Test Guideline 401). The FDP uses fewer animals and causes less suffering than the conventional test, while providing in...

journal_title：Human & experimental toxicology

authors： Stalla N,Whitehead A,Ridgway P

更新日期：2002-04-01 00:00:00

abstract：:Paraquat poisoning was studied in 174 patients over a 12-month period when a new, low concentration paraquat product (4.5% w/v paraquat ion mixed with 4.5% w/v diquat ion; 63 cases) replaced the original high concentration paraquat product (20% w/v paraquat ion only; 111 cases). In both groups approximately 60% of the...

journal_title：Human & experimental toxicology

authors： Yoshioka T,Sugimoto T,Kinoshita N,Shimazu T,Hiraide A,Kuwagata Y

更新日期：1992-07-01 00:00:00

abstract：:Safrole, a component of piper betle inflorescence, is a documented rodent hepatocarcinogen and inhibits bactericidal activity and the release of superoxide anion (O(2-)) by polymorphonuclear leukocytes (PMNs). In the present study, we investigated the effects of safrole on immune responses, including natural killer (N...

journal_title：Human & experimental toxicology

authors： Fan MJ,Lin SY,Yu CC,Tang NY,Ho HC,Chung HK,Yang JS,Huang YP,Ip SW,Chung JG

更新日期：2012-09-01 00:00:00

abstract：:1. 26Al and 67Ga were given as citrates to a healthy male volunteer by intravenous injection. The retention of both tracers was studied by body radioactivity measurement. Levels in blood and excreta were determined by gamma-ray spectrometry and/or accelerator mass spectrometry. 2. More than half of the 26Al had left t...

journal_title：Human & experimental toxicology

authors： Priest ND,Newton D,Day JP,Talbot RJ,Warner AJ

更新日期：1995-03-01 00:00:00

abstract：:Sulfur mustard (SM) represents a potential chemical warfare agent. In order to characterize SM-induced airway epithelial damage, we studied the effects of an intratracheal injection of 0.3 mg/kg of SM in guinea pigs, 5 h, 24 h, 14 days and 35 days after exposure. During the acute period, lesions prevailed in tracheal ...

journal_title：Human & experimental toxicology

authors： Calvet JH,Coste A,Levame M,Harf A,Macquin-Mavier I,Escudier E

更新日期：1996-12-01 00:00:00

abstract：:Previous studies have shown that environmental exposure to heavy metals has been related to epigenetic changes, such as DNA methylation in receptors involved in pathogenesis of asthma. One of these receptors is beta-2 adrenergic receptor (ADRB2). We conducted this study to examine the association between blood aluminu...

journal_title：Human & experimental toxicology

authors： Nafea OE,El-Korashi LA,Gehad MH,Yousif YM,Zake LG

更新日期：2020-10-01 00:00:00