Diminished parathyroid gland responsiveness to hypocalcemia in diabetic patients with uremia.

Abstract:

:The parathyroid gland responsiveness to hypocalcemia induced by short-term calcium-free hemodialysis in patients with insulin-dependent diabetes mellitus was investigated in comparison with 10 nondiabetic uremic patients and compared with test results from the autonomic nervous system. Diabetic patients had lower C-terminal parathyroid hormone (cPTH) levels before hemodialysis than uremic control patients and showed a significantly smaller increase in cPTH during hypocalcemia. The neurological tests revealed severe disturbances of the autonomic functions in the diabetic group. In conclusion, the disturbances observed in the parathyroid secretory pattern are probably caused by gland dysfunction; it is hypothesized that the defective autonomic nervous system has an additional effect on the development of this hormonal dysfunction.

journal_name

Nephron

journal_title

Nephron

authors

Heidbreder E,Götz R,Schafferhans K,Heidland A

doi

10.1159/000183689

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

285-9

issue

4

eissn

1660-8151

issn

2235-3186

journal_volume

42

pub_type

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