Effects of Lucilia sericata on wound healing in streptozotocin-induced diabetic rats and analysis of its secretome at the proteome level.

abstract：:Two studies were performed in order to evaluate cytochrome P450 1A2 mediated caffeine metabolism during different nutritional conditions. 1. In the first study, 23 healthy male non-smokers, mean age 25, changed from a customary mixed diet to a standard diet in 6 days. The 6 day's standard diet was based on bread, pota...

journal_title：Human & experimental toxicology

authors： Kall MA,Clausen J

更新日期：1995-10-01 00:00:00

abstract：:Generation of reactive oxygen species (ROS) leads to serious tissue injuries. The effect of cyclopiazonic acid (CPA) on oxidative stress markers in the liver and kidneys of broiler chicks was studied. Ten-day-old male broiler chicks (Ross 308) were assigned into the control and test groups, which received normal salin...

journal_title：Human & experimental toxicology

authors： Malekinejad H,Akbari P,Allymehr M,Hobbenaghi R,Rezaie A

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Oxidative stress is one of the major mechanisms of cyclophosphamide (CPX)-induced toxicities. However, it is unknown how CPX induces oxidative stress. Based on the available information, we speculated that CPX could increase iron content in the tissues and then induce oxidative stress. METHOD:We tested this ...

journal_title：Human & experimental toxicology

authors： Sheng Y,Chen YJ,Qian ZM,Zheng J,Liu Y

更新日期：2020-07-01 00:00:00

abstract：:The conventional method for the assessment of acute inhalation toxicity (OECD Test Guideline 403, 1981) uses death of animals as an endpoint to identify the median lethal concentration (LC50). A new OECD Testing Guideline called the Fixed Concentration Procedure (FCP) is being prepared to provide an alternative to Tes...

journal_title：Human & experimental toxicology

authors： Stallard N,Whitehead A,Indans I

更新日期：2003-11-01 00:00:00

abstract：:The epithelial Madin Darby canine kidney (MDCK) cell line and 17 human cell lines were examined for sensitivity to Clostridium perfringens type D epsilon-toxin. MDCK cells were confirmed as being sensitive to the toxin. In addition, the Caucasian renal leiomyoblastoma (G-402) human cell line was identified as being ep...

journal_title：Human & experimental toxicology

authors： Shortt SJ,Titball RW,Lindsay CD

更新日期：2000-02-01 00:00:00

abstract：:Many industrial and agricultural chemicals have steroid hormone agonist or antagonist activities and disrupt hormone-regulated gene expression. The widely-used agricultural insecticide, diazinon, was evaluated using MCF-7 cells - a breast cancer-derived, estrogen-dependent, human cell line - to examine the capacity of...

journal_title：Human & experimental toxicology

authors： Mankame T,Hokanson R,Fudge R,Chowdhary R,Busbee D

更新日期：2006-02-01 00:00:00

abstract：:1. Methylxanthines, ACTH and stress are well known to produce testicular pathology (e.g. seminiferous tubule atrophy). Methylxanthines, ACTH and stress alter hormone secretion, particularly from the pituitary-adrenocortical system. Consequently, it has recently been suggested that there may be a causal relationship be...

journal_title：Human & experimental toxicology

authors： Harvey PW,Er J,Fernandes C,Rush KC,Major IR,Cockburn A

更新日期：1992-11-01 00:00:00

abstract：:1. The effect of pyridostigmine on cardiorespiratory function after oxime + atropine injection was investigated in tabun poisoned guinea-pigs and without tabun poisoning. 2. The trachea, a carotid artery and jugular vein were cannulated in female urethane-anaesthetised Pirbright-white guinea-pigs. After baseline measu...

journal_title：Human & experimental toxicology

authors： Worek F,Kleine A,Szinicz L

更新日期：1995-08-01 00:00:00

abstract：:Oxidative stress has an important role in the pathophysiology of many occupational diseases. In this controlled exposure study, the intensity of oxidative stress biomarkers was assessed in the workers of natural sweet and sour gas refineries (SwGR and SoGR, respectively) and compared with controls. In addition, the ro...

journal_title：Human & experimental toxicology

authors： Mandegary A,Sezavar M,Saeedi A,Amirheidari B,Naghibi B

更新日期：2012-12-01 00:00:00

abstract：:1. The coumarin anticoagulant difenacoum was detected by high performance liquid chromatography (HPLC) with multi-wavelength UV detection in plasma from a 41 years old man who presented with a severe deficiency of vitamin K-dependent clotting factors of unknown aetiology. A longitudinal toxicological study of the cons...

