Abstract:
:Results obtained in long-term carcinogenicity studies with animals should be evaluated, first and foremost, by statistical comparisons of the data obtained from the treated group with that from the concurrent control group. Often the results are compared with data from so-called historical control groups in order to take variations in the incidences of spontaneous tumours into account. Because historical control data change in the course of time and for a variety of reasons, certain requirements must be met before they may be used in the evaluation of the results of long-term studies. The present paper discusses potential sources of variability of tumour incidences in untreated animals, presents databanks for historical control data, mentions the factors that affect tumour incidences in untreated animals and describes biostatistical data evaluation. Finally, details are given of the criteria used by the DFG Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area to decide whether historical control data may be applied. These include the requirement that the historical control data were obtained with animals of the same species and strain and from the same breeder. The data were obtained in the same laboratory, the study design, experimental methods and assessment criteria were the same, and the studies used for the comparison were carried out within a limited time window. Historical control data that have not been published may be used provided they fulfil the above criteria and have been made available in sufficient detail to be comprehensible.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Greim H,Gelbke HP,Reuter U,Thielmann HW,Edler Ldoi
10.1191/0960327103ht394oasubject
Has Abstractpub_date
2003-10-01 00:00:00pages
541-9issue
10eissn
0960-3271issn
1477-0903journal_volume
22pub_type
杂志文章,评审abstract::Inflammatory bowel disease (IBD) is a chronic condition of the intestine with unknown etiology involving multiple immune, genetic and environmental factors. We were interested in examining the effect of a total extract from Ziziphora clinopoides, an Iranian folk herbal medicine, in the prevention and control of experi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
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abstract::Coronary heart disease and in particular its most serious form - acute myocardial infarction (AMI) - represents the most common cause of mortality in developed countries. Better prognosis may be achieved by understanding the etiopathogenetic mechanisms of AMI. Therefore, a catecholamine model of myocardial injury, whi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109350665
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abstract::In responding to Drs Calabrese and Baldwin's question, 'At what point, if ever, should hormesis be employed as the principal dose response default assumption in risk assessment?', we examined the benefits of replacing traditional dose-response with hormesis. In general, hormesis provides more complete useful informati...
journal_title:Human & experimental toxicology
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abstract:INTRODUCTION:Automatic dishwashing rinse aids are drying aids which contain non-ionic surfactants, usually ethoxylated alcohols, typically at concentrations of ≤30%. OBJECTIVE:To assess the reported toxicity of rinse aids. METHODS:Telephone enquiries to the UK National Poisons Information Service were analysed from J...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327120901580
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abstract:UNLABELLED:We present the first ever case of homicidal poisoning due to injection of methidathion, an organophosphate insecticide. CASE:A 4-month-old baby presented to the emergency department with chief complaints of unconsciousness and irregular respiration. A bitter odour and an injection site with a greenish blue ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109348082
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abstract::Diazinon is one of the most widely used organophosphate insecticides (OPI) in agriculture and public health programs. The aim of this study was to investigate how an OPI, diazinon, affects lipid peroxidation (LPO) and the antioxidant defense system in vitro. For this purpose, two experiments were carried out. In exper...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
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abstract::Severe carbon monoxide (CO) poisoning causes fulminant deaths in common environment as well as neurological sequelae to survivors. Prevention of delayed neurological syndrome (DNS) after exposure to CO, the most important sequela, is based up to date on hyperbaric oxygen administration. Nevertheless, its use remains c...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
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abstract::Recent years have seen substantial shifts in cultural attitudes towards cannabis for medical and recreational use. However, legalizing recreational marijuana may have adverse effects on individual and public health. As the most widely used illicit agent, cannabis is commonly reported to disrupt learning and memory. Un...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119886037
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abstract::1. Osmolal and anion gaps are helpful in the diagnosis and evaluation of intoxications with methanol and ethylene glycol. Reported reference values for osmolal gap and anion gap are -1 (+/- 6) mosm kg-1 H2O and 16 (+/- 2) mmol l-1, respectively. However, we have repeatedly found unexplained increased gaps in patients ...
