Abstract：
:The study was done to find out whether subacute exposure to supercypermethrin forte (SCM) affected cellular and humoral immunity. Groups of 10 male Wistar rats were given SCM by gavage for 28 days at 12.5 mg kg-1 day-1 (1/14 LD50), 8.75 mg kg-1 day-1 (1/20 LD50) and 4.38 mg kg-1 day-1 (1/40 LD50) and the response of splenocytes to mitogens, natural killer cell activity, plaque forming cell assay and phagocytosis were examined. The response of splenocytes to the mitogens phytohaemagglutin and concanavalin A, and to a T-dependent antigen (sheep red blood cells), was enhanced at 1/40 LD50 SCM, and at 1/20 and 1/14 LD50 these variables were suppressed. In the group exposed to 1/14 LD40 SCM the suppression was statistically significant. A non significant but dose-related increase in NK-cell activity was observed. The phagocytic activity of polymorphes was not significantly affected. Thus, SCM at 1/14 LD50 had significant adverse effects on a number of immunological functions in rats, but lower doses had no effect on these activities.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Tulinská J,Kubová J,Janota S,Nyulassy Sdoi
10.1177/096032719501400502subject
Has Abstractpub_date
1995-05-01 00:00:00pages
399-403issue
5eissn
0960-3271issn
1477-0903journal_volume
14pub_type
杂志文章abstract：OBJECTIVES:Pesticide poisoning stands as a major public health issue worldwide. The objective of this study was to examine the epidemiologic characteristics of pesticide-related hospitalizations in South Korea. METHODS:Data from the Korea National Hospital Discharge Survey were analyzed to describe the epidemiologic c...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327111431709
更新日期：2012-08-01 00:00:00
abstract：:1 The urinary recovery of metabolites of aspirin (ASA) was studied in 45 volunteers who took a therapeutic dose (600 mg) of ASA by mouth and in 37 patients who took ASA in overdose. 2 The main metabolite recovered from the volunteers was the glycine conjugate, salicyluric acid (SUA), which accounted for 75.01 +/- 1.19...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719000900302
更新日期：1990-05-01 00:00:00
abstract：:1. Following the establishment, in the USA, of the first poisons information centre, in 1953, the movement has grown globally. Originally, such a service was intended to meet an emergency need. Its efficacy has still not been objectively audited. 2. The suggestion now is that clinical toxicology has become such a dive...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719101000606
更新日期：1991-11-01 00:00:00
abstract：:Hormesis can be considered as a parameter which has a non-monotonic relationship with some endpoint. Since caloric intake is such a parameter, and the impact of this parameter on risk assessment has been fairly well characterized, it can provide clues as to how to integrate the information from a hormetic parameter in...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719801700810
更新日期：1998-08-01 00:00:00
abstract：:Delta-aminolevulinate dehydratase (δ-ALA-D) enzyme is sensitive to pro-oxidant agents, including molecular oxygen. Here, we tested whether hyperoxygenation after total intravenous (i.v.) anesthesia could interact with the type of anesthesia (dexmedetomidine, continuous infusion; 0.5 μg/kg/h or remifentanil, continuous...
journal_title：Human & experimental toxicology
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doi：10.1177/0960327110372399
更新日期：2011-04-01 00:00:00
abstract：:1 The cytotoxicity of dichlorobenzenes in cultured rat liver slices has previously been shown to be strain specific and biotransformation related. 2 In order to extrapolate animal models to humans, the dichlorobenzenes were incubated with human liver slices to try to clarify their hepatotoxic potential in man. 3 The d...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719101000510
更新日期：1991-09-01 00:00:00
abstract：:1. Four different concentrations of quinalphos and methyl parathion were tested on human peripheral lymphocytes over different time periods, for the analysis of chromosomal aberrations and sister chromatid exchanges (SCEs). 2. A significant increase in chromosomal aberrations was observed when cells were treated with ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719000900605
更新日期：1990-11-01 00:00:00
abstract：:We have investigated the pituitary-testicular axis in a well-characterized population which was occupationally exposed to mercury vapour. Thyroid stimulating hormone and prolactin were also measured as indices of thyroid and pituitary endocrine function. We found no relation between blood or urine mercury levels or le...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719101000309
更新日期：1991-05-01 00:00:00
abstract：:Phagocytes remove and store mercury (Hg) that enters the body. Macrophages and granulocytes respond in opposite ways to Hg: macrophages loose cell viability, and neutrophils become protected from apoptosis. We have investigated the cytology of early intake of Hg by macrophages and neutrophils after a short period (2-4...
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更新日期：2004-08-01 00:00:00
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更新日期：1993-01-01 00:00:00
abstract：:Endogenous alcohol has been applied for spontaneous ethanol production via different metabolic pathways of the human body. Auto-brewery syndrome describes the patients with alcohol intoxication after ingesting carbohydrate-rich meals. The main objective of this study is to investigate the effect of diabetes mellitus (...
