Clinical features and treatment of Elapidae bites: report of three cases.

abstract：:Exposure to quartz induces pulmonary inflammation and development of fibrosis. In order to study the fibrosing process, we investigated morphology, function and phenotype of alveolar (AMs) and interstitial (IMs) macrophages at an early stage of fibrosis in rats. Rats were exposed by intratracheal instillations of 10 m...

journal_title：Human & experimental toxicology

authors： Zetterberg G,Elmberger G,Johansson A,Lundahl J,Lundborg M,Sköld CM,Tornling G,Camner P,Eklund A

更新日期：2000-07-01 00:00:00

abstract：:Three patients admitted to the Accident and Emergency Unit of Lagos University Teaching Hospital (LUTH) after eating a cassava based meal 'Gari' died shortly after admission. The patients vomited and complained of abdominal pain immediately after the meal. They were unconscious with renal failure and died of cardiopul...

journal_title：Human & experimental toxicology

authors： Akintonwa A,Tunwashe OL

更新日期：1992-01-01 00:00:00

abstract：:This study was focused on investigating the anticancer potential of indole-3-carbinol (I3C) against lung cancer H1299 cells via an increase in ROS levels. To investigate the induction of growth arrest and/or cell death in H1299 cells, a cell cycle arrest assay, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP...

journal_title：Human & experimental toxicology

authors： Lim HM,Park SH,Nam MJ

更新日期：2020-10-29 00:00:00

abstract：:Indomethacin, a non-steroidal anti-inflammatory drug is known to increase the efficacy and toxicity of methotrexate, the widely used anti-cancer drug in man. The mechanism for this interaction has not been clearly established. However, since these drugs bind with albumin, a possible displacement of methotrexate by ind...

journal_title：Human & experimental toxicology

authors： Raveendran R,Heybroek W,Caulfield M,Lawson M,Abrams SM,Wrigley PF,Slevin M,Turner P

更新日期：1992-07-01 00:00:00

abstract：:Oxidative stress has an important role in the pathophysiology of many occupational diseases. In this controlled exposure study, the intensity of oxidative stress biomarkers was assessed in the workers of natural sweet and sour gas refineries (SwGR and SoGR, respectively) and compared with controls. In addition, the ro...

journal_title：Human & experimental toxicology

authors： Mandegary A,Sezavar M,Saeedi A,Amirheidari B,Naghibi B

更新日期：2012-12-01 00:00:00

abstract：:N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (PK1) is a novel polymeric anticancer agent containing doxorubicin (approximately 8 wt%) bound to the polymer backbone via a Gly-Phe-Leu-Gly peptidyl linker. The approximate LD50 of PK1 in MF1 mice after a single i.v. injection was 63 mg/kg (doxorubicin-eq...

journal_title：Human & experimental toxicology

authors： Duncan R,Coatsworth JK,Burtles S

更新日期：1998-02-01 00:00:00

abstract：:Organic solvents can cause hearing loss themselves or promote noise-induced hearing loss. The objective of this study was to review the literature on the effects of low-level exposure to trichloroethylene on the auditory system and consider its relevance for the occupational settings. Both human and animal investigati...

journal_title：Human & experimental toxicology

authors： Vyskocil A,Leroux T,Truchon G,Lemay F,Gagnon F,Gendron M,Viau C

更新日期：2008-03-01 00:00:00

abstract：:To clarify the reproductive toxicity of polychlorinated biphenyl compounds through determination of testicular lipid peroxidation, reactive oxygen species and enzymatic and non-enzymatic antioxidants in rats exposed to Aroclor 1254. Adult male rats were administered Aroclor 1254 at a dose of 2 mg/kg per day ip for 30 ...

journal_title：Human & experimental toxicology

authors： Murugesan P,Senthilkumar J,Balasubramanian K,Aruldhas MM,Arunakaran J

更新日期：2005-02-01 00:00:00

abstract：:Previous studies have shown that environmental exposure to heavy metals has been related to epigenetic changes, such as DNA methylation in receptors involved in pathogenesis of asthma. One of these receptors is beta-2 adrenergic receptor (ADRB2). We conducted this study to examine the association between blood aluminu...

journal_title：Human & experimental toxicology

authors： Nafea OE,El-Korashi LA,Gehad MH,Yousif YM,Zake LG

更新日期：2020-10-01 00:00:00

abstract：:Acute exposure to systemic poisons represents an important challenge in clinical toxicology. We aimed to analyze the potential role of cardiac biomarkers, routine laboratory tests, and clinical scores as morbidity and in-hospital mortality predictors in patients intoxicated with various systemic poisons. We conducted ...

