Abstract:
:In an effort to elucidate immunopathogenic of membranous nephropathy (MN), freshly collected sera from patients with biopsy proven MN were assayed of circulating immune complexes (ICs) by the Raji cell method and for anti-renal tubular epithelial (RTE) antibodies by a newly established radioimmunoassay (RIA) and by indirect immunofluorescence. 6 of 26 MN patients tested by the Raji cell assay had detectable circulating ICs. However, 5 of these 6 patients had other medical conditions which might also explain the IC reactivity. 29 MN patients and 11 patients with other glomerular diseases had no demonstrable circulating anti-RTE antibodies. This study suggests that if RTE antigens possess a nephritogenic potential for man it is probably only rarely expressed. The inconstant detection of circulating immune complexes in idiopathic MN raises an speculation as to their immunopathogenic significance.
journal_name
Nephronjournal_title
Nephronauthors
Zager RA,Couser WG,Andrews BS,Bolton WK,Pohl MAdoi
10.1159/000181675subject
Has Abstractpub_date
1979-01-01 00:00:00pages
10-6issue
1eissn
1660-8151issn
2235-3186journal_volume
24pub_type
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