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更新日期：2017-05-01 00:00:00
abstract：:Amyloid beta (Aβ) peptide aggregation and cholinergic neurodegeneration are involved in the development of cognitive impairment. Therefore, in this article, we examined rosuvastatin (RSV), an oral hypolipidemic drug, to determine its potential as a dual inhibitor of acetylcholinesterase (AChE) and Aβ peptide aggregati...
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更新日期：2018-04-01 00:00:00
abstract：:1. The methods used to evaluate the toxicological effects of PCBs in animals have been reviewed. 2. The data show that Toxic Equivalency Factors (TEFs) could be developed to assess the potential toxicity of PCB mixtures for certain specific target organ effects (such as the liver and immune system) but would be inappr...
journal_title：Human & experimental toxicology
pub_type： 杂志文章,评审
doi：10.1177/096032719401300901
更新日期：1994-09-01 00:00:00
abstract：:The effects of moderate lead exposure on testicular endocrine function were evaluated in a group of 90 males who were occupationally exposed to inorganic lead. Lead concentrations in blood and bone were measured as indices of short-term and long-term, cumulative exposure, respectively. The results of this study show t...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719000900602
更新日期：1990-11-01 00:00:00
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journal_title：Human & experimental toxicology
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doi：10.1177/0960327119828123
更新日期：2019-05-01 00:00:00
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doi：10.1177/0960327115611970
更新日期：2016-09-01 00:00:00
abstract：:This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327111426584
更新日期：2013-06-01 00:00:00
abstract：:In this study, the effect of a combination of vitamin C, vitamin E and selenium on ethanol-induced duodenal mucosal damage in rats was investigated morphologically and biochemically. The duodenal mucosal injury was produced by oral administration of 1 mL of absolute ethanol to each rat. Animals received vitamin C (250...
journal_title：Human & experimental toxicology
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更新日期：2004-08-01 00:00:00
abstract：:Prolonged zidovudine (AZT) treatment in HIV-infected and AIDS patients is shown to induce liver toxicity leading to complications. Therapeutic regimen that could encounter this adverse effect is unavailable and management of toxicity is often symptomatic or is limited to withdrawal of therapy. In the present investiga...
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更新日期：2018-05-01 00:00:00
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doi：10.1177/0960327107085830
更新日期：2008-04-01 00:00:00
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journal_title：Human & experimental toxicology
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更新日期：2017-04-01 00:00:00
abstract：:Okadaic acid (OA) is the main toxin produced by dinoflagellates, which can accumulate in the hepatopancreas of mussels and cause diarrhoetic shellfish poisoning in consumers. This toxin is also a tumour promoter and a specific potent inhibitor of protein phosphatases 1 and 2A. The results in this study show for the fi...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719601500307
更新日期：1996-03-01 00:00:00
abstract：:The effects of low lead exposure were investigated in 96 children (7-12 years old) living and studying within a 1 km radius of a lead smelter (exposed population) located in Torreón, Coahuila, México, and compared with 30 children living and studying 4.5 km from the same smelter (control population). Both populations ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719601500406
更新日期：1996-04-01 00:00:00
abstract：:A retrospective review of medical records was carried out to determine the pattern of drug and chemical poisoning cases admitted to a teaching hospital in Malaysia. Medical records of patients admitted during the period January 1987 to December 1995 were reviewed. They accounted for 0.2% of total admissions during the...
journal_title：Human & experimental toxicology
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更新日期：2002-07-01 00:00:00
abstract：:Diabetes mellitus promoted an overproduction of free radicals and an increased incidence of both diabetic nephropathy and liver disease. In this report, we evaluated the effects of Chinese and Brazilian propolis on streptozotocin-induced hepatorenal injury in rats. The results demonstrated that Chinese propolis-treate...
journal_title：Human & experimental toxicology
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doi：10.1177/0960327110387456
更新日期：2011-09-01 00:00:00
abstract：:Resveratrol, a grape skin and red wine-derived polyphenolic phytoalexin, exhibits hormetic action delivering numerous health benefits at lower doses while being detrimental at higher doses. Epidemiologic and clinical trials need to be based on the clear understanding of hormetic health benefits of resveratrol. ...
journal_title：Human & experimental toxicology
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doi：10.1177/0960327110383626
更新日期：2010-12-01 00:00:00
abstract：:Stem cell transplantation has indicated great promise for cell therapy in a wide range of diseases, but poor and insufficient viability of cells within damaged tissues has limited its potential therapeutic effects. 17 β-Estradiol (E2) is a steroid hormone that plays an important role in expression of many genes and re...
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更新日期：2016-03-01 00:00:00
abstract：:Persistent organochlorine pollutants (POPs), such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dichloro diphenyl trichloroethane (DDT) and its major metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p' -DDE) have been associated with type 2 diabetes mellitus (T2DM) in rece...
journal_title：Human & experimental toxicology
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更新日期：2007-05-01 00:00:00