journal_title：Human & experimental toxicology

authors： Lionte C,Sorodoc V,Tuchilus C,Cimpoiesu D,Jaba E

更新日期：2017-07-01 00:00:00

abstract：:Until quite recently, pentabromodiphenyl ether (PentaBDE) was most commonly used as a flame retardant. Due to the considerably long atmospheric half-life of PentaBDE and its contribution to environmental pollution, it is categorized as a persistent organic pollutant (POP). As the data on the toxicity of PentaBDE is ra...

journal_title：Human & experimental toxicology

authors： Bruchajzer E,Frydrych B,Sporny S,Szymańska JA

更新日期：2011-05-01 00:00:00

abstract：:In this study we examined the effect of the aqueous extract of Thonningia sanguinea (T.S.) on 7-ethoxyresorufin O-deethylase (EROD, CYP1A1), 7-pentoxyresorufin O-dealkylase (PROD, CYP2B1/2), 7-methoxyresorufin O-demethylase (MROD, CYP1A2), aniline hydroxylase (aniline, CYP2E1), p-nitrophenol hydroxylase (PNPH, CYP2E1)...

journal_title：Human & experimental toxicology

authors： Gyamfi MA,Hokama N,Oppong-Boachie K,Aniya Y

更新日期：2000-11-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with high morbidity and mortality. miR-182-5p is overexpressed in several fibrosis-related diseases but its effect in pulmonary fibrosis has not been reported yet. To investigate the function of miR-182-5p in pulmonary fibrosis, we establish...

journal_title：Human & experimental toxicology

authors： Chen Y,Zhang Q,Zhou Y,Yang Z,Tan M

更新日期：2020-05-01 00:00:00

abstract：:The present study was undertaken to investigate the effects of maternal lead (Pb) exposure on the expression of interleukin (IL) 1β, IL 6, and glial fibrillary acidic protein (GFAP) in hippocampus of mice offspring. Pb exposure initiated from the beginning of gestation to weaning. Lead acetate (PbAc) administered in d...

journal_title：Human & experimental toxicology

authors： Li N,Liu X,Zhang P,Qiao M,Li H,Li X,Zhang H,Yu Z

更新日期：2015-04-01 00:00:00

abstract：:Accidental ingestion of electrical batteries occurs commonly in children. This rarely is associated with severe morbidity and mortality. Significant symptoms can arise due to leakage of alkali or heavy metals from the battery after degradation in the gastrointestinal tract. The main heavy metal of concern in electrica...

journal_title：Human & experimental toxicology

authors： Mallon PT,White JS,Thompson RL

更新日期：2004-04-01 00:00:00

abstract：:This study deals with pesticide exposure profile in some European countries with a specific focus on ethylenebisdithiocarbamates (EBDC). In all, 55 Bulgarian greenhouse workers, 51 Finnish potato farmers, 48 Italian vineyard workers, 42 Dutch floriculture farmers, and 52 Bulgarian zineb producers entered the study. Ea...

journal_title：Human & experimental toxicology

authors： Fustinoni S,Campo L,Liesivuori J,Pennanen S,Vergieva T,van Amelsvoort L,Bosetti C,Van Loveren H,Colosio C

更新日期：2008-09-01 00:00:00

abstract：:The time-dependent changes in lead (Pb) concentrations in major tissues, serum and urine, and the Pb biomarker delta-aminolevulinic acid (ALA) concentration in urine were studied in rats after sub-chronic Pb exposure. Female Sprague-Dawley (SD) rats were exposed to Pb in drinking water at concentrations of 100 ppm and...

journal_title：Human & experimental toxicology

authors： Kang HG,Jeong SH,Cho MR,Cho JH,Bischoff K

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:Accidental toxicity by organophosphate (OP) agents may occur among farmers during spraying season due to improper use and handling. Plasma cholinesterase (ChE) activity measurement is recommended to monitor the extent of exposure to the OP agent. The aim of the current study was to measure plasma ChE activ...

journal_title：Human & experimental toxicology

authors： Pakravan N,Shokrzadeh M,Bari MA,Shadboorestan A

更新日期：2016-03-01 00:00:00

abstract：:Methyl salicylate (oil of wintergreen) is widely available in many over-the-counter liniments, ointments, lotions or medicated oils for the relief of musculoskeletal aches and pains. Ingestion of methyl salicylate poses the threat of severe, rapid-onset salicylate poisoning because of its liquid, concentrated form and...