journal_title：Human & experimental toxicology

authors： McCarthy PT,Cox AD,Harrington DJ,Evely RS,Hampton E,al-Sabah AI,Massey E,Jackson H,Ferguson T

更新日期：1997-03-01 00:00:00

abstract：:Organic solvents can cause hearing loss themselves or promote noise-induced hearing loss. The objective of this study was to review the literature on the effects of low-level exposure to trichloroethylene on the auditory system and consider its relevance for the occupational settings. Both human and animal investigati...

journal_title：Human & experimental toxicology

authors： Vyskocil A,Leroux T,Truchon G,Lemay F,Gagnon F,Gendron M,Viau C

更新日期：2008-03-01 00:00:00

abstract：:Progesterone (a neurosteroid) is an important modulator of the nervous system functioning. Organophosphorus pesticides like phosphamidon have been shown to adversely affect memory and induce oxidative stress on both acute and chronic exposure. The present study was therefore designed to investigate the effects of prog...

journal_title：Human & experimental toxicology

authors： Sharma AK,Bhattacharya SK,Khanna N,Tripathi AK,Arora T,Mehta AK,Mehta KD,Joshi V

更新日期：2011-10-01 00:00:00

abstract：:The synthetic catecholamine isoprenaline (ISO) has been used as an inductor in the acute myocardial infarction model for more than a half century. Despite the fact that many articles were published on this topic, precise early haemodynamic pathology remains unknown. Acute haemodynamic changes were measured in rats; fi...

journal_title：Human & experimental toxicology

authors： Filipský T,Zatloukalová L,Mladěnka P,Hrdina R

更新日期：2012-08-01 00:00:00

abstract：:The aim of the study was to evaluate the effect of bisphenol A (BPA) on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression by neutrophils with regard to sex and nuclear factor-κB (NF-κB) pathway participation in this process. This study demonstrated that BPA intensifies the production o...

journal_title：Human & experimental toxicology

authors： Ratajczak-Wrona W,Nowak K,Garley M,Tynecka M,Jablonska E

更新日期：2019-02-01 00:00:00

abstract：:In order to assess the effect of arsenic on the male reproductive impairment in mice, 7-week-old animals were exposed to 7.5 mg sodium arsenite (NaAsO(2))/kg body weight, during 35 days (one spermatogenic cycle). One group of animals was sacrificed after exposure, while another group received distilled water for an ad...

journal_title：Human & experimental toxicology

authors： Ferreira M,Matos RC,Oliveira H,Nunes B,Pereira Mde L

更新日期：2012-03-01 00:00:00

abstract：:The objective of the present study was to perform histological and stereological examination of alcohol-induced changes in the optic nerve, considered an extension of white matter of the brain, in rats. This study included 20 male Wistar albino rats aged 60 days and weighing 190-220 g. The rats were divided into three...

journal_title：Human & experimental toxicology

authors： Igit T,Colcimen N

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Chronic obstructive pulmonary disease (COPD) due to sulfur mustard (SM), known as mustard lung, is an important late pulmonary complication of SM poisoning. Due to the possible role of systemic inflammation in mustard lung, we evaluated the serum levels of adiponectin and leptin in these patients. MATERIA...

journal_title：Human & experimental toxicology

authors： Rokni Yazdi H,Lari SM,Attaran D,Ayatollahi H,Mohsenizadeh A

更新日期：2014-06-01 00:00:00

abstract：:9-(4'-Aminophenyl)-9H-pyrido [3,4-b] indole (aminophenylnorharman, APNH) is a novel mutagenic heterocyclic amine, produced by the reaction of norharman with aniline in the presence of S9 mix. In the present study, the maternal and developmental toxicity of APNH were investigated in ICR mice administered oral doses of ...

journal_title：Human & experimental toxicology

authors： Naga T,Yoshimura S,Totsuka Y,Wakabayashi K

更新日期：2002-03-01 00:00:00

abstract：:Persistent organic pollutants (POPs) are organic (carbon-based) compounds that include synthesized substances (pesticides and polychlorinated biphenyls [PCBs]) and other by-product substances generated as a result of human and natural activity (dioxins and furans). Extensive scientific studies have shown that POPs are...

journal_title：Human & experimental toxicology

authors： Mansour SA

更新日期：2009-09-01 00:00:00

abstract：:Previous studies have shown that environmental exposure to heavy metals has been related to epigenetic changes, such as DNA methylation in receptors involved in pathogenesis of asthma. One of these receptors is beta-2 adrenergic receptor (ADRB2). We conducted this study to examine the association between blood aluminu...

