Influence of long-term amelioration of anemia and blood pressure control on left ventricular hypertrophy in hemodialyzed patients.

abstract：:In a 21-year-old Caucasian women with von Hippel-Lindau disease, norepinephrine-producing adrenal pheochromocytoma was identified as the underlying cause of severe hypertension. She was found to have extremely elevated levels of circulating renin and aldosterone, and she was markedly hypokalemic. Administration of cap...

journal_title：Nephron

authors： Lenz T,Thiede HM,Nussberger J,Atlas SA,Distler A,Schulte KL

更新日期：1992-01-01 00:00:00

abstract：:The effects of chitosan-coated dialdehyde cellulose (chitosan DAC), a newly developed oral adsorbent for urea and ammonia, were examined in a glomerulonephritis model in rats. Mesangial proliferative glomerulonephritis accompanied with proteinuria was induced by an intravenous injection of anti-rat Thy-1.1 monoclonal ...

journal_title：Nephron

authors： Yagi M,Kato S,Nishitoba T,Sato H,Kobayashi N,Iinuma N,Nagano N

更新日期：1998-01-01 00:00:00

abstract：:The three-dimensional ultrastructure of glomerular basement membrane (GBM) in surgically resected human kidneys was observed by the quick-freezing and deep-etching method. In three layers of human GBM, the middle layer exhibited polygonal meshwork structures, which were composed of fine fibrils. In addition, the outer...

journal_title：Nephron

authors： Moriya T,Ohno S,Yajima Y

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Outcomes in patients treated with haemodialysis(HD) are potentially influenced by the delivered dose of dialysis. The UK Renal Association publishes clinical practice guidelines recommendations for dialysis dose. The urea reduction ratio (URR) is a widely used measure of dialysis dose and has been historical...

journal_title：Nephron

authors： Shaw C,Steenkamp R,Davenport A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Idiopathic membranous nephropathy remains the leading cause of nephrotic syndrome in Caucasian adults. Immunosuppressive therapy with cyclosporine (CSA) is often successful in reducing proteinuria, but its use is associated with a high relapse rate. Rituximab, a monoclonal antibody that specifically targets ...

journal_title：Nephron

authors： Fervenza FC,Canetta PA,Barbour SJ,Lafayette RA,Rovin BH,Aslam N,Hladunewich MA,Irazabal MV,Sethi S,Gipson DS,Reich HN,Brenchley P,Kretzler M,Radhakrishnan J,Hebert LA,Gipson PE,Thomas LF,McCarthy ET,Appel GB,Jeffers

更新日期：2015-01-01 00:00:00

abstract：:We determined the clinical and immunopathological effects of dilazep hydrochloride (dilazep) on IgA nephropathy of ddY mice. Group I (early-treatment group, n = 10) was orally treated with 300 mg/kg body weight of this drug from 12 weeks of age until 60 weeks of age, and group II (late-treatment group, n = 10) was als...

journal_title：Nephron

authors： Hayashi T,Kaneko S,Thang NT,Shou I,Shirato I,Tomino Y

更新日期：2000-11-01 00:00:00

abstract：:We found a strain of nonobese, nondiabetic (NON) mice which has spontaneous lipid deposition in glomerular capillary lumina. This strain was developed together with a diabetic strain of nonobese diabetic (NOD) mice for the generation of mouse models of diabetes mellitus. In the NON strain, contrary to the name, impair...

journal_title：Nephron

authors： Watanabe Y,Itoh Y,Yoshida F,Koh N,Tamai H,Fukatsu A,Matsuo S,Hotta N,Sakamoto N

更新日期：1991-01-01 00:00:00

abstract：:Micropuncture studies were performed in intact and thyroparathyroidectomized (TPTX) dogs to evaluate the relationship between the absolute level of serum ultrafilterable phosphate concentration (SUFP) and proximal bicarbonate reabsorption. In both groups of animals, a reverse linear relationship was noted between the ...

journal_title：Nephron

authors： Puschett JB,Fernandez PC

更新日期：1977-01-01 00:00:00

abstract：:The ability of cultured peripheral-blood mononuclear cells (PBMC) to release interleukin-1 alpha and beta (IL-1 alpha, IL-1 beta) in response to concanavalin A (con A) was investigated in patients with chronic renal failure (CRF) and in renal transplant recipients. Mean IL-1 alpha level released by PBMC of healthy sub...

journal_title：Nephron

authors： Kang XX,Hirano T,Oka K,Tamaki T,Sakurai E,Kaji N,Yoshida M,Kozaki M

更新日期：1991-01-01 00:00:00

abstract：:An abnormal level of serum lipids may be one of the major risk factors for the development of atherosclerosis in patients with chronic renal failure (CRF). In the present study, the effect of polyunsaturated fatty acid-rich and low carbohydrate diet on serum lipids and HDL-cholesterol was studied in 6 nonnephrotic and...

