Onset, time course, and persistence of increased haemodialysis-induced breath isoprene emission.

Abstract:

:Recent findings of increased isoprene emission in the exhaled breath of patients undergoing haemodialysis and experimental evidence of the potential toxic and cancerogenic effects of isoprene hydrocarbon led us to assess how long haemodialysis patients are exposed to how much isoprene after a single haemodialysis session. Patients with end-stage renal failure on regular 4-hour (from 08.00 to 12.00 h) maintenance haemodialysis three times weekly were monitored. The breath isoprene content was analyzed by gas chromatography. Intrapatient evaluations were performed by collecting samples before, during, and immediately after the haemodialysis session, during the following hours, and on the following nondialysis day. The breath isoprene content increased in all patients. Isoprene overproduction showing a biphasic pattern was first detected soon after the dialysis session ended. These data show that haemodialyzed patients seem to be consistently exposed to high endogenous isoprene concentrations. The mechanisms and implications of this endogenous isoprene overproduction need to be elucidated with regard to the mevalonic pathway and in the physiopathological setting of the uraemia-dialysis syndrome.

journal_name

Nephron

journal_title

Nephron

authors

Trovarelli G,Brunori F,De Medio GE,Timio M,Lippi G,Pelli MA,Capodicasa E

doi

10.1159/000045958

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

44-7

issue

1

eissn

1660-8151

issn

2235-3186

pii

45958

journal_volume

88

pub_type

杂志文章

相关文献

NEPHRON文献大全
  • Persistent post-transplant autonomous hyperparathyroidism despite 23 years of excellent renal allograft function.

    abstract::Hyperparathyroidism is a common problem for patients on renal replacement therapy programs. Many long-term dialysis patients require parathyroidectomy while on dialysis. Some patients, however, despite severe renal osteodystrophy, are transplanted, and in these a large proportion show a slow resolution of bony problem...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000046051

    authors: Goldsmith D,Owen WJ

    更新日期:2001-09-01 00:00:00

  • Blood rheology after renal transplantation.

    abstract::Cardiovascular complications seriously affect posttransplant survival in patients after successful renal transplantation. Abnormalities in blood rheology may contribute to these complications. Therefore, we studied the blood rheology before and during a 1-year observation period after grafting in 9 patients by serial ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189330

    authors: Koppensteiner R,Derfler K,Ehringer H

    更新日期:1996-01-01 00:00:00

  • Effect of a low-protein diet on urinary albumin excretion in uremic patients.

    abstract::Fifteen patients with advanced renal failure (creatinine clearance less than 25 ml/mn) and with severe albuminuria (greater than 1.5 g/24 h) were put on a low-protein (0.3 g/kg body weight), low-phosphorus (5-7 mg/kg body weight) diet supplemented with essential amino acids and ketoanalogues. During the 6-month follow...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185189

    authors: Aparicio M,Bouchet JL,Gin H,Potaux L,Morel D,de Precigout V,Lifermann F,Gonzalez R

    更新日期:1988-01-01 00:00:00

  • Expression of intercellular adhesion molecule-1 and infiltration of lymphocytes in glomeruli of patients with IgA nephropathy.

    abstract::Using immunofluorescence, we studied 19 patients with IgA nephropathy to determine whether the expression of intercellular adhesion molecule (ICAM)-1 in glomeruli might reflect the disease activity. The relationship between the expression of ICAM-1 and the infiltration of lymphocytes, monocytes and polymorphonuclear l...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187984

    authors: Tomino Y,Ohmuro H,Kuramoto T,Shirato I,Eguchi K,Sakai H,Okumura K,Koide H

    更新日期:1994-01-01 00:00:00

  • A magnetic resonance imaging study of destructive spondyloarthropathy in long-term hemodialysis patients.

    abstract::It is most important to differentiate destructive spondyloarthropathy (DSA) from vertebral osteomyelitis (VOM), both showing similar roentgenographic findings and evaluate the spinal involvement of DSA. Magnetic resonance imaging (MRI) is useful for morphological and biochemical analysis of spinal lesions, but few stu...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186521

    authors: Maruyama H,Gejyo F,Arakawa M

    更新日期:1991-01-01 00:00:00

  • Effect of parathyroid hormone on antioxidant enzyme activity and lipid peroxidation of erythrocytes in five-sixths nephrectomized rats.

    abstract::The purpose of the study was to investigate the effects of parathyroid hormone (PTH) infusion on antioxidant enzyme activity and lipid peroxidation of erythrocytes in five-sixths nephrectomized (Nx) rats. Five-sixths Nx rats had a higher osmotic fragility in red blood cells (RBC). Thyroparathyroidectomy (TPTX) effecti...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189046

    authors: Chen SM,Young TK

    更新日期:1996-01-01 00:00:00

  • Critically ill patients requiring acute renal replacement therapy are at an increased risk of long-term renal dysfunction, but rarely receive specialist nephrology follow-up.