journal_title:Human & experimental toxicology
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abstract::1 The concentrations of a range of organochlorine pesticide residues have been determined in 168 samples of human milk collected between January 1997 and May 1998 in the UK. 2 Of the 18 residues sought, only p,p'-DTT, p,p'-DDE, dieldrin, HCB, beta-HCH and gamma-HCH were detected. 3 The continuing trend of a reduction ...
journal_title:Human & experimental toxicology
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abstract::Enterococcus faecalis is a facultative anaerobic gram-positive commensal bacterium common in the gastrointestinal tract of animals and humans. This study aimed to investigate the protective effects of heat-killed E. faecalis EF-2001 (EF-2001) on acute gastric ulcer using a murine model of ethanol (EtOH)-induced acute ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119899987
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abstract::We have investigated the pituitary-testicular axis in a well-characterized population which was occupationally exposed to mercury vapour. Thyroid stimulating hormone and prolactin were also measured as indices of thyroid and pituitary endocrine function. We found no relation between blood or urine mercury levels or le...
journal_title:Human & experimental toxicology
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doi:10.1177/096032719101000309
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abstract::This study was carried out on rodents, to explore the neurobehavioral effects of acrylonitrile (AN) administered in drinking water. Thirty, male, Sprague-Dawley rats were randomly divided into three groups: two exposure groups (50 and 200 ppm AN), and one control group (tap water without AN). Three tests, including th...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107070563
更新日期:2007-03-01 00:00:00
abstract::A retrospective study was conducted on 269 patients with anticholinesterase poisoning who had been admitted to the Internal Medicine and Pediatric Clinics over the past 10 years. Their ages ranged from 17 d to 62 years. In adults, suicide was the most common means of intoxication. Miosis was the most frequent symptom ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719000900503
更新日期:1990-09-01 00:00:00
abstract::Comparisons on a linear and the Rozman logarithmic scale for dosage versus carcinogenicity in rodents are presented for methyl eugenol (ME), nitrosodiethylamine (NDEA), ethyl carbamate (EC) and 2-acetylaminofluorene (AAF). Each of these chemicals has been shown to be carcinogenic in experimental animals and, in additi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327105ht525oa
更新日期:2005-06-01 00:00:00
abstract::The fixed-dose procedure (FDP) was introduced as OECD Test Guideline 420 in 1992, as an alternative to the conventional median lethal dose (LD50) test for the assessment of acute oral toxicity (OECD Test Guideline 401). The FDP uses fewer animals and causes less suffering than the conventional test, while providing in...
journal_title:Human & experimental toxicology
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doi:10.1191/0960327102ht239oa
更新日期:2002-04-01 00:00:00
abstract::The renin-angiotensin system (RAS) subserves vital physiological functions and also implicated in certain pathological states. Modulation of this system has been proposed in recent studies to be a promising strategy in treating liver fibrosis. We investigated the effect of the pharmacologic inhibition of RAS with angi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111401051
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate, the cytotoxicity of orthodontic composites in vitro as a function of degree of conversion (DC) and the light curing units (LCU) employed on mouse fibroblast (L929). MATERIALS AND METHODS:Cured samples of the composites Light bond (Reliance Orthodontic Products, Itasca,...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113520020
更新日期:2014-10-01 00:00:00
abstract::1. Alveolar macrophages efficiently phagocytize particles deposited in the alveolar part of the lung. Phagolysosomal pH in alveolar macrophages from rabbits, dogs, baboons and guinea pigs is around 5 pH units. A low pH is of importance for clearance of inorganic particles and probably also for defence against bacteria...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719401300307
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abstract::This study was designed to evaluate the maternal toxicity and teratogenicity of fenproporex, one of the most widely-used anorectic drugs in many countries, including Brazil. Three periods of exposure were evaluated: (a) 30 days before mating; (b) from gestational day (GD) 0 to 14; and (c) 30 days before mating and dur...