journal_title：Human & experimental toxicology

authors： Chan TY

更新日期：1996-09-01 00:00:00

abstract：:The aim of this study was to investigate the possible protective role of caffeic acid phenethyl ester on testicular toxicity of methotrexate in rats. Nineteen male rats were divided into three groups as follows: group I, control; group II, methotrexate-treated; group III, methotrexate + caffeic acid phenethyl ester-tr...

journal_title：Human & experimental toxicology

authors： Armagan A,Uzar E,Uz E,Yilmaz HR,Kutluhan S,Koyuncuoglu HR,Soyupek S,Cam H,Serel TA

更新日期：2008-07-01 00:00:00

abstract：:Rosiglitazone is in the thiazolidinedione class of drugs used in the treatment of type 2 diabetes mellitus. It works as an insulin sensitizer by binding to the peroxisome proliferator-activated receptor gamma. We investigated the effects of prenatally administered rosiglitazone on pyramidal cell numbers and morphologi...

journal_title：Human & experimental toxicology

authors： Sağır D,Eren B,Yılmaz BD,Eren Z,Keleş ON,Gökçe AB

更新日期：2018-08-01 00:00:00

abstract：:This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...

journal_title：Human & experimental toxicology

authors： El-Ebiary AA,Abuelfadl AA,Sarhan NI,Othman MM

更新日期：2013-06-01 00:00:00

abstract：:The present study was designed to evaluate the cardioprotective potential of lycopene (LCP) against isoproterenol (ISP)-induced myocardial infarction (MI), by assessing hemodynamic, biochemical and histopathological parameters. Wistar male albino rats were orally administered with LCP (0.5, 1.0 and 1.5 mg/kg) or with ...

journal_title：Human & experimental toxicology

authors： Ojha S,Goyal S,Sharma C,Arora S,Kumari S,Arya DS

更新日期：2013-05-01 00:00:00

abstract：:Phosphorus flame retardants are a group of chemicals that are used to slow or prevent the spread of fire. These compounds have been detected in different environments including human organism. In the present study, we have investigated DNA-damaging potential and effect on DNA methylation of tris(2-chloroethyl) phospha...

journal_title：Human & experimental toxicology

authors： Bukowski K,Wysokinski D,Mokra K,Wozniak K

更新日期：2019-06-01 00:00:00

abstract：:The epithelial Madin Darby canine kidney (MDCK) cell line and 17 human cell lines were examined for sensitivity to Clostridium perfringens type D epsilon-toxin. MDCK cells were confirmed as being sensitive to the toxin. In addition, the Caucasian renal leiomyoblastoma (G-402) human cell line was identified as being ep...

journal_title：Human & experimental toxicology

authors： Shortt SJ,Titball RW,Lindsay CD

更新日期：2000-02-01 00:00:00

abstract：:The identification of biomarkers for toxicity prediction is crucial for drug development and safety evaluation. The selective and specific biomarkers for antihistamines-induced cardiotoxicity is not well identified yet. In order to evaluate the mechanism of the life-threatening effects caused by antihistamines, we use...

journal_title：Human & experimental toxicology

authors： Yun JS,Kim SY

更新日期：2015-08-01 00:00:00

abstract：:1. In humans CaNa2EDTA increases urinary excretion of lead as well as that of essential metals such as zinc, ferrum and manganese but not that of copper. 2. We studied the effect of CaNa2EDTA injection on serum dopamine-beta-hydroxylase, a copper-dependent enzyme, in three male lead welders hospitalized for suspected ...

journal_title：Human & experimental toxicology

authors： De Paris P,Caroldi S

更新日期：1994-04-01 00:00:00

abstract：:The conventional method for the assessment of acute inhalation toxicity (OECD Test Guideline 403, 1981) uses death of animals as an endpoint to identify the median lethal concentration (LC50). A new OECD Testing Guideline called the Fixed Concentration Procedure (FCP) is being prepared to provide an alternative to Tes...

journal_title：Human & experimental toxicology

authors： Stallard N,Whitehead A,Indans I

更新日期：2003-11-01 00:00:00

abstract：:The objective of the present study was to perform histological and stereological examination of alcohol-induced changes in the optic nerve, considered an extension of white matter of the brain, in rats. This study included 20 male Wistar albino rats aged 60 days and weighing 190-220 g. The rats were divided into three...

journal_title：Human & experimental toxicology

authors： Igit T,Colcimen N

更新日期：2019-05-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA) is a powerfully addictive psychostimulant with pronounced effects on the central nervous system, but the precise mechanism of MDMA-induced toxicity remains unclear, specifically on the retina. This study was performed to investigate the effects of MDMA treatment on the retina a...

journal_title：Human & experimental toxicology

authors： Ma Y,Bian C,Song D,Yao G,Nie R

更新日期：2020-11-01 00:00:00