    abstract:BACKGROUND:Episodes of acute kidney injury (AKI) have been associated with the development of chronic kidney disease (CKD). However, follow-up pathways for patients who have survived AKI complicating critical illness are not well established. We hypothesised that patients who had AKI requiring renal replacement therapy...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000371448

    authors: Kirwan CJ,Blunden MJ,Dobbie H,James A,Nedungadi A,Prowle JR

    更新日期:2015-01-01 00:00:00

  • Case report of amyloidosis-like glomerulopathy with hepatic involvement.

    abstract::A few cases of nephrotic syndrome with the glomerular deposition of an amyloid-like material which did not stain with Congo red have been documented. But extrarenal deposits have not been previously reported in this disease. We describe here a case of nephrotic syndrome associated with the deposition of an amyloid-lik...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186449

    authors: Ozawa K,Yamabe H,Fukushi K,Osawa H,Chiba N,Miyata M,Seino S,Inuma H,Sasaki T,Yoshikawa S

    更新日期:1991-01-01 00:00:00

  • Hemodialysis Patients Display a Declined Proportion of Th2 and Regulatory T Cells in Parallel with a High Interferon-γ Profile.

    abstract:BACKGROUND:A high prevalence of cardiovascular diseases (CVDs) and infections in patients with chronic kidney disease (CKD) arises partly due to a high inflammatory state and aberrations in immune cells function. Following in vitro stimulation of leukocytes with different T-cell mitogens, we observed a lower level of i...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000471814

    authors: Mansouri L,Nopp A,Jacobson SH,Hylander B,Lundahl J

    更新日期:2017-01-01 00:00:00

  • Mesangial deposition of J chain-linked polymeric IgA in IgA nephropathy.

    abstract::Renal biopsy specimens from 8 patients with IgA nephropathy (Berger's disease) were examined immunocytochemically at the light and electron microscopic levels with peroxidase-labeled antibodies to IgA, IgM, J chain and secretory component. In 2 of the 8 specimens heavy deposits of IgA, but no IgM, were found in the me...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182907

    authors: Komatsu N,Nagura H,Watanabe K,Nomoto Y,Kobayashi K

    更新日期:1983-01-01 00:00:00

  • Activation of epidermal growth factor receptor in the early phase after renal ischemia-reperfusion in rat.

    abstract::In order to estimate a regenerative response in the early phase after renal ischemia-reperfusion in rat, we examined the time course of the activation of epidermal growth factor receptor (EGFR) as a response of signal transduction pathway after 45 min ischemia in kidney. The activation of EGFR was observed 5-30 min af...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045281

    authors: Yano T,Yazima S,Hagiwara K,Ozasa H,Ishizuka S,Horikawa S

    更新日期:1999-02-01 00:00:00

  • Changes in active and inactive renin with haemodialysis.

    abstract::Active (A) and inactive (I) plasma renin concentrations (PRC) were examined during haemodialysis in relation to blood pressure and body weight changes. Patients had either one (n = 15) or two (n = 51) remnant kidneys in situ, or were anephric (n = 4). 6 of the two remnant kidney patients had non-functioning renal allo...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182848

    authors: Thatcher R,Whitworth JA,Skinner SL

    更新日期:1982-01-01 00:00:00

  • Improvement of histological and immunological change in steroid and immunosuppressive drug-resistant lupus nephritis by high-dose intravenous gamma globulin.

    abstract::From July 1984 to December 1987, 9 patients with lupus nephritis did not respond to the administration of two courses of methylprednisolone pulse therapy and cyclophosphamide treatment for 56 days. Therefore, high-dose intravenous human gamma-globulin (IVIG) was administrated. Before IVIG therapy, renal biopsy showed ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185772

    authors: Lin CY,Hsu HC,Chiang H

    更新日期:1989-01-01 00:00:00

  • Trajectory of Estimated Glomerular Filtration Rate Predicts Renal Injury in Children with Multicystic Dysplastic Kidney.

    abstract:BACKGROUND/AIMS:Children with a solitary functioning kidney have a risk of renal injury caused by hyperfiltration. Timely intervention with renin-angiotensin inhibitors may be beneficial. We examined whether trajectory of estimated glomerular filtration rate (eGFR) would predict renal injury, defined as microalbuminuri...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000490200

    authors: Matsumura K,Sugii K,Awazu M

    更新日期:2018-01-01 00:00:00

  • Neutrophil adhesion molecules in chronic hemodialysis patients.