journal_title:Human & experimental toxicology
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journal_title:Human & experimental toxicology
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doi:10.1177/096032719601500513
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abstract::Exposure to quartz induces pulmonary inflammation and development of fibrosis. In order to study the fibrosing process, we investigated morphology, function and phenotype of alveolar (AMs) and interstitial (IMs) macrophages at an early stage of fibrosis in rats. Rats were exposed by intratracheal instillations of 10 m...
journal_title:Human & experimental toxicology
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doi:10.1191/096032700678816124
更新日期:2000-07-01 00:00:00
abstract::A xenobiotic, well tolerated by the majority of treated patients, can cause serious complications in patients with individual susceptibility. Based on the hypothesis that such a phenomenon may occur in rare cases of rhabdomyolysis attributed to fenoverine (DCI), we designed a protocol to look for a genetic predisposit...
journal_title:Human & experimental toxicology
pub_type: 临床试验,杂志文章
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更新日期:1996-10-01 00:00:00
abstract:AIM:To assess the systemic inflammatory response (SIR) and the multi-organ damage after large-volume liver radiofrequency ablation (RFA) with or without concurrent Pringle maneuver. METHODS:Wistar rats were subjected to 30% liver RFA (group RFA), liver RFA under 30-min Pringle maneuver (group RFA + P), Pringle only (g...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111401438
更新日期:2011-11-01 00:00:00
abstract::In this study, genotoxic activities of four halogenated anesthetics (halothane, isoflurane, sevoflurane and desflurane) were investigated in human peripheral blood lymphocytes (PBLs) and sperm cells in vitro by alkaline comet assay. For this purpose, sperm or lymphocyte suspension was exposed to different concentratio...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327112446818
更新日期:2012-12-01 00:00:00
abstract::To clarify the reproductive toxicity of polychlorinated biphenyl compounds through determination of testicular lipid peroxidation, reactive oxygen species and enzymatic and non-enzymatic antioxidants in rats exposed to Aroclor 1254. Adult male rats were administered Aroclor 1254 at a dose of 2 mg/kg per day ip for 30 ...
journal_title:Human & experimental toxicology
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更新日期:2005-02-01 00:00:00
abstract::Sterigmatocystin (Stg), a major secondary metabolite of Aspergillus versicolor and A. nidulans, is the precursor of aflatoxin B1. In this study, male albino rats were treated with Stg-contaminated diet for 30 days, resulting in reduced levels of glutathione, ascorbic acid, and alpha-tocopherol. The activity of catalas...
journal_title:Human & experimental toxicology
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abstract::4-hydroxynonenal (4-HNE) and 6-hydroxydopamine (6-OHDA)-mediated damage in dopaminergic neurons is well documented. Protective potential of steroidal hormone (17β-estradiol) has also been suggested. However, therapeutic potential of such promising hormone is hampered due to complex brain anatomy and physiology. Thus, ...
journal_title:Human & experimental toxicology
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更新日期:2011-08-01 00:00:00
abstract::Phagocytes remove and store mercury (Hg) that enters the body. Macrophages and granulocytes respond in opposite ways to Hg: macrophages loose cell viability, and neutrophils become protected from apoptosis. We have investigated the cytology of early intake of Hg by macrophages and neutrophils after a short period (2-4...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327104ht472oa
更新日期:2004-08-01 00:00:00
abstract::In this study, we aimed to investigate disulfide/thiol homeostasis in trichloroethylene (TCE) exposure. The study was carried out in 30 nonsmoker TCE-exposed workers with a variety of occupations. Additionally, 30 healthy nonsmoker volunteers were recruited as the control group. TCE exposure was determined by measurin...
journal_title:Human & experimental toxicology
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更新日期:2016-09-01 00:00:00