journal_title：Nephron

authors： Tsukamoto Y,Okubo M,Yoneda T,Marumo F,Nakamura H

更新日期：1982-01-01 00:00:00

abstract：:ExHC rats were bred from the Sprague-Dawley strain and are highly susceptible to dietary hypercholesterolemic stimuli. Although chemical and histological examination of the aorta from ExHC rats fed a diet containing 3% cholesterol, 0.6% sodium cholate and 15% olive oil (high-cholesterol diet, HCD) has been reported, r...

journal_title：Nephron

authors： Hattori M,Yamaguchi Y,Kawaguchi H,Ito K

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are a new class of treatment for renal anemia in patients with chronic kidney disease (CKD). This meta-analysis was designed to evaluate their efficacy and safety. METHOD:Eight databases were searched for randomized controlled trials (RCTs). ...

journal_title：Nephron

authors： Wen T,Zhang X,Wang Z,Zhou R

更新日期：2020-01-01 00:00:00

abstract：:Acute interstitial nephritis (AIN) has been reported in association with therapy with a number of drugs. We report a patient who developed drug-related AIN while receiving intravenous amoxicillin therapy. The patient developed rash, secondary temperature elevation, and eosinophilia in association with nonoliguric rena...

journal_title：Nephron

authors： Appel GB,Garvey G,Silva F,Francke E,Neu HC,Weissman J

更新日期：1981-01-01 00:00:00

abstract：:Malignant hypertension and high plasma renin activity was found in a 39-year-old woman with an aldosterone-producing adenoma. Only 3 similar cases have been previously reported, and all patients died before or after identification of the adenoma. The present paper documents the first reported case of a successfully ma...

journal_title：Nephron

authors： Ideishi M,Kishikawa K,Kinoshita A,Sasaguri M,Ikeda M,Takebayashi S,Arakawa K

更新日期：1990-01-01 00:00:00

abstract：:The acute renal hemodynamic changes during induction of passive Heymann nephritis (PHN) may be of importance for the understanding of the pathogenesis of this model. We studied the renal blood flow (RBF) and glomerular filtration rate (GFR) during and after infusion of anti-FxlA into the left renal artery of rats for ...

journal_title：Nephron

authors： Sekse I,Iversen BM,Matre R,Ofstad J

更新日期：1989-01-01 00:00:00

abstract：:Cardiovascular disease remains the major cause of mortality in hemodialysis patients. Abnormal oxidative stress and impaired antioxidant defense may contribute to accelerated atherogenesis associated with uremia. As oxidative modification of lipids appears to be a prerequisite for the development of atherosclerotic le...

journal_title：Nephron

authors： Lim PS,Chan EC,Lu TC,Yu YL,Kuo SY,Wang TH,Wei YH

更新日期：2000-12-01 00:00:00

abstract：:In kidney allografts, focal segmental glomerulosclerosis (FSGS) has been described as recurrent, de novo, or a histological variant of chronic transplant glomerulopathy. We describe a unique case of de novo FSGS in a renal transplant not accompanied by any feature of rejection in a patient who had not been immunosuppr...

journal_title：Nephron

authors： Trimarchi HM,Gonzalez JM,Truong LD,Brennan TS,Barrios R,Suki WN

更新日期：1999-01-01 00:00:00

abstract：:A 57-year-old man with renal cell carcinoma associated with membranous glomerulonephropathy (MGN) developed a transient amelioration of the nephrotic syndrome after excision of the tumor. We tried to identify a nephritogenic tumor antigen using the immunoblotting technique in this patient with MGN, since previous stud...

journal_title：Nephron

authors： Togawa A,Yamamoto T,Suzuki H,Watanabe K,Matsui K,Nagase M,Hishida A

更新日期：2002-02-01 00:00:00

abstract：:Serum ferritin level has been shown by many investigators to be a good indicator of bone marrow iron stores in normal subjects. Although this correlation may hold in some pathological situations, it is lost in others. In leukemia a dissociation has been observed between serum ferritin levels and bone marrow iron store...

journal_title：Nephron

authors： Nuwayri-Salti N,Jabre F,Saab G,Daouk M,Salem Z

更新日期：1991-01-01 00:00:00

abstract：INTRODUCTION:In an attempt to decrease mortality in patients with end-stage renal disease, an increase in the lifetime of these patients without much focus on health-related quality of life (HRQOL) was pursued for a long period of time. However, lately, an improvement in the quality of this extended lifetime has focuse...

journal_title：Nephron

authors： Grincenkov FR,Fernandes N,Pereira Bdos S,Bastos K,Lopes AA,Finkelstein FO,Pecoits-Filho R,Qureshi AR,Divino-Filho JC,Bastos MG