    abstract::The expression of the adhesion molecules LFA-1 (CD11a-CD18), Mac-1 (CD11b-CD18), and LAM-1 on predialysis and intradialysis neutrophils (PMN) was analyzed by flow cytometry in 10 chronic hemodialysis patients (CHD) and compared with age-matched normal controls. All patients were dialyzed either with a polyacrylonitril...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188255

    authors: Zachée P,Daelemans R,Pollaris P,Boogaerts MA,Lins RL

    更新日期:1994-01-01 00:00:00

  • Porphyrins in renal transplantation.

    abstract::The porphyrin status of 38 renal transplant patients was investigated using a sensitive thin-layer chromatographic assay. Abnormalities of porphyrin synthesis observed in patients on hemodialysis were generally reversed on receipt of a transplant with sustained good renal function. Urinary coproporphyrin levels and th...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182426

    authors: Day RS,Eales L

    更新日期:1982-01-01 00:00:00

  • Influence of long-term amelioration of anemia and blood pressure control on left ventricular hypertrophy in hemodialyzed patients.

    abstract::The course of left ventricular hypertrophy was investigated in anemic hemodialysis patients treated with recombinant human erythropoietin (r-huEPO). 12 patients, aged 60.8 +/- 9.9 years (mean +/- SD) were treated for 18.8 +/- 2.7 months. Left ventricular size was estimated by echocardiography performed before treatmen...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186829

    authors: Zehnder C,Zuber M,Sulzer M,Meyer B,Straumann E,Jenzer HR,Blumberg A

    更新日期:1992-01-01 00:00:00

  • High proximal excretion of sodium during activation of beta 2-adrenoreceptors in humans.

    abstract::The effects of acute beta 2-type adrenoreceptor activation with intravenous albuterol on plasma and urinary sodium, potassium, calcium, magnesium, phosphate and lithium were investigated in 9 volunteers during acute hydration. When compared with the control infusion with inactive vehicle, beta 2-type adrenoreceptor ac...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187403

    authors: Duss G,Bianchetti MG,Cattaneo FA,Mullis PE,Krämer R,Peheim E,Oetliker OH

    更新日期:1993-01-01 00:00:00

  • Effect of the immunosuppressive agent, ciclosporin, on experimental immune complex glomerulonephritis in rats.

    abstract::Effect of the immunosuppressive agent, ciclosporin (CS), on bovine serum albumin (BSA) nephritis in rats was evaluated. Eight weeks after immunization, 19 male Wistar rats received a daily intravenous dose of BSA (2 mg). Two weeks later, 11 rats received BSA and an oral dose of CS (10 mg/kg), and 8 rats received only ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186251

    authors: Fujita M,Iida H,Asaka M,Izumino K,Takata M,Sasayama S

    更新日期:1991-01-01 00:00:00

  • Renal Injury During Preclampsia: Role of Extracellular Vesicles.

    abstract::Preeclampsia (PE) represents an important cause of acute kidney injury during pregnancy with a high rate of both maternal and fetal morbidity and mortality. The presence of endothelial dysfunction is the main cause of PE development; however, the pathogenic mechanisms are not still fully elucidated. A plethora of harm...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000502456

    authors: Pagani F,Cantaluppi V

    更新日期:2019-01-01 00:00:00

  • Percutaneous renal biopsy in children: a 27-year experience.

    abstract:BACKGROUND:The introduction of automated biopsy devices and the localization of the kidney by ultrasound were aimed at optimizing efficacy and safety of the percutaneous renal biopsy procedure. We evaluated these technological advances in our renal biopsies performed in children. METHODS:We sequentially used the Silve...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000045090

    authors: Feneberg R,Schaefer F,Zieger B,Waldherr R,Mehls O,Schärer K

    更新日期:1998-08-01 00:00:00

  • Radial arterial spasm in uremic patients undergoing construction of arteriovenous hemodialysis fistulas: diagnosis and prophylaxis with intravenous nicardipine.

    abstract::Radial arterial spasm in uremic patients undergoing construction of internal arteriovenous (AV) dialysis fistulas was investigated transcutaneously using ultrasonic Doppler flowmetry. In 5 of 15 patients, radial arterial blood flow was significantly decreased 5 min after anastomosing the radial cephalic vein with the ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187390

    authors: Owada A,Saito H,Mochizuki T,Tanaka M,Otsuka M,Yokoyama Y,Fukuda S

    更新日期:1993-01-01 00:00:00

  • Aseptic peritonitis in patients on maintenance peritoneal dialysis.