journal_title：Human & experimental toxicology

authors： Nafea OE,El-Korashi LA,Gehad MH,Yousif YM,Zake LG

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondial...

journal_title：Human & experimental toxicology

authors： Karadas S,Aslan M,Ceylan MR,Sunnetcioglu M,Bozan N,Kara H,Demir H

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The mortality rate associated with human glufosinate poisoning is high. We evaluated the usefulness of serum ammonia and sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation II (APACHE II) scores for early prediction of in-hospital mortality in glufosinate ammonium po...

journal_title：Human & experimental toxicology

authors： Lee J,Lee Y,Kim YS,Choi JG,Go TH,Kim H,Cha YS

更新日期：2019-09-01 00:00:00

abstract：:Airborne mono-2-ethylhexyl phthalate (MEHP) was studied for acute airway effects using a bioassay with BALB/c mice. Concentration- and time-dependent effects were obtained by continuous monitoring of the breathing pattern during exposure to 0.3-43.6 mg/m3 MEHP for 60 min. Additionally, inflammatory effects of MEHP wer...

journal_title：Human & experimental toxicology

authors： Larsen ST,Hansen JS,Hammer M,Alarie Y,Nielsen GD

更新日期：2004-11-01 00:00:00

abstract：:Personal reflections on radiation hormesis for the past 50 years are presented. The causes of ignoring and rejections of this phenomenon by international and national bodies and by radiation protection establishment are analyzed. The opposition against nuclear weapons and preparations for nuclear war was probably the ...

journal_title：Human & experimental toxicology

authors： Jaworowski Z

更新日期：2010-04-01 00:00:00

abstract：:In the 1980s, villages in the Kurdistan region of Iraq were exposed to chemical weapons (CWs), which killed and injured thousands of civilians. There has been no clinical assessment of the long-term effects of CWs exposure on those injured. We report the first such evaluation of CW effects on long-term health of child...

journal_title：Human & experimental toxicology

authors： Talabani JM,Ali AI,Kadir AM,Rashid R,Samin F,Greenwood D,Hay A

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Mushroom poisoning is still a significant health-care problem, with the potential to affect blood parameters. The present study analyses the effect of mushroom poisoning on complete blood cell parameters, cell ratios, and cell volume indices and the effect of the mentioned parameters on prognosis/hospital len...

journal_title：Human & experimental toxicology

authors： Doğan M,Karahan I

更新日期：2019-10-01 00:00:00

abstract：:Apoptosis induction in cancer cells is one of the most efficient ways to treat cancer and find anticancer compounds. The aim of this study was to evaluate the cytotoxic effects of heat-killed indigenous probiotic bacteria and apoptosis induction in the HT-29 human colon adenocarcinoma cell line. The growth-inhibitory ...

journal_title：Human & experimental toxicology

authors： Karimi Ardestani S,Tafvizi F,Tajabadi Ebrahimi M

更新日期：2019-09-01 00:00:00

abstract：:Drugs intended for use in preventing allograft rejection in transplant patients are likely to be administered chronically; thus, it is normally expected that sponsors would conduct nonclinical studies to determine the carcinogenic potential of candidate compounds. For pharmaceuticals other than biologic agents, this w...

journal_title：Human & experimental toxicology

authors： Hastings KL

更新日期：2000-04-01 00:00:00

abstract：:This study evaluated the protective potential of curcumin on the possible side effects of bortezomib (Bt) therapy on normal cells in mice. The mice were segregated into three groups (n = 10) that included normal control, Bt-treated, and Bt + curcumin-treated groups. The Bt treatment resulted in significant decrease in...

journal_title：Human & experimental toxicology

authors： Kumar RR,Malhotra A

更新日期：2015-07-01 00:00:00

abstract：:In this study we examined the effect of the aqueous extract of Thonningia sanguinea (T.S.) on 7-ethoxyresorufin O-deethylase (EROD, CYP1A1), 7-pentoxyresorufin O-dealkylase (PROD, CYP2B1/2), 7-methoxyresorufin O-demethylase (MROD, CYP1A2), aniline hydroxylase (aniline, CYP2E1), p-nitrophenol hydroxylase (PNPH, CYP2E1)...

journal_title：Human & experimental toxicology

authors： Gyamfi MA,Hokama N,Oppong-Boachie K,Aniya Y

更新日期：2000-11-01 00:00:00