更新日期：2015-01-01 00:00:00

abstract：:In order to elucidate the mechanism of peritoneal dialysis fluid inhibition of cell functions, laboratory-prepared fluids were used to investigate the specific influences of low pH and high lactate concentration on neutrophil viability, phagocytosis, respiratory burst activation and leukotriene B4 (LTB4) generation. I...

journal_title：Nephron

authors： Liberek T,Topley N,Jörres A,Petersen MM,Coles GA,Gahl GM,Williams JD

更新日期：1993-01-01 00:00:00

abstract：:Efficacy and safety of a low-molecular-weight heparin (LMWH) were studied in 33 stable maintenance hemodialysis patients who had a bleeding tendency on unfractionated heparin. The optimal dose of LMWH for each patient was titrated before the study; the mean total LMWH dosage was 1,152 +/- 574 IU. No major bleeding or ...

journal_title：Nephron

authors： Leu JG,Chiang SS,Lin SM,Pai JK,Jiang WW

更新日期：2000-12-01 00:00:00

abstract：:Plasma and urine beta-2-microglobulin (B2m) were measured in 37 renal transplant recipients and 34 healthy subjects. Serum B2m was found to be a more sensitive index of renal function than serum creatinine. Renal transplant recipients had significantly higher urine B2m when compared with normal controls. Normal subjec...

journal_title：Nephron

authors： Woo KT,Lee EJ,Lau YK,Lim CH

更新日期：1985-01-01 00:00:00

abstract：:Ischemic acute kidney injury (AKI) is predominantly mediated by the innate inflammatory response to damage-associated molecular patterns released during the reperfusion phase of the ischemic event. In this study, we show that pre-emptive IgM infusions to increase binding of natural IgM (nIgM) anti-leucocyte autoantibo...

journal_title：Nephron

authors： Lobo PI,Okusa MD

更新日期：2019-01-01 00:00:00

abstract：:Gentamicin doses of 40 mg/kg body weight/day were administered intravenously to 62 Wistar rats. Nineteen animals were also treated orally with an NaHCO3 solution in place of water. The gentamicin-treated animals showed increased albuminuria immediately after the 3rd day of treatment. The fact that this increase was ma...

journal_title：Nephron

authors： Coimbra TM,Lachat JJ

更新日期：1988-01-01 00:00:00

abstract：:Platelet-activating factor (PAF) belongs to a new class of lipid chemical inflammatory mediators described as acetyl glyceryl ether phosphorylcholine. Although PAF has been implicated in kidney injury, its role in renal immune injury has not been clearly defined yet. We studied the levels of PAF in the plasma and urin...

journal_title：Nephron

authors： Iatrou C,Moustakas G,Antonopoulou S,Demopoulos CA,Ziroyiannis P

更新日期：1996-01-01 00:00:00

abstract：:The effect of the antiplatelet agents, ticlopidine and dipyridamole, on nephrotoxic serum nephritis (NTN) was evaluated in rats. An accelerated form of NTN was induced with preimmunization of rabbit IgG 7 days before injection of rabbit antirat nephrotoxic serum. Twelve animals received a peroral dose of 20 mg of ticl...

journal_title：Nephron

authors： Izumino K,Iida H,Asaka M,Sasayama S

更新日期：1987-01-01 00:00:00

abstract：:Mixed IgM-IgG cryoglobulins were present in the serum of a patient with the nephrotic syndrome, recurrent purpura, chronic active hepatitis and ascites. A renal biopsy demonstrated deposition of IgM, IgG, and complement components C3 and C4 in intracapillary 'coagula' and glomerular capillary walls. No glomerular depo...

journal_title：Nephron

authors： Zimmerman SW,Dreher WH,Burkholder PM,Goldfarb S,Weinstein AB

更新日期：1976-01-01 00:00:00

abstract：:Two patients with AIDS-related complex who presented with renal failure and microscopic hematuria were found to have mesangial deposits of IgA at renal biopsy. Though such glomerular deposits have not yet been reported in patients with HIV infection, their occurrence is most likely not coincidental. Indeed, there are ...

journal_title：Nephron

authors： Kenouch S,Delahousse M,Méry JP,Nochy D

更新日期：1990-01-01 00:00:00

abstract：:Methylguanidine (MG), guanidinosuccinic acid (GSA) and creatinine (Cr), which accumulate in the body in parallel with the progress of renal failure after adenine administration, were given separately to rats in order to compare their toxicities. Food containing adenine was given to rats for 24 days to induce renal fai...

journal_title：Nephron

authors： Yokozawa T,Mo ZL,Oura H

更新日期：1989-01-01 00:00:00