    abstract::An 'epidemic' of aseptic peritonitis occurred in our peritoneal dialysis unit, affecting 5 of 20 patients. Acute and convalescent viral titers were normal in all 5. The peritoneal fluid of the affected patients was not tested for endotoxin, but endotoxin was found in subsequent dialysis fluids from two machines in the...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181728

    authors: Gandhi VC,Kamadana MR,Ing TS,Daugirdas JT,Viol GW,Robinson JA,Geis WP,Hano JE

    更新日期:1979-01-01 00:00:00

  • Exercise and Prediabetes after Renal Transplantation (EXPRED): Protocol Description.

    abstract:BACKGROUND:Post-transplant diabetes mellitus (PTDM) is a frequent and severe complication after renal transplantation. In fact, PTDM is a risk factor for both infection and cardiovascular diseases. The prevalence and incidence of PTDM have a bimodal evolution: early (up to 3 months) and late PTDM (beyond 12 months). Th...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000511320

    authors: Morales Febles R,Negrín Mena N,Rodríguez-Rodríguez AE,Díaz Martín L,González Rinne F,Marrero Miranda D,González Rinne A,Álvarez González A,Pérez Tamajón L,Acosta Sørensen C,Rodríguez Hernández A,Domínguez-Rodríguez A,García Baute

    更新日期:2021-01-01 00:00:00

  • Studies on abnormal lipid metabolism in experimental nephrotic syndrome.

    abstract::The specific lipid alterations in plasma and four different tissues, as well as the activities of plasma lecithin-cholesterol acyltransferase (LCAT) and tissue lipolytic enzymes were determined in experimental nephrotic and control rats. In nephrotic rats, the cholesterol level in the heart was significantly increased...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187323

    authors: Agbedana ED,Yamamoto T,Moriwaki Y,Suda M,Takahashi S,Higashino K

    更新日期:1993-01-01 00:00:00

  • Cellular component of vascular calcification. Fibroblasts are essential for calcium deposition in cultured cells.

    abstract::It has been reported that calcium deposition and calcium content in cultured human aortic smooth muscle cells (SMC) increased when the cells are incubated in a medium with a high phosphate concentration (2 mM). To determine the cellular components or soluble factors contributing to the deposition, we cultured commerci...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000065461

    authors: Watanabe Y,Suzuki M,Oyama Y,Kusano E,Tamba K,Iimura O,Ito C,Imai M,Asano Y

    更新日期:2002-12-01 00:00:00

  • A new kindred with hereditary hypophosphatemic rickets with hypercalciuria: implications for correct diagnosis and treatment.

    abstract::Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is a new autosomal form of hypophosphatemic rickets, recently described. This disease is characterized, and differs from other forms of hereditary hypophosphatemic rickets and/or osteomalacia by increased serum levels of 1,25-dihydroxyvitamin D, hypercalci...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187029

    authors: Tieder M,Arie R,Bab I,Maor J,Liberman UA

    更新日期:1992-01-01 00:00:00

  • Non-A, non-B hepatitis in patients on dialysis: retrospective evaluation of measures taken to limit the diffusion of the virus.

    abstract::329 patients were evaluated from 1978 to 1990. 40 new cases of non-A non-B hepatitis were observed, all regarding patients on hemodialysis. Since the beginning of 1989, we introduced measures to limit the diffusion of the virus: reduction to a minimum of blood transfusions and a new disinfection protocol for monitors,...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186929

    authors: La Russa A,Bufano G,Cauzzi L,Pecchini P

    更新日期:1992-01-01 00:00:00

  • Serum aluminium level in the veneto chronic haemodialysis population: cross-sectional study on 1,026 patients.

    abstract::A total of 1,026 patients undergoing haemodialysis as the only chronic treatment were studied in all the dialysis units of the Veneto region, Italy. Aluminium was determined in water, dialysis fluids, and patients' serum. Aluminium mean concentration was 9.1 micrograms/l in tap water and 13.3 and 15.7 micrograms/l in ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185381

    authors: Piccoli A,Andriani M,Mattiello G,Nordio M,Modena F,Dalla Rosa C

    更新日期:1989-01-01 00:00:00

  • Reduced collagenolytic activity of rat kidneys with steptozotocin diabetes.

    abstract::Collagenolytic activity of rat kidneys with streptozotocin diabetes was estimated by means of a biological collagenase assay and compared to healthy controls. Collagenolytic activity was found significantly decreased in rat kidneys with diabetes correlating with blood glucose levels (r = -0.82, p less than 0.001). Ele...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182517

    authors: Lubec G,Leban J,Peyroux J,Sternberg M,Pollak A,Latzka U,Coradello H

    更新日期:1982-01-01 00:00:00